DNA Repair

648 Pages·2011·28.163 MB·English

by  I. Kruman

DNA REPAIR

Edited by Inna Kruman
DNA Repair
Edited by Inna Kruman

Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia

Copyright © 2011 InTech
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Publishing Process Manager Alenka Urbancic
Technical Editor Teodora Smiljanic
Cover Designer Jan Hyrat
Image Copyright ZF, 2011. Used under license from Shutterstock.com

First published October, 2011
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]

DNA Repair, Edited by Inna Kruman
p. cm.
ISBN 978-953-307-697-3
free online editions of InTech
Books and Journals can be found at
www.intechopen.com

Contents

Preface XI
Part 1 DNA Damage Response 1
Chapter 1 A Recombination Puzzle Solved: Role for New DNA Repair
Systems in Helicobacter pylori Diversity/Persistence 3
Ge Wang and Robert J. Maier
Chapter 2 RloC: A Translation-Disabling tRNase Implicated in
Phage Exclusion During Recovery from DNA Damage 21
Gabriel Kaufmann, Elena Davidov, Emmanuelle Steinfels-Kohn,
Ekaterina Krutkina, Daniel Klaiman, Tamar Margalit,
Michal Chai-Danino and Alexander Kotlyar
Chapter 3 The Role of DDB2 in Regulating Cell Survival and Apoptosis
Following DNA Damage - A Mini-Review 45
Chuck C.-K. Chao
Chapter 4 The Potential Roles of DNA-Repair
Proteins in Centrosome Maintenance 57
Mikio Shimada, Akihiro Kato and Junya Kobayashi
Chapter 5 Shared Regulatory Motifs in
Promoters of Human DNA Repair Genes 67
Lonnie R. Welch, Laura M. Koehly and Laura Elnitski
Chapter 6 Mitochondrial DNA Damage:
Role of Ogg1 and Aconitase 85
Gang Liu and David W. Kamp
Chapter 7 Structure-Function Relationship of DNA Repair
Proteins: Lessons from BRCA1 and RAD51 Studies 103
Effrossyni Boutou, Vassiliki Pappa, Horst-Werner Stuerzbecher
and Constantinos E. Vorgias
VI Contents

Chapter 8 The Involvement of E2F1 in the Regulation of
XRCC1-Dependent Base Excision DNA Repair 127
Yulin Zhang and Dexi Chen
Chapter 9 Posttranslational Modifications of Rad51 Protein and
Its Direct Partners: Role and Effect on Homologous
Recombination – Mediated DNA Repair 143
Milena Popova, Sébastien Henry and Fabrice Fleury
Chapter 10 Post-Transcriptional Regulation of E2F Transcription Factors:
Fine-Tuning DNA Repair, Cell Cycle Progression and
Survival in Development & Disease 161
Lina Dagnino, Randeep Kaur Singh
and David Judah
Chapter 11 Eidetic Analysis of the Premature
Chromosome Condensation Process 185
Dorota Rybaczek
Chapter 12 A DNA Repair Protein BRCA1 as a Potentially Molecular
Target for the Anticancer Platinum Drug Cisplatin 205
Adisorn Ratanaphan
Chapter 13 Saccharomyces cerevisiae as a Model System to Study
the Role of Human DDB2 in Chromatin Repair 231
Kristi L. Jones, Ling Zhang and Feng Gong
Chapter 14 Cell Cycle and DNA Damage Response
in Postmitotic Neurons 241
Inna I. Kruman
Chapter 15 TopBP1 in DNA Damage Response 281
Ewa Forma, Magdalena Brys and Wanda M. Krajewska
Chapter 16 Post-Meiotic DNA Damage
and Response in Male Germ Cells 305
Guylain Boissonneault, Frédéric Leduc, Geneviève Acteau,
Marie-Chantal Grégoire, Olivier Simard, Jessica Leroux,
Audrey Carrier-Leclerc and Mélina Arguin
Chapter 17 BRCA2 Mutations and Consequences for DNA Repair 327
Erika T. Brown
Chapter 18 Roles of MicroRNA in DNA Damage and Repair 341
Xinrong Chen and Tao Chen
Part 2 Evolution of DNA Repair 355
Chapter 19 Meiosis as an Evolutionary Adaptation for DNA Repair 357
Harris Bernstein, Carol Bernstein and Richard E. Michod
Contents VII

Chapter 20 From Seed to Tree: The Functioning
and Evolution of DNA Repair in Plants 383
Jaana Vuosku, Marko Suokas, Johanna Kestilä,
Tytti Sarjala and Hely Häggman
Part 3 Mechanisms of DNA Repair 399
Chapter 21 The Gratuitous Repair on Undamaged DNA Misfold 401
Xuefeng Pan, Peng Xiao, Hongqun Li, Dongxu Zhao and Fei Duan
Chapter 22 ATP-Binding Cassette Properties of
Recombination Mediator Protein RecF 431
Sergey Korolev
Chapter 23 DNA Damage Recognition for Mammalian Global
Genome Nucleotide Excision Repair 453
Kaoru Sugasawa
Chapter 24 DNA Double-Strand Break Repair Through Non-Homologous
End-Joining: Recruitment and Assembly of the Players 477
Radhika Pankaj Kamdar and Yoshihisa Matsumoto
Part 4 Polymorphism of DNA Repair Genes 503
Chapter 25 DNA Repair Capacity-Related to Genetic Polymorphisms of
DNA Repair Genes and Aflatoxin B1-Related Hepatocellular
Carcinoma Among Chinese Population 505
Xi-Dai Long, Jin-Guang Yao, Zhi Zeng, Cen-Han Huang,
Pinhu Liao, Zan-Song Huang, Yong-Zhi Huang,
Fu-Zhi Ban, Xiao-Yin Huang, Li-Min Yao,
Lu-Dan Fan and Guo-Hui Fu
Chapter 26 Low Penetrance Genetic Variations in DNA
Repair Genes and Cancer Susceptibility 525
Ravindran Ankathil
Chapter 27 Polymorphisms in Nucleotide Excision Repair Genes and
Risk of Colorectal Cancer: A Systematic Review 539
Rikke Dalgaard Hansen and Ulla Vogel
Chapter 28 Variants and Polymorphisms of DNA Repair
Genes and Neurodegenerative Diseases 567
Fabio Coppedè
Part 5 Telomeres and DNA Repair 583
Chapter 29 Characterization of 5’-Flanking Regions of Various Human
Telomere Maintenance Factor-Encoding Genes 585
Fumiaki Uchiumi, Takahiro Oyama, Kensuke Ozaki
and Sei-ichi Tanuma
VIII Contents

Chapter 30 Roles of DNA Repair Proteins in
Telomere Maintenance 597
Masaru Ueno
Part 6 Measuring DNA Repair Capacity 613
Chapter 31 DNA Repair Measured by the Comet Assay 615
Amaya Azqueta, Sergey Shaposhnikov and Andrew R. Collins