Dormancy and Low Growth States in Microbial Disease PDF
Preview Dormancy and Low Growth States in Microbial Disease
Dormancy and Low-Growth States in Microbial Disease Organismsmultiplyonlywhentheconditionsarebeneficial,andwhennot multiplying,theyconcentrateonsurvivalofenvironmentalstress.Manybac- teriathatharmhumanssurviveformostoftheperiodofinfectioninalow- growth state. This book addresses the basic scientific aspects of microbial dormancyandlow-growthstates,andplacestheminthecontextofhuman medicine. The book introduces basic scientific aspects of bacterial growth, non-growth,culturability,andviability.Laterchapterscoverthecrucialrela- tionshipbetweenlow-growthstatesandsurvivalofstress,thesurvivalofthe immuneresponse,andinterbacterialsignalling.Thisisfollowedbychapters on aspects that are of direct importance to medicine, namely antibiotic re- sistancearisinginstationaryphase,biofilms,tuberculosis,andthebacteria, whichcausegastriculcers. anthony r. m. coatesiscurrentlyProfessorofMedicalMicrobiologyand ChairmanoftheDepartmentofMedicalMicrobiologyatSt.George’sHos- pitalMedicalSchool,London.Hisresearchbackgroundisinthemolecular pathogenesisofinfectionwithaparticularinterestintuberculosis. Publishedtitles 1. BacterialAdhesiontoHostTissues.EditedbyMichaelWilson0521801079 2. BacterialEvasionofHostImmuneResponses.EditedbyBrianHendersonand PetraOyston0521801737 Forthcomingtitlesintheseries SusceptibilitytoInfectiousDiseases.EditedbyRichardBellamy0521815258 MammalianAntimicrobialPeptides.EditedbyDeirdreDevineandRobert Hancock0521822203 TheDynamicBacterialGenome.EditedbyPeterMullany0521821576 BacterialProteinToxins.EditedbyAlistairLax052182091X BacterialInvasionofHostCells.EditedbyRichardLamont0521809541 Over the past decade, the rapid development of an array of techniques in thefieldsofcellularandmolecularbiologyhastransformedwholeareasof researchacrossthebiologicalsciences.Microbiologyhasperhapsbeeninflu- encedmostofall.Ourunderstandingofmicrobialdiversityandevolution- arybiology,andof howpathogenicbacteriaandvirusesinteractwiththeir animalandplanthostsatthemolecularlevel,forexample,hasbeenrevolu- tionized.Perhapsthemostexcitingrecentadvanceinmicrobiologyhasbeen thedevelopmentoftheinterfacedisciplineofcellularmicrobiology,afusion ofclassicmicrobiology,microbialmolecularbiology,andeukaryoticcellular and molecular biology. Cellular microbiology is revealing how pathogenic bacteriainteractwithhostcellsinwhatisturningouttobeacomplexevolu- tionarybattleofcompetinggeneproducts.Molecularandcellularbiologyare Y nolongerdiscretesubjectareasbutvitaltoolsandintegratedpartsofcurrent G O microbiologicalresearch.Aspartofthisrevolutioninmolecularbiology,the L O genomesofagrowingnumberofpathogenicandmodelbacteriahavebeen I B fullysequenced,withimmenseimplicationsforourfutureunderstandingof O R micro-organismsatthemolecularlevel. C AdvancesinMolecularandCellularMicrobiologyisaserieseditedbyre- I M searchersactiveintheseexcitingandrapidlyexpandingfields.Eachvolume R A willfocusonaparticularaspectofcellularormolecularmicrobiology,and L U willprovideanoverviewofthearea,aswellasexaminingcurrentresearch. L L Thisserieswillenablegraduatestudentsandresearcherstokeepupwiththe E C rapidlydiversifyingliteratureincurrentmicrobiologicalresearch. (cid:1) AMCM D SeriesEditors N A ProfessorBrianHenderson R A UniversityCollegeLondon L U C ProfessorMichaelWilson E L UniversityCollegeLondon O M ProfessorSirAnthonyCoates N St.George’sHospitalMedicalSchool,London I S E ProfessorMichaelCurtis C N St.Bartholemew’sandRoyalLondonHospital,London A V D A AdvancesinMolecularandCellularMicrobiology3 Dormancy and Low-Growth States in Microbial Disease EDITEDBY Anthony R. M. Coates St.George’sHospitalMedicalSchool,London. Cambridge, New York, Melbourne, Madrid, Cape Town, Singapore, São Paulo Cambridge University Press The Edinburgh Building, Cambridge , United Kingdom Published in the United States of America by Cambridge University Press, New York www.cambridge.org Information on this title: www.cambridge.org/9780521809405 © Cambridge University Press 2003 This book is in copyright. Subject to statutory exception and to the provision of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. First published in print format 2003 - isbn-13 978-0-511-06407-4 eBook (NetLibrary) - isbn-10 0-511-06407-1 eBook (NetLibrary) - isbn-13 978-0-521-80940-5 hardback - isbn-10 0-521-80940-1 hardback Cambridge University Press has no responsibility for the persistence or accuracy of s for external or third-party internet websites referred to in this book, and does not guarantee that any content on such websites is, or will remain, accurate or appropriate. Contents (cid:1) vii Contributors ix Preface xiii 1 Physiologicalandmolecularaspectsofgrowth,non-growth, culturabilityandviabilityinbacteria 1 M.R.Barer 2 Survivalofenvironmentalandhost-associatedstress 37 PetraDerschandRegineHengge-Aronis 3 Survivingtheimmuneresponse:animmunologist’s perspective 75 DavidR.KatzandGabrielePollara 4 Quantitativeandqualitativechangesinbacterialactivity controlledbyinterbacterialsignalling 101 SimonSwift 5 Mechanismsofstationary-phasemutagenesisinbacteria andtheirrelevancetoantibioticresistance 131 DigbyF.WarnerandValerieMizrahi 6 Biofilms,dormancyandresistance 161 AnthonyW.SmithandMichaelR.W.Brown 7 Tuberculosis 181 YanminHuandAnthonyR.M.Coates 8 Gastritisandpepticulceration 209 C.StewartGoodwin 9 Resumptionofyeastcellproliferationfromstationaryphase 223 GeraldC.JohnstonandRichardA.Singer 10 Restingstateinseedsofhigherplants:dormancy, persistenceandresiliencetoabioticandbioticstresses 235 HughW.PritchardandPeterE.Toorop Index 265 Colorplatefollowspage82. (cid:1) viii s t n e t n o c Contributors (cid:1) ix M.R.Barer DepartmentofMicrobiologyandImmunology MedicalSciencesBuilding POBox138 UniversityRoad LeicesterLE19HN UK MichaelR.W.Brown DepartmentofPharmacyandPharmacology UniversityofBath ClavertonDown BathBA27AY UK AnthonyR.M.Coates DepartmentofMedicalMicrobiology StGeorge’sHospitalMedicalSchool LondonSW170RE UK PetraDersch Institutefu¨rBiologie,Mikrobiologie FreieUniversita¨tBerlin Ko¨nigin-Luise-Str.12-16 14195Berlin Germany
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