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74 Pages·2006·29.89 MB·English

respiration
Products Page No.
Ventilation Selection Guide F3
Inspira Advanced Safety Ventilators F4 - F6
687 & 683 Volume Controlled Ventilators F7 Inspira- Advanced Safety
Ventilator (ASV),
MicroVent Ventilator for Prenatal Mice F8 see pages F4-F6
MiniVent Ventilator for Mice F9
KTR-5 Ventilator F10 - F11
Multi-Channel Ventilator for Large Rodents F12
Harvard Apparatus Intermediate Animal Ventilator F13
Harvard Apparatus UK Starling Ventilator F13
MicroVent,
Harvard Apparatus Large Animal F14 see page F8
Volume Controlled Ventilator
Connection Kits for Ventilators to Anesthesia Machines F14
Nebulizers F15
Tracheal and Intubation Cannulae F15 - F16
n
o
How to Select Anesthesia Equipment F17 - F18 Multi-Station Research ati
Anesthesia System, r
How to Select Evacuation System F19 - F20 see page F27 pi
s
e
Common Anesthesia Setups F21 - F23 R
Anesthesia Machines F24 - F27
Evacuation Systems F27 - F29
Anesthetic Vaporizers F30
Pure-Guard,
Manifold, Regulators, Hoses and Adapters F31 - F32 see page F29
Induction Chambers and Masks F33 - F34
Anesthesia Circuits F35
IMS Anesthesia Equipment F36 - F45
Pneumotachs F46 - F50
Differential Pressure Transducers F51 Single Chamber Plethysmograph
for Anesthetized Rodents,
New Capnograph from HSE F52 see page F68
Research Spirometer System F32
Spirometers and Dry Gas Meter F54 - F55
Respiratory Valves F56 - F57
Gas Collection Bags F58
Nose Clips, Mouth Pieces and Breathing Tubes F59 Double Chamber Plethysmograph,
see page F72
Douglas Bags F60 - F62
Respiratory Systems F63 - F74
Harvard Apparatus • phone[phone] • toll free U.S.800.272.2775 • fax[phone] • www.harvardapparatus.com F1
ventilators
How to Select Your Ventilator
1)In order to choose the proper ventilation product you must first decide Use the following formula for mammals. After calculating, locate
on the mode of ventilation control required: appropriate species, tidal volume and respiratory rate in the chart
below. Go to the pages indicated for more information or call Technical
Volume Constant Pressure
Support at 800-272-2775 US or visit our web site for the nearest dealer.
Regulation Regulation Both
Tidal Volume Respiration Rate
Go to question 2 Go to question 2 Inspira Only *Vt(milliliters) = 6.2 x Mb1.01 **Rate (min-1) = 53.5 x Mb-0.26
(see page F4) (M = Animal Mass, kg)
b
2)You must know the specie or species you want to ventilate (select all 2B) If you want Constant Pressure Mode, look at the chart below and
that apply). Once selected, go to 2A or 2B. compare Inspira to the HSE KTR and select the appropriate animal
weight under the correct species. Go to the pages indicated for more
Perinatal Mice, Small Bird Rat, Guinea Pig* Rabbit, Cat Dog
information or call Technical Support at 800-272-2775 US.
2A)If you want Volume Regulation Mode you must calculate the tidal
* To ventilate more than one rat or guinea pig simultaneously, see the Multiple Channel
volume and respiratory rate in order to choose the correct ventilator.
Ventilator for Large Rodents on page F12.
Ventilator Selection Chart
DC1 73-3591 DC1 73-0043 DC1 55-7058 DC1 55-0001 DC1 55-0000 DC1 55-0798, DC1 55-0806 DC1 55-0715 DC1 55-7059
R Model MicroVent MiniVent Inspira ASV Mouse 687 Starling Miniature Small Animal 683 Intermediate Animal 665 Large Animal 613 Inspira Multi-Channel Ventilator KTR-5
e
sp Control Modes Volume Ventilators Volume Ventilators Pressure Ventilators
ir
a Species newborn mice, mice, pre-natal rats, mice, rats, guinea pigs, mice, perinatal rats, rats, guinea pigs, rats, guinea pigs, rabbits, cats, dog rats, guinea pigs, mice, rats, guinea pigs, rats, guinea pigs mice, rats, guinea pigs,
tio small birds small birds rabbits, cats small birds rabbits, cats rabbits, cats cats, dogs rabbits, cats rabbits
n
Animal Weight up to 50 g 15 g to 10 kg 150 g 250 g to 10 kg (22 lbs) 250 g to 10 kg (22 lbs) 1 kg (2.2 lbs) to 1.5 kg (3.3 lbs) to 15 g to 10 kg 150 g to 1 kg 150 g to 5.5 kg
30 kg (66 lbs) 50 kg (110 lbs)
v
e
