Diseases of the breast PDF
Preview Diseases of the breast
Diseases of the Breast Harris_9781451186277_FM.indd 1 2/22/2014 2:31:05 PM Harris_9781451186277_FM.indd 2 2/22/2014 2:31:05 PM F i F t h E d i t i o n Diseases of the Breast EditEd by Jay R. Harris, MD Monica Morrow, MD Professor Anne Burnett Windfohr Chair of Clinical Oncology Department of Radiation Oncology Chief, Breast Surgery Service Harvard Medical School Memorial Sloan-Kettering Cancer Center Chair Professor of Surgery, Weill Cornell Medical College Department of Radiation Oncology New York, New York Dana-Farber Cancer Institute and Brigham and Women’s Hospital C. Kent Osborne, MD Boston, Massachusetts The Tina and Dudley Sharp Chair of Oncology Professor of Medicine and Molecular and Cellular Marc E. Lippman, MD, MACP Biology Kathleen & Stanley Glaser Professor Director, Dan L. Duncan Cancer Center University of Miami Miller School of Director, Lester and Sue Smith Breast Center Medicine Baylor College of Medicine Miami, Florida Houston, Texas Harris_9781451186277_FM.indd 3 2/22/2014 2:31:06 PM Senior Executive Editor: Jonathan W. Pine, Jr. Acquisition Editor: Julie Goolsby Senior Product Development Editor: Emilie Moyer Senior Production Product Manager: Bridgett Dougherty Senior Manufacturing Coordinator: Beth Welsh Marketing Manager: Stephanie Manzo Senior Design Coordinator: Teresa Mallon Production Service: SPi Global Copyright © 2014 by Wolters Kluwer Health Two Commerce Square 2001 Market Street Philadelphia, PA 19103 USA LWW.com First Edition © 1996 Lippincott-Raven Publishers Second Edition © 2000 Lippincott Williams & Wilkins Third Edition © 2004 Lippincott Williams & Wilkins Fourth Edition © 2010 Lippincott Williams & Wilkins All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above- mentioned copyright. Printed in China Library of Congress Cataloging-in-Publication Data Diseases of the breast (Harris) Diseases of the breast / edited by Jay R. Harris, Marc E. Lippman, Monica Morrow, C. Kent Osborne. — Fifth edition. p. ; cm. Includes bibliographical references and index. ISBN 978-1-4511-8627-7 I. Harris, Jay R., editor of compilation. II. Lippman, Marc E., 1945- editor of compilation. III. Morrow, Monica, editor of compilation. IV. Osborne, C. Kent, editor of compilation. V. Title. [DNLM: 1. Breast Neoplasms—diagnosis. 2. Breast Diseases. 3. Breast Neoplasms—therapy. WP 870] RC280.B8 616.99′449—dc23 2013036272 Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, com- pleteness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice. To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300. Visit Lippincott Williams & Wilkins on the Internet: at LWW.com. Lippincott Williams & Wilkins customer service represen- tatives are available from 8:30 am to 6 pm, EST. 10 9 8 7 6 5 4 3 2 1 Harris_9781451186277_FM.indd 4 2/22/2014 2:31:06 PM To the many talented and dedicated laboratory and translational investigators and clinical researchers who have been committed to the breast cancer problem and have contributed to the substantial progress made in recent decades in fighting this disease. In memory of Jonathan Pine, our highly esteemed editor, who left all of us much too soon. Harris_9781451186277_FM.indd 5 2/22/2014 2:31:06 PM C o n t r i B u t o r s Albert J. Aboulafia, MD, FACS, MBA Nils D. Arvold, MD Susan K. Boolbol, MD, FACS Director, Sarcoma Services Assistant Professor Associate Professor of Clinical Surgery Alvin and Lois Lapidos Cancer Department of Radiation Oncology Albert Einstein College of Medicine Center Harvard Medical School Chief Department of Orthopaedic Surgery Attending Physician Appel-Venet Comprehensive Breast Sinai Hospital Department of Radiation Oncology Service Assistant Clinical Professor Dana-Farber/Brigham and Women’s Beth Israel Medical Center University of Maryland Cancer Center New York, New York Baltimore, Maryland Boston, Massachusetts Ron Bose, MD, PhD David H. Abramson, MD, FACS Alan Ashworth, FRS, FMedSci Assistant Professor of Medicine Professor of Ophthalmology Chief Executive Department of Internal Medicine Weill Cornell Medical Center