Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment PDF
Preview Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment
Christopher C. Chang Gary A. Incaudo M. Eric Gershwin Editors Diseases of the Sinuses A Comprehensive Textbook of Diagnosis and Treatment Second Edition 123 Diseases of the Sinuses Christopher C. Chang (cid:129) Gary A. Incaudo (cid:129) M. Eric Gershwin Editors Diseases of the Sinuses A Comprehensive Textbook of Diagnosis and Treatment Second Edition Editors Christopher C. Chang, MD, PhD, MBA, FAAAAI, FACAAI M. Eric Gershwin, MD, MACP, MACR, FAAAAI Division of Allergy and Immunology The Jack and Donald Chia Distinguished Professor of Medicine Department of Pediatrics Division of Rheumatology, Allergy and Clinical Immunology Thomas Jefferson University University of California School of Medicine Wilmington , DE Davis , CA USA USA Gary A. Incaudo, MD, FAAAAI, FACAAI Division of Rheumatology, Allergy and Clinical Immunology University of California School of Medicine Davis , CA USA ISBN 978-1-4939-0264-4 ISBN 978-1-4939-0265-1 (eBook) DOI 10.1007/978-1-4939-0265-1 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2014940551 © Springer Science+Business Media New York 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher's location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. W hile the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Even a single drop of water will eventually hollow out a stone. We hope this text will be such a drop for sufferers of disease and especially victims of upper airway pathology. CC, GI, and MEG Pref ace The study of sinus diseases crosses the boundaries of many specialties, but it is primarily the domain of allergists and otolar- yngologists. Other disciplines that care for patients with sinus disease include pulmonology, infectious disease, and rheuma- tology. Since the publication of our fi rst edition, our understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the fi eld of immunology. New immunologic concepts relating to both the innate and adaptive immune systems have helped us to recognize that sinus disease may be more of an infl ammatory rather than an infectious process. Since the fi rst edition, pathogen-associated molecular patterns (PAMPs), danger-associated molecular patterns (DAMPs), and their receptors known as pattern recognition receptors (PRRs) have been discovered, and the signaling pathways that lead to chronic infl ammation have been refi ned. New cytokines have been discovered, and the role of IL-17 in chronic infl ammation is now being investigated for its role in sinusitis. Other ongoing research concerns the role of other cells including T regulatory cells, dendritic cells, and neutrophils and the pathways that lead to their prolifera- tion, recruitment, and activity. New concepts such as biofi lms and their role in chronic sinusitis have afforded us a greater understanding of the pathogenic mechanisms behind the disease. The concept of the unifi ed airway has helped to direct new therapeutic strategies in the treatment of sinusitis, and the mechanism behind the activity of leukotriene and prostaglandin pathways in aspirin-exacerbated respiratory disease and the related sinus disease is of great interest to clinicians and scientists. This textbook is divided into sections addressing separately the pathogenesis, clinical presentation, and medical and surgi- cal management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinus- itis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodefi ciency is also addressed. The management section has been updated from the previous edition to incorporate new medical modalities and surgical procedures. While sinus problems are extremely common, there is very little organized teaching in medical schools. It is the goal of this textbook to provide a comprehensive source of information regarding the basic science of the sinuses and the clinical approach to sinusitis. Sinusitis is not just one disease, and the etiologic factors are likely multifactorial. The authors of this textbook are experts in their fi eld from all over the world and share their expertise and insights from years of collective expe- rience in treating sinus diseases. The book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health profes- sionals. Internists, pediatricians, allergists, otolaryngologists, and infectious disease specialists will fi nd the book to be a comprehensive source of knowledge. Physician assistants and nurse practitioners who work with specialists who treat sinus disease would also benefi t from the book. We are hopeful that this comprehensive textbook on sinus disease from many experts in the fi eld will provide the reader with different perspectives on how various medical professions or specialties approach the diverse array of sinus problems experienced by our patients. Philadelphia, PA Christopher C. Chang, MD, PhD, MBA, FAAAAI, FACAAI Davis, CA Gary A. Incaudo, MD, FAAAAI, FACAAI Davis, CA M. Eric Gershwin, MD, MACP, MACR vii Acknowledgments The editors of this book would like to thank all the authors for their tireless contribution to their respective chapters. We would also like to thank our administrative coordinator, Dolores DiStefano, for her communications with all the authors dur- ing the preparation phase. The editors would also like to thank their families for their sacrifi ces in order that we may work on this book during weekends and holidays. Finally, we would like to thank our publisher, Richard Lansing, and his staff for their assistance in bringing this textbook to fruition. ix
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