n Tidal Volume 0 to 130 µl 0.03 to 0.35 ml 0.1 to 100 ml 0.1 to 1.0 ml 0.25 to 2.5 ml 0.5 to 5 ml 4 to 100 ml 30 to 750 ml NOT AVAILABLE NOT AVAILABLE NOT AVAILABLE
tila 3 to 30 ml 3.0 to 30 ml
to Respiratory Rate 60 to 400 60 to 400 5 to 200 30 to 150 10 to 200 30 to 150 10 to 200 7 to 50 5 to 200 30 to 100 1 to 200
rs (breath/min)
Certification CE CE CE CE CE, EMC CE CE, EMC CE CE CE CE
% Inspiratory Time 1:1 1:1 1:4 to 4:1 1:1 1:1 1:1 35% to 65% of a 25% to 50% of a 1:4 to 4:1 10% to 80% of a 1 to 99%
(I:E ratio) single stroke cycle single stroke cycle single stroke cycle
Multiple Animal NO NO NO NO NO NO NO NO NO Up to eight NO
with individual volumes simultaneously
Requires Compressed Air NO NO NO NO NO NO NO NO NO yes 4 (58 lbs) to 8 bar (116) NO
Sigh Pressure NOT AVAILABLE NOT AVAILABLE NOT AVAILABLE NOT AVAILABLE NOT AVAILABLE NOT AVAILABLE NOT AVAILABLE NOT AVAILABLE 0 to 50 cmHO NOTAVAILABLE 0.1 to 50 cm HO
2 2
0.1 to 20 cm HO
2
Ext Trig Input NO NO 5 to 12 V peak pulse NO NO NO NO NO 5 to 12 V peak pulse NO NO
Pressure Range NO NO 0 to 50 cmHO NO NO NO NO NO 0 to 50 cmHO NO NO
2 2
Sigh Frequency NO NO auto or manual NO NO NO NO NO auto or manual NO NO
Auto SET-UP NO NO YES NO NO NO NO NO YES NO NO
Safety Alarms NO NO YES NO NO NO NO NO YES NO NO
Built-in Overpressure – – YES – – – – – YES NO NO
Release
Ventilation Pressure NO NO YES NO NO NO NO NO YES 100 cmHO NO
2
Pressure Control NO NO OPTION NO NO NO NO NO YES 2 to 100 cmHO NO
2
Peep yes (attach yes (attach built in yes (attach yes (attach yes (attach yes (attach yes (attach built in yes (attach yes (attach
column of water) column of water) column of water) column of water) column of water) column of water) column of water) column of water) column of water)
Computer/Transducer NO NO YES NO NO NO NO NO YES NO NO
Safety Pressure
Port Size OD 4 mm (5/32 in), OD 6.3 mm, ID 4.8 mm OD 5 mm (3/16 in), OD 7.9 mm, ID 6.4 mm OD 15.9 mm, ID 12.7 mm
ID 2.2 mm (0.866 in) ID 3.5 mm (1/8 in)
Size 8 x 10 x 20 cm 8 x 10 x 20 cm 17.8 x 25.4 x 40.6 cm 25 x 32.5 x 20 cm 25 x 32.5 x 20 cm 35 x 20 x 45 cm 30 x 50 x 22.5 cm 17.8 x 25.4 x 40.6 cm 37 x 15 x 26 cm
(3.2 x 3.9 x 7.9 in) (3.2 x 3.9 x 7.9 in) (8 x 10 x 17.25 in) (10 x 13 x 7.9 in) (10 x 13 x 7.9 in) (14 x 8 x 18 in) (12 x 20 x 9 in) (8 x 10 x 17.25 in) (14.6 x 5.9 x 10.2 in)
Page F8 F9 F4 F7 F13 F7 F13 F14 F4 F12 F10
Price $ 5,830.00 3,195.00 5,375.00 3,475.00 5,126.00 or 4,780.00 3,440.00 6,450.00 4,460.00 6,510.00 Depends on configuration 8,094.00
F2 Harvard Apparatus • phone[phone] • toll free U.S.800.272.2775 • fax[phone] • www.harvardapparatus.com
ventilators
How to Select Your Ventilator (continued)
Harvard Apparatus has manufactured animal ventilators for more than 75 In addition to our line of animal ventilators we also offer virtually all of
years. These ventilators are based on the designs of Dr. William T. Porter, the other accessories necessary to make your animal ventilation safe and
a Professor of Physiology at Harvard Medical School, a strong proponent reliable. Anesthesia machines are available in several different styles and
of physiology education and training through The American Physiological form factors suitable for a wide range of animal sizes.
Society and the founder of Harvard Apparatus. A range of animal
The multi-station ventilator and the multi-station anesthesia system offer
ventilators is available for species from mice to large dogs (15 g to 50 kg).
larger research groups the opportunity to anesthetize multiple animals
We now offer the most advanced animal ventilator on the market, the using a single anesthesia setup.
new Inspira, Advanced Safety Ventilator. Inspira offers microprocessor
Our vaporizer line has been expanded to include both refurbished Tech 4
control, easy-setup and operation, alphanumeric display, airway pressure
and new-Series 100 anesthetic vaporizers with a choice of Isoflurane,
monitoring, assist mode, sigh breath, variable Inspiratory: Expiratory (I:E)
Halothane and Sevoflurane. Intubation and tracheal cannulae have been
ratios, digital rate and digital volume. The Inspira ventilators also feature
expanded to include sizes suitable for mice, rats and guinea pigs.
