03-B-aa8 Award ember: DAMDL? TITLE: 13°" tnternatioaal Hypoxia syrposiun fer tne Publishing of the Coaferenue Pzuceedinge for 2003 Conference PRINCIZAL TRVRSTTCATOR: Robest Rosch, Pa.D pever ‘lackel © Wagner CONTRACT=NG ORSNNTAATIOW: University of Colorado Dealch Sclenves Center Aursrs, Colorado apcas- asce Fanvary 2004 TEPE cy Fiuul Proneedings PREPARED PCR: U.S. Arwy Medical Research and Pommand Fort Letrick, Narylan¢ 21702-2012 DISYRIBUTICH STATHVENT: Approved for Public Release; Digcribstion taluiled The views, opincona and/or tindinge contained in chis report are those of the author(s) aud should not he coastrued as an official Dopartnest of she Army position, policy or decigion umleun an Gesignated by otaex documeatation. Form Aaproved OMB Ne 074.0766 ‘deme Bn Bazuacy 2004 Flusl groveedinge (19 Doc 02-18 Des 031 1a" tatavnat ional nypoeia syeposium for the publishicg | aano17-05-7-0226 fe Conference Proceed ing fee 2902 Coates AUTHOR Robert Roach, £0: ever Unekett 7 PERFOR ORGATIERTION HAWES AND ADDRESSES, “5 FERFORIIG ORGANIZATION University of Colorado Heath Selozoes Dentor REPORT NUMBER Burara, colorado a604s-0508 Etta rroschshypoxia net ‘AGeNeY Nowe} AND ADORESSIES ‘ane erg MUMERER 3.8. Remy Hodica? Research axé materiel command Fort Detrick, Naxy-end 21762-5012 Original conts-ns color plates. ALL TIC reprod Approved for eublic Releane; DisLy:nution Untia ved ‘The publication Hypoxia: Through the Tifoeycle, publixted in December, 2003 by Menum Klusver Acadernic Publishers, NY, NY is he result of U.S. Army Medical Research and Materic] Command support of the 13" Internationet Hypoxis Symposican, syparia, perfornasce, exerc‘ee Daeraae! fied Ueclaceisied unt imi tog EN TSA SD Sa RETR AB ey 2p HYPOXIA Through the Lifecycle .. 20040206 087 ADVANCES IN EXPERIMENIAL MEDICINE AND BIOLOGY Rose Ye i ti aie Vetus 35 ALYCODILACY ND aN Es iy labs ©. utd setae 36 CCHRMOKECEPTION: Pom Ct Sopy 1 Fein Pacts TEs by leah Pagne, Cantanla Gnas, Cain 8. Nine, ‘Nitaus We aba, an oe Dinas ‘MATHTABATICAL MODELING MA NOTRITION AS TRE HEATTH SCIPNCFS "ln haa A. Nason. Mel H.C aC. Boxon Solume 38 MORPEAR AR AND CALLULAR ASPECTS OF MUSCLE CONTRACTION Til hy Harts Sag ote 9 BLADDER DISEASE, Par ant Pat 8: Hassach Concept nea Aicus ‘Bed by Hoon Aue and Debt lado. OXYGEN TRASSPORT Ta. SST, Yor URE 2 ‘Eta Ey Mitten Thome, Did Asso, a PbilpT. Tres ote $31 FRONTIERS Te CLINIC aed by Tass ee ohms $82 QUATIT OF FRESH AND PROCRSSED: FOODS died by Phd Se AA Bp CF Tg Uo, Tay Brags [NEUMOSLIENCE: Newspeurin ud Neropreeton Noe 3 LHYPORIA: Tog the feet ald by Rob. Ron Pe D. Vag. eter H-Hckae oun 46 PLRORISUMAL DISORDERS AND RLGULALIUS OF GENES eid hy en Rete Mori Rage an Sella D> Blo HYPOXIA Through the Lifecycle Fated by Robert C. Roach Peter D, Wagner caf eaten S os and Peter H. Hackett Kluwer Academic/Plenum Publishers [New York, Boston, Dordrccht, Loniton, Mascow ra — eM nxn meme Ba © 5-5 Dwnicngsy Pepe Mou Gober Cy bebe FT Wapurs PB. iheer D3 Tio. 1 sale Songs FV 1682 704) mare bea nan ihr mera ey ety na AUTHORS FOR CORRESPONDENCE Stephen Le Aruker Univer af Ate Huxpls CB Waller © htonaie Health Seeness {Cenir, Fdmentan, T6C287, Cua ‘el: 10.81.8558 Ba Fela 602 nat srcberDese.ab 2a (Chapee20) ‘Danan Mes Bailey Reader u Pisology, Uyposta Research Uns, Depraent f Pogslogy. Unieeriy of amargan, Pontypris, Seth We, WK C¥57 HOT, ‘TeleoL44 482296 Tas (0113) 482285 Lull dhileygfam acne (Chapter 4) ‘Luciano Beveardi ‘Ciiea Medica, IRCCS $ Mateo und University of Pain 27100 Pavia. ale Tel 99.0383-500979 Fox 1329-0982-52196, Ea bea 2asipeit (Chapter 11, Richard Comelussea Deparinent ofPiysiolegy CCaiorasolr Research Eas Meutielt ouzaich Unley PO Ben 86, 6200 MD Mansi The Neterts a3 HT Fax a1 3861106 Final: Richard Comnelesvn@. le aan ane 9) rank 4. Dinenso ‘Mayo Cle and Foundaion Tepanusat of Ansethesalogy 200 Fit Suse SW Resheser, MN 35405 Fas. (597) 255.1300 rol nena dana (Chapter 16) Sandra Donnelly isin of Nephrolvey St Misael Henpa 61 Quesn Sue Eat, Flour Terao, Otro, MSC 272, Cal Tes eT U6! Fx 35T- 3684 tl: [email protected] AChagoer3) seat orage Tamer Immm:agy Progra Dowtches Kober np ra Neuembsimer Fold 240 69126 Heidelberg, Gemmary Phone +49-6221-103706 ax 440-6201 -12076 Tina: WDeocgofgDKEZde (Chapter 13) ‘Max Gosemana Taste of Veterinary hysislogy Uniseriy of 7h Winethrerstose 260 CUOS? Zikich, Swizeran, Talsdt) 1618802 Fax (Hl) 1635 66 4 Ell: mexeBiceesvmihch (Chopter 6,20) * ACTHORS FOR CORRESPONDENCE Sarah a. Gebd Mathew Kinser C¥PLabortary Ar Ritsn Cllege 0" Metisine ‘aversity Cloris Heth Scien Cir POR 226 200 3 Avenue New York HY 10159.0226 Denver, C0 90262 USA Ta Larr.en4009 TA GASHI5-510¢ Fax H.505434.6179 Fax (0098154871 Email: ekdoseydEnecum, put Farsi sarc getngchac cd (Chagner 10) (Chaplets Fahlnla tdn-Velarde nich Gnaiger Unie Pena Cagetana Heredia Deparment of Tanaplan Srgery lle Haan Delgada 182 1, Swarovski Reseach Laboratory San Bimin de Pars Ap, Lima, Bow Univesity Hospital beck TSU OOF Anka, 35, 46020 Fsroes, Ausia Fax #51.1 310.0018 Tel 43 512 $04 4523 Fail: Bbiolnupchedape Fax 493 512505 4605 AChapter 26) Bail weshasaigeruithocal (Chaptes3) Dareo Maguoria Inteonve Care Unt DIM Yel KH Univer Hospi 122 silage al Rimini 100. 12a aise of Ono N80 Zurich, Gwitveand Eugene, OF 903.1405 8 Tel O06) 1255 2204 Tal ah) 386-8415 Fa GML 125934 ax (S41) 346-2884 nui: blame usu ona Binal: bale @ooegone (Chapter 13) Chapter 18) Avan K MeMartry ‘Thora R Horabsin VP Lebertery Deprtiment of Anestesiol Univesity Colrado Meath Seienoes Cr Uniersily Bishingloa School Medicine ZOU, Th Avemte Seni, A, USA Denver, Colerado 80262 USA Tel s25787-4836 vel (03) 318-4476 Fie 0577071858 oe G00) 315-4871 ail: bomb: achington ct una ivanraemimygQuetse cot Chapter 1) (Coayter AUTTIORS FoR CORRESPOSDENCR (Cheicopher T Minson ‘eperimen of Exereze ad Moventeet seienoe Unies of ego 1220 Caiveeny of Oregon Bagens, OR 793-1240 TSA Ta SAT 346-4108 Fae AU-3462041 [mail risondoregenuocegonel Chapeer 17 Ghaudle Stor MIAMI, BAUT.HS Tis do Bugoon. 