Download Harvard Apparatus Regenerative Medecine Catalog

112 Pages·2011·5.82 MB·English

advanced technologies for
Regenerative
Medicine
from Research
to Clinical
Injection & Perfusion
Bioreactors
Biosensing
Total Solutions
Support
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Electro- Behavioral Harvard Electro- Molecular
physiology Research Apparatus poration Sample
& Pumps & Preparation
Cell Biology Electrofusion
Research
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Developed with Leading
Scientists and Surgeons! I
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Imaging Technique, IRCI (Infrared Contrast Imaging)
Visualize tissue and organ metabolic activity, vascularization of tissue and disease
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conditions in a bioreactor or during cell therapy. The new IRCI technology allows you E
to visualize events and evaluate treatment site conditions providing a new and W
powerful tool for regenerative medicine. P
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Dedicated Lung Bioreactor with Online Pulmonary
Monitoring used in Successful Lung Regeneration
and Transplant
Proven and published whole organ bioreactor specifically designed in conjunction
with Massachusetts General Hospital for generation of rodent lungs. Active
ventilation and real-time monitoring of respiratory mechanics for organ performance
validation and successful transplatation.
See page 39.
Imaging Multi-well Bioreactor/Incubator
Now accelerate your tissue, cell and organ research. 4, 8, 16, 24, 48, 96 well imaging
plates on the microscope. 4 wells with active independent perfusion. Now perform
simultaneous experiments in multi-well format for high throughput screening of
decellularization and recellularization conditions.
See page 44.
Pressure Controlled Infusion Pump
Now a system to deliver pressure-controlled fluid injection to intact organs and
tissues. The system delivers rapid injections while simultaneously monitoring
pressure at the injection site. Measured pressure modulates pump speed for tight
control of delivered injection pulse. Ideal for delivering a pressure controlled
injection.
See page 12.
In 2011, Harvard Apparatus was chosen as the #1 most Innovative Biotechnology Company in
Massachusetts by the Boston Globe. To view press release, use your smart phone to scan the
QR code or visit www.harvardbioscience.com/releases.cfm.
FOR PRODUCT INFORMATION 508.893.8999 [email protected] www.harvardapparatus.com 1
INTRODUCTION
NEW Regenerative Medicine
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I Do It Yourself Rugged Heparin Coating Kit
Now in your lab you can coat glass, plastic and metal with a rugged heparin coating
ts to reduce clot formation in bioreators, culture dishes, biomaterial and fluids. Lab Site
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Woven Synthetic Scaffold Material
Accelerate tissue and cell engineering protocols with ready-made and precisely-
defined scaffold sheets and nibs. Biocompatible and cell friendly polymer material
with special configurations available. Works with multi-well bioreactors.
See page 60.
A Family of Cell Friendly Pumps
When pumping cell suspensions, these gentle pumps produce reduced cell damage
caused by conventional roller pumps. These advanced pump designs are ideal for cell
and 3D organ bioreactors.
See page 23.
Ultra Microliter Injection Systems
These zero dead volume, 40, 60, 80 micron needles delliver precision trace chemicals
with minimium tissue damage. Ideal for small volume injection utilizing the NanoCool
injector either hand held or in a stereotaxic frame.
See page 11.
Note: Products in this catalog are for Research Use Only. Not for use on humans
unless proper investigational device regulations have been followed.
