Drug Resistance PDF
Preview Drug Resistance
DRUG RESISTANCE CANCER TREATMENT AND RESEARCH Emil J Freireich, M.D., D.Se. (Hon.), Series Editor Nathanson 1. (ed): Malignant Melanoma: Biology, Diagnosis, and Therapy. 1988. ISBN 0-89838-384-6. Pinedo H.M., Verweij J. (eds): Treatment of Son Tissue Sarcomas. 1989. ISBN 0-89838-391-9. Hansen H.H. (ed): Basic and Clinical Concepts of Lung Cancer. 1989. ISBN 0-7923-0153-6. Lepor H., RatliffT.L. (eds): Urologic Oncology. 1989. ISBN 0-7923-0161-7. Benz c., Liu E. (eds): Oncogenes. 1989. ISBN 0-7923-0237-0. Ozols R.F. (ed): Drug Resistance in Cancer Therapy. 1989. ISBN 0-7923-0244-3. Surwit E.A., Alberts D.5. (eds): Endometrial Cancer. 1989. ISBN 0-7923-0286-9. Champlin R. (ed): Bone Marrow Transplantation. 1990. ISBN 0-7923-0612-0. Goldenberg D. (ed): Cancer Imaging with Radiolabeled Antibodies. 1990. ISBN 0-7923-0631-7. Jacobs C. (ed): Carcinomas of the Head and Neck. 1990. ISBN 0-7923-0668-6. Lippman M.E., Dickson R. (eds): Regulatory Mechanisms in Breast Cancer: Advances in Cellular and Molecular Biology of Breast Cancer. 1990. ISBN 0-7923-0868-9. Nathanson, L. (ed): Malignant Melanoma: Genetics, Growth Factor;, Metastases, and Antigens. 1991. ISBN 0-7923-0895-6. Sugarbaker, P.H. (ed): Management of Gastric Cancer. 1991. ISBN 0-7923-1102-7. Pinedo H.M., Verweij j., Suit, H.D. (eds): Soft Tissue Sarcomas: New Developments in the Multidisciplinary Approach to Treatment. 1991. ISBN 0-7923-1139-6. Ozols, R.F. (ed): Molecular and Clinical Advatlces in Anticancer Drug Resistance. 1991. ISBN 0-7923-1212-0. Muggia, EM. (ed): New Drugs, Concepts and Resu1ts in Cancer Chemotherapy 1991. ISBN 0-7923-1253-8. Dickson, R.B., Lippman, M.E. (eds): Genes, Oncogenes, and Hom10nes: Advances in Cellular and Molecular Biology of Breast Cancer. 1992. ISBN 0-7923-1748-3. Humphrey, G. Bennett, Schraffordt Koops, H., Molenaar, W.M., Postma, A. (eds): Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies. 1993. ISBN 0-7923-1905-2. Benz, CC, Liu, E.T. (eds): Oncogenes and Tumor Suppressor Genes in Human Malignancies. 1993. ISBN 0-7923-1960-5. Freireich, E.j., Kantaljian, H. (eds): Leukemia: Advances in Research and Treatment. 1993. ISBN 0-7923-1967-2. Dana, B.W. (ed): Malignant Lymphomas, Including Hodgkin's Disease: Diagnosis, Management, and Special Problems. 1993. ISBN 0-7923- 2171-5. Nathanson, L. (ed): Current Research and Clinical Management of Melanoma. 1993. ISBN 0-7923-2152-9. Verweij, j., Pinedo, H.M., Suit, H.D. (eds): Multidisciplinary Treatment of Soft Tissue Sarcomas. 1993. ISBN 0-7923-2183-9. Rosen, ST., Kuzel, T.M. (eds): lmmunoconjugate Therapy of Hematologic Malignancies. 1993. ISBN 0-7923-2270-3. Sugarbaker, P.H. (ed): Hepatobiliary Cancer. 1994. ISBN 0-7923-2501-X. Rothenberg, M.L. (ed): Gynecologic Oncology: Controversies and New Developments. 1994. ISBN 0-7923-2634-2. Dickson, R.B., Kippman, M.E. (eds): Mammary Tumorigenesis and Malignant Progression. 1994. ISBN 0-7923-2647-4. Hansen, H.H. (ed): Lung Cancer. Advances in Basic and Clinical Research. 1994. ISBN 0-7923-2835-3. Goldstein, L.J., Ozols, R.F. (eds): Anticancer Drug Resistance. Advances in Molecular and Clinical Research. 1994. ISBN 0-7923-2836- 1. Hong. W.K., Weber, R.S. (eds): Head and Neck Cancer. Basic and Clinical Aspects. 1994. ISBN 0-7923-3015~3. Thall, P.F. (ed): Recent Advances in Clinical Trial Design and Analysis. 1995. ISBN 0-7923-3235-0. Buckner, CD. (ed): Technical anp Biological Components of Marrow Transplantation. 1995. ISBN 0-7923-3394-2. Muggia, F.M. (ed): Concepts, Mechanisms, and New Targets for Chemotherapy. 1995. ISBN 0-7923-3525-2. Klastersky, J. (ed): Infectious Complications of Cancer. 1995. ISBN 0-7923-3598-8. Kurzrock, R., Talpaz, M. (eds): Cytokines: Interleukins and Their Receptors. 1995. ISBN 0-7923-3636-4. Sugarbaker, P. (ed): Peritoneal Carcinomatosis: Drugs and Diseases. 1995. ISBN 0-7923-3726-3. Sugarbaker, P. (ed): Peritoneal Carcinomatosis; Principles of Management. 