Drugs and Central Synaptic Transmission

385 Pages·1976·40.389 MB·English

by  P. B. Bradley, B. N. Dhawan (eds.)

DRUGS AND CENTRAL SYNAPTIC TRANSMISSION
DRUGS AND CENTRAL
SYNAPTIC TRANSMISSION
Edited by
P. B. BRADLEY
Department of Pharmacology (Preclinical),
Medical School, Birmingham, U.K.
and
B. N. DHAWAN
Division of Pharmacology,
Central Drug Research Institute,
Lucknow, India
M
ISBN 978-1-349-01249-7 ISBN 978-1-349-01247-3 (eBook)
DOI 10.1007/978-1-349-01247-3
© The Contributors 1976
Softcover reprint of the hardcover 1st edition 1976 978-0-333-12735-3
All rights reserved. No part of this publication may be reproduced or
transmitted, in any form or by any means, without permission.
This book is sold subject to the standard conditions of
the Net Book Agreement.
First published 1976 by
THE MACMILLAN PRESS LIMITED
London and Basingstoke
Associated companies in New York Dublin
Melbourne Johannesburg and Madras
SBN 333 12735 8
Filmset by Thomson Press (India) Limited, New Delhi, India
Contents
Symposium delegates IX
Preface X Ill
Introduction K. P. Bhargava 1.
Reviews
1. The use of transmitter antagonists in microelectrophoretic investi-
gations of central synaptic transmission D. R. Curtis 7
2. Steady state and dynamics of putative neurotransmitters in tel
diencephalic nuclei: a study using multiple ion detection E. Costa,
D. L. Cheney and G. Racagni 37
3. Effects ofd rugs on the dopamine mechanisms in the corpus striatum
and in the limbic system and on the noradrenaline and 5-hydroxy-
tryptamine mechanisms in the spinal cord N.-E. Anden 49
Papers
4. Influence of adrenergic and cholinergic mechanisms on the central
cardiovascular structures and their interactions H. Schmitt 63
5. Mechanisms of acetylcholine synthesis by rat brain choline acetyl
transferase and its regulation by products and inhibitors
B. V. Rama Sastry and G. I. Henderson 89
6. Cholinergic inhibitory mechanism in the cerebral cortex
V. K. Bhargava 99
7. Functioning muscarinic receptors on cholinergic pathways to
Renshaw cells R. W. Ryall 107
8. The role of cholinergic transmission in learning H. Matthies,
E. Kammerer and Christine Rauca 115
9. Role of putative central neurotransmitters in self-stimulation
behaviour S. N. Pradhan 121
10. Interactions of morphine and atropine with putative transmitters
W. -?,ieglgansberger and]. Bayerl 131
11. Effect of nicotine administration into the lateral cerebral ventricles
of mice p~ovides evidence for cholinergic mechanisms in the CNS
R. C. Saxena, K. S. Dixit, K. M. Dhasmana and R. P. Kohli 139
12. Effects of centrally acting drugs on the activity of tyrosine hydroxy-
lase in the rat midbrain B. Bhagat 145
13. Studies on the role of brain monoamines in the anticonvulsant action
of diphenylhydantoin and nialamide-induced potentiation of di
phenylhydantoin in albino rats S. K. Bhattacharya, P. K. S. P. Reddy
and P. K. Das !55
14. Possible role of 2-phenylethylamine in the modulation of extra
pyramidal function H. C. Sabelli, A. D. Mosnaim, R. L. Borison and
M. E. Wolf 165
15. Mechanisms of L-DOPA effects on EEG and behaviour R. H. Rech
and P. D. Thut 175
16. Delta-9-tetrahydrocannabinol and brain biogenic amines
M. K. Poddar, B. Biswas and]. ]. Ghosh 193
17. Selective reversal of haloperidol-induced inhibition of brain self
stimulation by the anticholinergic dexetimide A. Wauquier,
C.]. E . .Niemegeers and H. Lal 201
18. The use of monoamine antagonists to identify a neurotransmitter
function for 5-hydroxytryptamine in the spinal cord
M. H. T. Roberts and S. Barasi 211
19. Response of rat cortical neurones to some microiontophoretically
applied monoamines and their antagonists ]. N. Sharma 219
20. Pharmacological profile of inhibition in the vestibular and ocular
nuclei R. Baker 227
21. Microelectrophoretic studies on neurones in the Clarke's column
M. Randic and .N. R. Myslinski 235
22. Pharmacological characterisation of central receptors for thermo-
regulation K. K. Tangri, ] . .N. Sinha, N. Misra and K. P. Bhargava 245
23. Pharmacological characterisation of central receptors in the release
r.