The Institute of Cancer Research Division of Oncology Chief, Ophthalmic Oncology Service London, United Kingdom Washington University School of Department of Ophthalmic Oncology Medicine Memorial Sloan-Kettering Cancer Aditya Bardia, MBBS, MPH Attending Physician Center Attending Physician Division of Oncology New York, New York Massachusetts General Hospital Department of Medicine Cancer Center Barnes Jewish Hospital Brian M. Alexander, MD, MPH Harvard Medical School St. Louis, Missouri Assistant Professor of Radiation Boston, Massachusetts Oncology Glenn D. Braunstein, MD Harvard Medical School Christopher A. Barker, MD Professor of Medicine Disease Center Leader, Radiation Assistant Member Department of Medicine Oncology Department of Radiation Oncology Vice President for Clinical Innovation Center for Neuro-Oncology Memorial Sloan-Kettering Cancer Cedars-Sinai Health System Department of Radiation Oncology Center Los Angeles, California Dana-Farber/Brigham and Women’s Assistant Attending Radiation Cancer Center Oncologist Edi Brogi, MD, PhD Boston, Massachusetts Department of Radiation Oncology Associate Professor of Clinical Memorial Hospital for Cancer and Pathology and Laboratory Medicine Kimberly H. Allison, MD Allied Diseases Weill Cornell Medical College Associate Professor of Pathology New York, New York Attending Pathologist—Director of Department of Pathology Breast Pathology Stanford University Medical Center José Baselga, MD, PhD Department of Pathology Stanford, California Physician-in-Chief Memorial Sloan-Kettering Cancer Center Memorial Sloan-Kettering Cancer New York, New York Benjamin O. Anderson, MD, FACS Center Director New York, New York Powel H. Brown, MD, PhD Breast Health Clinic Professor and Chairman Seattle Cancer Care Alliance (SCCA) J. Sybil Biermann, MD Department of Clinical Cancer Professor of Surgery and Global Health Professor Prevention Medicine Department of Orthopaedic Surgery Professor and Chairman University of Washington Director, Musculoskeletal Oncology Breast Medical Oncology Seattle, Washington Department of Orthopaedic Surgery The University of Texas MD Anderson University of Michigan Cancer Center Carlos L. Arteaga, MD University of Michigan Hospital Houston, Texas Professor of Medicine and Cancer Ann Arbor, Michigan Biology Thomas A. Buchholz, MD, FACR Associate Director for Clinical Richard J. Bleicher, MD, FACS Frank T. McGraw Memorial Chair in Research Associate Professor and Co-Leader the Study of Cancer Director Breast Cancer Program Breast Service Line Division Head, Department of Department of Medicine (Oncology) Director, Breast Fellowship Program Radiation Oncology Vanderbilt-Ingram Cancer Center Department of Surgical Oncology The University of Texas MD Anderson Vanderbilt University Fox Chase Cancer Center Cancer Center Nashville, Tennessee Philadelphia, Pennsylvania Houston, Texas vi Harris_9781451186277_FM.indd 6 2/22/2014 2:31:07 PM ContriButors vii Nigel J. Bundred, MD, FRCS Maggie Chon U Cheang, PhD Graham A. Colditz, MD, DrPH Professor of Surgical Oncology Research Associate Niess-Gain Professor Academic Surgery Department of Genetics Department of Surgery University of Manchester University of North Carolina at Chapel Washington University in St. Louis Consultant Oncoplastic Breast Surgeon Hill School of Medicine Surgical Oncology Chapel Hill, North Carolina St. Louis, Missouri University of South Manchester Manchester, United Kingdom M. Jennifer Cheng, MD Robert E. Coleman, MBBS, MD, FRCP, Postdoctoral Research Fellow FRCPE Burcu Cakar, MD Department of Palliative Medicine Director Oncologist Johns Hopkins School of Medicine Cancer Research UK/YCR Sheffield Tulay Aktas Oncology Hospital Baltimore, Maryland Cancer Research Center Ege University School of Medicine University of Sheffield Izmir, Turkey Nathan I. Cherny, MBBS, FRACP, Hon. Consultant Medical Oncologist FRCP (Lon.) Weston Park Hospital Kristine E. Calhoun, MD Associate Professor of Medicine Sheffield, United Kingdom Associate Professor Ben Gurion University Department of Surgery Beer Sheba, Israel Laura C. Collins, MD Division