SafeRange™, a rapid setup system which uses the animals weight to
calculate ‘average’ ventilation parameters such as rate and tidal volume.
DC1 55-0000 DC1 55-0798, DC1 55-0806 DC1 55-0715 DC1 55-7059
Small Animal 683 Intermediate Animal 665 Large Animal 613 Inspira Multi-Channel Ventilator KTR-5 n
o
Volume Ventilators Pressure Ventilators ati
r
rats, guinea pigs, rabbits, cats, dog rats, guinea pigs, mice, rats, guinea pigs, rats, guinea pigs mice, rats, guinea pigs, pi
rabbits, cats cats, dogs rabbits, cats rabbits es
R
250 g to 10 kg (22 lbs) 1 kg (2.2 lbs) to 1.5 kg (3.3 lbs) to 15 g to 10 kg 150 g to 1 kg 150 g to 5.5 kg
30 kg (66 lbs) 50 kg (110 lbs) s
orrs
30.3.050 t ttooo 3 510 5 mm0ll 41 t0o t1o0 200 m0 l 30 7to t o7 5500 m l NOT 5A tVoA 2I0L0A B LE NOT3 0A VtoA 1IL0A0 B LE NOT 1A tVoA 2I0L0ABLE entilatntilato
ve
v
CE CE, EMC CE CE CE CE
1:1 35% to 65% of a 25% to 50% of a 1:4 to 4:1 10% to 80% of a 1 to 99%
single stroke cycle single stroke cycle single stroke cycle
NO NO NO NO Up to eight NO
with individual volumes simultaneously
NO NO NO NO yes 4 (58 lbs) to 8 bar (116) NO
NOT AVAILABLE NOT AVAILABLE NOT AVAILABLE 0 to 50 cmHO NOTAVAILABLE 0.1 to 50 cm HO
2 2
0.1 to 20 cm HO
2
NO NO NO 5 to 12 V peak pulse NO NO
NO NO NO 0 to 50 cmHO NO NO
2
NO NO NO auto or manual NO NO
NO NO NO YES NO NO
NO NO NO YES NO NO
– – – YES NO NO
NO NO NO YES 100 cmHO NO
2
NO NO NO YES 2 to 100 cmHO NO
2
yes (attach yes (attach yes (attach built in yes (attach yes (attach
column of water) column of water) column of water) column of water) column of water)
NO NO NO YES NO NO
OD 5 mm (3/16 in), OD 7.9 mm, ID 6.4 mm OD 15.9 mm, ID 12.7 mm
ID 3.5 mm (1/8 in)
25 x 32.5 x 20 cm 35 x 20 x 45 cm 30 x 50 x 22.5 cm 17.8 x 25.4 x 40.6 cm 37 x 15 x 26 cm
(10 x 13 x 7.9 in) (14 x 8 x 18 in) (12 x 20 x 9 in) (8 x 10 x 17.25 in) (14.6 x 5.9 x 10.2 in)
F7 F13 F14 F4 F12 F10
3,440.00 6,450.00 4,460.00 6,510.00 Depends on configuration 8,094.00
Harvard Apparatus • phone[phone] • toll free U.S.800.272.2775 • fax[phone] • www.harvardapparatus.com F3
ventilators
Ventilator (ASV)
Inspira – Advanced Safety Ventilator (ASV)
One Ventilator – Many Animals
Inspira – Advanced Safety Ventilator (ASV)
This is Harvard Apparatus’ first ventilator that can ventilate animals from
mice to cats using the same machine. It provides respiration rates from 5
to 200 bpm. The tidal volume is adjustable from 0.1 ml to 100 ml. It is no
longer necessary to purchase one ventilator for mice and another for large
rodents. The Inspira can do it all!
Easy to Use
Simply enter the animal’s weight and press run! A microprocessor
recommends the respiratory profile for a user-entered animal weight. The
user may override respiratory parameters if needed. The ventilators have a
bright, easy-to-read display and simple to use keypad.
All gas connections are positioned on the front of the machine for
convenience. In addition to the gas ports, two analog outputs, an external
trigger connector, and sync out connector are also located on the front of
the machine. An RS-232 port is located on the back of the machine and
can be used for remote control, data logging, or printer connection.
Airway Pressure Monitoring
Built-in pressure sensor monitors airway pressure. Under and over
R pressure limits are monitored. Starting limits are selected by built-in
e
s controller.
p Two models available:
ir
ation • IVnoslpuimrae A Cdovnatnrocellded S (aAfeStVyV V)entilator – SSeattfineg Rupa tnheg AeS™Vventilators is both easy and safe thanks to the Safe
• Inspira Advanced Safety Ventilator – Range™software. Once the animal’s body weight has been entered the
v
en Pressure Controlled (ASV ) software computes the median settings for tidal volume and respiratory
tila Both ventilators are the result Pof extensive research rate. These same equations are used to calculate a Safe Range™around
tor and development. Each features an easy to use the median values. All the default parameter settings can be overridden. If
s you enter a setting outside of the Safe Range for the body mass of the
keypad, bright display, and all gas ports located on
animal to be ventilated you are warned that the value is outside the Safe
the front panel. Advanced functions include Airway
Range™and asked to confirm the setting.
