Drug Delivery: Materials Design and Clinical Perspective PDF
Preview Drug Delivery: Materials Design and Clinical Perspective
Eric P. Holowka · Sujata K. Bhatia Drug Delivery Materials Design and Clinical Perspective Foreword by Enrico G. Bellomo Drug Delivery Eric P. Holowka (cid:129) Sujata K. Bhatia Drug Delivery Materials Design and Clinical Perspective Foreword by Enrico G. Bellomo Eric P. Holowka Sujata K. Bhatia DuPont Central Research and Development School of Engineering and Applied Science Wilmington , USA Harvard University Cambridge , MA , USA ISBN 978-1-4939-1997-0 ISBN 978-1-4939-1998-7 (eBook) DOI 10.1007/978-1-4939-1998-7 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2014952080 © Springer Science+Business Media New York 2014 T his work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. T he use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) About the Authors Eric P. Holowka is a Senior Research Investigator with DuPont Central Research & Development and holds appointments as Visiting Assistant Professor in both the Materials Science & Engineering Department at Drexel University and the Chemistry Department at Haverford College. Since 2007, he has led different research discovery and/or implementation efforts within Central Research involving the application of drug delivery methodologies to a broad range of technology areas encompassing regenerative medicine, energy storage, food science, agriculture, and nutrition, which has led to the publication of over 16 patents. He earned his bache- lor’s degree in chemistry with a minor in Polymer, Colloidal, and Surface Science at Carnegie Mellon University, while concurrently studying at the Center for Macromolecular Engineering under the guidance of Krzysztof Matyjaszewski as a Howard Hughes undergraduate research fellow. He then attended the University of California Santa Barbara (UCSB), where he earned his Ph.D in Materials Science & Engineering as a California NanoSystems Institute Fellow under Timothy Deming for his work on the design and implementation of self-assembled polypeptide copo- lymers for use in targeted drug delivery and tissue engineering. Prior to joining DuPont, he worked in research and development, intellectual property, and in-vitro trials at University of California Los Angeles’ (UCLA) Department of Biomedical Engineering and in immunology, biochemistry, and cell biology at Cornell University’s Department of Chemistry and Chemical Biology. The drug delivery technologies that Dr. Holowka developed in his time at UCSB and UCLA have been featured in Chemical & Engineering News (Technology Concentrates 2006), cited over 500 times in scientifi c journals and textbooks, and licensed to several biotech- nology and drug delivery companies as part of their core technology platforms. He has been invited to speak at a number of universities for his work on “Rational Biomaterial Design for use in Intracellular Drug Delivery”. In 2010, he published a textbook, “ Copolypeptide Vesicles: Size Control for Intracellular Drug Delivery, ” which discusses core technologies behind the design and implementations of p eptide-based drug delivery systems from the synthetic chemistry and materials science perspective. v vi About the Authors Sujata K. Bhatia is a faculty member in Biomedical Engineering at Harvard University, and serves as the Assistant Director for Undergraduate Studies in Biomedical Engineering at Harvard. She is also an Associate of the Harvard Kenned School of Government, and a faculty member in the Harvard Kennedy School Executive Education program on Innovation for Economic Development. She earned three bachelor’s degrees, in biology, biochemistry, and chemical engineer- ing, and a master’s degree in chemical engineering at the University of Delaware. She then attended the University of Pennsylvania School of Medicine, where she earned her M.D. and Ph.D in bioengineering. Prior to joining Harvard, she worked in research and development, intellectual property, and clinical trials at DuPont. From 2003 to 2008, she worked to develop tissue adhesives for closure of wounds. In 2009, she spent a year on technology licensing for cancer drug discovery. In 2010 and 2011, she led clinical trials of omega-3 fatty acids for heart health. She was an invited participant in the 2005 U.S. Frontiers of Engineering and 2006 Japan-U.S. Frontiers of Engineering symposia, and a co-organizer of the 2007 Japan-U.S. Frontiers of Engineering symposium. In 2010, she published a textbook, “Biomaterials for Clinical Applications,” which discusses opportunities for both biomaterials scientists and physicians to alleviate diseases worldwide. In 2011, she published another book, “Engineering Biomaterials for Regenerative Medicine.” In 2013, Sujata was awarded the Capers and Marion McDonald Award for Excellence in Mentoring and Advising, the highest award