of Surgical Oncology Norman Levan Chair of Humanistic Associate Professor of Pathology University of Washington School of Medicine Department of Pathology Medicine Director Cancer Pain and Palliative Beth Israel Deconess Medical Center Seattle, Washington Medicine and Harvard Medical School Department of Oncology Associate Director Rena D. Callahan, MD Shaare Zedek Medical Center Division of Anatomic Pathology Assistant Clinical Professor of Medicine Jerusalem, Israel Department of Pathology Clinical Instructor Beth Israel Deconess Medical Department of Medicine Andrea L. Cheville, MD, MSCE Center Division of Hematology Oncology Associate Professor and Research Boston, Massachusetts University of California at Los Angeles Chair of Physical Medicine and Los Angeles, California Rehabilitation Steven Come, MD Mayo Clinic Associate Professor of Medicine Lisa A. Carey, MD Rochester, Minnesota Department of Medicine Preyer Distinguished Professor in Harvard Medical School Breast Cancer Research Rowan T. Chlebowski, MD, PhD Director Chief Professor of Medicine Breast Medical Oncology Program Division of Hematology / Oncology Department of Medicine Department of Medicine Department of Medicine David Geffen School of Medicine at the Beth Israel Deaconess Medical University of North Carolina at Chapel University of California–Los Angeles Center Hill Los Angeles, California Boston, Massachusetts Physician-in-Charge Chief North Carolina Cancer Hospital Division of Medical Oncology and Christopher E. Comstock, MD Medical Director Hematology Attending Radiologist UNC Breast Center Department of Medicine Director of Breast Imaging UNC Healthcare Harbor-University of California Medical Postgraduate Training and Education Chapel Hill, North Carolina Center Department of Radiology Torrance, California Memorial Sloan-Kettering Cancer Center Robert W. Carlson, MD New York, New York Professor of Medicine, Emeritus Alice P. Chung, MD, FACS Division of Medical Oncology Assistant Professor Adriana D. Corben, MD Stanford University Medical Center Department of Surgery Assistant Attending Stanford, California Division of Surgical Oncology Department of Pathology Adjunct Professor of Medical Cedars-Sinai Medical Center Memorial Sloan-Kettering Cancer Oncology Los Angeles, California Center Department of Medical Oncology Staff Physician New York, New York Fox Chase Cancer Center Department of Surgery Philadelphia, Pennsylvania Saul and Joyce Brandman Breast Chau Dang, MD Center Associate Professor of Medicine Anees B. Chagpar, MD, MSc, MA, Los Angeles, California Weill Cornell Medical College MPH, FACS, FRCS(C) Associate Attending Physician Associate Professor Hiram S. Cody III, MD Department of Medicine Memorial Department of Surgery Professor of Clinical Surgery Sloan-Kettering Cancer Center Yale University School of Medicine Weill Cornell Medical College New York, New York Director Attending Surgeon The Breast Center Breast Service Andrew J. Dannenberg, MD Smilow Cancer Hospital at Yale New Department of Surgery Professor of Medicine Haven Memorial Sloan-Kettering Cancer Center Weill Cornell Medical College New Haven, Connecticut New York, New York New York, New York Harris_9781451186277_FM.indd 7 2/22/2014 2:31:07 PM viii ContriButors Nancy E. Davidson, MD A. Heather Eliassen, ScD Shari Gelber, MS, MSW Director Assistant Professor Biostatistician University of Pittsburgh Cancer Department of Medicine Adult Oncology Institute and UPMC Cancer Center Harvard Medical School Dana-Farber Cancer Institute Distinguished Professor of Medicine Associate Epidemiologist Boston, Massachusetts and Pharmacology and Chemical Department of Medicine Elizabeth S. Ginsburg, MD Biology Channing Division of Network Medicine Assistant Professor of Obstetrics, University of Pittsburgh Brigham and Women’s Hospital Gynecology and Reproductive Biology Pittsburgh, Pennsylvania Boston, Massachusetts Department of Obstetrics and Lisa M. DeAngelis, MD Matthew J. Ellis, MB, Bchir, PhD, Gynecology Professor of Neurology FRCP Harvard Medical School Department of Neurology Professor Medical Director, In