Table Of Content

Disease Management Second edition Disease Management A guide to clinical pharmacology Michael D Randall MA, PhD Associate Professor and Reader in Cardiovascular Pharmacology University of Nottingham Medical School Nottingham, UK Karen E Neil BPharm (Hons), PhD, MRPharmS Pharmacist Nottingham, UK London •Chicago Published by the Pharmaceutical Press An imprint of RPS Publishing 1 Lambeth High Street, London SE1 7JN, UK 100 South Atkinson Road, Suite 200, Grayslake, IL 60030–7820, USA © Michael D Randall and Karen E Neil 2009 is a trade mark of RPS Publishing RPS Publishing is the publishing organisation of the Royal Pharmaceutical Society of Great Britain First edition published 2003 Second edition published 2009 Typeset by Type Study, Scarborough, North Yorkshire Printed in Great Britain by Cambridge University Press, Cambridge ISBN 978 0 85369 767 1 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without the prior written permission of the copyright holder. The publisher makes no representation, express or implied, with regard to the accuracy of the information contained in this book and cannot accept any legal responsibility or liability for any errors or omissions that may be made. The right of Michael D Randall and Karen E Neil to be identiﬁed as the authors of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act, 1988 A catalogue record for this book is available from the British Library Cert no. SA-COC-1527 This book is dedicated to our other halves, Clare and Geoff, and to Thomas and Tamsin Randall and Jenna Neil. Contents Preface xi General reading xiii Note to the reader xv Acknowledgements xvi About the authors xvii Abbreviations xviii Part A The patient 1 1 Signs and symptoms 3 2 Clinical laboratory tests 15 3 Lifestyle 21 4 Herbal medicine and alternative remedies 37 Part B Treatment 47 5 Adverse drug reactions and interactions 49 6 Clinical pharmacokinetics 73 Part C Gastrointestinal diseases 83 7 Dyspepsia and peptic ulcer disease 85 8 Nausea and vomiting 97 viii Contents 9 Lower gastrointestinal problems 103 10 The liver patient 113 Part D Cardiovascular diseases 117 11 Hypertension 119 12 Hyperlipidaemia 133 13 Obesity 147 14 Ischaemic heart disease 157 15 Heart failure 169 16 Thromboembolic prophylaxis 185 17 Anaemias 193 18 The renal patient 199 Part E Respiratory diseases 207 19 Coughs and colds 209 20 Allergy 217 21 Respiratory diseases: asthma and chronic obstructive pulmonary disease 225 Part F Central nervous system disorders 239 22 Migraine 241 23 Epilepsy 249 Contents ix 24 Affective disorders 259 25 Anxiety disorders 285 26 Insomnia 295 27 Schizophrenia 303 28 Parkinson’s disease 317 Part G Pain and palliation 325 29 Pain management 327 30 Musculoskeletal pain 347 31 The cancer patient: cancer and palliative care 361 Part H Infections 375 32 Bacterial infections 377 33 Non-bacterial infections 397 Part I Dermatology 405 34 Dermatology 407 Part J Endocrine disorders 425 35 Diabetes mellitus 427 36 Thyroid disorders 441