Pressure Monitoring, Assist Mode, Programmable
Sigh Breaths, and Adjustable I:E Ratio.
• Ventilates mice to cats with one ventilator
(15 g to 10 kg)
• Easy to use
• Two models available:
— Volume-Controlled ASV
v
— Pressure-Controlled ASV
p
• Airway pressure monitoring detects over/under
pressurization of lungs
• Assist Mode helps wean animal off the ventilator
• Built in sigh breath maintains optimal lung
functioning
• Adjustable I:E ratio (1:4 to 4:1)
• Ability to ventilate with air or non-flammable
anesthetic gases
• Quiet
F4 Harvard Apparatus • phone[phone] • toll free U.S.800.272.2775 • fax[phone] • www.harvardapparatus.com
ventilators
Ventilator (ASV)
Inspira – Advanced Safety Ventilator (ASV) (continued)
Bright,Easy-To-
Read Display Easy-To-Use
Keypad
Quick setup of all ventilator parameters by simply entering the
animal weight.Built-in software sets default values that can be
overridden to meet the specific needs of your experiment.
n
o
ati
r
All Gas pi
Connections s
e
at Front of R
Machine
s
r
o
at
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e
v
Two Analog Outputs for
Monitoring Pressure,Flow,
or Other Analog Signals
Sync Out for Synchronizing Other Trigger in for Externally
Instruments with Ventilator Triggering Respiration
Side Window Allowing
User to See Piston Motion
RS-232 Ports on Rear of Machine for
Remote Control,Data Logging,or Printer
Connection.
User I/O on Rear of machine
Bright & Easy to Read Display Membrane Keypad
This new display has two lines each with 20 characters. Both the The new keypad is simple and intuitive. Respiration rate, tidal volume,
respiration rate and tidal volume are brightly displayed simultaneously. animal weight, sigh breath, I:E ratio, and pressure limits are all
accessed directly via a button on the keypad. For customized ventilation
Two RS-232 Ports
protocols, simply press the ‘SET’ button and then the desired button to
The rear of the machine has two RS-232 ports for remote control, data
enter the required value on the numeric keypad. Pressing the ‘ENTER’
logging, or printer connection and also User I/O. To the side of the
button inputs the value.
machine there is a window allowing the user to view piston motion.
Harvard Apparatus • phone[phone] • toll free U.S.800.272.2775 • fax[phone] • www.harvardapparatus.com F5
ventilators
Ventilator (ASV)
Inspira – Advanced Safety Ventilator (ASV) (continued)
to zero or near zero at the end of the expiratory phase. When the PEEP
Pressure Assist Mode
pressure is reached, the expiration valve closes until the next inspiration
Set with cycle begins. This allows the lungs to maintain a positive pressure through
Inspiratory
Pressure most or all of the breathing cycle which is a more natural state for the
lungs.
Piston/Cylinder Assembly
The Inspira Ventilators use a glass and graphite piston/cylinder assembly
Set With
PEEP and a microprocessor controlled actuation mechanism to precisely control
respiration profiles. Two easily interchangeable piston/cylinder assemblies
Assist Sense
are available to provide 0.1 ml to 10 ml and 10 ml to 100 ml tidal volumes.
Changing the piston/cylinder assembly is simple. Open the top chassis
Determined by animal, cover, unscrew the assembly, and install the new piston/cylinder
but must be at least as Time
frequent as the rate assembly. The ventilator automatically detects which size cylinder is
installed. Variable flow valves control the inhalation and exhalation gas
flow. A window shows the piston/cylinder assembly at work inside!
Assist Mode
Anesthetic Ventilator
Both the volume and pressure controlled ventilators support an Assist
Both Inspira ventilators can be used with anesthesia machines to deliver
Mode. This feature helps to wean the animal off the ventilator. When the
non-flammable anesthetic gases such as Sevoflurane, Halothane or
animal attempts to initiate a breath on its own, a pressure sensor detects
Isoflurane, see pages F17 to F27 for our complete line of anesthesia
R the drop in lung pressure. This drop initiates a ventilation cycle.
e machines and accessories. Please call Harvard Apparatus for more
s
pira TThhee sveennstiiltaivtoitry leotfs t hthee A asnsiimsta Ml ionditeia itse abdrjeuastthasb lien dferopmen –d1e nttol y– a1s0 lcomngH 2aOs. its information.
tio breathing rate is greater than the respiration rate set by the user or Specifications
n
calculated by the microprocessor.
Animal Size 15 g to 10 kg
v
en Sigh Breath Tidal Volume 0.1 to 100 ml
tila With continuous, long term ventilation and the force of gravity, the Port Size Adjustable 1/16 in, 1/8 in, 5/32 in, 3/16 in
tor animal’s lungs begin to collapse. Introducing a larger than normal tidal Control Modes Volume or assist (pressure optional)
s
volume over inflates the animal’s lungs, periodically replicating the natural Respiratory Rate 5 to 200 breaths/min
sigh. It allows the lungs to expand and opens the collapsed alveoli. The
% Inspiratory Time 20 to 80% of cycle time
frequency of the sigh breath is user selectable and available in both the
Sigh Pressure 0 to 50 cmHO
ASV and the ASV models. 2
V P Inspiratory Flow 0 to 12 SLPM
For both ventilators, the sigh breath information is entered via the keypad.
