DTIC ADA435925: Quantification of Lewisite in Air by Liquid Chromatography Mass Spectrometry (LC/MS) PDF
Preview DTIC ADA435925: Quantification of Lewisite in Air by Liquid Chromatography Mass Spectrometry (LC/MS)
NOITACIFITNAUQ FO ETISIWEL NI RIA YB DIUQIL YHPARGOTAMORHC SSAM YRTEMO)RSTMC/ECPLS( snikn enJor a,Aregrebnedue reFve t,Sdleiffe hySrre h,Skcarbnac ryEelseW noitaropro Cygolonhce Tdn aecneic S TCARTSBA hlli wetisiwe ltah tdenimrete dnee bsa htI snoitidno ctneibm aredn uezidix odn aezylordy sdohte mdehsilbu ptso M.dnuopmo c5+s An as ihcih w)ARVC (dic acinosr alynivorolh cmro fot o tdnuopmo cloihti dahti wetisiwe lf onoitazitavire deh teriuqe retisiwe lf osisylan aeh trof tca hdtnuopm oeaccudorp sdoht enmoitazitavir eed h.Thpargotamor hsc agagni sduezyla n eanba ARV Ceh ttah ttca feh to teu ds ihcih wnoisicer pdn aytilibicudorpe rroo peva hyllareneg ri an adehsilbats eeva hsrohtu aeh T.dnuopmo cloihti deh ty bdezitavire de bto nlli wdnuopmoc inom gniru dri aeh tmor fdelpma sARV Cdn aetisiwe lhto bro ftnuocc alli wtah tdohte mgnirot d neab uttnebr odsil ofas fdoetcart xee rAaR VdC neatisiw ehlt o.Bsdoir egpnilpm assuoirav .yrtemortce psssam/yhpargotamor hdciuq i yldbezylana NOITCUDORTNI siweL 2e(ti s tieic n. idSnuopm olcacines r-caix o sat)ienisraorolhcidlynivorolhc rekr otwceto r opdterotin o emtbs usmnoitartnecn orcop a,vnegonicr adcetceps u sasdaezirogetac e bo tgnio gs idnuopmo ceh tereh wdn aderot ss ilacimeh ceh tereh wsaer an iytefas . dezilartu en r itanereff ildareveS tro semo sdeyolpm eeva hll adn adepoleve dnee -beva hsdohte mgnirotinom seuqinhce tnoitazivitavire de h .Tetisiwe lf otnuom aeh tyfitnau qo teuqinhce tnoitazivitavire dfo hti dhti wetisiwe lf onoitcae rlacimeh can oyler elbanem aero ms itah tdnuopmo caecudor po tloi ,ycaruc cda nnaoisice rrpo ohpt idweuga lnpe eebv asheuqinhc eets e. hyThpargotamor hsc aogt .sru ooh wdtnoy esbem intoitarip shat iywlralucitrap yCm rsAeta tdSeti neU h ttsaroht uea h ytdbemrofr ehpcraeseR snoitinu Mtneg Alacimeh d nyacaruc cdaevorp mhit idwoht e namdietaniml usc a)hSDMACAS Um(ets ylSasopsiD tnebro sdilo sssal gasyolpm edohte meh T.sdohte mruo hevlew tgnitsix eo tderapmo cnoisicerp rop asavtcell otca h)ths e0m4/06(ATxan ehTt idwekc aepbut evlew tf odoire parev oelpma s enax ehht idwetcart x,eeb uttnebr oes h ntdoetcell o sceitisi w. eeLtun irm espret i5l . t0saruoh y bdeifitnau qs itcartx eeh T.edixore pnegordy h% 6gnidd ay bdezidix odn alonahte mdna LC/MS. 1 Report Documentation Page Form Approved OMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. 