Drug Effects on Neuroendocrine Regulation PDF
Preview Drug Effects on Neuroendocrine Regulation
PROGRESS IN BRAIN RESEARCH ADVISORY BOARD W. Bargmann Kiel H. T. Chang Shanghai E. De Robertis Buenos Aires J. C. Eccles Canberra J. D. French Los Angeles H. Hydtn Giiteborg J. Ariens Kappers Amsterdam S. A. Sarkisov Moscow J. P. SchadC Amsterdam F. 0. Schmitt Brookline (Mass.) T. Tokizane Tokyo J. Z. Young London PROGRESS IN BRAIN RESEARCH VOLUME 39 DRUG EFFECTS ON NEUROENDOCRINE REGULATION EDITED BY E. ZIMMERMANN Department of Anatomy University of California, School of Medicine Los Angeles, Calif. 90024, U.S.A. W. H. GISPEN Rudolf Magnus Institute for Pharmacology University of Utrecht, Medical Faculty Vondellaan 6, Utrecht, The Netherlands B. H. MARKS Department of Pharmacology The Ohio State University Columbus, Ohio 43210, U.S.A. D. DE WIED Rudolf Magnus Institute for Pharmacology University of Utrecht, Medical Faculty Vondellaan 6, Utrecht, The Netherlands ELSEVIER SCIENTIFIC PUBLISHING COMPANY / / AMSTERDAM LONDON NEW YORK 1973 ELSEVIER SCIENTIFIC PUBLISHING COMPANY 335 JAN VAN GALENSTRAAT P.O. BOX 1270, AMSTERDAM, THE NETHERLANDS AMERICAN ELSEVIER PUBLISHING COMPANY, INC. 52 VANDERBILT AVENUE NEW YORK, NEW YORK 10017 LIBRARY OF CONGRESS CARD NUMBER: 73-77069 ISBN 0-444-41129-1 WITH 197 ILLUSTRATIONS AND 50 TABLES COPYRIGHT @ 1973 BY ELSEVIER SCIENTIFIC PUBLISHING COMPANY, AMSTERDAM ALL RIGHTS RESERVED. NO PART OF THIS PUBLICATION MAY BE REPRODUCED, STORED IN A RETRIEVAL SYSTEM, OR TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC, MECHANICAL, PHOTO- COPYING, RECORDING, OR OTHERWISE, WITHOUT THE PRIOR WRITTEN PERMISSION OF THE PUBLISHER, ELSEVIER SCIENTIFIC PUBLISHING COMPANY, JAN VAN GALENSTRAAT 335, AMSTERDAM PRINTED IN THE NETHERLANDS List of Contributors R. ADER,D epartment of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, N.Y. 14642, USA. M. AMOS, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, Calif. 92037, U.S.A. J. D. BARCHASD,e partment of Psychiatry, Stanford University Medical School, Stanford, Calif., USA. H. BARRY1,1 1, University of Pittsburgh School of Pharmacy, Pittsburgh, Pa. 15261, U.S.A. P. BERGERD, epartment of Psychiatry, Stanford University Medical School, Stanford, Calif., U.S.A. B. BOHUS,R udolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Vondellaan 6, Utrecht, The Netherlands R. A. BROWNINGD,e partment of Pharmacology, The University of Chicago, Chicago, 111. 60637, U.S.A. R. BURGUST,h e Salk Institute, 10010 North Torrey Pines Road, La Jolla, Calif. 92037, U.S.A. K. D. CAIRNCROSSSc,h ool of Biological Sciences, Macquarie University, North Ryde, N.S.W. 21 13, Australia R. D. CIARANELLSOe,c tion on Pharmacology, Laboratory of Clinical Science, National Instit Ute of Mental Health, Bethesda, Md., USA. R. COLLUD, epartment of Pediatrics, University of Montreal, Canada 0. M. CRAMERD, epartment of Physiology, The University of Texas Southwestern Medical School, Dallas, Tex. 75235, U.S.A. D. DE WIED,R udolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Vondellaan 6, Utrecht, The Netherlands W. W. DOUGLADS,e partment of Pharmacology, Yale University Medical School, 333 Cedar Street, New Haven, Conn. 06510, U.S.A. H. W. ELLIOTT,D epartment of Medical Pharmacology and Therapeutics, California College of Medicine, University of California, Irvine, Calif., U.S.A. A. G. FRANTZD, epartment of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, N.Y. 10032, U.S.A. F. FRASCHINDI,e partment of Pharmacology, University of Milan, Milan, Italy J. F. GARCIAL, awrence Radiation Laboratory, University of California, Berkeley, Calif., U.S.A. R. GEORGED, epartment of Pharmacology and Brain Research Institute, Center for the Health Sciences, University of California, Los Angeles, Calif. 