Vitro Fertilization Weill Cornell Medical College Department of Medical Oncology Department of Obstetrics and Chairman Washington University School of Gynecology Department of Neurology Medicine Brigham and Women’s Hospital Memorial Sloan-Kettering Cancer Center Director of Breast Cancer Program Boston, Massachusetts New York, New York Department of Medical Oncology Armando E. Giuliano, MD, FACS, Barnes Jewish Hospital and Siteman FRCSEd Eli L. Diamond, MD, MPhil Cancer Center Clinical Professor Instructor St. Louis, Missouri Department of Surgery Department of Neurology University of California Weill Cornell Medical College Joann G. Elmore, MD, MPH Executive Vice Chair Assistant Attending Professor Department of Surgery Department of Neurology Department of Medicine Cedars-Sinai Medical Center Memorial Sloan-Kettering Cancer Center School of Medicine Los Angeles, California New York, New York Adjunct Professor of Epidemiology School of Public Health Aron Goldhirsch, MD Deborah Dillon, MD University of Washington School of Professor of Medical Oncology Assistant Professor Medicine University of Bern Department of Pathology Attending Physician Bern, Switzerland Harvard Medical School Department of Medicine Director Staff Pathologist Harborview Medical Center Department of Medicine Department of Pathology Seattle, Washington European Institute of Oncology Brigham and Women’s Hospital Milan, Italy Boston, Massachusetts Francisco J. Esteva, MD, PhD Professor of Medicine Mehra Golshan, MD J. Michael Dixon, BSC, MBChB, MD, New York University Cancer Institute Associate Professor of Surgery FRCS, FRCS (Ed), FRCP (Hon) New York University Department of Surgery Professor of Surgery Director Harvard Medical School Edinburgh Breast Unit Breast Medical Oncology Program Director of Breast Surgical Services University of Edinburgh Division of Hematology/Oncology Dana-Farber/Brigham and Women’s Consultant Surgeon New York University Langone Medical Cancer Center Edinburgh Breast Unit Center Dr. Abdul Mohsen and Sultana Western General Hospital New York, New York Al-Tuwaijri Distinguished Chair in Edinburgh, United Kingdom Surgical Oncology Alain Fourquet, MD Department of Surgery Susan M. Domchek, MD Chairman Brigham and Women’s Hospital Basser Professor in Oncology Department of Radiation Oncology Boston, Massachusetts Director Institut Curie Basser Research Center Paris, France Rodrigo Goncalves, MD University of Pennsylvania Research Associate Philadelphia, Pennsylvania Patricia A. Ganz, MD Department of Medical Oncology Distinguished University Professor Washington University Mitchell Dowsett, PhD, BSc Department of Medicine and Health St. Louis, Missouri Professor of Biochemical Policy and Management Endocrinology David Geffen School of Medicine and William J. Gradishar, MD, FASCO, FACP Department of Biochemistry Fielding School of Public Health at Betsy Bramsen Professor of Breast Institute of Cancer Research UCLA Oncology Head of Biochemistry and Centre Los Angeles, California Director for Molecular Pathology Maggie Daley Center for Women’s Royal Marsden Hospital Richard D. Gelber, PhD Cancer Center London, United Kingdom Professor Robert H. Lurie Comprehensive Cancer Department of Biostatistics Center Ian F. Dunn, MD Harvard School of Public Health Feinberg School of Medicine Assistant Professor of Neurosurgery Senior Biostatistician Northwestern University Department of Neurosurgery Department of Biostatistics and Attending Physician Harvard Medical School Computational Biology Department of Hematology/Oncology Brigham and Women’s Hospital Dana-Farber Cancer Institute Northwestern Memorial Hospital Boston, Massachusetts Boston, Massachusetts Chicago, Illinois Harris_9781451186277_FM.indd 8 2/22/2014 2:31:07 PM ContriButors ix Michael W. Groff, MD Douglas W. Hanto, MD, PhD Bruce E. Hillner, MD Director of Spinal Neurosurgery Lewis Thomas Professor of Surgery Professor of Medicine and Eminent Department of Neurosurgery Emeritus University Scholar Brigham and Women’s Hospital Harvard Medical School Department of Internal Medicine Harvard Medical School