1. REPORT DATE 2. REPORT TYPE 3. DATES COVERED 00 JAN 2002 N/A - 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Quantification Of Lewisite In Air By Liquid Chromatography Mass 5b. GRANT NUMBER Spectrometry (Lc/Ms) 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION Science and Technology Corporation REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release, distribution unlimited 13. SUPPLEMENTARY NOTES This article is from ADA409494 Proceedings of the 2001 ECBC Scientific Conference on Chemical and Biological Defense Research, 6-8 March , Marriott’s Hunt Valley Inn, Hunt Valley, MD., The original document contains color images. 14. ABSTRACT 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF 18. NUMBER 19a. NAME OF ABSTRACT OF PAGES RESPONSIBLE PERSON a. REPORT b. ABSTRACT c. THIS PAGE UU 8 unclassified unclassified unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 DNUORGKCAB oyrtsimeh cehT tah tstnemirepx eeh tf oemo shti wgnol adessucsi de blli wetisiwe Lf .snoitcae reh tetadila vo tdetcudno cerew ETISIWELSNOITCAER .sisylord y shdiip atrs o em. hsTnoitca etrnereff ildarev esseogred neutisiweL lCsAHCHClC +H O (cid:224))HO(sAH CH ClC +H lC 2 2 2 )AA V eC t(d ii sc ia s w u e o Ln o s r al y n i v o r o l h C os lna aAc A. 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eswretlif e hbtros boyattili bs a tfeiosuaceb ndietari p sear eswelpm a es. hrT iea hmto rnfegyxo .)%09> (devorpm ihcu mere wseirevoce retisiwe leh tdn aerofe bs arenna mema seht NOI TEAPTDIISXIOWEL ET ADR NYAAWHTA er eswtnemirep xoe w,tet adr nyaawht anpoitca eer hdtn i ofdt nyaroe het htts ertehtr uofT t. enAsoitadi x oortoi rrpuc c oodt ashisylord y fheinimret e odst atwsr i ef. hdTemrofrep hti wdelli fsregnipm issal gfo dekip shca eere wlonahte mhti wdelli fte srehton adn aretaw r espret i5l . t0saregnip mei hhtguor hdtelbb usb arw idaesserp m. oeCtisiw e fl goh1utiw e. hDTSM/CL P yHebtisiw erl odfezyla near eswelpm a es. hrTu oeh nro oeftunim hte mhti wdelli fsregnipmi reta whti wdelli fsregnipm ie h .T%0 9f oyrevoce rada hlona sAiA V oCettisiw eel h ftsoisylord ytha hetdulcn osctlus e er. h%T0 1 f<yorevoc edarah .noitadi x nopie ttssr iefht tisiw e fLnooitadi xeo hrt oeft anroitca eeartamit s oest atws edtnoc eeshT .AARV Co te t1saetun ir5m odfetarip sda neatisiw e fl go0n8 0h1t idweki pesr esweb uttnebr o fstoes 2 detarips adn aetisiwe lf og n080 1hti wdekip sere wsebu tf ote srehto n .Aetuni mre pretil la ns aaewlpm ah.sc eatEun ir mespret i5 l.ts0aru o2rh1of .ARV Cdn aetisiwe lro fdezy e h ntdoe s. asBetun i 5md1 n,asetun i 0m,3ru o,1hsru or2 hodfetaep esr aswseco rspihT ne hdt nnaoitarip s fasoetun i 5md1 nsaetun in5meewt erbuc c oostnig