Drugs Affecting Lipid Metabolism: Proceedings of the Third International Symposium on Drugs Affecting Lipid Metabolism, held in Milan, Italy, September 9–11, 1968

670 Pages·1995·26.432 MB·English

by  Daniel Steinberg (auth.), William L. Holmes, Lars A. Carlson, Rodolfo Paoletti (eds.)

Drugs Affecting Lipid Metabolism
ADVANCESIN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
Nathan Back Chairman, Department of Biochemical Pharmacology, School of Pharmacy,
State University of New York, Buffalo, New York
N. R. Di Luzio Chairman, Department of Physiology,
Tulane University School of Medicine, New Orleans, Louisiana
Alfred Gellhorn University of Pennsylvania Medical School, Philadelphia, Pennsylvania
Bernard Halpern Director of the Institute of Immuno·Biology, Paris, France
Ephraim Katchalski Department of Biophysics, The Weizmann Institute of Science, Rehovoth, Isra
David Kritchevsky Wistar Institute, Philadelphia, Pennsylvania
Abel Lajtha New York State Research Institute for Neurochemistry and Drug Addiction,
Ward's Island, New York
Rodolfo Paoletti Institute 01 Pharmacology, University 01 Milan, Milan, Italy, and
Institute 01 Pharmacology, University 01 Cagliari, Cagliari, Italy
Volume 1
THE RETICULOENDOTHELIAL SYSTEM AND ATHEROSCLEROSIS
Edited by N. R. Di Luzio and R. Paoletti • 1%7
Volume 2
PHARMACOLOGY OF HORMONAL POLYPEPTIDES AND PROTEINS
Edited by N. Back, L. Martini, and R. Paoletti • 1968
Volume 3
GERM·FREE BIOLOGY - EXPERIMENTAL AND CLINICAL ASPECTS
Edited by E. A. Mirand and N. Back· 1969
Volume 4
DRUGS AFFECTING LIPID METABOLISM
Edited by W. L. Holmes, L. A. Carlson, and R. Paoletti· 1969
Drugs Affecting Lipid Metabolism
Proceedings of the Third International Symposium on
Drugs Affecting Lipid Metabolism, held in Milan, Italy,
September 9·11, 1968
Edited by
William L. Holmes
Director, Division of Research
Lankenau Hospital
Philadelphia, Pennsylvania
Lars A. Carlson
Professor and Chairman,
Department of Geriatrics, Faculty of Medicine
University of Uppsala, Uppsala
and King Gustaf V th Research Institute,
Stockholm, Sweden
Rodolfo Paoletti
Chairman, Institute of Pharmacology
University of Cagliari
Ca gliari, I tal y
~PLENUM
PRESS - NEW YORK -1969
First Printing-March 1969
Second Printing-January 1974
ISBN 978-1-4615-6868-1 ISBN978-1-4615-6866-7 (eBook)
DOl 10.1007/978-1-4615-6866-7
0-306-39004-3
Library of Congress Catalog Card Number 77·76508
ij) 1969 Plenum Press
Softcover reprint of the hardcover I st edition 1969
A Division of Plenum Publishing Corporation
227 West 17th Street, New York, N. Y. 10011
All rights reserved
No part of this publication may be reproduced in
any form without written permission from the publisher
A CKNOWLEDG MENTS
Acknowledgement is gratefully made for the valuable finan
cial support received from the following organizations:
American Heart Association New York, U. S. A.
AB Astra S"o dert1a1 lJ• e, Sweden
Ayerst Laboratories New York, U. S. A.
Bristol Laboratories Syracuse, U.S.A.
Burroughs Wellcome & Co. , Inc. Tuckhahoe, U. S. A.
Carlo Erba S. p. A. Milan, Italy
Ciba Industria Chimica Origgio, Italy
Ciba Pharmaceutical Co. Summi t, U. S. A.
Crinos S.p.A. Villaguardia, Italy
Fa rmitalia S. p. A. Milan, Italy
J. R. Geigy SA. Basel, Switzerland
Hoffman-La Roche Inc. Nutley, U. S. A.
Imperial Chemical Industries Macclesfield, England
Instituto Biochimico Italiano Milan, Italy
Lilly Research Laboratories Indianapolis, U. S. A.
Prodotti Roche S. p. A. Milan Italy
I
Dr. R. & C. Ravasini Rome, Italy
Rega Instituut Leuven, Belgium
Riker Laboratories Northridge, U. S. A.
Sandoz AG. Basel, Switzerland
Sandoz Pharmaceuticals Hanover, U. S. A.
Schering Corp. Bloomfield, U. S. A.
Smith, Kline & French Labs. Philadelphia U. S. A.
I
The Wm. S. Merrell Co. Cincinnati, U. S. A.
The Upjohn Co. Kalamazoo, U. S. A.
Wallace Laboratories Cranbury, U. S. A.
Without this assistance we would not have been able to arrange the
I
Symposium, which was attended by some four hundred research and
clinical workers concerned with the problems of Drugs Affecting
Lipids.