of antidiuretic hormonr V. K. Kulshrestha, P. Srivastava and
K. P. Bhargava 255
24. The use of pharmacological agents to investigate inhibition in the
lateral geniculate nucleus R. Morgan, A. M. Sillito and
]. H. Wolstencroft 263
25. Some effects of picrotoxin on afferent terminals in the cuneate nucleus
of the cat K. Krnjevic and M. E. Morris 273
26. Pharmacological characterisation of central receptors in aggressive
behaviour Ch. Ammiraju, G. P. Gupta and K. P. Bhargava 283
27. Is apomorphine an agent inducing stereotypy? P. C. Dandiya,
S. K. Kulkarni and H. L. Sharma 291
28. Evidence for non-dopaminergic nature of apomorphine-induced
pecking in pigeons B . .N. Dhawan and G. K. Patnaik 30 I
29. Studies of the effects of morphine and related substances on single
neurones in the brainstem P. B. Bradley, G. ]. Bramwell and A. Dray 309
30. Effects of opiates and opiate antagonists on cortical neurones in naive
and tolerant-dependent rats M. Satoh, W. ,Zieglgiinsberger, W. Fries
and A. Herz 317
31. Possible involvement of a dopaminergic link in the analgesic action
of morphine G. B. Singh,]. N. Sharma and B. N. Dhawan 325
32. Studies on the role of brain monoamines in the potentiation of
morphine analgesia by monoamine oxidase inhibitors nialamide and
mangiferin in albino rats S. K. Bhattacharya, A. K. Sanyal and S. Ghosal 333
33. Participation of a central adrenergic synapse in the cardiovascular
actions of intracerebroventricular ouabain P. R. Saxena and
K. P. Bhargava 341
34. Effects of cobra neurotoxin on membrane properties of synaptosomes
Beatri;:: M. Braganca and Yasmin S. Bhagalia 351
35. Biogenic amine metabolism and defective brain development during
experimental cretinism R. L. Singhal, R. B. Rastogi and P. D. Hrdina 359
36. Pharmacological studies of histamine as a central neurotransmitter
J-C. Schwartz, M. Baudry, S. Bischoff, lvf.-P. Martres, H. Pollard,
C. Rose and M. Verdiere 371
Index 383
Sytnposiulll delegates
Ammiraju, Ch., Department of Pharmacology and Therapeutics, King George's
Medical College, Lucknow, India
Anden, N-E., Department of Pharmacology, University ofGoteberg, Sweden
Baker, R., Division of Neurobiology, Department of Physiology and Biophysics,
University oflowa, USA
Bapna, J. S., Department of Pharmacology, University College of Medical
Sciences, New Delhi, India
Barasi, S., Department of Physiology, University College, Cardiff, UK
Barthawal, J.P., DepartmentofPharmacology and Therapeutics, King George's
Medical College, Lucknow, India
Bhagalia, Y. S. (Miss), Biochemistry Division, Tata Memorial Centre, Cancer
Research Institute, Bombay, India
Bhagat, B., Department of Physiology, St. Louis University, School of Medicine,
USA
Bhargava, K. P., Department of Pharmacology and Therapeutics, King George's
Medical College, Lucknow, India
Bhargava, V. K., Department of Pharmacology, H. P. Medical College, Simla,
India
Bhattacharya, S. K., Department of Pharmacology, Institute of Medical
Sciences, Banaras Hindu University, Varanasi, India
Boakes, R.J., Department of Pharmacology (Preclinical), Medical School,
Birmingham, UK
Bradley, P. B., Department of Pharmacology (Preclinical), Medical School,
Birmingham, UK
Braganca, B. M. (Miss), Biochemistry Division, Tata Memorial Centre, Cancer
Research Institute, Bombay, India
Ciplea, A., D. Danielopolu Institute for Normal and Pathologic Physiology,
Bucharest, Rumania
Costa, E., Laboratory of Preclinical Pharmacology, National Institute of
Medical Health, St. Elizabeth's Hospital, Washington D.C., USA
Curtis, D. R., Department of Pharmacology, Australian National University,
Canberra, Australia
Dandiya, P. C., Department of Pharmacology, S.M.S. Medical College,Jaipur,
India
Dhawan, B. N., Central Drug Research Institute, Lucknow, India
Dhawan, K. N., Department of Pharmacology and Therapeutics, King George's
Medical College, Lucknow, India
Dua, P.R., Central Drug Research Institute, Lucknow, India
Ghosh, J. ]., Department of Biochemistry, University College of Science,
Calcutta University, India
Gupta, G. P., Department of Pharmacology and Therapeutics, King George's
Medical College, Lucknow, India
Gupta, P. K., Industrial Toxicology Research Centre, Lucknow, India
Harper, M. J. K., Human Reproduction Unit, World Health Organisation,
Geneva, Switzerland
Herz, A., Department of Neuropharmacology, Max-Planck Institute of
Psychiatry, Munich, W. Germany
Kathur, K. B., Central Drug Research Institute, Lucknow, India
Kishor, K., Department of Pharmacology and Therapeutics, King George's
Medical College, Lucknow, India
Kohli, J. D., Industrial Toxicology Research Centre, Lucknow, India
Kohli, R. P., Department of Pharmacology and Therapeutics, King George's
Medical College, Lucknow, India.