90024, U.S.A. W. H. GISPENR, udolf Magnus Institute for Pharmacology and Laboratory for Physiological Chem- istry, University of Utrecht, Medical Faculty, Utrecht, The Netherlands R. A. GORSKID, epartment of Anatomy and Brain Research Institute, UCLA School of Medicine, Los Angeles, Calif. 90024, U.S.A. G. GRANTT, he Salk Institute, 10010 North Torrey Pines Road, La Jolla, Calif. 92037, U.S.A. P. GRAYR, ockefeller University, New York, N.Y., U.S.A. H. M. GREVENR, esearch Laboratories, Organon, Oss, The Netherlands L. J. GROTAD, epartment of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, N.Y. 14642, U.S.A. R. GUILLEMINTh, e Salk Institute, 10010 North Torrey Pines Road, La Jolla, Calif. 92037, U.S.A. A. HELLERD, epartment of Pharmacology, The University of Chicago, Chicago, Ill. 60637, U.S.A. T. HIGUCHIS, econd Dcpartment of Physiology, Yokohama City University School of Medicine, Yokohama, Japan L. E. HOLLISTERV,e terans Administration Hospital and Stanford University School of Medicine, Palo Alto, Calif. 94304, U.S.A. M. HYYPPAL, aboratory of Neurocndocrine Rcgulation, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Mass., U.S.A. D. M. JACOBOWITLZa,b oratory of Clinical Science, National Institute of Mental Health, Bethesda, Md. 20014, U.S.A. S. A. JOSEPHD, epartment of Anatomy, The University of Rochester School of Medicine and Den- tistry, Rochester, N.Y. 14642, U.S.A. P. S. KALRAD, epartment of Physiology, University of Texas Southwestern Medical School, Dallas, Tex., U.S.A. LIST OF CONTRIBUTORS VII I. A. KAMBERDI, epartment of Obstetrics and Gynecology, UCLA School of Medicine, Harbor General Hospital Campus, Division of Reproductive Biology, Torrance, Calif. 90509, U .S.A. A. J. KASTINV, A Hospital, Tulane University School of Medicine and Louisiana State University at New Orleans and Medical Center, New Orleans, La., U.S.A. M. KAWAKAMSIe, cond Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan F. KIMURA,S econd Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan H. G. KING,S chool of Biological Sciences, Macquarie University North Ryde, N.S.W. 2113, Australia K. M. KNIGGED, epartment of Anatomy, The University of Rochester School of Medicine and Dentistry, Rochester, N.Y. 14642, USA. N. KOKKAD, epartment of Medical Pharmacology and Therapeutics, California College of Medicine, University of California, Irvine, Calif. USA. N. KONDA,S econd Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan L. KORANYIIn, stitute of Physiology, University Medical School, Pks, Hungary W. KRIVOYN, ational Institute of Mental Health, Addiction Research Center, Lexington, Ky., U.S.A. R. K. KUBENAI,C I America, Inc., Wilmington, Del. 19899, USA. S. LANDEY, ale University School of Medicine, Department of Dermatology, New Haven, Conn., USA. N. A. LFDPOLD,D epartment of Neurology, Boston University School of Medicine, Boston, Mass., U.S.A. N. LING,T he Salk Institute, 10010 North Torrey Pines Road, La Jolla, Calif. 92037, USA. B. H. MARKSD, epartment of Pharmacology, The Ohio State University Columbus, 0.43210, U.S.A. L. MARTINID, epartment of Pharmacology, University of Milan, Milan, Italy S. M. MCCANN,D epartment of Physiology, University of Texas Southwestern Medical School, Dallas, Tex., USA. B. S. MCEWENR, ockefeller University, New York, N.Y., U.S.A. B. MESSD, epartment of Anatomy, University Medical School, Szigeti ut 12, Pkcs, Hungary B. J. MEYERSODNe, partment of Pharmacology, Biomedicum, Box 573, 75123 Uppsala, Sweden L. H. MILLERV, A Hospital, Tulane University School of Medicine and Louisiana State University at New Orleans and Medical Center, New Orleans, La., U.S.A. M. MONAHANT,h e Salk Institute, 10010 North Torrey Pines Road, La Jolla, Calif. 