Boston, Massachusetts School of Medicine Boston, Massachusetts Associate Dean for Continuing Virginia Commonwealth Medical Education University Ayca Gucalp, MD Professor of Surgery Attending Physician Assistant Member Washington University School of Department of Internal Medicine Department of Medicine Medicine Virginia Commonwealth University Memorial Sloan-Kettering Cancer Center Chief Medical Center Instructor General Surgery Service Richmond, Virginia Department of Medicine Department of Surgery Weill Cornell Medical College St. Louis Veteran’s Administration Alice Y. Ho, MD, MBA Assistant Attending Physician Medical Center Assistant Attending Breast Cancer Medicine Service St. Louis, Missouri Assistant Member Division of Solid Tumor Department of Radiation Department of Medicine Jay R. Harris, MD Oncology Memorial Sloan-Kettering Cancer Center Professor Memorial Sloan-Kettering Cancer New York, New York Department of Radiation Oncology Center Anthony J. Guidi, MD Harvard Medical School New York, New York Chair Assistant Clinical Professor Department of Pathology Department of Radiation Gabriel N. Hortobagyi, MD, FACP, Tufts University School of Medicine Oncology FASCO Boston, Massachusetts Dana-Farber Cancer Institute and Professor Chair Brigham and Women's Hospital Co-Director of the Breast Cancer Department of Pathology Boston, Massachusetts Research Program Newton-Wellesley Hospital Department of Breast Medical Daniel F. Hayes, MD, FASCO Newton, Massachusetts Oncology Professor The University of Texas MD Anderson Carolina Gutiérrez, MD Department of Internal Medicine Cancer Center University of Michigan School of Associate Professor Houston, Texas Medicine Department of Pathology and Lester Clinical Director and Sue Smith Breast Center Clifford A. Hudis, MD Breast Oncology Program Director of Breast Pathology Member Department of Internal Medicine Baylor College of Medicine Department of Medicine University of Michigan Health Houston, Texas Memorial Sloan-Kettering Cancer System Center Bruce G. Haffty, MD, FACR, FASTRO Ann Arbor, Michigan Professor of Medicine Professor and Chair Department of Medicine Department of Radiation Oncology James A. Hayman, MD, MBA Weill Cornell Medical College Rutgers Cancer Institute of New Jersey Professor Attending Physician and Chief Rutgers, The State University of New Department of Radiation Oncology Breast Cancer Medicine Service Jersey University of Michigan Health Division of Solid Tumor Chair System Department of Medicine Robert Wood Johnson University Hospital Ann Arbor, Michigan Memorial Sloan-Kettering Cancer New Brunswick, New Jersey Aditi Hazra, PhD, MPH Center New York, New York Susan E. Hankinson, ScD Assistant Professor of Medicine Professor of Epidemiology Department of Medicine Kevin S. Hughes, MD, FACS Department of Public Health Harvard Medical School Associate Professor of Surgery University of Massachusetts, Boston Brigham and Women’s Department of Surgery Epidemiologist Hospital Harvard Medical School Department of Medicine Boston, Massachusetts Co-Director Brigham and Women’s Hospital Boston, Massachusetts Mark A. Helvie, MD Avon Comprehensive Breast Evaluation Professor Center Nora M. Hansen, MD Director of Breast Imaging Department of Surgery Associate Professor of Surgery Department of Radiology Massachusetts General Hospital Department of Surgery University of Michigan Health Boston, Massachusetts Feinberg School of Medicine System Northwestern University Ann Arbor, Michigan Kelly K. Hunt, MD Director Professor Lynn Sage Comprehensive Breast Cancer Dawn Hershman, MD Department of Surgical Oncology Chief, Division of Breast Surgery Associate Professor of Medicine Chief Department of Surgery and Epidemiology Breast Surgical Oncolgy Prentice Women’s Hospital of Department of Medicine The University of Texas MD Anderson Northwestern Memorial Hospital Columbia University Cancer Center Chicago, Illinois New York, New York Houston, Texas Harris_9781451186277_FM.indd 9 2/22/2014 2:31:07 PM x ContriButors Claudine Isaacs, MD, FRCPC Janice N. Kim, MD Nancy U. Lin, MD Professor of Medicine Associate