Disentangling Brain Networks in Adult ADHD: Studies with fMRI and TMS

187 Pages·2012·4.31 MB·English

Disentangling Brain Networks in Adult ADHD:
Studies with fMRI and TMS
Marc Schneider

Disentangling Brain Networks in Adult ADHD:
Studies with fMRI and TMS
Het ontrafelen van neuronale netwerken bij volwassenen met ADHD:
Klinische onderzoeken met fMRI en TMS
Proefschrift
ter verkrijging van de graad van doctor aan de
Erasmus Universiteit Rotterdam
op gezag van de
rector magnificus
Prof.dr. H.G. Schmidt
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
donderdag 29 november 2012 om 13.30 uur
door
Marc Karl-Friedrich François Schneider
geboren te Fontainebleau (Frankrijk)
Promotiecommissie
Promotor:
Prof.dr. W.M.A. Verhoeven
Overige leden:
Prof.dr. S.A. Kushner
Prof.dr. A. Aleman
Prof.dr. J.W. van Strien
Copromotor:
Dr. J.H.M. Tulen
The research described in this thesis was carried out at the Institute for Forensic
Psychology and Psychiatry and the Clinics for Psychiatry and Psychotherapy of
the University of Homburg/ Saar, Germany.
ISBN: 978-94-6191-479-8
Design/lay-out: In Zicht Grafisch Ontwerp, www.promotie-inzicht.nl
Print: Ipskamp Drukkers, www.ppi.nl
© 2012 Marc K.F. Schneider
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means,
electronic or mechanical, including photocopying, recording or any information storage and retrieval without
prior permission of the holder of the copyright.
Für meine Familie

Table of Contents
1| General Introduction 9
2| Brain imaging in adult Attention deficit hyperactivity disorder (ADHD) 27
Key Issues in Mental Health. Attention-Deficit Hyperactivity Disorder (ADHD) in adults.
Karger, Basel (2010). Vol. 176: 88-104.
3| Impairment of fronto-striatal and parietal cerebral networks correlates 49
with Attention Deficit Hyperactivity Disorder (ADHD) psychopathology
in adults – a functional magnetic resonance imaging (fMRI) study
Psychiatry Res (2010) 183(1):75-84.
4| Impaired cortical inhibition in adult ADHD patients: a study with 77
transcranial magnetic stimulation
J Neural Transm Suppl (2007) 72:303-9.
5| The effects of long acting Methylphenidate in adults with Attention 95
Deficit Hyperactivity Disorder: A study with paired pulse Transcranial
Magnetic Stimulation
Neuropsychobiology (2011) 64(4):195-201.
6| Reduced cortical inhibition in first-episode schizophrenia 111
Schizophr Res (2008) 105(1-3):252-61.
7| A similar but distinctive pattern of impaired cortical excitability in 131
first-episode schizophrenia and ADHD
Accepted in Neuropsychobiology.
8| General Discussion and conclusions 151
*| References 161
Summary 171
Samenvatting 173
Zusammenfassung 177
Acknowledgements 181
Curriculum vitae 183
List of publications 185

1
| General Introduction