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Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer © AGO e.V. in der DGGG e.V. sowie in der DKG e.V. Guidelines Breast Version 2014.1 Complementary Therapy Survivorship Complementary Therapy – Hormonal Treatment and Alternatives in Breast Cancer Survivors – Survivorship © AGO e.V. Version 2002–2013: in der DGGG e.V.  sowie in der DKG e.V. Bauerfeind / Blohmer / Gerber / Göhring/ Guidelines Breast Version 2014.1 Hanf / Janni / Kümmel / von Minckwitz / Oberhoff / Scharl / Schmidt / Schütz/ Thomssen Version 2014:  Albert / Hanf / Fersis / Friedrich www.ago-online.de „Alternative“ Therapies © AGO e.V. in der DGGG e.V. sowie in der DKG e.V. „Integrative Oncology“ „Unconventional Guidelines Breast Version 2014.1 methods“ CAM UCT Complementary + alternative medicine Unconventional Thx Complementary Alternative Unconventional www.ago-online.de In addition to Instead of Unproven outsider scientifically scientifically methods based medicine based medicine Complementary Therapy Pre- and Postoperative © AGO e.V. in der DGGG e.V. Oxford AGO sowie in der DKG e.V. LoE / GR Preoperative: Guidelines Breast Version 2014.1  Hypnosis (reduces anxiety, pain, fatigue, nausea) 1b B +/- Postoperative:  Acupuncture (pain relief) 2b B +/- www.ago-online.de  Acupuncture (nausea, vomiting) 2b B +  Early postop. exercise reduces upper-limb 1a A + dysfunction (beware: increased wound drainage)  Prophylactic lymph drainage 1b B - Complementary Treatment Impact on Toxicity I © AGO e.V. While on anti-cancer treatment: Oxford / AGO in der DGGG e.V. beware of drug interactions sowie LoE / GR in der DKG e.V. Guidelines Breast Version 2014.1 www.ago-online.de Complementary Treatment Impact on Toxicity II © AGO e.V. Oxford / AGO in der DGGG e.V. sowie LoE / GR in der DKG e.V. Guidelines Breast Version 2014.1 Antioxidant supplements 1b B - High dose vitamine C 1b C - Vitamine E 2b D - Selenium for alleviating side effects of therapy1b B - Co-Enzyme Q 10 (fatique, QoL) 1b B - Proteolytic enzymes in order to reduce www.ago-online.de chemotherapy-induced toxicity 3b B - Chinese herbal medicine improves wound healing after mastectomy 1b B -*inf Oxygen and ozone therapy 5 D - - *inf: i.v.-infusion (in Germany not approved) Additional Complementary Therapy Side Effects Related to Cancer Treatments e.g. Chemotherapy Oxford AGO © AGO e.V. LoE / GR in der DGGG e.V. sowie in der DKG e.V.  Chinese medicinal herbs to treat the side effects of 1b B - Guidelines Breast chemotherapy in breast cancer patients Version 2014.1  May offer some benefit to breast cancer patients in terms of bone marrow improvement and quality of life  Homoeopathic medicines for adverse effects of cancer 1b B +/- treatments  Topical calendula (>= 20% Calendula amount) for prophylaxis of acute dermatitis during radiotherapy  Traumeel S mouthwash to treat chemotherapy-induced stomatitis  Topical Silymarin for prophylaxis of acute dermatitis 3a B +/- during radiotherapy www.ago-online.de  Acupuncture in order to improve on 1a B +  Chemotherapy-induced >=nausea and vomiting 2b C +  Aromatase-inhibitor treatment induced arthralgia 5 D +/-  Cognitive dysfunction 1a B +/-  Fatigue 1a B +/-  Pain 2b B -  Leucopenia Complementary Treatment Mind-Body Medicine I Oxford / AGO © AGO e.V. in der DGGG e.V. LoE / GR sowie in der DKG e.V. Guidelines Breast Version 2014.1 MBSR 1b A + (Mindfulness-Based Stress Reduction) Programme improves quality of life, coping strategies, attentiveness, lowers stress and depressive syndromes) Physical exercise / sport 1a A ++ min. 150 min. moderate endurance training per week in combination with work out exercises (2x per week) www.ago-online.de improve quality of life, cardio-respirat. fitness, physical performance and fatique Complementary Treatment Mind-Body Medicine II © AGO e.V. in der DGGG e.V. Oxford / AGO sowie in der DKG e.V. LoE / GR Guidelines Breast Version 2014.1 ____________ Yoga Improves sleep, quality of life, stress, anxiety, 1b A + depression Improves fatigue 2a B +/- Qi Gong 2a B +/- May improve quality of life, fatigue, mood www.ago-online.de Tai Chi 2b D +/- Improves quality of life, physical performance Hypnosis (in combination with cognitive training) 2a B +/- Improves fatigue and muscle weakness under radiation therapy Modifiable Lifestyle Factors Prevention of Recurrence I © AGO e.V. Oxford / AGO in der DGGG e.V. sowie in der DKG e.V. LoE / GR Guidelines Breast Version 2014.1  Physical exercise 1a A ++ (Equivalents to 3–5 hrs moderate walking per week improves DFS and OS, cardio- respiratory fitness, physical functioning)  Smoking 1b A - www.ago-online.de  Alcohol consumption (>6 g/die) 1b A -

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(2007): The effect of preemptive HAN'S acupoint nerve stimulator on Stimulation of the wrist acupuncture point P6 for preventing postoperative
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