1011 Lausanne CHT ‘pt, Sites ‘Tereat 265140076 Fx H4121 31409 28 iil = Chautia Santeria (Chipter 189 sebopprich Pav Schumacher patent Medicine MCGO2S 5841 South Merjand AvorDe (icago, IL 60637 US Tet 779 2-600 Fag 774 702-136 Era: ola vet (Chapters) edicinebedaeieag “ona W, Severingbaas PO Ra 974 Hoss 04 94957 C84 TeA(A1D) 486 4503 Yun (15) 785-3480 mud onde vested (Chapter2) H Kennath Storey Initae of Bache Carlton Uhiverety tt, Ort, Canada, Te ersNISte Fay 61552022568 En: RomoreGoe.ctletan.on (Chapter, 25) Robert J. Tomanck: eapartagnt of Anacamy and Cel Bistogy sats HSH Untensty of ee loss Cay 1A 82202 8A TAG} 35-760 ee (5199 335-7194 Raul: robee-omenetiiuow. elu (Chases) Richard D. Venn {Cente for Hyperbari Medicine and Froironcitat Pissiologe Depiinent uf Anesbesislegy BO. Bow 3823, Duke Deivesiy Medical Center, Dear, NC 7710 US, ‘Tevlo-e84-3305, Fax 915-680-4002 irl: ranma PREFACE, ‘The Intemational Hypoxia Sympasinm convenes bianzually to bring topethes linexnacionl expens from many Belds to explote estate oft atin normal na pulhuphysiclopical responses to hypoxia, Ropreventatives from five continents and 32 sourires joined together February 2003 for four days inthe dramatic ‘mounluine of Baal, Albert, [As edie of the Praceedings ofthe lncernationst Hypoxia Symposia, we sive ta maintain 2 26 six year waition of preventing u sGmlating bled of etnical and husie seience papers focused on itypania, Tapien covered in 2003 inclede bibemation avd hypova, hypoxia and fetal developmeat and new advances in high aliude pubhophysiclogs, oxidative ress and membrane dumee, hypoxle segulation af blond flow, lial shuck pivteins in hypoxia, and futare directions in yposta search 1.2003 we also lad the privilege of honoring Join W Severinzhans as a ftend, csolleagro, montar and inspiration to many in the field, Tora Homateti’s personal ‘ule to Tohn Sovcvingtians isthe fee chapter in this volume, fllowed by an cntcriining update of the history of the discovery of oxygen writen by Jun Sevoringhaus, ‘Acibule by Ke Storey to out fate ttend and collongus, Par Hochachk isin (Chapter23. Peer eas s longtime supporter ofthe Intemational Hypoxia Symposia, and a deat personal fiend hoi grwtly missod! Another rule for the Interntionsl Hyporia Symposia is to serve 25 an ingeruational forum fora variety af working ureups focused on particular problems, oul related ty bh aliude physiology o¢ pathophysiology. The Internacional Hypoxia Sympesia are hore tn the Lake nese Avute Mountain Sickmess (AMS) ‘Scot; the Chiceen's AMS Score an the Guidelines for Children st High Attitude. ‘Continuing that radon we prevent u paper Gum the chronic maustainsickaass seorking group. A now CMS scare is presoated, and the first Englich ‘paper of CMS and is seating, “La desadasracion a fa ‘da en las grande’ Alteas” 1s presented along withthe orginal article in Spanish ‘Ansther working group met atthe Intemational Hypoxia Symuposia preset in ‘Chapter 25 thle proposal fora scandaed approach 1o AMS epidemiology: “The abstract from the 2003 meeting were published in Tigh Aivude Mediaine ‘aud Biology 3(4), 2000, with several fate absaacla prevented in Chapter 26 ‘We hege that this collection of papers especially prepared for this volume allow us to share witha broader audience some of the inellectual exceamet cht embodies the sprit ofthe Hypexda meet Robert C Roach, Peter D. Wegner, Peter H, Heche, Ealtors, May 2002,