Diseases of Renal Parenchyma

314 Pages·2012·5.526 MB·English

by  M. Sahay

DISEASES OF RENAL
PARENCHYMA

Edited by Manisha Sahay
Diseases of Renal Parenchyma
Edited by Manisha Sahay

Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia

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Technical Editor Teodora Smiljanic
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First published March, 2012
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]

Diseases of Renal Parenchyma, Edited by Manisha Sahay
p. cm.
ISBN 978-953-51-0245-8

Contents

Preface IX
Part 1 Glomerular Diseases 1
Chapter 1 The Power of Molecular Genetics in
Establishing the Diagnosis and Offering
Prenatal Testing: The Case for Alport Syndrome 3
Constantinos Deltas, Konstantinos Voskarides,
Panagiota Demosthenous, Louiza Papazachariou,
Panos Zirogiannis and Alkis Pierides
Part 2 Tubular Disorders 15
Chapter 2 Dent’s Disease 17
Elena Levtchenko, Arend Bökenkamp,
Leo Monnens and Michael Ludwig
Part 3 Systemic Diseases of Kidney 33
Chapter 3 Plasma Concentration of Adipokines,
Obstructive Sleep Apnea Syndrome and
Chronic Kidney Disease in Patients with Metabolic
Syndrome and Non-Alcoholic Fatty Liver Disease 35
Mariya Severova, Evgeniya Saginova, Marat Galliamov,
Nickolay Ermakov, Alla Rodina, Mikhail Severov,
Andrey Pulin, Viktor Fomin and Nikolay Mukhin
Chapter 4 The Obesity Epidemic and
Kidney Disease: A Literature Review 45
Veeraish Chauhan, Megha Vaid, Nishtha Chauhan
and Akhil Parashar
Chapter 5 Uric Acid and Renal Function 57
Guilherme Ambrosio Albertoni, Fernanda Teixeira Borges
and Nestor Schor
VI Contents

Chapter 6 Renal Disease and Pregnancy 75
Marius Craina, Elena Bernad, Răzvan Niţu, Paul Stanciu,
Cosmin Cîtu, Zoran Popa, Corina Şerban and Rodica Mihăescu
Chapter 7 Arterial Hypertension and Renal Disease 93
Corina Şerban, Rodica Mihăescu, Lavinia Noveanu,
Ioana Mozoş, Ruxandra Christodorescu and Simona Drăgan
Chapter 8 Sickle Cell Disease and Renal Disease 113
Mathias Abiodun Emokpae and Patrick Ojiefo Uadia
Chapter 9 Renal Cortical Neoplasms and
Associated Renal Functional Outcomes 135
Gina M. Badalato, Max Kates, Neda Sadeghi and
James M. McKiernan
Chapter 10 The Role of B-Cells and B-Cell
Targeted Therapies in Lupus Nephritis 153
Irene Blanco, Saakshi Khattri and Chaim Putterman
Part 4 Diabetes and Kidney 177
Chapter 11 Diabetic Nephropathy:
Current and Novel Therapeutic Approaches
to Prevent Its Development and Progression 179
Karly C. Sourris and Josephine M. Forbes
Chapter 12 Antioxidant Therapy for Diabetic Kidney Disease 203
Alina Livshits and Axel Pflueger
Chapter 13 Is Limb Loss Always Inevitable for Critical Neuro-Ischemic
Foot Wounds in Diabetic Patients with End Stage Renal
Disease and Unfit for Vascular Reconstructions? 229
Vlad Alexandrescu
Chapter 14 Diabetes and Renal Disease 247
Rodica Mihăescu, Corina Şerban, Simona Drăgan, Romulus Timar,
Ioana Mozoş, Marius Craina and Adalbert Schiller
Chapter 15 Diabetic Nephropathy: A Cardiovascular Risk Factor 271
Caroline Jane Magri and Stephen Fava

Preface

The first section of this book deals with various primary glomerular diseases. It
discusses the pathogenic aspects of Alport’s syndrome. The second section focuses on
tubular diseases. Dent’s disease, which is an important tubular disorder, has also been
highlighted. The third section gives some insight into the kidney's role in various
systemic diseases, as illustrated in the chapters on diabetic kidney disease. The other
important systemic disease that has significant renal involvement is systemic lupus
erythematosus. The latest developments in the field of SLE which have been
incorporated will be of use to the readers in their clinical practice.
The role of uric acid in health and disease is an area of active research. Kidney diseases
may be the cause or effect of disturbed uric acid metabolism, which is very well
illustrated in the chapter on uric acid and the kidney. The book also provides insight into
the effect of pregnancy on the kidney. The kidney is an innocent bystander in various
hemolytic anemias and the renal involvement in sickle cell disease highlights this point.
It is widely recognized that obesity contributes to morbidity and mortality from
diabetes, heart disease, stroke, and some forms of cancer, yet the important role that it
plays in the progression of kidney disease is rarely mentioned. The chapter on obesity
and kidney disease aims to raise awareness about the importance of obesity in chronic
kidney disease.
This book will contribute to the readers' development of a lifelong interest in
nephrology. The aim of this book is to give ample opportunities to the learners as well
as masters of the subject.

Dr. Manisha Sahay
Professor and Head, Dept. of Nephrology,
Osmania General Hospital / Osmania Medical College, Hyderabad
Consultant Nephrologist, Aditya Hospital, Tilak Road, Abids
Member of Young Nephrologists Committee - International Sociey of Nephrology
Executive Committee Member - Indian Society of Nephrology (Central)
Executive Committee Member - Southern Chapter of Indian Society of Nephrology
Ameerpet, Hyderabad
India