1995. ISBN 0-7923-3727-1. Dickson, R.B., Lippman, M.E. (eds): Mammary Tumor Cell Cycle, Differentiation, and Metastasis. 1995. ISBN 0-7923-3905-3. Freireich, EJ" Kantarjian, H. (eds): Molecular Genetics and Therapy of Leukemia. 1995. ISBN 0-7923-3912-6. Cabanillas, F., Rodriguez, M.A. (eds): Advances in Lymphoma Research. 1996. ISBN 0~7923-3929-0. DRUG RESISTANCE Edited by WILLIAM N. HAlT, M.D., Ph.D. The Cancer Institute of New Jersey University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School Piscataway, New Jersey . ., ~ KLUWER ACADEMIC PUBLISHERS BOSTON/DORDRECHTI LONDON Distributors for North America: Kluwer Academic Publishers 101 Philip Drive Assinippi Park Norwell, Massachusetts 02061 USA Distributors for all other countries: Kluwer Academic Publishers Group Distribution Centre Post Office Box 322 3300 AH Dordrecht, THE NETHERLANDS Library of Congress Cataloging-in-Publication Data Drug resistance! edited by William N. Halt. p. cm. - (Cancer treatment and research: CTAR 87) Includes bibliographical references and index. ISBN-13: 978-1-4612-8540-3 e-ISBN-13: 978-1-4613-1267-3 DOl: 10.1007/978-1-4613-1267-3 1. Drug resistance in cancer cells. I. Hait, William N. II. Series: Cancer treatment and research; v. 87, [DNLM: 1. Drug Resistance. 2. Antineoplastic Agents pharmacology. 3. Neoplasms-drug therapy. WI CA693 v.87 1996 ! QV 267 0794 1996] RC271.C3D78 1996 616.99'4061-dc20 DNLM/DLC for Library of Congress 96-7538 CIP Copyright © 1996 by Kluwer Academic Publishers Softcover reprint of the hardcover 1s t edition 1996 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photo-copying, recording, or otherwise, without the prior written permission of the publisher, Kluwer Academic Publishers, 101 Philip Drive, Assinippi Park, Norwell, Massachusetts 02061 Printed on acid-free paper. CONTENTS List of Contributors vii Introduction xvii I. MEMBRANE TRANSPORT MECHANISM 1. P-Glycoprotein-Mediated Multidrug Resistance: Experimental and Clinical Strategies for its Reversal 3 JAMES M. fORD, JIN-MING YANG, AND WILLIAM N. HAlT 2. Multidrug Resistance Associated with Overexpression of MRP 39 SUSAN P.C. COLE AND ROGER G. DEELEY II. RESISTANCE TO ALKYLATING AGENTS 3. Mechanisms of Resistance to Alkylating Agents 65 PHILIP G. PENKETH, KRISHNAMURTHY DHYAM, AND ALAN C. SARTORELLI 4. Glutathione S-Transferases 83 ABHIJlT RAHA AND KENNETH D. TEW 5. Role of DNA Repair in Resistance to Drugs that Alkylate 06 of Guanine 123 OMER N. KOt;:, WELDON P. PHILLIPS, JR., KEUNMYOUNG LEE, LILI LIU, NASIR H. ZAIDI, JAMES A. ALLAY, AND STANTON L. GERSON III. RESISTANCE TO MICROTUBULE ACTIVE DRUGS 6. Paclitaxel (Taxol®): Mechanisms of Resistance 149 ANNA M. CASAZZA AND CRAIG R. fAIRCHILD v vi Contents IV. RESISTANCE TO ANTIMETABOLITES 7. Mechanisms of Clinical Resistance to 5-Fluorouracil Chemotherapy 175 EDWARD CHU AND CARMEN J. ALLEGRA 8. Antifolates: Current Developments 197 ELIZABETH A. RAYL AND GIUSEPPE PIZZORNO 9. Human Immunodeficiency Virus Replication in the Presence of Antiretroviral Drugs: Analogies to Antineoplastic Drug Resistance 225 ROGER K. STRAIR AND DANIEL ]. MEDINA V. TOPOISOMERASES 10. Cellular Resistance to Topoisomerase Poisons 243 ERIC H. RUBIN, TSAI-KUN LI, PU DUANN, AND LEROY F. LIU VI. RESISTANCE TO ENDOCRINE THERAPIES 11. Acquisition of an Antiestrogen Resistant Phenotype in Breast Cancer: Role of Cellular and Molecular Mechanisms 263 ROBERT CLARKE, TODD SKAAR, FABIO LEONESSA, BRENDA BRANKIN, MATTIE JAMES, NILS BRUNNER, AND MARC E. LIPPMAN 12. Androgen Receptor Mutations in Prostate Cancer 285 EDWARD P. GEL MANN VII. RESISTANCE TO RETINOIDS 13. Retinoids in Clinical Cancer Therapy 305 ]OSEPHIA R.F. MUINDI VIII. NOVEL MECHANISMS AND APPROACHES 14. Apoptosis and Cancer Chemotherapy 345 STUART LUTZKER AND ARNOLD ]. LEVINE 15. Interaction of Chemotherapy and Biological Response Modifiers in the Treatment of