2 FOR PRODUCT INFORMATION 508.893.8999 [email protected] www.harvardapparatus.com
Table of Contents
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Table of Contents for Regenerative Medicine R
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Company Information 4-5 Digital Gas Mixer 51-53 U
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Harvard Apparatus In the News 6-7 HPC-3, Hydrostatic Perfusion Chamber 54 T
Injection and Perfusion 8 C-Pace Cell Culture EP Stimulator 55-57 IO
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Cell Injection System Poster fold out Stimulator C 58
NanoCool Cell Delivery System 9-10 Stimulator CS for Isolated Cells 59
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UI Ultra-Microliter Injection System 11 Synthetic Scaffold Material 60-61 a
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Pressure Controlled Injection System 12 Lab Site Heparin Coating 62 le
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PHD ULTRA™Gradient System 13 Flow Through Device Accessories 63 f C
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PHD ULTRA™Electrospinning Scaffolds 14 Biosensing 64 n
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PHD ULTRA™Continuous Flow Syringe Pump 15 Biosensing Introduction 65 n
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Fast Bolus Injector for Cell Therapy 16 PLUGSYS Modular Measuring Control System 66
Advanced Features of the PHD ULTRA™Family 17-20 PowerLab Data Acquisition System 67-68
Pulsatile Blood Pumps 21-22 Polestar Florescence-based Biosensors 69-72
Centrifugal Pump for Blood 23 Universal Perfusion Solution Monitor 73
REGLO Digital/Analog Programmable Peristaltic Pumps 24 Handheld Microscopes 74-75
MCP Pump Drive 25 Infrared Contrast Imaging (IRCI) 76
Pump Head 380AD for Biologicals, Gentle Peristaltic 26 Infrared Contrast Imaging (IRCI) Poster fold out
SB Pumo Head for Standard Applications 27 IRCI Cameras 77-79
Gentle Pumping Pump Heads for MCP & BUP Pump Drives 28 IRCI Camera Selection Guide 80-81
Perfusion Accessories 29 Infrared Contrast Imaging Guide 82-85
SWS-10, SWS-60 & SWS-140 Syringe Warmers 30 IRCI Imaging Kidney and Lung 86
SC-20 Dual In-Line Solution Heater/Cooler 30 Visualizing Vascularization Changes 87
Guide to Pump Capabilities 31 Visualization of Vessel and Vascular Leaks During Surgery 88
Regenerative Medicine Pumping Technologies 32-33 Visualizing Aerosols 89
Bioreactors 34 Visualization of Water Flow 90
3D and Multi-Well Bioreactors 36 Emissivity, Enhanced Visualization with IRCI 91-93
InBreath 3D Bioreactor for Hollow Organs,
Visualize with ICI Imaging 94-95
Bronchus, Trachea & Blood Vessels 37-38
LB-2 Bioreactor for Mouse and Rat Lung Regeneration 39-40 Total Solutions and Support 96
3D Bioreactor Poster fold out Regenerative Medicine Phases 97-98
Regenerated Trachea Poster fold out Solutions for Regenerative Medicine Applications 99-102
Lung Bioreactor Poster fold out Selected References 103-104
Infrared Contrast Imaging Poster fold out Index 105-108
KLB-2 Kidney and Liver Bioreactor 41
Linear Stress and Relaxation Bioreactor 42 T E C H N I C A L
High Precision 3-Axis Imaging Platform 43 S U P P O R T
Harvard Apparatus Accelerator 1000 Multi-Well 44-45
Contact us anytime to
3-Axis Imaging Platform Poster fold out
speak with one of our
Imaging Bioreactor and Incubator 46 technical experts.
RC-37F and RC-367W 47
Email:
RC-37FC and RC-36WC 48 [email protected]
Electric CO Microscope Stage Incubator 49
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Electric CO Microscope Stage Incubator Accessories 50
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FOR PRODUCT INFORMATION 508.893.8999 [email protected] www.harvardapparatus.com 3
INTRODUCTION
Harvard Bioscience companies have partnered
with leading global scientists to provide
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Harvard Apparatus necessary to meet the demands of cutting-edge life
and the Harvard science techniques.
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o Bioscience family of In keeping with this tradition, we look forward to working
ati companies are with you to develop and supply the next generation of
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uniquely positioned to
r tools to solve the new challenges of Regenerative
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nf develop advanced instrumentation to accelerate Tissue Medicine from the research lab bench to the patient.
ny I EMnegdiniceineeri.n Fgr oanmd oCuerl lo Trihgeinrasp iny t1r9e0at1m, Henartvsa inrd R Beiogsecnieernacteive There are thousands of publications in regenerative
pa Companies have worked closely with leading global medicine and stem cell research utilizing Harvard
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Apparatus products and we are now introducing a full
o researchers across many disciplines to produce clinical
C range of newly developed products including 3D Organ
and research equipment with
Bioreactors for organ generation and small volume cell
– the highest performance delivery systems for cell therapy. These unique products
– unmatched quality will serve the researcher and the physician and accelerate
the translation of novel therapies from research to
– expert support
clinical practice.