The Organizing Committee
v
CONTENTS
Opening Remarks • • • 1
Daniel Steinberg
DRUGS AFFECTING FFA MOBILIZATION
The Regulation of Cyclic AMP and Lipolysis in Adipose
Tissue by Hormones and Other Agents 5
R. W. Butcher and C. E. Baird
Nervous and Pharmacological Regulation of Vascular
Reactions in Adipose Tissue ••••• 25
S. Rosell
Evidence That the Rise in Temperature Produced by d-Amphe
tamine Is Caused by a Peripheral Action of the
Drug • • • • • • • • • • • •• 35
G. L. Gessa, G. A. Clay, and B. B. Brodie
Effects of Adrenergic Blocking Agents on FFA Mobilization 45
E. Westermann and K. Stock
Adenosine 3',5'-Monophosphate and Regulation of
Lipolysis in Rat Adipose Tissue •••• • • •• 63
B. Mosinger and M. Vaughan
Factors Modifying the Effect of Prostaglandin E1 on
Lipolysis in Adipose Tissue •••••••••• 75
H. Micheli
Pyridines Affecting FFA Mobilization !n ~ . . . . . . .. 85
L. A. Carlson, C. Hedbom, E. He1gstrand,
B. SjBberg, and N. E. StjernstrBm
Effects of 5-Methy1pyrazo1e-3-Carboxy1ic Acid, U-19425,
on FFA Mobilization •• • • • • • • • • • 93
G. C. Gerritsen, W. E. Dulin, and F. P. Kupiecki
vii
viii CONTENTS
Effect of 5-Methylpyrazole-3-Carboxylic Acid (MPCA)
on Fat Mobilization, Ketogenesis, and
Glucose Metabolism During Exercise in Man 105
R. J. Havel, N. Segel, and E. O. Balasse
Transport-Inducing Antibiotics (Gramicidin and Valinomycin)
as Inhibitors of Catecholamine-Stimulated
Lipolysis In Y1!!£ 117
G. Fassina and P. Dorigo
Studies of the Mechanism of Prevention of Fatty Livers by
the Administration of Adenosine Triphosphate 125
D. E. Hyams, A. Bizzi, A. Lietti, and S. Garattini
Action of Norepinephrine and Propranolol on the Turnover
Rate of Free Fatty Acids and the Esterifica
tion Rate of Free Fatty Acids to Plasma
Triglycerides in Man • • • • • • • • • • 135
S. Sailer, F. Sandhofer, K. Bolzano, and H. Braunsteiner
EFFECT OF DRUGS ON PLASMA AND
TISSUE TRIGLYCERIDES
In ~ and In Y1!!£ Studies of Plasma Post-Heparin
Lipolytic Activity in Subjects with
Hyperchylomicronemia (Fat-Induced Lipemia) 145
R. H. Bradford, R. H. Furman, and H. B. Bass
Isolated Fat Cells: Morphology and Possible Role of
Released Lipoprotein Lipase in Deposition
of Lipoprotein Fatty Acids • • • • • • • 161
D • ~ 0
M. C. Schotz, J. E. Stewart, A. S. Garfinkel,
C. F. Whelan, N. Baker, M. Cohen, T. J. Hensley,
and M. Jacobson
Regulatory Factors in Ketogenesis and in the Metabolism
of Triglycerides by Liver ••••• 185
M. Heimberg, D. R. Van Harken, I. Weinstein, and
M. Kohout
Correlation Between the Effect of Drugs on Plasma Free
Fatty Acids and on Tissue Triglycerides 201
A. Bizzi and S. Garattini
The Effects of 5-Methylpyrazole-3-Carboxylic Acid (U-19,425)
and Nicotinic Acid (NA) on Free Fatty Acids
(FFA), Triglycerides (TG) and Cholesterol in Man 213
K. Gundersen and H. V. Demissianos
CONTENTS ix
Studies with 5-(3-Pyridy1)Tetrazo1e, a Long-Acting
Lipolysis Inhibitor ••••••••• 227
J. N. Pereira, G. F. Holland, F. Hochstein,
S. Gi1gore, S. DeFelice, and R. Pinson
Influence of Lipolytic and Anti1ipo1ytic Agents on
Synthesis of Adipose Tissue Lipoprotein Lipase. 239
E. A. Nikki1~ and O. Pyk~list~
Effects of Estradiol-17~ and Progesterone on
Experimental Mammary Carcinoma Lipid 249
000 0 0 0
E. D. Rees
Some Factors Affecting Release of Clearing Factor Lipase
from Isolated Perfused Rat Heart • • • • • • 261
H. C. Meng, E. Aktin, M. F. Crass, III, and
M. Ghosa1
Carnitine Regulation of Fatty Acid Metabolism in Heart 279
G. V. Vahouny, S. L. Rodis, E. Koch, and P. D'Amato
Neurotoxic Organophosphorus Esters and Lipid Metabolism • 295
G. Porcellati