Professor Assistant Professor Department of Medicine and Department of Radiation Oncology Department of Medicine Oncology University of Washington Medical Harvard Medical School Co-Director Fisher Center for Familial Center Clinical Director Cancer Research Seattle, Washington Breast Oncology Center Lombardi Comprehensive Cancer Department of Medical Oncology Center Gretchen Kimmick, MD, MS Dana-Farber Cancer Institute Georgetown University Associate Professor of Medicine Boston, Massachusetts Washington, DC Department of Breast Medical Oncology Marc E. Lippman, MD, MACP Sarika Jain, MD Duke University Medical Center Kathleen & Stanley Glaser Professor Assistant Professor of Medicine Durham, North Carolina University of Miami Miller School of Department of Medicine Medicine Northwestern University and Robert Tari A. King, MD, FACS Miami, Florida H. Lurie Comprehensive Cancer Associate Attending Surgeon Center Jeanne A. Petrek Junior Faculty Jennifer K. Litton, MD Attending Physician |Chair Associate Professor Department of Medicine Breast Service Breast Medical Oncology Northwestern Memorial Hospital Memorial Sloan-Kettering Cancer The University of Texas MD Anderson Chicago, Illinois Center Cancer Center Associate Professor of Surgery Houston, Texas Maxine S. Jochelson, MD Weill Cornell Medical Collegef Associate Professor of Clinical New York, New York Suling Liu, PhD Radiology School of Life Sciences Department of Radiology Youlia M. Kirova, MD University of Science and Technology Weill Cornell Medical College Senior Radiation Oncologist of China Associate Clinical Member Department of Radiation Oncology Hefei, Anhui, China Department of Radiology Institut Curie Memorial Sloan Kettering Cancer Paris, France Stephen V. Liu, MD Center Assistant Professor New York, New York Ian E. Krop, MD, PhD Department of Medicine Assistant Professor of Medicine Lombardi Comprehensive Cancer Stephen R.D. Johnston, MA, PhD, Department of Medicine Center FRCP Harvard Medical School Georgetown University Professor of Breast Cancer Senior Physician and Director of Washington, DC Medicine Clinical Research Department of Medical Oncology Breast Oncology Center Charles L. Loprinzi, MD Consultant Medical Oncologist Department of Medical Oncology Regis Professor of Breast Cancer The Breast Unit, The Royal Marsden Dana-Farber Cancer Institute Research NHS Foundation Trust Boston, Massachusetts Department of Oncology Royal Marsden Hospital Mayo Clinic London, United Kingdom Christoph I. Lee, MD, MSHS Rochester, Minnesota Assistant Professor Atif Khan, MD Department of Radiology Associate Professor of Radiation University of Washington School of Cynthia X. Ma, MA, MD, PhD Oncology and Medical Director Medicine Associate Professor of Medicine Proton Therapy Seattle, Washington Department of Internal Medicine Robert Wood Johnson Medical Division of Oncology School Susan Carole Lester, MD, PhD Washington University School of Rutgers Cancer Institute of New Assistant Professor Medicine Jersey Department of Pathology Barnes Jewish Hospital Radiation Oncologist Harvard Medical School St. Louis, Missouri Department of Radiation Oncology Chief Robert Wood Johnson Hospital Breast Pathology Services Yanling Ma, MD New Brunswick, New Jersey Department of Pathology Associate Professor of Clinical Brigham and Women’s Hospital Pathology Seema A. Khan, MD, PhD Boston, Massachusetts Department of Pathology and Professor of Surgery Laboratory Medicine Department of Surgery Jennifer A. Ligibel, MD University of Southern California Northwestern University Assistant Professor Keck School of Medicine Surgeon Department of Medicine Physician Specialist Department of Surgery Harvard Medical School Department of Pathology and Robert H. Lurie Comprehensive Cancer Senior Physician Laboratory Medicine Center Adult Oncology Norris Comprehensive Cancer Center Northwestern Memorial Hospital Dana-Farber Cancer Institute University Hospital Chicago, Illinois Boston, Massachusetts Los Angeles, California Harris_9781451186277_FM.indd 10 2/22/2014 2:31:07 PM
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