92037, U.S.A. P. L. MUNSOND, epartment of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, N.C. 27514, U.S.A. R. NOCKMN,V A Hospital, Tulane University School of Medicine and Louisiana State University at New Orleans and Medical Center, New Orleans, La., USA. E. PAPAIKONOMODUep, artment of Pharmacology, Free University Medical Faculty, Amsterdam, The Netherlands J. L. PERHACHJr,. , Mead Johnson Research Center, Evansville, Ind. 47721, U.S.A. S. PODOLSKBYo, ston University School of Medicine; Intermediate Care Service and Clinical Metabolic Research Unit, Veterans Administration Hospital, Boston, Mass., USA. J. C. PORTERD, epartment of Physiology, The University of Texas Southwestern Medical School, Dallas, Tex. 75235, U.S.A. P. PREZIOSIIn, stitute of Pharmacology, University of Naples, Via Pansini 5, 80131 Naples, Italy R. L. REITERD, epartment of Anatomy, The University of Texas Medical School at San Antonio, San Antonio, Tex. 78229, U.S.A. J. RIVER,T he Salk Institute, 10010 North Torrey Pines Road, La Jolla, Calif. 92037, USA. C. A. SANDMAVNA, Hospital, Tulane University School of Medicine and Louisiana State University at New Orleans and Medical Center, New Orleans, La., U.S.A. M. SAR, Departments of Anatomy and Pharmacology, Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, N.C. 27514, USA. U. SCAPAGNINInI,s titute of Pharmacology, University of Naples, Via Pansini 5, 80131, Naples, Italy A. V. SCHALLYV,A Hospital, Tulane University School of Medicine and Louisiana State University at New Orleans and Medical Center, New Orleans, La., USA. S. SCHOFIELDSc, hool of Biological Sciences, Macquarie University, North Ryde, N.S.W. 21 13, Australia VIII LIST OF CONTRIBUTORS P. SCHOTMARNu, dolf Magnus Institute for Pharmacology and Laboratory for Physiological Chem- istry, University of Utrecht, Medical Faculty, Utrecht, The Netherlands A. J. SILVERMADNe, partment of Anatomy, The University of Rochester School of Medicine and Dentistry, Rochester, N.Y. 14642, U.S.A. P. G. SMELIKD, epartment of Pharmacology, Free University Medical Faculty, Amsterdam, The Netherlands L. 0. STRATTONV,A Hospital, Tulane University School of Medicine and Louisiana State University at New Orleans and Medical Center, New Orleans, La., USA. W. E. STUMPFD, epartments of Anatomy and Pharmacology Laboratories for Reproductive Biology, University of North Carolina, Chapel Hill, N.C. 27514, U.S.A. E. TERASAWSAe,c ond Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan L. TIMA,D epartment of Anatomy, University Medical School, Szigeti ut 12, Pks, Hungary G. P. TRENTINDI, epartment of Pathology, University of Modena, Via Berengario 4,41100 Modena, Italy S. VAALAD, epartment of Anatomy, The University of Rochester School of Medicine and Dentistry, Rochester, N.Y. 14642, U.S.A. W. VALET, he Salk Institute, 10010 North Torrey Pines Road, La Jolla, Calif. 92037, U.S.A. J. VERNIKOS-DANELLBIiSo,m edical Research Division, Ames Research Center, NASA, Moffett Field, California, USA. P. H. VOLKMADNe, partment of Pharmacology, The University of Chicago, Chicago, Ill. 60637, U.S.A. R. I. WEINERD, epartment of Anatomy, University of Southern California, School of Medicine, Los Angeles, Calif. 90033, U.S.A. J. M. WEISS,R ockefeller University, New York, N.Y., U.S.A. A. WITTERR, udolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Vondellaan 6, Utrecht, The Netherlands R. J. WURTMANL,a boratory of Neuroendocrine Regulation, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Mass., U.S.A. E. ZIMMERMANNNa,t ional Institute of Mental Health, Addiction Research Center, Lexington, Ky., U.S.A. The proceedings of the International Symposium “Drug Effects on Neuroendocrine Regulation” are dedicated to the late Professor GEOFFREWY. HARRIS,w hose outstanding work has been a major impetus in the development of . Neuroendocrinology Preface Several years ago, a group representing the scientific disciplines of pharmacology, psychology, neuro-anatomy and endocrinology met in conference in Vierhouten, The Netherlands, to evaluate the state of our knowledge concerning the mutual interaction between the