Drugs and nutrients: the interactive effects PDF
Preview Drugs and nutrients: the interactive effects
DRUGS AND NUTRIENTS DRUGS AND THE PHARMACEUTICAL SCIENCES A Series of Textbooks and Monographs Edited by James Swarbrick School of Pharmacy University of North Carolina Chapel Hill, North Carolina Volume 1. PHARMACOKINETICS, Milo Gibaldi and Donald Perrier (out of print) Volume 2. GOOD MANUFACTURING PRACTICES FOR PHARMACEUTICALS: A PLAN FOR TOTAL QUALITY CONTROL, Sidney H. Willig, Murray M. Tuckerman, and William S. Hitchings IV (out of print) Volume 3. MICROENCAPSULATION, edited by J. R. Nixon Volume 4. DRUG METABOLISM: CHEMICAL AND BIOCHEMICAL ASPECTS, Bernard Testa and Peter Jenner Volume 5. NEW DRUGS: DISCOVERY AND DEVELOPMENT, edited by Alan A. Rubin Volume 6. SUSTAINED AND CONTROLLED RELEASE DRUG DELIVERY SYSTEMS, edited by Joseph R. Robinson Volume 7. MODERN PHARMACEUTICS, edited by Gilbert S. Banker and Christopher T. Rhodes Volume 8. PRESCRIPTION DRUGS IN SHORT SUPPLY: CASE HISTORIES, Michael A. Schwartz Volume 9. ACTIVATED CHARCOAL: ANTIDOTAL AND OTHER MEDICAL USES, David 0. Cooney Volume 10. CONCEPTS IN DRUG METABOLISM (in two parts), edited by Peter Jenner and Bernard Testa Volume 11. PHARMACEUTICAL ANALYSIS: MODERN METHODS (in two parts), edited by James W. Munson Volume 12. TECHNIQUES OF SOLUBILIZATION OF DRUGS, edited by Samuel H. Yalkowsky Volume 13. ORPHAN DRUGS.edited by Fred E. Karch Volume 14. NOVEL DRUG DELIVERY SYSTEMS: FUNDAMENTALS, DEVELOPMENTAL CONCEPTS, BIOMEDICAL ASSESSMENTS, edited by Yie W. Chien Volume 15. PHARMACOKINETICS, Second Edition, Revised and Expanded, Milo Gibaldi and Donald Perrier Volume 16. GOOD MANUFACTURING PRACTICES FOR PHARMACEUTICALS: A PLAN FOR TOTAL QUALITY CONTROL, Second Edition, Revised and Expanded, Sidney H. Willig, Murray M. Tuckerman, and William S. Hitchings IV Volume 17. FORMULATION OF VETERINARY DOSAGE FORMS, edited by Jack Blodinger Volume 18. DERMATOLOGICAL FORMULATIONS: PERCUTANEOUS ABSORPTION, Brian W. Barry Volume 19. THE CLINICAL RESEARCH PROCESS IN THE PHARMACEUTICAL INDUSTRY, edited by Gary M. Matoren Volume 20. MICROENCAPSULATION AND RELATED DRUG PROCESSES, Patrick 8. Deasy Volume 21. DRUGS AND NUTRIENTS: THE INTERACTIVE EFFECTS, edited by Daphne A. Roe and T. Colin Campbell Volume 22. BIOTECHNOLOGY OF INDUSTRIAL ANTIBIOTICS, Erick J. Vandamme Volume 23. PHARMACEUTICAL PROCESS VALIDATION, edited by Bernard T. Loftus and Robert A. Nash Other Volumes in Preparation DRUGS AND NUTRIENTS The Interactive Effects edited by Daphne A. Roe T. Colin Campbell Division of Nutritional Sciences Cornell University Ithaca, New York MARCEL DEKKER, INC. New York and Basel Library of Congress Cataloging in Publication Data Main entry under title: Drugs and nutrients. (Drugs and the pharmaceutical sciences; v. 21) Includes bibliographies and indexes. 1. Drug-nutrient interactions. I. Roe, Daphne A. II. Campbell, T. Colin, [date] . III. Series. [DNLM: 1. Drug interactions. 2. Drug therapy-Adverse effects. 3. Drugs-Metabolism. 4. Nutrition-Drug effects. 5. Nutrition disorders-Chemically induced. Wl DR 893B v. 21 / QV 38 D79525] RM302. 4.D77 1984 615'. 7045 83-27169 ISBN 0-8247-7054-4 COPYRIGHT © 1984 by MARCEL DEKKER, INC. ALL RIGHTS RESERVED Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy- ing, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher. MARCEL DEKKER, INC. 270 Madison Avenue, New York, New York 10016 Current printing (last digit): 10 9 8 7 6 5 4 3 2 1 PRINTED IN THE UNITED STATES OF AMERICA Preface This book was conceived in response to requests for a state-of-the-art text on drug-nutrient interactions. When we accepted the editorship of this volume, we decided that the book should be divided into two parts, with Part I being devoted to the effects of food and of nutrient intake on the disposition of foreign compounds and Part II having to do with effects of drugs on nutrition. We made an early decision to choose as our authors those scientists whose research is currently in these fields. Our authors were asked to stress methodological issues and to provide critical subject matter reviews. They have complied fully. The book is intended for toxicologists who have the difficult task of interpreting serial or parallel studies of xenobiotics in experimental animals fed different diets. It is intended for oncologists who seek a better understanding of how nutrients affect chemical carcinogenesis. It is also aimed to meet the needs of nutritionists and clinical investiga- tors concerned with interpretation of aberrant effects of therapeutic drugs which may be explained by food effects on drug disposition or drug effects on nutritional status. Our thanks are due to the editorial staff of Marcel Dekker for guiding this book to publication. We are also indebted to our sec- retaries, Beverly Hastings and Joan McLain, who have communica- ted with our authors as well as our publishers and who have given us assistance in the many activities necessary to bring this book to completion. Daphne A. Roe T. Colin Campbell iii Contents Preface iii Contributors vii Introduction xi Part I NUTRITIONAL EFFECTS ON DRUG AND FOREIGN COMPOUND ACTIVITIES 1. Methodologies Used for the Determination of Chemical Body Burdens 3 J. Donoso 2. Plasma Binding, Distribution, and Elimination 21 G. R. Wilkinson 3. Dietary Lipids and Foreign Compound (Carcinogen) Metabolism 51 Bandaru S. Reddy and Peggy Smith-Barbaro 4. Retinoids and Drug-Metabolizing Enzymes 95 Rajendra S. Chhabra 5. Availability of Cosubstrates as a Rate-Limiting Factor 119 Gerard J. Mulder and Klaas R. Krijgsheld V
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