enboitadi x,oatad s i. h )Te1rug ieFe ss(etun i 5mr1et ffa fsolevel noitadix oeh to teu dyleki ltso msi .ri aeh tn inegyx of onoitartnecno ceh to teu dmuirbiliuq en agnihcae rnoitcaer etisiweL fo noitadixO %06 %05 %54 %05 %73 %04 %83 %04 %03 dnu oAFR Vf%Co %51 %02 %01 %0 % of CVRA Found minu5t es mi1n5u tes mi3n0u tes mi6n0u tes m1i2n0u tes m7i2n0u tes noitarips AemiT)setunim( .eb uttnebr odsi l noeaostisiw efnlooitadi x.eO1rugiF ECTAS PEASTRDVACEH le ff omar g1yletamixorppA e. hlTonahtem/AR VLCm/ g7u 9 n6dieka oesr eswd atp eb uttnebr ohast idwelpm ass aewcapsda e eh. hrTebma hdceta e nahdieca lepr eswdap s aewrudeco reprit ne.e hSTM/ C yLAbR VrC odfezyla nsa aewlpm ae.s hrTu or1hof 0,7erutarepm ettneib m tadaemrofrep ndinu oAfR V% C1 s .<ae0 w r.0e C5hd 1TnCa .draz arhop atav oynllaitnes s seAiR VtCa hntoisulcn osacwa rhdci h,wecapsda eehht tnacifingi sadn alonahtem/etisiwe lLm/g u79 8gnis udetaepe rsa wtnemirepx eeritn eehT u teh tn odnuo fsa wetisiwe lf otnuoma ht iAwR V fCeorusse rrpop aev hetrapm o. oceTb Lm/g u52 4gnis udetaepe rniag asa wtnemirepx eeh t,tneg alacimeh cnwon kaf otaht s atwnuo mtanacifing ida snDaPF/ C yGdbezyla nsa a Xwe.V hlTonaporposi/XV .derevocer VC/etisiw etla hetveil esbroht ueahT hguohtl ao .Setartsbu san oezidix oyln olli wAA daer pedsblu od cndaraz athcat n sto,aiicdraz arhop atvnacifin g t i aossAniRVC .tnerr urc i yadbeirr agcni edb nsaelcitr atps u ndgonitisop e ydrb iea hhtguorht 3 YGOLODOHTEM reh tgniweive rretfA lli wetisiwe ltah tyllacificep s,stnemirepx esuoiver peh tf ostluse 2 1adesopor psrohtu aeh t,emi tf onoitcnu fas aezidix oneh tdn aytidimu ho teu dri an iezylordyh reh T.to nr odezidix osa wetisiwe leh trehteh wkro wdluo wtah tdohte mgnirotino mri aruoh erofe . deniat b eodblu orw idaelpm aes h ntnioitartnecn oectisiw eel h ftnooitatneserp eertaruc cear oam .wol edbenilt u sodioht eem hettadil a ovdtemrofr esp atwa hytdu tyscaruc cda nnaoisice rephT NOITARIPSA ilpu dn idekip sere wsebu ttnebro sevlewT 0g 8n ,d0 4gn 1,6 na0g 8 , 4 n6egt5,1tna02ac feogare vtahgi eewm iet hstem i5t .,10 .,18 .,05 .,02 . o0dtednopserr osceki pe.s hg0Tn261 sseco rs pi. heTtun irm espret i5l . t0saru oehvle wrt odfetarip sear esweb ue.t h3Tm/ g3m00.0 rf odfetaep esraw .selp mlf8a ao4s r tsoao yftraudo EXTRACTION mets y es. hmTets ynsoitcart xeesa hdpil odseifid ogamni sduetcart xee rsaelpmaS odte se ursap ietttep icpit s.a plmP umpuu c da anvkac alr a ,iadvlofin anmoitcart x nfesaotsisnoc nsieb uttnebr oes httif eh totn idetresn is ipi te h .T) 2erugi Fees (dlofina mmuuca veh tot deso lec rsaevl atvr onpoitcart x le. lpA ictitsa lep hott ndieca l speib uttnebr oes hdt ndalofinam .n odehctiw ss ipmu pmuuca veh tdna o teh to tdeilpp as ienaxe hf oL m52. 