Drugs of Abuse

130 Pages·2016·3.87 MB·English

Alcohol and
Other Drug Abuse 101
Christina M. Delos Reyes, MD
Medical Consultant, Center for Evidence-Based Practices
Evidence-Based Practices Conference 2016
October 19 and 20, 2016
Cleveland, Ohio

www.centerforebp.case.edu
www.centerforebp.case.edu
Learning Objectives
Part I. What are the drugs of abuse? What are their
effects?
Part II. What is addiction? What are substance use
disorders?
Part III. How do I work with individuals with substance
use disorders? What strategies will keep
them engaged in treatment?
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Classes of Drugs of Abuse
 Stimulants
 Caffeine
 Nicotine
 Cannabis
 Opioids
 Sedative-hypnotics
 Hallucinogens
 Dissociative Drugs
 “Club drugs”
 Anabolic Steroids
 Inhalants
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Stimulants
 Examples:
 Amphetamine (prototype)
 Cocaine (most common, includes “crack”)
 Methamphetamine (“crank,” “ice”)
 MDPV (“bath salts”)
 Methylphenidate
 Ephedrine
 Khat
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Stimulants
 All have sympathomimetic activity and cause
euphoria
 Routes of administration: Oral, IN, IV, smoked
 Reinforcing effects are predominantly related to
dopaminergic effects in the nucleus accumbens
 Tolerance and cross-tolerance occur
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Stimulants
 Medical uses
 Attention deficit disorder
 Narcolepsy
 Treatment resistant depression
 Obesity (YIKES!)
 Local anesthesia (cocaine)
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