Melanoma 357 ANTONIO C. BUZAID, CLAY M. ANDERSON, AND ELIZABETH A. GRIMM 16. Multifunctional Modulators of Drug Resistance 381 JOHN R. MURREN, GERMANA RAPPA, AND YUNG-CHI CHENG Index 409 CONTRIBUTING AUTHORS James A. Allay, PhD. Division of Hematology and Oncology Department of Medicine and the CWRU/Ireland Cancer Center Case Western Reserve University School of Medicine University Hospitals of Cleveland BRB-3 10900 Euclid Avenue Cleveland, OH 44106-4937 Carmen J. Allegra, M.D. Chief, NCI-Navy Medical Oncology Branch National Cancer Institute Division of Cancer Treatment Naval Hospital Bethesda 8901 Wisconsin Avenue Building 8, Room 5101 Bethesda, MD 20889-5105 Clay M. Anderson, M.D. Fellow, Medical Oncology Department of Medical Oncology Melanoma/Sarcoma Section viii Contributing authors Division of Medicine The University of Texas M.D. Anderson Cancer Center Box 77 1515 Holcombe Blvd. Houston, TX 77030 Brenda Brankin, Ph.D. Vincent T. Lombardi Cancer Center The Research Building, Room W 405A Georgetown University School of Medicine 3970 Reservoir Road NW Washington, DC 20007-2197 Nils Brunner, M.D., Ph.D. Finsen Laboratory Strandboulevarden 49 Copenhagen, DK-2100 Denmark Antonio C, Buzaid, M.D. Assistant Professor of Medicine Department of Medical Oncology Melanoma/Sarcoma Section Division of Medicine The University of Texas M.D. Anderson Cancer Center Box 77 1515 Holcombe Blvd. Houston, TX 77030 Anna M. Casazza, Ph.D. Executive Director Experimental Therapeutics Oncology Drug Discovery Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton, NJ 08543-4000 Yung-chi Cheng, Ph.D. Yale Cancer Center Yale University School of Medicine Department of Pharmacology Contributing authors ix 333 Cedar St., NSB 287 New Haven, CT 06520 Edward Chu, M.D. NCI-Navy Medical Oncology Branch National Cancer Institute National Institutes of Health Bethesda, MD 20889 Robert Clarke, Ph.D. Associate Professor Department of Physiology & Biophysics Director, Lombardi Cancer Center Animal Core Program Georgetown University School of Medicine The Research Building, Room W 405A Vincent T. Lombardi Cancer Center 3970 Reservoir Road NW Washington, DC 20007-2197 Susan P.e. Cole, Ph.D. Career Scientist of the Ontario Cancer Foundation Professor of Oncology Cancer Research Laboratories Queen's University Kingston, Ontario, Canada K7L 3N6 Roger G. Deeley, Ph.D. Stauffer Research Professor Cancer Research Laboratories Queen's University Kingston, Ontario, Canada K7L 3N6 Pu Duann, M.D., Ph.D. Department of Pharmacology University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School Research Tower, Room 436 675 Hoes Lane Piscataway, NJ 08854 Craig R. Fairchild Oncology Drug Discovery & Exploratory Research Bristol-Myers Squibb x Contributing authors Pharmaceutical Research Institute P.O. Box 4000 Princeton, NJ 08543-4000 James M. Ford, M.D. Departments of Biological Sciences and Internal Medicine (Oncology) Herrin Biology Laboratories Stanford University Stanford, CA 94305-5020 Edward P. Gelmann, M.D. Professor of Medicine and Cell Biology Division of Hematology/Oncology Department of Medicine Lombardi Cancer Center Georgetown University Medical Center 3800 Reservoir Road, NW Washington, DC 20007 Stanton L. Gerson, M.D. Division of Hematology and Oncology Department of Medicine and the CWRU/lreland Cancer Center Case Western Reserve University School of Medicine University Hospitals of Cleveland BRB-3 10900 Euclid Avenue Cleveland, OH 44106-4937 Elizabeth A. Grimm, Ph.D. Professor of Biology Department of Tumor Biology Division of Research The University of Texas M.D. Anderson Cancer Center Box 77 1515 Holcombe Blvd. Houston, TX 77030 William N. Hait, M.D., Ph.D. The Cancer Institute of New Jersey Departments of Medicine and Pharmacology University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School 679 Hoes Lane, Room 242
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