0touqil anA d n )ae3rug ieFe se(b uttnebr oes h ftpo dewoll as iebu te h .Tylthgil sevla veh tgninep oy bebu teh thguorh tdellu pe bo tdewoll aylwols L5m2 .l0anoitid d. nadAeso l sceivl aev hhtci hrwet fsadnoc e 0sy1letamixorp pra oyf rrd ioat saeinax e fhtoouqila tnebro seh thguorh twol fo tdewoll adn aebu ttnebro seh tf opo teh to tdeilpp .kca reh tn iebu ttxe neh to tn osevo mtsylan ae h .Trenna mema seh tni noitcart xeem aes hstmrofr etpsyla nea h,tenax ehht idwetcart xnee eebv asheb ult lraetfA hti werudecorp stcart xeenax eehsuac edbe seu rsatnevl otsnereff i od. wlTonaht e fmsotouqi l4a ll itw uAbR VsCtcart xleonaht edm nAaR VtCcart xte olnl itw uebb uet h nttonese reptisiw eylna .etisiw etlcart xyeletauqe dtaon Lo5m2 .,0detcart xnee eebv asheb uet hrtetfA hca eo tdedd as iedixore pnegordy h% 6f .ARV Cotn itneser pAAV Cr oetisiwe lyn asezidix osi h .Tlaiv 4 .mets ynsoitcart xeeb uttnebr odsi l. eo2rSugiF .erudeco rnpoitcart xgenir uedb uttnebr o osttnevl ogsnid dtasyl a . ne3ArugiF SISYLANA maS ss a em. hSTM/CL P0H0 1s1eigolonhc etTneli g nA nadoezyla nea rsaelp ecru oysarpsortce lneoitazin oeirusse rcpirehpsom that iewloparda ueqlgn isas arhetemortceps nis uedo mevitage nn idemrofre ps isisylan aelpma se h .T)stnio pte sf otsi lro f1elba Tees( g 5 gnitlus e er. h)Tz /9m.2 2d1 nza /9m.8 4,1z /9m.6 8,1z /9m.4 8s1n ori ogfnirotin onm oeivitceles n oliat oet hgtni sdueifitna udq nsaoit anr oairtce psss adm neam intoitnet e yrdbeifitne d siaitad ott ndiediv ied r,aselpm a 2s f1to ehs c. amEargotamorhc gnie bte shca ehti w, 6f oste sow .tsyla ntanereff i yaddbezylana NOITARBILAC slionaht e nmeitisiw eLLm/ g 6u f 1no2oitartnecn o taceatisiw e fLnooitul odsradna tAs CL Pe Hhettarbil aodctesu -r odsil ogsniki pydsberape re prsaevr uncoitarbil a.CDSM seb uttneb dradna tes h ftnooitcej nhic aree t. feAtisiw e flgon02 6d1 n,a g0n8 0,1 g6n 1h2t iewtacilp undi e h.Tetunim/sret i0 l.y1letamixorp ptsaaetu n ri 5omdfetarip se arsaeb uttnebr oe sh,tnoitulos ep hgtni sduezyla nda ndaetcart xee rsaeb uttnebros noitatSmeh Ce h .Tevob adenife dserudecor .selpm adsezyla nyafitna u oqdt naat aedvr uncoitarbil aec hdtroc e ordte s sueirawtfos STATISTICAL RESULTS sisyla nlaacitsita toast ndieret nde npauo reglgn ioast ndielo oepr eswtni oapt a 8dl4lA ll amcargorp dnu oef hstusr envoitartnecn otcegr aet htto l opdte ssu amwargo r ep. hyTfitr edCe .noitalup oapt aed hrt onfoitartnecnoc e . h 2%Ts9 aswelpm aes h ftyorevoc eergare vea hT .4%0. 