Drugs of Abuse: Pharmacology and Molecular Mechanisms PDF
Preview Drugs of Abuse: Pharmacology and Molecular Mechanisms
Drugs of Abuse Pharmacology and Molecular Mechanisms Drugs of Abuse Pharmacology and Molecular Mechanisms Sherrel G. Howard, Ph.D. MolecularandMedicalPharmacologyandChildPsychiatry UniversityofCalifornia,LosAngeles Thiseditionfirstpublished2014 C⃝2014byJohnWiley&Sons,Inc. Editorialoffices: 1606GoldenAspenDrive,Suites103and104,Ames,Iowa50010,USA TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UK 9600GarsingtonRoad,Oxford,OX42DQ,UK Fordetailsofourglobaleditorialoffices,forcustomerservicesandforinformationabouthowtoapply forpermissiontoreusethecopyrightmaterialinthisbookpleaseseeourwebsiteat www.wiley.com/wiley-blackwell. Authorizationtophotocopyitemsforinternalorpersonaluse,ortheinternalorpersonaluseofspecific clients,isgrantedbyBlackwellPublishing,providedthatthebasefeeispaiddirectlytotheCopyright ClearanceCenter,222RosewoodDrive,Danvers,MA01923.Forthoseorganizationsthathavebeen grantedaphotocopylicensebyCCC,aseparatesystemofpaymentshasbeenarranged.Thefeecodes forusersoftheTransactionalReportingServiceareISBN-13:978-1-1182-8845-0/2014. Designationsusedbycompaniestodistinguishtheirproductsareoftenclaimedastrademarks.All brandnamesandproductnamesusedinthisbookaretradenames,servicemarks,trademarksor registeredtrademarksoftheirrespectiveowners.Thepublisherisnotassociatedwithanyproductor vendormentionedinthisbook. LimitofLiability/DisclaimerofWarranty:Whilethepublisherandauthor(s)haveusedtheirbest effortsinpreparingthisbook,theymakenorepresentationsorwarrantieswithrespecttotheaccuracy orcompletenessofthecontentsofthisbookandspecificallydisclaimanyimpliedwarrantiesof merchantabilityorfitnessforaparticularpurpose.Itissoldontheunderstandingthatthepublisheris notengagedinrenderingprofessionalservicesandneitherthepublishernortheauthorshallbeliable fordamagesarisingherefrom.Ifprofessionaladviceorotherexpertassistanceisrequired,theservices ofacompetentprofessionalshouldbesought. LibraryofCongressCataloging-in-PublicationData Howard,SherrelG.,author. Drugsofabuse:pharmacologyandmolecularmechanisms/SherrelG.Howard. p. ; cm. Includesbibliographicalreferencesandindex. ISBN978-1-118-28845-0(cloth) I. Title. [DNLM: 1. CentralNervousSystemAgents–metabolism. 2. StreetDrugs–pharmacology. 3. Substance-RelatedDisorders–therapy. QV76.5] RC564 362.29–dc23 2013045068 AcataloguerecordforthisbookisavailablefromtheBritishLibrary. Wileyalsopublishesitsbooksinavarietyofelectronicformats.Somecontentthatappearsinprintmay notbeavailableinelectronicbooks. CoverdesignbyMattKuhns Setin9.5/12.5ptPalatinobyAptaraInc.,NewDelhi,India 1 2014 Dedication Thisbookisdedicatedtomyson,Jon-ErikAkashiandmystudentsinNS 182,fromwhomIhavelearnedsomuch. Contents ContributorList ix Preface xi Acknowledgments xiii 1 Introduction 1 PartI Stimulants 13 2 BiochemistryofNeurotransmission 15 3 AmphetamineandAmphetamineAnalogs 33 4 Cocaine 65 PartII Depressants,SedativeHypnotics,andAnxiolytics 75 5 BenzodiazepinesandBarbiturates 77 PartIII DissociativeAnesthetics 93 6 PhencyclidineandKetamine 95 7 γHydroxybutyrate 105 PartIV Analgesics 115 8 MorphineandMorphineAnalogs 117 CarlosCepeda PartV Hallucinogens 135 9 LysergicAcidDiethylamideandMescaline 137 10 Marijuana 153 11 InhalantsandMiscellaneousDrugs 167 PartVI RecoveryandRelapse 181 12 TreatmentofSubstanceDependency 183 MarkDeAntonio Index 189 vii
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