Pressure Signal 0 to 5 V analog (representing 0 to 50 cmHO)
2
For Inspira ASV, the user enters a sigh breath volume. With the Inspira
V Gas Supply Room air or non-flammable mixed gas
ASV, the user enters a sigh breath pressure. For both ventilators the sigh
P External Trigger Input +5 to +12 V peak pulse
breath frequency may be programmed which automatically initiates sigh
Resolution 1 breath/min
breaths. These breaths may also be triggered manually by pressing the
I/E Ratio 4:1 to 1:4
SIGH button on the keypad during respiration.
Pressure Range 0 to 50 cmHO
2
Volume-Controlled vs. Pressure Controlled
Sigh Frequency Auto or manual
The Inspira ASV delivers the desired tidal volume to the animal by precisely
V Respiratory Assist Available
controlling the stroke of the piston. Stroke speed is controlled during
Signal Inputs External trigger
inspiration and expiration allowing variable inspiration-to-expiration ratios.
Signal Outputs Sync out, 2 analog outputs (user selectable)
The Inspira ASVPdelivers gas during inhalation by moving the piston while Display 2 line x 20 character VFD display
continuously monitoring the airway pressure. The microprocessor reads
Power AC 85 to 132 V, 170 to 264 V, 50/60 Hz
the increasing pressure and compares it to the maximum inspiration
Dimensions, H x W x D 20.3 x 25.4 x 43.8 cm (8 x 10 x 17.25 in)
pressure set by the user. When the maximum pressure is reached, the
Weight 9.1 kg (20 lb)
piston stops. The exhale valve opens at the appropriate time determined
by % inspiration time and closes when the PEEP (positive end expiratory
Order # Product Price $
pressure) setting is reached.
DC1 55-7058 Inspira - Advanced Safety Ventilator, 5,375.00
PEEP - Positive End Expiratory Pressure
Volume Controlled ASV
(Inspira ASV Only) v
P DC1 55-7059 Inspira - Advanced Safety Ventilator, 6,510.00
The Inspira ASV also has a built in PEEP feature. This feature allows a Pressure Controlled ASV
P p
positive pressure to be maintained between inspirations instead of falling
F6 Harvard Apparatus • phone[phone] • toll free U.S.800.272.2775 • fax[phone] • www.harvardapparatus.com
ventilators
683 Small Animal and 687 Mouse Ventilators
Harvard Apparatus’683 Mouse Ventilator.The
same great Ventilator with a new,more
functional design
adjusted while the ventilator is running. Both ventilators have four gas
inlet and outlet ports: supply gas in, gas out (to animal), gas return (from
animal) and ventilator exhaust. The ventilator exhaust can be attached to
a column of water to achieve PEEP (positive end expiratory pressure)
n
when long term animal ventilation is necessary. o
• Two models available: Overhaul kits are available for both ventilator models and are specific for rati
– Model 683 for small animals from the type of cylinder used. Overhaul kits include complete instructions and spi
e
250 g to 10 kg (22 lb) e.g. rats, hamsters, replacement parts, but do not include replacement cylinders. Replacement R
rabbits, cats, monkeys, small dogs, etc. cylinders must be purchased separately.
s
r
– Model 687 for mice and perinatal rats up to o
Specifications at
200 g (7 oz) ntil
• CE approved Rate Adjustable from 30 to 150 strokes/min while the e
ventilator is running v
Phase Ration 1:1 fixed
Harvard Apparatus is proud to offer the 683 and 687 Ventilators. Beside
Dimensions, H x L x W 25 x 32.5 x 20 cm (10 x 13 x 7.9 in)
the sleek new look, these ventilators have some advantages over the older
Weight 9.5 kg (21 lbs)
style ventilators:
Power 115/230 VAC, 50/60 Hz
• Ability to monitor PEEP
Ventilator Small Animal Mouse
(Positive End Expiratory Pressure)
• New tubing graduated sizing connectors that are Tidal Volume Adjustable from 0.2 to Adjustable from 0.05 to
30 ml/stroke while the 1 ml/stroke while the
accommodate different size tubing easily
ventilator is running ventilator is running
• Permanent etched volume graduations on the
Port Size, ID 3/16 in 1/8 in
cylinder so they can’t rub off
Model 683 687
• Volume and rate control are now linear
The Model 683 Small Animal Ventilator comes standard with two piston Order # Product Price $
and cylinder assemblies. The smaller piston (which comes installed) DC1 55-0000 Model 683, Small Animal Volume 3,440.00
allows tidal volumes to be set from 0.5 to 5.0 cc in 0.5 cc increments and Controlled Ventilator
the larger cylinder allows tidal volumes of 3.0 to 30 cc in 0.3 cc DC1 55-0001 Model 687, Mouse Volume Controlled Ventilator 3,475.00
increments. Setting the cylinder stroke between gradations it is possible DC1 55-5281 Overhaul Kit for 687 Ventilator for 1 cc Cylinder* 60.00
to achieve finer resolution in tidal volume settings.
