Drug Metabolism Concepts PDF
200 Pages·1977·3.065 MB·English
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Content: Cytochrome P-450 : its role in oxygen activation for drug metabolism / R.W. Estabrook and J. Werringloer -- Synthetic models for the reaction stages of cytochrome P-450 / James P. Collman and Thomas N. Sorrell -- Biochemical studies on drug metabolism : isolation of multiple forms of liver microsomal cytochrome P-450 / M.J. Coon, J.L. Vermilion, K.P. Vatsis, J.S. French, W.L. Dean, and D.A. Haugen -- Resolution of multiple forms of rabbit liver cytochrome P-450 / Eric F. Johnson and Ursula Muller-Eberhard -- Enantiomeric selectivity and perturbation of product ratios as methods for studying the multiplicity of microsomal enzymes / William F. Trager -- Role of purified cytochrome P-448 and epoxide hydrase in the activation and detoxification of benzo[a]pyrene / W. Levin, A.W. Wood, A.Y.H. Lu, D. Ryan, S. West, A.H. Conney, D.R. Thakker, H. Yagi, and D.M. Jerina -- In vitro reactions of the diastereomeric 9,10-epoxides of (+) and ( -- )-trans-7,8-dihydroxy-7,8-dihydrobenzo-[a]pyrene with polyguanylic acid and evidence for formation of an enantiomer of each diastereomeric 9,10-epoxide from benzo[a]pyrene in mouse skin / P.D. Moore, M. Koreeda, P.G. Wislocki, W. Levin, A.H. Conney, H. Yagi, and D.M. Jerina -- Role of metabolic activation in chemical-induced tissue injury / Sidney D. Nelson, Michael R. Boyd, and Jerry R. Mitchell.
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