Krnjevic, K., Department of Research in Anaesthesia, McGill University,
Montreal, Canada
Kulshrestha, V. K., Department of Pharmacology and Therapeutics, King
George's Medical College, Lucknow, India
La!, H., Department of Pharmacology and Toxicology, University of Rhode
Island, USA
Mamboj, V. P., Central Drug Research Institute, Lucknow, India
Matthies, H., Institute of Pharmacology and Toxicology, Medical Academy,
Magdeburg, GDR
Mehrotra, P. K., Central Drug Research Institute, Lucknow, India
Mishra, N. (Mrs), Department of Pharmacology and Therapeutics, King
George's Medical College, Lucknow, India
Mukherjee, K. C., Central Drug Research Institute, Lucknow, India
Nath, R. K. (Mrs), Department of Pharmacology and Therapeutics, King
George's Medical College, Lucknow, India
Nitya Nand, Central Drug Research Institute, Lucknow, India
Nityanand, S. (Mrs), Central Drug Research Institute, Lucknow, India
Pradhan, S. N., Department of Pharmacology, Howard University College
of Medicine, Washington D.C., USA
Prasad, C. R., Central Drug Research Institute, Lucknow, India
Rama Sastry, B. V., Department of Pharmacology, Vanderbilt University
School of Medicine, Nashville, USA
Randic, M., Department of Biochemistry and Pharmacology, Tufts Universiiy
School of Medicine, Boston, USA
Rastogi, R. P., Central Drug Research Institute, Lucknow, India
Ray, C., Central Drug Research Institute, Lucknow, India
Rech, R. H., Department of Pharmacology, Michigan State University, USA
Roberts, M. H. T., Department of Physiology, University College Cardiff, UK
Roy, S. K., Central Drug Research Institute, Lucknow, India
Ryall, R. W., DepartmentofPharmacology, UniversityofCambridge, UK
Sabelli, H. C., Department of Pharmacology, The Chicago Medical School,
USA
Sagar, P., Central Drug Research Institute, Lucknow, India
Saxena, A. K., Department of Pharmacology and Therapeutics, King George's
Medical College, Lucknow, India
Saxena, P. R., Department of Pharmacology, Medical Faculty, Erasmus
University, Rotterdam, Holland
Saxena, R. C., Central Drug Research Institute, Lucknow, India
Saxena, V. S., May and Baker (India) Limited, New Delhi, India
Schmitt, H., Department of Pharmacology, Faculty of Medicine, Paris-
Broussais Hotel-Dieu, Paris, France
Schwartz, J.-C., The Neurobiology Unit INSERM, Paris, France
Seth, P. K., Industrial Toxicology Research Centre, Lucknow, India
Sharma, j. N., Central Drug Research Institute, Lucknow, India
Singh, G. B., Central Drug Research Institute, Lucknow, India
Singhal, R. L., Department of Pharmacology, Faculty of Medicine, University
of Ottawa, Canada
Sinha, J. N., Department of Pharmacology and Therapeutics, King George's
Medical College, Lucknow, India
Srimal, R. C., Central Drug Research Institute, Lucknow, India
Srivastava, A. K., Central Drug Research Institute, Lucknow, India
Srivastava, K., Central Drug Research Institute, Lucknow, India
Tandon, H. C., Department of Physiology, G.S.V.M. Medical College, Kanpur,
India
Tangri, K. K., Department of Pharmacology and Therapeutics, King George's
Medical College, Lucknow, India
Wolstencroft, J. H., Department of Physiology, Medical School, University of
Birmingham, UK
Zieglgansberger, \V., Department ofNeuropharmacology, Max-Planck Institute
of Psychiatry, Munich, West Germany