DC1 55-5282 Overhaul Kit for 683 Ventilator for 5 cc Cylinder* 45.00
The Model 687 Mouse Ventilator has a single piston and cylinder DC1 55-5283 Overhaul Kit for 683 Ventilator for 30 cc Cylinder* 45.00
assembly. The tidal volume range is 0.1 to 1 cc in 0.1 cc increments. DC1 55-5284 Overhaul Kit for Older 68x Ventilators, including 155.00
Setting the cylinder stroke between gradations it is possible to achieve Models 680, 681 and 683 ventilators without a
finer resolution in tidal volume settings. For both ventilator models, the numeric LED rate display*
piston travels to the end of the cylinder completely emptying the cylinder *Overhaul Kits do not include cylinder
and minimizing the dead space of the breathing circuit.
Both models feature a numerical LED to display the respiratory rate which
can be set from 18 to 150 strokes/minute. Volume and rate settings can be
Harvard Apparatus • phone[phone] • toll free U.S.800.272.2775 • fax[phone] • www.harvardapparatus.com F7
ventilators
MicroVent Prenatal Mouse Ventilator
and Battery Pack
The MicroVent Ventilator is supplied with the following components:
MicroVent
Ventilator Product Qty.
AC Wall Mounted Power Supply (115 V or 220 V) 1
Silicone Tubing, 1.5mm ID, 3.0 mm OD, 14cm Length 2
DC1 73-2731 1.0 mm OD Tracheotomy Cannula 1
DC1 73-2737 1.0 mm OD Intubation Cannula 1
Specifications
Stroke Volume Continuously adjustable from 0 to 130 µl
Respiratory Rate Continuously adjustable from 60 to 400 breaths/min
Power 12 V DC, 0.5 A through external mains adapter
• Ideal very small animals, perinatal mice, birds...
Dimensions, H x W x D 8 x 10 x 20 cm (3.2 x 3.9 x 7.9 in)
• Stroke volume range from 0 to 130 µl Weight:
• Ventilation rate from 60 to 400 breaths/minute MicroVent 1 kg (2.2 lb)
• Simple adjustment of stroke volume while running AC Adapter 0.3 kg (0.7 lb)
• Valveless piston pump, no valves to clog
Order # Model Product Price $
• Very small instrument/circuit dead space volume
R DC1 73-3591 848 MicroVent Ventilator, 110 VAC XX.00
e • Compact construction, place close to animal
s DC1 73-3590 848 MicroVent Ventilator, 230 VAC XX.00
p • No vibrations, very low noise
ir DC1 73-2731 Repl. Tracheotomy Cannula, 1.0 mm OD XX.00
a
tion HSE-HA MicroVent Ultra-Low Volume DC1 73-2737 Repl. Intubation Cannula, 1.0 mm OD XX.00
DC1 73-0027 Package of 10 small Y adapters, each XX.00
Ventilator for Newborn Mice, Birds
v with 2x silicone tubing 1.5 mm ID,
e
n 3 mm OD, 14 cm long
tilato Tlighhet n weweilgyh dt euvlterlaolpoewd vMoliucmroeV evnetn tMilaotdoer.l T8h4e8 MVeicnrtoilVaetonrt iiss ath qeu iideet,a cl ovmenptailcatt oarn dfor
rs very small animals (e.g. birds and perinatal mice) which requires tidal volumes
Batery Pack
in the range of 0 to 130 µl and respiratory rates of 60 to 400 breaths per minute.
with
The MicroVent Ventilator is a constant-volume respiration pump operating MiniVent
on the Starling principle. Unlike conventional units for larger animals, this
ventilator employs a rotary plunger and has no valves. During each
ventilation cycle, the plunger performs a synchronized forward and rotating
Battery Pack
movement. Cleverly arranged bores and channels in the cylinder and
plunger control inspiration and expiration during each stroke of the plunger.
• Provides transportability while under ventilation
The extremely light weight and compact construction, in addition to the
convenient rod clamp, allow the MicroVent ventilator to be positioned directly • Up to 40 hours of use from a single charge
next to the animal. Typical setups with larger ventilators produce large tubing
and instrument dead space volumes. These larger volumes introduce greater Battery Pack for MiniVent and MicroVent
system compliance which can affect the accuracy with which the full tidal
volume is introduced into the animal’s lungs. With the MicroVent, the tidal The Battery pack for the MiniVent or MicroVent respirator is used to run
volume error due to system compliance is reduced to less than 3 µl. these Ventilators independent from a power supply. This is important when
the surgery and the experiment have to be performed in different rooms and
Tidal volume and respiration rate can be set exactly to the values required
the animal must be moved under ventilation using the MiniVent or MicroVent.
for animal ventilation. The level of precision and control available to the
investigator minimizes the danger of hyperventilation or hypoventilation. The Battery pack is connected to the Ventilator instead of the power
supply. For charging the Battery pack it is disconnected from the ventilator
The tidal volume can be varied continuously from 0 to 130 µl during
and connected to the suitable charger.
operation without having to interrupt ventilation. The respiration rate is
also continuously adjustable from 60 to 400 strokes/min. The expired air The Battery pack is a 8 cell NiMH (Nickel - Metal hydride) battery, which
can be recovered at the collection port for sampling, recycling or for the has with 2300 mAh (a large capacity). It can run the MiniVent or
generation of a positive end-expiratory pressure (PEEP). Room air or any MicroVent for approximately 40 hours.
non-explosive gas mixture can be used to feed the pump intake.
