Drug Dependence and Emotional Behavior: Neurophysiological and Neurochemical Approaches

495 Pages·1986·20.87 MB·English

by  M. M. Kozlovskaya

DRUG DEPENDENCE
AND
EMOTIONAL BEHAVIOR
Ne urophysi 01 ogi cal
and
Neurochemical Approaches
DRUG DEPENDENCE
AND
EMOTIONAL BEHAVIOR
Neurophysiological
and
Neurochemical Approaches
Edited by
A. V. Valdman
Institute of Pharmacology
Academy of Medical Sciences of the USSR
Moscow, USSR
Translated by
L. R. Sandler
Translation Edited by
M. Sandler
Queen Charlotte's Hospital
London, England
CONSULTANTS BUREAU • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
Drug dependence and emotional behavior.
Includes bibliographies and index.
l. Neuropsychopharmacology. 2. Drug abuse-Physiological aspects. 3. Psycho-
tropic drugs-Physiological effect. I. Val'dman, A. V. (Artur Viktorovich) II. Sandler,
Merton. [DNLM: 1. Behavior-drug effects. 2. Nervous System-drug effects. 3.
Substance Dependence. QV 76.5 D794]
RM315.D789 1986 615'.78 86-8127
ISBN-13: 978-1-4684-1658-9 e-ISBN-13: 978-1-4684-1656-5
DOl: 10.1007/978-1-4684-1656-5
This translation is published under an agreement with the Copyright Agency of the
USSR (VAAP)
© 1986 Consultants Bureau, New York
Softcover reprint of the hardcover 1st edition 1986
A Division of Plenum Publishing Corporation
233 Spring Street, New York, N.Y. 10013
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
Contributors
Allikmets L. H.2 Kud r in V. S. I
Andreev B. V. 3 Maisky A. I. I
Avdulov N. A. I Mineyeva M. F. I
Badyshtov B. A.4 Mucinieze R. K. 5
Blednov Yu. A.4 Poshivalov V. p.3
Bondarenko N. A.I Rayevsky K. S. I
Borisenko S. A. I Rojanetz V. V. l
Burov Yu. V. I Shemanov A. Yu. l
Galustyan G. E. 3 Shevchenko N. M.4
Garibova T. L. I Seredenin S. B.4
Ignatov Yu. D.3 Valdman A. V. I
Kampov-Polevoi A. B.I Vedernikova N. A.I
Katkova E. B.3 Voronina T. A. I
Kharlamov A. N. I Yukhanov R. Yu. I
Khodorova N. A.I Zarkovsky A. M.2
Klusha V. E. 5 Zhukov V. N. I
Kovalev G. I. I Zvartau E. E.3
Kozlovskaya M. M.I
1. Institute of Pharmacology, ~cademy of Medical Sciences of the
USSR, Baltiyskaya str. 8, 125315 Moscow, USSR.
2. Department of Pharmacology, Tartu University, 202400 Tartu,
Ulikooli 18, USSR.
3. Department of Pharmacology, Pavlov Medical Institute, Tolstoy
str., 6/8, 197089, Leningrad, USSR.
4. Laboratory of Pharmacological Genetics, Second Medical Institute,
Ostrovityanova str. 1, 117437 Moscow, USSR.
5. Institute of Organic Synthesis, Latvian Academy of Sciences,
Ayzkraukles str. 21, 226006 Riga, USSR.
v
Foreword
English-speaking scientists start with one vast advantage: the
bulk of the world's scientific transactions are conducted in English.
There are many who would go further and say that any scientific work
of importance is published in English. This book, which is, in
effect, the tip of a large iceberg, gives them the lie! In the
Soviet Union alone we have a vast wealth of expertise supported by a
treasury of books and publications, but it is effectively cut off
from Western scrutiny by the language barrier. It therefore seems
timely to lift the curtain a little and put some of the best of it on
display.
In this excellent compilation, Professor Valdman and Dr. Burov
have assembled a cast list of leading Soviet scientists who provide
us with a refreshingly different slant on a set of problems of con-
cern to neuroscientists throughout the world. These scientific
presentations are neither better, nor worse than but, rather, com-
plementary to Western pharmacological thinking. Traditional Soviet
