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Drug Use and Abuse PDF

498 Pages·2007·100.86 MB·English
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FIFTH EDITION i Drug Use and Abuse Stephen A. Maisto Mark Galizio Gerard J. Connors Glossary of Drug Slang Stang Names for Drugs amphetamines ayl/butyl nitrate jones; jonesing junkie Kchole roached rolling speedhall stoned works, rig mescaline MDMA nitrous oxide phencyclidine hook up, connect, dank, doobi grass, hes, J joint hi. meryane, pot reelze, rome, spi ince, emok adam, E, ecsasy, 1 XUxTC palloons, luihing wltippe: angel dust, animal tran Orn EDITION Drug Use ae Abuse Med a PAD. in ‘spermental pychalogy fram ths Unser of Wisconsin Nitwsukee and especiales in cries payeholog fam Gsorge Peabocy Collga of Vander Uva Hes & professor of payenolegy st Syracuse Univers He hae been engages i researc, teaching cca pace, se cl 1 Masta nas pulsed ‘rer 0 ericles, 25 book haptes, ana eeve'a books supgored by he National Department of veteans asters Dr Maisto Peycroogeal Assce ton ‘xnenean 25yehoi0g cal Saciaty Research Society scoaton fr Behav ra 1d Cogntve Therapies roi ie PRD. n ‘ecperimertalpoychoogy i 175 fore te Unive Mest abut on Dr ‘Abuse, He fs cha an atlono Wing Alesis pect nee 80 yon Hotes yuo ianiea enact been supported by grams Nevrolegiel Disesse are Afellow of he Ameican Peyenelogial Assocation Phamacoagy and Substance Rause and Diision of Behavior Analysis) ar past presleort of the Ditton 8° Behavor Analy, is drector ofthe Rocearch tuts on fdectons at ‘excrad his doctoral degree fn clea payehloay ir anders Univer in 980. 3r Connor esearch (Gt and abuse relapse Peretiion salbhckr group ‘inkers and Weatmest Pralanb, He a eto Ihe Anesisan Paphaical Pssviaton (Dinars Cina Poesy ad Peflitions, Dr, Conners has ‘authored or coautrored oaks, and book evap His curtent research acti we func ty farts irom the Naderal Frgatut on Aleohel Au Drug Use end Abuse: General Issues 1 Drug Use: Yesterday andl Today 24 Drugs and the Nervous Systern 45 Pharmacology 65 Prychopharmacology and New Drug Development 92 Cocaine, Amphetamines, and Related Stimulants 118 Nicotine 141 Caffeine ‘Alcohol 185 Opiates 228 Marijuana 248 Hallucinogens 2/6 Psychotherapeutic Medications 301 (Other Prescription and Overthe-Counter Drugs 335 ‘Treatment of Substance-Use Disorders 361 Prevention of Substance Abuse 8 Pharmacology and Drugs. 3 Drug Clasifeaton 4 The Drug Experience 5 ‘Alcohol and Drug Us9 in the United States 6 National Houschold Survey Summary ° Mukiple Drug Use Incecnational parsons of Drug Use 11 Negative Consequences of Alcohol ard Drug Use 12 Defining Harmful Drug Use 14 ‘Lieofthe DSM-IV 15 Drug Tolersace, Wit ard Drug-laking Behavior 1 Overview of the Text 19 Evaluating Websites 19 Summary 20 Historical Overview 25 Drug Use the United States Mecical Science and Drug Use 3: Development of Drug Laws 32 The Sin Francisco Ordinance Pure Food and Daug Ace 33 Hatsison Narcotics 1 Alcobel Pobibaien Post Prohibition Legislation 36 Current Drug Laws. 37 Summary 41 Contents Prue “9 Major Neurotransmitter Systems 51 eetlcholine 5 Other Trensmiters 54 ‘The Nervous System 55 The Brain 56 The Midbrain 58 he Forebein 58 Tracing the Hsia Brap 1 Summary 62 rd Neural Transmission ie EES Pharmac Pharmacokinetics 67 DrgDaw 6? Touts of Miminiseton 68 ees Drug Dott Dig Elian Pharmacodynamics 80 The Tose Fert Co Effective and Lethal Dy Drng Intentions. 6 Summary 89 Characteristics of the User 93 Biologia Characteristics 9 aychelogieal Characteristics 94 Social and Environmental Factors. 97 Tolerance 98 Typer of Tolerance 98 Byplanations oF Tolerance 99 Behavioral Pharmacology 102 (Operant Prnepies and Dag Dependence 104 Lrg Dseemination 1s Animal Models and Human Drug Use 108 Human Bshavioral Pharmacology 107 Ethical lsues "107 Phesbo Control. 107 New Drug Dowelopment. 