A multi-gas inlet adapter is available for the MicroVent so that alternate gas Order # Product Price $
mixtures and nebulized substances are delivered to the MicroVent inlet port
DC1 73-3736 Battery Pack for MiniVent and MicroVent xxx.00
at atmospheric pressure. The adapter provides ports for multiple selectable
gas mixtures (hypoxic, anesthetic...) and a port for the Aerosol Nebulizer.
F8 Harvard Apparatus • phone[phone] • toll free U.S.800.272.2775 • fax[phone] • www.harvardapparatus.com
ventilators
MiniVent Ventilator for Mice
A multi-gas inlet adapter is available for the MiniVent so that alternate
DC1 73-2919 MiniVent
gas mixtures and nebulized substances are delivered to the MiniVent inlet
Multi-Gas Inlet Adapter
port at atmospheric pressure. The adapter provides ports for multiple
DC1 73-0043 selectable gas mixtures (hypoxic, anesthetic...) and a port for the Aerosol
HSE-HA MiniVent
Nebulizer.
Ventilator for Mice
The MiniVent Ventilator is supplied with the following:
Product Qty.
AC Wall Mounted Power Supply (115 V or 220 V) 1
Silicone Tubing, 1.5 mm ID, 3.0 mm OD, 14cm Length 2
DC1 73-1963 HSE-HA
Aerosol Nebulizer DC1 73-2730 1.3 mm OD Tracheotomy Cannula 1
DC1 73-0049 Tracheal Cannula DC1 73-2844 1.2 mm OD Intubation Cannula 1
1.3 x 1 mm,OD x ID
Specifications
Stroke Volume Continuously adjustable from 30 to 350 µl
• Ideal ventilator for mice
Respiratory Rate Continuously adjustable from 60 to 400 breaths/min
• Stroke volume range from 30 to 350 µl Power 12 V DC, 0.5 A through external main adapter
• Ventilation rate from 60 to 400 breaths/minute Dimensions, H x W x D 8 x 10 x 20 cm (3.2 x 3.9 x 7.9 in)
Weight:
• Simple adjustment of stroke volume while running n
MiniVent 1 kg (2.2 lb) o
• Valveless piston pump, no valves to clog AC Adapter 0.3 kg (0.7 lb) ati
r
• Very small instrument/circuit dead space volume pi
s
• Compact construction, easy to install close to animal Order # Model Product Price $ Re
• No vibrations, very low noise DC1 73-0043 845 MiniVent Ventilator for Mice, 3,195.00
s
110 VAC or
Tvehnet iMlaitnoirV. eWnth iMleo idt ewl a8s4 5d eVseingtnileadt osrp iesc aif iqcuailelyt ,f ocor mmpicaec,t tahned M liignhiVt ewnet icgahnt DC1 73-0044 845 2M3i0n iVVAeCnt Ventilator for Mice, 3,189.00 entilat
be used for any animal (e.g. birds and perinatal rats) which requires tidal DC1 73-3077 MiniVent Anesthesia Machine 93.00 v
volumes in the range of 30 to 350 µl and respiratory rates of 60 to 400 Tubing Connection Kit
breaths per minute. Spares and Accessories for MiniVent and MicroVent
The MiniVent Ventilator is a constant-volume respiration pump operating on DC1 73-1963 Aerosol Nebulizer, see page F15 265.00
the Starling principle. Unlike conventional units for larger animals, this DC1 73-3300 Tubing Connection Kit for 78.00
ventilator employs a rotary plunger and has no valves. During each Aerosol Nebulizer
ventilation cycle, the plunger performs a synchronized forward and rotating DC1 73-2919 MiniVent and MicroVent 1,029.00
movement. Cleverly arranged bores and channels in the cylinder and plunger Multi-Gas Inlet Adapter
control inspiration and expiration during each stroke of the plunger. DC1 73-0049 Repl. Y-piece with 1.3 mm OD 83.00
Tracheal Cannula and Connecting Tubes
The extremely light weight and compact construction, in addition to the
DC1 73-2730 Repl. Tracheotomy Cannula, 68.00
convenient rod clamp, allow the MiniVent ventilator to be positioned directly
1.3 mm OD
next to the animal. Typical setups with larger ventilators produce large
DC1 73-2844 Repl. Intubation Cannula, 68.00
tubing and instrument dead space volumes. These larger volumes introduce
1.2 mm OD
greater system compliance which can affect the accuracy with which the
DC1 73-0027 Small Y Adapters, each with 32.00
full tidal volume is introduced into the animal’s lungs. With the MiniVent,
2x silicone tubing 1.5 mm ID,
the tidal volume error due to system compliance is reduced to 3 µl. 3 mm OD, 14 cm long, pkg. of 10
Tidal volume and respiration rate can be set exactly to the values required DC1 73-0032 5 Medium Y adapters, each with 40.00
for mouse ventilation. The level of precision and control available to the 2x silicone tubing 6 mm ID,
investigator minimizes the danger of hyperventilation or hypoventilation. 9 mm OD, 80 cm long, pkg. of 5
The tidal volume can be varied continuously from 30 to 350 µl during
operation without having to interrupt ventilation. The respiration rate is
also continuously adjustable from 60 to 400 strokes/min. The expired air
can be recovered at the collection port for sampling, recycling or for the
generation of a positive end-expiratory pressure (PEEP). Room air or any
non-explosive gas mixture can be used to feed the pump intake. For Battery Pack for use with MiniVent, see facing page.