Advanced Solutions for Regenerative Medicine & Tissue Engineering & Cell Therapy
Phase 1 Phase 2 Phase 3 Phase 4 Phase 5
PREPARATION & ENGINEERING & CULTURING & CONDITION
WEBSITE
HARVESTING MODIFICATIONS GROWTH MONITORING
(cid:129) Fast Bolus Injections (cid:129) Live Imaging
(cid:129)Identification Products
(cid:129) Cell Delivery Systems (cid:129) Blood Gas Measurements
Harvard (cid:129) Ventilators (cid:129) Iontophoresis (cid:129) 3D Bioreactors (cid:129) Metabolic Monitoring web:
(cid:129) Anesthesia (cid:129) Toxin & Chemical Removal www.harvardapparatus.com
Apparatus (cid:129) Liposome Prep (cid:129) Data Aquisition & Analysis
(cid:129) Surgical Tools (cid:129) Perfusion Systems ph: [phone]
(cid:129) Drug Delivery Systems (cid:129) Feedback & Control
(cid:129) Infusion Pumps
(cid:129) Capillary Glass Syringes
(cid:129) Spinner Flasks (cid:129) Centrifuge (cid:129) Transfection Reagents (cid:129) Spinner Flasks (cid:129) Protein Measurements
Denville (cid:129) Pipetting Systems (cid:129) Ligation Kits (cid:129) Standards (cid:129) Centrifuges (cid:129) ssDNA (cid:129) RNA web:
www.denvillescientific.com
Scientific (cid:129) Incubators (cid:129) Shakers (cid:129) Visualization Kits (cid:129) Pipetting Systems (cid:129) Phosphorus
ph: [phone]
(cid:129) Sterilizers (cid:129) DNA Polymerase (cid:129) PCR (cid:129) Incubators (cid:129) Shakers (cid:129) Enzyme Kinetics
Hugo Sachs (cid:129) Ventilators (cid:129) Isolated Organ Baths (cid:129) Electrophysiology web:www.hugo-sachs.de/
(cid:129) Operating Tables (cid:129) Tissue Baths (cid:129) Cardiopulmonary Mechanics
Elektronik ph: +49 76 65 - 92 00-0
s (cid:129) Vital Signal Monitors (cid:129) 3D Organ Bioreactors (cid:129) Data Aquisition & Analysis
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ni (cid:129) Molecular Spectroscopy
a (cid:129) Protein Analysis
mp Biochrom (cid:129) Oligonucleotide Primers (cid:129) Molecular Spectroscopy (cid:129) Molecular Spectroscopy web:www.biochrom.co.uk/
(cid:129) DNA Melts (cid:129) Media Monitoring (cid:129) Amino Acid Analyzers ph: [phone]
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C (cid:129) Molecular Analysis
e (cid:129) Amino Acids Analysis
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n (cid:129) Electrodes (cid:129) Amplifiers
e (cid:129) Perfusion Chambers
ci Warner (cid:129) pH Monitoring (cid:129) Imaging Chambers web:www.warneronline.com
os Instruments (cid:129) Cell Imaging (cid:129)(cid:129) SPpeirlflu Sseionns oCrhsambers (cid:129) Ion Channel Monitoring ph: [phone]
Bi (cid:129) Ussing Chambers
d (cid:129) Temperature Control
var (cid:129)(cid:129) MCeolll eMcuelmarb rAannaelsysis (cid:129) Molecular Sample Prep web:
ar Hoefer (cid:129) Cytoplasm Toxin Measure (cid:129) Electrophoresis (cid:129) Affinity www.hoeferinc.com
H (cid:129) Cell Signaling Chemicals (cid:129) Ion Exchange (cid:129) SEC/GPC ph: [phone]
(cid:129) Filtration (cid:129) Dialysis
(cid:129) Blotting
(cid:129) Electroporation
BTX (cid:129) Electrofusion web:www.btxonline.com
(cid:129) In-vivo Transfection ph: [phone]
(cid:129) Pneumatic Injection
(cid:129) Behavioral Apparatus: web: www.panlab.com
Panlab/
- Mazes - Rota Rods ph: 34 934 750 697
Coulbourn - Treadmills web: www.coulbourn.com
- Activity Monitors ph: [phone]
CMA (cid:129) Microdialysis web: www.microdialysis.se
ph: [phone]
4 FOR PRODUCT INFORMATION 508.893.8999 [email protected] www.harvardapparatus.com
Harvard Apparatus is uniquely positioned to
develop new tools for Regenerative Medicine
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110 YEARS INTERNAL EXPERTS LARGEST GLOBAL RELATIONSHIPS N
DESIGNING & EXPERTISE RESEARCH with global scientific
leaders: technology,
specialty physiology & in organisms, organs, tissue USER BASE
research and policy C
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for small animals
products p
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(cid:129)Physiological sensors and devices (cid:129) Low Volume Fluidics (cid:129) Hundreds of Isolated Organ and (cid:129) Sponsored Research Programs f
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Perfusion systems in labs r
(cid:129) Microscopic imaging chambers (cid:129) Low Volume Sensors worldwide (cid:129) Exclusive Licences m
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(cid:129) Isolated ogran baths (cid:129) Respiratory Mechanics (cid:129) >100,000 physiological fludic (cid:129) Research and Development tio