DRUGS AND SERUM LIPOPROTEINS
The Typing of Hyper1ipoproteinemia: A Progress Report (1968) 307
D. S. Fredrickson, R. I. Levy, P. O. Kwiterovich, Jr.,
and A. Jover
The Effect of Nicotinic Acid Treatment on the Chemical
Composition of Plasma Lipoprotein Classes
in Man • • 327
III • • lit " 0 0 • 0 0 iii 0 ., " 0 "
L. A. Carlson
A Primary Prevention Trial Using Clofibrate (Atromid-S) • •• 339
M. F. Oliver
Environmental Effects on the Structure of Human Serum
High Density Lipoprotein and Its Apoprotein 345
A. M. Scanu
The Effects of Trans Isomerized Tri1ino1ein on Plasma
Lipids of Man • • • • • • • • • • 355
M. A. Mishke1 and N. Spritz
CONTENTS
Selective Inhibition of Hepatic but Not Intestinal
~-Lipoprotein Production and Triglyceride
Transport in Rats Given Orotic Acid 365
H. G. Windmueller, Ro I. Levy, and Ao E. Spaeth
The Efficacy of Clofibrate (CPIB) in Familial
Hyperlipoproteinemias 377
R. I. Levy, SO H. Quarfordt, W. Vo Brown, H. R. Sloan,
and D. S. Fredrickson
The Effect of Chlorophenoxyisobutyrate (CPIB) in Various
Types of Primary Hyperlipidemia ••••• • 389
G. Schlierf and W. Kahlke
Interrelationship of Chlorophenoxyisobutyrate, Ubiquinone,
and Cholesterol ••• • • • • • • • • 395
T. Ramasarma, Ko V. Krishnaiah, A. R. lnamdar, and
H. N. Aithal
DRUGS ACTING ON CHOLESTEROL
AND BILE METABOLISM
The U. S. Veterans Administration Cardiology Drug-Lipid
Study: An Interim Report •••••••• 405
H. K. Schoch
Effect of Drugs on Bile Acid Metabolism • . • • • • • • • • • 421
E. H. Mosbach
Factors Influencing Cholesterol 7a -Hydroxylase
Activity in the Rat Liver ••••• 443
G. S. Boyd, N. A. Scholan, and J. R. Mitton
Effect of Hypocholesteremic Agents on an Experimental
Brain Tumor in Mice • • • • 457
E. Grossi Paoletti, C. R. Sirtori, J. F. Weiss,
and R. Paoletti
Butyrophenones as Inhibitors of Cholesterol Biosynthesis 473
G. A. Braun
Evaluation of Phenolic Ethers as Hypolipidaemic Agents:
Effects of CIBA l3,437-SU ••• 483
0 • • • •
R. Hess, R. Maier, and W. St~ubli
Linoleamides: A New Class of Hypocholesteremics 491
K. Toki and Ho Nakatani
CONTENTS xi
The Influence of Anovulatory Compounds on Cholesterol
Metabolism •• 501
0 0 • 0 0 0 0 0 0 0 0
R. B. Alfin-Slater and L. Aftergood
The Effect of Hypoglycemic Agents on Cholesterol
Biosynthesis • • 511
0 • • • • • • • 0 0
M. Eo Dempsey
Hypophyseal Mediation of Estrogen-Induced Hypocholesterolemia 521
M. Steinberg
Drugs Affecting the Enterohepatic Circulation of Cholesterol 531
M. G. Horning, D. Rybiski, E. C. Horning,
G. L. Jordan, Jr., and C. Po Schaffner
Oxidation of Cholesterol by Rat Liver Mitochondria:
Influence of Ethyl a-p-Chlorophenoxyisobutyrate 543
D. Kritchevsky, S. A. Tepper, P. Sallata,
J. R. Kabakjian, and V. J. Cristofalo
Cholesterol-Lowering Effect of Sulfaguanidine in Mice
and Ra ts • • • 549
0 • • • • 0
H. J. Eyssen, J. F. Van den Bosch, and G. A. Janssen
METHODOLOGY AND MISCELLANEOUS
Use of High-Efficiency Nonpolar Columns in Systematic
Separation and Identification of Steroids by
Combined TLC-GLC Method of Analysis •••• 559
F. A. Vandenheuvel
The Analysis of Blood Lipids by Chromatography and
Infrared Spectrophotometry • 583
0 0 • 0 •
G. J. Nelson
The Characterization of Phospholipids by Gas Phase
Analytical Methods ••••••• 597
0 0 ••
G. Casparrini, M. G. Horning, and E. C. Horning
Ether-Linked Lipids in Neoplasms of Man and Animals:
Methods of Measurement and the Occurrence and
Nature of the Alkyl and Alk-l-Enyl Moieties 609
Fo Snyder
Lipoprotein Patterns in Primary Hyperlipidemias, as
Registered by Agarose Gel Electrophoresis 621
W. Kahlke, G. Schlierf, and J. Papenberg