approaches to animal psychology are here coupled with sophisticated
latter-day neurochemistry and neurophysiology and, in the process,
provide us with new insights into the molecular bases of animal
responses to environment and to certain drugs. Apart from shedding
new light on many contemporary problems, the findings reported here
provide an important window on the thought processes of the foremost
neuroscientists of the Soviet Union. This book cannot fail to be of
interest to all who work in this expanding (and exciting) area.
M. Sandler
vii
Contents
EMOTIONAL BEHAVIOR
(Edited by A.V. Valdman)
PSYCHOPHYSIOLOGICAL BEHAVIOR AND PHARMACOLOGICAL ASPECTS
Combined Method for Evaluating Emotional States
and Individual Response of Cats under
Conditions of Social Interaction 3
M. M. Kozlovskaya and A. V. Valdman
Factor Analysis of Emotional/Behavioral Reac.tions
in Cats of Different Types 39
A. V. Valdman and E. B. Katkova
Hereditary Traits of Animals with Different Types
of Reaction to Stress and Benzodiazepine
Tranquilizers 49
S. B. Seredenin, Yu. A. Blednov, B. A. Badyshtov
and N. M. Schevchenko
Qualitative and Quantitative Assessment of
Benzodiazepine Action on Emotional/Behavioral
RE::sponsiveness 79
A. V. Valdman, E. B. Katkova and M. M. Kozlovskaya
Psychophysiological and Neurochemical Analysis of
Benzodiazepine Tranquilizers' Activating Effect 101
A. V. Valdmau and B. V. Andreev
PEPTIDERGIC AND NEUROCHEHICAL ASPECTS
Neurotransmitter and Peptidergic Mechanisms of
Intraspecies Aggression and Sociability 145
V. P. Poshivalov
ix
x CONTENTS
Psychotropic Effect of Tuftsin, a Natural Phagocytosis-
stimulating Peptide, and Some of its Analogs 175
A. V. Valdman, N. A. Bondarenko and M. M. Kozlovskaya
Monoaminergic Mechanisms of Psychotropic Action of
Short Peptides 203
A. V. Valdman, M. M. Kozlovskaya, N. A. Bondarenko,
V. V. Rojanetz, N. A. Avdulov, V. E. Klusha,
and R. K. Mucinieze
The GABA System as a Factor in Adaptation and
Pharmacological Treatment of Stress 239
Yu. D. Ignatov, B. V. Andreev and G. E. Galustyan
Neurochemical Pharmacology of GABA-ergic Drugs 261
K. S. Rayevsky, G. I. Kovalev and A. N. Kharlamov
&lalysis of Dopamine Receptor Supersensitivity
After Chronic Neuroleptic Treatment in Rats 289
A. M. Zharkovsky and L. H. Allikmets
Neuroleptics - Allosteric Tyrosine Hydroxylase
Regulators 303
M. F. Mineyeva, V. S. Kudrin and A. Yu. Shemanov
Correlation Between the Affinity of Antidepressants for
Membranes and Their Influence on Monoamine Transport 327
N. A. Avdulov and A. V. Valdman
DRUG DEPENDENCE
(Edited by Yu.V. Burov)
Psychophysiological and Genetic Factors Responsible
for Alcohol and Morphine Dependence in Animals 341
Yu. V. Burov, S. A. Borisenko, A. B. Kampov-Polevoi
and A. I. Maisky
The Role of Catecholamines and Serotonin in the Formation
and Maintenance of Susceptibility to Alcohol 367
V. N. Zhukov, Yu. V. Burov and N. A. Khodorova
The Importance of Some CNS Pep tides in the Development
of Experimental Alcoholism 389
Yu. V. Burov, R. Yu. Yukhananov and A. I. Maisky
CONTENTS xi
Endocrine Factors in the Pathogenesis of Experimentally-
induced Alcoholism 415
Yu. V. Burov and N. N. Vedernikova
The Role of Reward and Punishment Brain Systems in
the Development of Drug Dependence 433
A. V. Valdman and E. E. Zvartau
Characteristics and Mechanisms of Tolerance to
Benzodiazepines 453
T. L. Gariboba and T. A. Voronina
Index 479
Emotional Behavior
Edited by A.V. Valdman
Psychophysiological Behavior and
Pharmacological Aspects