devices in use n
(cid:129) Physiological acquisition (cid:129) Isolated Organ Baths (cid:129) Industrial Partnerships
and control (cid:129) Familiar with global regulatory
(cid:129) Cell Perfusion and Imaging (cid:129) GMP Manufacturing
compliance and manufacturing
(cid:129) Macro and micro fluidic 2D reactors
(cid:129) Environmental Control: regulations
(cid:129) 3D organ bioreactors pH, Temperature, Nutrition
(cid:129) GMP manufacturing in UK and US
(cid:129) Infusion pumps (cid:129) Amplifiers, Filters and Data
(cid:129) Global manufacturing centers in
Acquistion
(cid:129) Ventilation systems Germany, Spain, Sweden, United
(cid:129) Imaging Chambers Kingdom and United States
(cid:129) Spectroscopy and Cell Injection, (cid:129) WEE and RoHS compliant, FDA QSR
3D Organ Bioreactors and ISO13485 Certified
(cid:129) Largest catalog and global
distribution in physiological
specialty research apparatus
FOR PRODUCT INFORMATION 508.893.8999 [email protected] www.harvardapparatus.com 5
INTRODUCTION
Harvard Apparatus
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Harvard Bioscience’s Bioreactor Used to Produce a
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When Harvard Apparatus develops new products for a
new market, we team up with leading scientists around
the world. We use their input to develop new tools
specifcally designed to help solve real research
and clinical problems.
We are proud and grateful to be part of the successful
implementation of these new research devices. Some
new tools have even been successfully used in human
medical proceedures under approval of local government
and Institutional Review Boards.
Harvard Apparatus would like to thank our users for
allowing us to be part of this exciting new field of
First use of 3D organ First in Man transplant of
regenerative medicine and look forward to more
bioreactor to produce regenerated human bronchi
collaborations and breakthoughs in the future.
successful regenerative with decellurized organ
medicine transplant
Surgeons Carry Out First Lab-Made Trachea Saves Man Patient Gets World’s First
Synthetic Windpipe Transplant Tumor-Blocked Windpipe Replaced Using Artificial Trachea
Synthetic Materials, Patient’s Own Cellls
Lab-Made Organ Implanted for World’s First Laboratory- Stem Cells Grow New
First Time Grown Windpipe is Windpipe
Transplanted in Patient
Note: Products in this catalog are for Research Use Only. Not for use on humans unless proper investigational device regulations have been followed.
6 FOR PRODUCT INFORMATION 508.893.8999 [email protected] www.harvardapparatus.com
in the News
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Can We Live Forever? How to Build a
Replacing Body Parts. Beating Heart.
FOR PRODUCT INFORMATION 508.893.8999 [email protected] www.harvardapparatus.com 7
INJECTION & PERFUSION
solutions for regenerative medicine:
injection & perfusion
Table of Contents
NanoCool™Poster fold out between8-9
NanoCool™Cell Delivery System 9-10
Cooled Injection System to
UI Ultra-Microliter Injection System 11
Maintain Cell Viability Pressure Controlled Injection System 12
see pages 9-10 PHD ULTRA™Gradient System 13
PHD ULTRA™Electrospinning Scaffolds 14
& PHD ULTRA™Continous Flow Syringe Pump 15
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N O Fast Bolus Injector for Cell Therapy 16
TIOUSI Advanced Features of the PHD ULTRA™Family 17-20
CF Harvard Apparatus Pulsatile Blood Pumps 21-22
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JE Centrifugal Pump for Blood 23
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REGLO Digital/Analog Programmable
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Peristaltic Pumps 24
MCP Pump Drive 25
Pump Head 380AD 26
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Micro Valves & Micro Connectors 29
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f SWS-10, SWS-60 & SWS-140 Syringe Warmers 30
o SC-20 Dual In-line Solution Heater/Cooler 30
e Guide to Pump Cababilities 31
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ab Regenerative Medicine Pumping Technologies 32-33
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Zero Dead Volume
Injection Needle,
see page 11
Automatic Gradient
Composition System,
see page 13
PHD ULTRA™Push-Pull
Programmable Syringe Pump
see page 15
8 FOR PRODUCT INFORMATION 508.893.8999 [email protected] www.harvardapparatus.com