Harvard Apparatus • phone[phone] • toll free U.S.800.272.2775 • fax[phone] • www.harvardapparatus.com F9
ventilators
KTR-5 Ventilator
The connection to the tracheal cannula is made through a specially
DC1 73-3597
formed Y-shaped ventilation cannula. It carries the following tubing on its
ends: 4 mm ID for rats and 1.5 mm ID for mice.
The ventilation air required is normally supplied by a built-in pump. There
is also a provision for introducing ventilation gas from outside (max.
pressure: 0.5 bar, 7.5 psi). A special version has the internal pump replaced
by a precision pressure regulator; in this case the supply has to be provided
by an external pressure source (pressure range: 2 - 8 bar, 29 - 116 psi).
The ventilation cannula is a linked to the KTR-5 ventilator by a Y-shaped
connector and suitable tubing. Different type of cannulae and Y-connections
are available depending on the application and on the species.
Specifications
Respiration Rate 1 - 200 bpm (breaths per minute)
Inspiration Duration 10 - 79% of ventilation cycle
• Different Versions available
Duration of Plateau 1 - 50% (of total cycle time)
• From mouse to rabbit EIP Limit:
• Avoids the danger of excessively extending and Rat 0.1 - 50 cm HO
2
R damaging the lung Mouse 0.1 - 20 cm HO
e 2
spira •• V“Parlaiatebaleu ”In fsu/Enxcpti orna ttioo maintain the end- LMeaakx iAmlaurmm Sigh Pressure: 0 - 10 cmH2O
tio inspiratory pressure Rat 0.1 - 50 cmHO
n 2
• Sigh function Mouse 0.1 - 20 cmHO
2
v
e Sigh Number 1 - 10
n
tilato Tmhoes tK fTrRe-q5u eisn talvya uilsaebdl ea ninim daiflfse rine ntth eve lrasbioonra. tIot riys, ufrsoemd fmoor uvseen ttiola rtainbgb itth. eIt AAdirj uFslotawble Continuous 5c0o0m0p mrel/smsoinr )m* aximum (with internal
rs employs Microprocessor control. This permits flexible adaptation of the Minute Volume Range Up to 2500 ml/min (50% INSPIR, depending
on compliance)*
ventilation parameters to the most diverse experimental conditions. The
Displays LC-display, 3 lines of 12 characters; 7 LED's
functional sequence is signaled by suitably marked signal LED’s. The for function control
ventilation sequence can also be influenced by external signals.
Electrical outputs:
Unlike a STARLING piston pump, use of the KTR-5 avoids the danger of Recorder Output For measured ventilation pressure: 0.1 V/cm
excessively extending and damaging the lung of the ventilated animal HO
2
through incorrect setting of the stroke volume. The electronic control of Trigger Output (TTL for synchronizing external equipment
the KTR-5 also permits free selection of the ventilation timing over a wide Other functions Alarm function, visual and audible, on
range in order to adapt it to the requirements of your experiment. pressure fall, alarm limit adjustable on
“LEAK ALARM” control; indication of
The KTR-5 operates on the principle of intermittent positive pressure functional sequence by signal LED's; remote
control
ventilation. A continuously adjustable air (gas) stream is passed by
solenoid valves either to the animal or to an overflow outlet. The effective Air/gas Connections Outlet for expiration air/gas (EXHAUST
EXPIR), immersion tube for PEEP adjustment
pressure in the ventilation cannula is measured and indicated. By suitable
is connected to this outlet, also used for gas
settings on the unit it is possible to utilize the measuring circuit to sampling to analyze the expired gas
terminate the inspiration process when a given adjustable ventilation Outlet for excess air or gas (EXHAUST OVERFLOW) connection for
pressure has been reached (EIP LIMIT: 0–29 cmH0). This effectively Halothane Vaporizer (FROM, TO
2 HALOTHANE VAPORIZER) inlet for external
protects the animal against excessive pressure rise in the lung.
supply (2 bar max.)
Through the “Plateau” function, the end-inspiratory pressure can be Air/gas supply Internal compressor 5 l/min maximum,
maintained constant over an adjustable period of time (% of cycle). This external supply from tank or central supply
using pressure reducer and particle filter.
function permits direct control of the inspired air retention.
Maximum pressure 2 bar
Measurements can also be performed in the inspired condition.
The air flow to the ventilated animal is adjusted by means of a built-in
needle valve. The set air flow is indicated on a float flow meter (Rota
meter). A sigh (or a number of sighs) can be induced at any time by key
stroke.
F10 Harvard Apparatus • phone[phone] • toll free U.S.800.272.2775 • fax[phone] • www.harvardapparatus.com