8s 3asws admnu onyfitniatrecnu E CDNLAETIPFECCA mre tgno leh ttse toT .demrofre psa wydut senilesa bya d0 3adohte mwe neh tf oytilibats d ndaetcart x,edetarip sear eewb uktna ld)a bneatisiw e gL0n80 1e(b udteki psasru o 2hy1revE o fkee wasya d5detaepe rsa wssecor psi h .Tdohte meh tn iserudecor peh tgniwollo fdezylana r 4 . 4erugi Fn idezirammu ser aseirevoce rtneg ae h .Tskeew Lewisite 12 Hr DAAMS Baseline Study %00.041 PercentRecovery %00.021 UCL %00.001 UWL %00.08 LCL %00.06 LWL %00.04 egarevA %00.02 %00.0 %9.78 = egarevA %39.31 = noitaiveD dtS .leR dt s *1=LW dts * 2 = LC etaD noitaripsA .yramm ueSniles arBu o 2H .1e4rugiF 6 ARU GTINFENMOUCRTSNI TION dohte meh tpoleve do tdes unoitatnemurtsn ieh tf oyrammu sas i) 1elbaT (gniwollo fehT ye keh tdna .tnemurts nei hrt osftni otpes t etSnemur t.Es 1LnBIAT - .stniop noitatnemurtsnI ss aBM649 1hGt ihwpargotamor hdCiuq ieLcnamrofr ehPg i0H0 1s1eigolonhc etTneligA .ecru oysarpsortce lnEoitazin oeIrusse rcPirehpsom t nAgani sruetemortcepS otP etSnemurtsnI doht eAMR VrC osftni Cdnetx Eseigolonhce Ttneli g :AnmuloC - m,5u m0m 5mx1m1 .821 nim/l m2 . :0wol FpmuP lonahteM/HO 4 2HM0 N.502/ 5:7esa hePliboM des Ut o :Nrotcete Dyarr AedoiD I P:Aed onMoitazin oDISM - ES delban E:retli FemiT ni m01. 0:htdiwkaeP MoIIS :9n. 221 : 0r9otnemgarF :9 n.M o8II4S1 : 0r7otnemgarF :9 n.M o4II8S1 : 0r5otnemgarF :9 n.M o6II8S1 : 0r5otnemgarF :0 n.i 1aVGME : DpsSmaM eGCT053 nim /0:L. s 2ag1Gniy rDDSM g:i es5rp3usse rrPezilub eDNSM : p Da 0SC0MV0V4 emulo VnoitcejnI :0L1u C: 5t2atsomre hnTmuloC setuni m7 . :1emi Tnoitnete RdetcepxE SROVAE DENREUTUF rorr edecudn if oecnah ctsetaer geh tdohte meh tn iserudecor peh tf ohca egniweive rretfA de esntsyla neare hkws adtetnei rloiat e sad. tinIoitcart xee hgtnir usdi dn agniniar tdoo geva ho t ydbesserd dgani e sbeius sei hytltner r. usCtlus eertaruc cda neasice repcudo r opetcitcarp .rorr eetanimrete deh tezimini mdluo wtah tmetsy snoitcartx edetamotu an agnipoleved NOISULCNOC aile ryln oer asdohte mnoitazitavireD ts o .Mtneser ps iAAV Cr oetisiwe Lneh welb eh t,dezidix os ietisiwe leh tf .Inoitadix oo teu detisiwe lf osso leh tro ftnuocc ato no dsdohtem gniru dyllaiceps eseirevoce retisiwe lwo ls itluse rdn ee h .Tkro wto nlli wnoitcae rnoitazitavired rip sraegnol dl e. i)Fsru o2h >s(em intoita we nelbai vadet-artsnome dsa hdohte msih tgnitset .ycarucc adn anoisicer pdoo ghti wetisiwe lro fnoitcete df odohtem 7 STNEMGDELWONKCA tinu Mtneg Alacimeh Ceh tf oes ueh tro fymr A.S. Ueh tknah to teki ldluo wsrohtu aehT snoi si hgtnik a nmtiropp urs oxf onCell adD nnaell aeMve toSs lda nyatilic amfets ylSasopsiD .elbiss ohpcraeser 8
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