in the Harvard School of Engineering and Applied Sciences for excellence in advising. She was also awarded the Star Family Prize for Excellence in Advising, a distinguished award from Harvard University for exemplary intellectual and personal guidance of undergraduate stu- dents. In 2013, she was selected by the U.S. National Academy of Engineering for Frontiers of Engineering Education, a recognition for the most innovative engineer- ing educators in the nation. In 2014, she was voted by the Harvard College Class of 2014 as a Harvard Yearbook Favorite Professor. Foreword E mbarking upon the journey of teaching the design principles of drug delivery sys- tems and their clinical application is a daunting task. Many current offerings in this area typically either fail to address the complexity of the physiology where they seek to operate, while highlighting innovative system designs, or choose outdated systems to address complex physiological problems. What remains absent is an approach both targeted at multidisciplinary design solutions rooted in biology, engi- neering, chemistry, and physics validated with an applied knowledge in clinical research and application. In order for this approach to be effective, the authors have to be as uniquely diverse and experienced as the material they are about to cover. For the material design sections, Eric Holowka is astutely equipped for the challenge. In a young career, Holowka has been able to successfully extend his scientifi c interests into areas of polymer science (B.S. Carnegie Mellon University), immunology (Cornell University), materials science and engineering (Ph.D. University of California Santa Barbara), biomedical engineering (University of California Los Angeles), and nanotechnology (California NanoSystems Institute). Holowka has published a book, C opolypeptide Vesicles: Size Control for Intracellular Drug Delivery , and holds patents in diverse areas of technology application, which include drug deliv- ery, food science, nutrition, agriculture, energy storage, and nanotechnology. He currently holds a position in DuPont Central Research & Development, with Visiting Assistant Professor appointments in the Materials Science & Engineering Department at Drexel University and the Chemistry Department at Haverford College. On the clinical perspective side, Sujata Bhatia assumed a strongly diverse counterpoint. In her short career, Bhatia has earned three B.S. degrees, in biology, biochemistry, and chemical engineering, an M.S. degree in chemical engineering (University of Delaware), a Ph.D. in bioengineering, and an M.D. (University of Pennsylvania). Bhatia has published two books in the fi eld of biomedical engineer- ing, B iomaterials for Clinical Applications and E ngineering Biomaterials for Regenerative Medicine. She currently holds the position of Assistant Director of Undergraduate Studies in Biomedical Engineering at Harvard University. vii viii Foreword A uthors with such a broad technical range of applied knowledge are uniquely capable of distilling complex principles associated with structure, function, and application for the reader. These principles are not abandoned with the reader, but instead are reinforced with thoughtful examples and problem sets within each chap- ter. Taken as a whole, in addition to serving as a resource for undergraduates, gradu- ate students, and medical students with an interest in biomedical science, this text stands as a solid resource for physicians and surgeons who desire novel therapeutic approaches, patient advocacy groups and educated patient populations, and industry executives desiring to learn about biomaterials. This text holds a unique perspective for young scientists, engineers, and physicians to effectively understand the fi eld of drug delivery from multiple perspectives. I am confi dent that with Eric and Sujata as your guides, prepare to be not only edifi ed, but also entertained. You are in very capable hands. Los Angeles, CA, USA Enrico G. Bellomo, Ph.D. Biomolecular Research & Development NantPharma, LLC Acknowledgments The authors would like to thank Dr. Enrico G. Bellomo and Professor Philip J. Costanzo, who graciously gave their time to read and comment on the technical text and problem sets within this manuscript. Their suggestions for improvements and corrections proved a valuable resource. We would also like to thank the students from the Chemistry Department at Haverford College and the Biomedical Engineering Department at Harvard University for their input into various topic areas and current research trends. We are especially indebted to Jennifer and Alex, who always offered their unwavering love and support while we weathered the long nights of researching, writing, and editing. To all these wonderful individuals, we offer our humblest gratitude. ix
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