pituitary-adrenal system and the brain. The proceedings of that conference were published in 1970 as Pituitary, Adrenal, and The Brain, in Progress in Brain Research, Vol. 32 (Elsevier, Amsterdam). It was clear from that meeting that we were on the threshold of exciting new developments in relationship to the interactions between the endocrine and nervous systems. The second discovery which many of us made was that the special combination of disciplines represented at that meeting provided for particularly interesting and enthusiastic discussions and that the group dynamics generated were rather special. It was with the background of that experience at Vierhouten that a group of us felt impelled to organize a meeting in the U.S.A. several years later in order to measure the advances that had taken place in the understanding of the regulation of the neuro-endocrine system. So it was, therefore, that scientists representing the same combination of disciplines gathered at Snowmass-At-Aspen, Colorado, in the splendid isolation of the Rocky Mountains, to exchange ideas about mechanisms that regulate neuro-endocrine function. There were 90 participants present, including both senior professors and young postdoctoral men and women just entering their careers in neuro-endocrinology. It was apparent from the beginning that the spirit of free exchange, of friendship and of the search for real understanding was with us at this meeting. This spirit was evident from the first morning session, devoted to neuro- anatomical and neuro-chemical aspects of neurosecretion. The vigorous and critical exchange continued through intervening sessions which considered various steroid, biogenic amine and drug effects on neuro-endocrine mechanisms, and great interest and enthusiasm were generated by the discussion of pituitary-adrenal effects upon learning and behavior, the final scientific session. For all of the good fellowship and invaluable intellectual stimulation, we express sincere gratitude to all of the speakers and to the conference participants in general for their excellent discussion. All of this was made possible by the effort of the various session chairmen, who were instrumental in arranging the program and in insuring the prompt publication of these proceedings-John Porter, Charles Sawyer, Joan Vernikos-Danellis, Lucian0 Martini, Samuel McCann, William Krivoy, Emery Zimmermann, Robert Ader, Willem Gispen-thank you all! On a more personal note, our thanks and admiration to our conference secretaries Daria Cverna and Carol Jones, and the graduate students Kenneth Kellar, Paul XI1 PREFACE McCauley and David Schneider, who made impossible tasks look easy. We also like to thank Greet Hoekstra and Victor Wiegant for their assistance in editing the manu- scripts. Finally, the cooperation of the organizing committee, including Willem Gispen, Harold Goldman, William Krivoy and Emery Zimmermann, made it possible for the initial plans for the conference to be fulfilled. BERNARDH . MARKS Professor of Pharmacology Chairman of the Department of Pharmacology Ohio State University Columbus, Ohio, U.S.A. DAVIDD E WIED Professor of Pharmacology Chairman of the Rudolf Magnus Institute for Pharmacology State University of Utrecht Utrecht, The Netherlands Acknowledgements We gratefully acknowledge the National Institute of Mental Health (U.S.A.) and the National Aeronautics and Space Administration (U.S.A.) for sponsoring this International Symposium. We also like to express our gratitude to the following organizations: Abbott Laboratories Carter-Wallace, Incorporated CIBA Pharmaceutical Company Organon Company Schering Corporation G. D. Searle and Company Smith Kline and French Laboratories Dr. Saal van Zwanenberg Stichting Wyeth Laboratories for their generous additional financial support.
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