109 Summary 113, ee = History of Tobacco Use 143 The West Discovers Tobacco 143 Tobacco as Panscen 148 From Panices ro Paoned 145 Prevalence of Tabacco Use 145 Sinking iv the United States 14 Tvittion of Smoking 146 Sickles Tobacen Use 148 Pharmacelogy of Nicotine 148 ‘Sicsof Action 148 Phuincokineti 49 Tolerance and Dependence 150 Tolerance 150 Physica Dependence 151 ‘Acute Effects of Nicotine 152 Nicotine’s Dependence Liablry 15 Effects of Chronic Tobacco Use 154 “Tar, Nicotine, and Carhon Monoxide incase: Linked to Cigarette Smoking Odher Tobacco Products and Halen Passive Smoking, 157 ‘Teatment of Cigarette Smoking 159 “The Necesty of Formal Treszment 160 Treaiment Effectiveness 161 CCanelusioas about the Treutment of Cigarte Smoking 163 Summary 164 mB: Sercorel Ge. 5 Histon of Cafe Use. 170 Provlones of oti Concunpton hrmacsogy oF ease 174 Dacia 1d Tiosres eo eunilk 4e ac anaes Acute tects of Cafe 178 Behavioral and Pychologcal Fees 176 rcioys among Cafcine Nieotins, Akoiol 177 Acute Tone Ecce of Cafcine 178 Chronic Effects of Caffeine Uso 180, Therapeutic User of Caffeine 182 Conclusions 182 Summary 183, Wisi Aicohelic Beverages 186 Fermentation end Dilation 9186 Tigran ofa Revenge 18% History of Alcohol Use 189 Consumption of Alcohol and Heavy Drinking inthe United States 191 Per Capite Consumption | 191 (Consumption of Alcohol and Hleawy Drinking ainona College Students 194 Pharmacclagy of Aleshol 196 Stor oF Action 196 oF Alcohol 196. Tolerance and Dependence 200 Tuerasce 200 Physical Dep ‘Therapeutic Uses 203 ‘Acute Effects of Alcohol 203, Phares Physiological Elects 208 Sensorimotor EMfects 306 cohol and Deving Abity 206 syerologca Fees 208 Noho! and Rehavinr 209) Effects of Chronic Hetvy Drinking 214 coho an Besin Functioning, 214 Acoli and che Lier 216 Alcoioé and Repetitive Denctioning 217 Moverste Dsinking and Health 219 The Development of Alcohol Abuse land Dependence 220 radicional Approsches to Etiology 220 “Bopsyehosoeial™ Approash ta Etiology 222 Summary 223 History of the Opiates 229 Eacly History 229 Opiate Une in the 19th Century 230 (Opiate Use in the 20th Century and Tsay papter 10 Pharmacokinetics 238 Absorption 238 Distribution, Metaboli, an Mechanisms of Opiate Action Discovery of Enlorphirs What Do Endorphins Do? Medical Use of Opiate Druge 240 ‘Acute Psychological and Physiologicl Effects ‘of Opiates, 243 239 0 Chronic Effacts of Opiates 244 Tolerance Wiha at 14 Dependence Summary 246 Historical Overview 250 Cannabis in the Ne Gommitice Repos on Marfuana Epidemiology 255 Methods of Use 259 ‘Active Ingredients 259, Pharmacokinetics Aorpion 250 World 259 Diseutian, Merbolim, iid Exercion 260 Mechanisms of Action Reels Fi 260 Tolerance ind Depenlsike ‘Medical and Psychotherapeutic Uses 262 History of Therapeutic Use Cachexia 265 Glaucoma 265 Other ses 266 Physiological Effects 266 Rute Fete 266 TongetTern Elects 266 24 Paychological Eels 268 Anviniiey Agente 218 cheval ects 268 Moat Sting Dever 31 Goethe Hse 20 Paychotherapeutie Drags and Pregnancy 323 Social and Environmental Effects 27 Summary, oe Summary. 272 wus Chapter 14 tel aah Chapter 12 Aa Bsc id allucinogens 276 = Counter Drugs 339 Overview 240 Prescription Drugs 340 Birth Conel Drage 340 Anabolic Steoide 343, Overview 277 Serotonergic Halluinogenst LSD and Related Compounds 278 Recent History. 281 Overthe-Counter Drugs 248 Mectanims of Action of LSD-Like Drugs 284 FDA Chaitin 48 50" Gold sn Alls Mesa Paycrotherapeutic Uses 285 eects of Serotonere Haliseinogens 286 ‘Over the-Coure Stnulanes and Sedatives 351 Fallacnogens 287 Herbal Procucts, Hormones, and Dietary Methylated Amphetamines 288 Supplements 351 Overview 288 wee as History and Spileniology 290 DHEA Erect of Metipated Amphetamines 292 Fohedea/Me Huang 55 Toxicity 293, Ginkgo Bobi 358 Resiul Efketsof MDMA 294 Kava 354 Melatonin 354 Antichotinorgic Halluchogens 296 an a i cls a S-Adenosy-Methionine 354 ssocative Anesthetic Hallucinogen: 297 Be Finny Si, Joba's Wore 385 Prarmcinti, 298 Senne Efe of PCP nd Kesane | 298, Gama Eydronyhuore 355 Summary. 299 Inhalants 356 Summary 358 2a a poole me oe eke rps BB oicrders 36 Anesleprenane 312 Dther Self Help Groups 368;

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