Digital Health Approach for Predictive, Preventive, Personalised and Participatory Medicine

99 Pages·2019·2.841 MB·English

by  Lotfi Chaari

Advances in Predictive, Preventive and Personalised Medicine
Series Editor: Olga Golubnitschaja
Lotfi  Chaari Editor
Digital Health
Approach for
Predictive, Preventive,
Personalised and
Participatory Medicine
Digital Health Approach for Predictive, Preventive,
Personalised and Participatory Medicine
Advances in Predictive, Preventive and Personalised
Medicine
Volume 10
SeriesEditor:
OlgaGolubnitschaja
Moreinformationaboutthisseriesathttp://www.springer.com/series/10051
Lotfi Chaari
Editor
Digital Health Approach
for Predictive, Preventive,
Personalised and
Participatory Medicine
123
Editor
LotfiChaari
MIRACLLaboratory
UniversityofSfax
Sfax,Tunisia
DigitalResearchCentreofSfax
Sfax,Tunisia
ISSN2211-3495 ISSN2211-3509 (electronic)
AdvancesinPredictive,PreventiveandPersonalisedMedicine
ISBN978-3-030-11799-3 ISBN978-3-030-11800-6 (eBook)
https://doi.org/10.1007/978-3-030-11800-6
©SpringerNatureSwitzerlandAG2019
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What This Book Series Is About
Current Healthcare:What IsBehind theIssue?
For many acute and chronic disorders, the current healthcare outcomes are con-
sidered as being inadequate: global figures cry for preventive measures and per-
sonalised treatments. In fact, severe chronic pathologies, such as cardiovascular
disorders, diabetes and cancer, are treated after onset of the disease, frequently
at near end stages. Pessimistic prognosis considers pandemic scenario for type 2
diabetes mellitus, neurodegenerative disorders and some types of cancer over the
next 10–20 years followed by the economic disaster of healthcare systems in a
globalscale.
AdvancedHealthcareTailoredtothe Person:What IsBeyond
the Issue?
Advancedhealthcarepromotestheparadigmchangefromdelayedinterventionalto
predictivemedicinetailoredtotheperson,fromreactivetopreventivemedicineand
from disease to wellness. The innovative Predictive, Preventive and Personalised
Medicine (PPPM) is emerging as the focal point of efforts in healthcare aimed
at curbing the prevalence of both communicable and non-communicable diseases,
such as diabetes, cardiovascular diseases, chronic respiratory diseases, cancer and
dentalpathologies.Thecost-effectivemanagementofdiseasesandthecriticalrole
of PPPM in modernisation of healthcare have been acknowledged as priorities by
globalandregionalorganisationsandhealth-relatedinstitutions,suchastheUnited
NationsOrganisation,theEuropeanUnionandtheNationalInstitutesofHealth.
vi WhatThisBookSeriesIsAbout
Why IntegrativeMedicalApproachbyPPPMastheMedicine
ofthe Future?
PPPM is the new integrative concept in healthcare sector that enables to predict
individualpredispositionbeforeonsetofthedisease,toprovidetargetedpreventive
measuresandtocreatepersonalisedtreatmentalgorithmstailoredtotheperson.The
expectedoutcomesareconducivetomoreeffectivepopulationscreening,prevention
earlyinchildhood,identificationofpersonsatrisk,stratificationofpatientsforthe
optimal therapy planning, prediction and reduction of adverse drug-drug or drug-
disease interactions relying on emerging technologies, such as pharmacogenetics,
pathology-specificmolecularpatters,subcellularimaging,diseasemodelling,indi-
vidual patient profiles, etc. Integrative approach by PPPM is considered as the
medicine of the future. Being at the forefront of the global efforts, the European
Association for Predictive, Preventive and Personalised Medicine (EPMA, http://
www.epmanet.eu/) promotes the integrative concept of PPPM among healthcare
stakeholders, governmental institutions, educators, funding bodies, patient organ-
isationsandpublicdomain.
Current book series, published by Springer in collaboration with EPMA,
overview multidisciplinary aspects of advanced biomedical approaches and
innovative technologies. The integration of individual professional groups into
the overall concept of PPPM is a particular advantage of this book series. Expert
recommendations focus on the cost-effective management tailored to the person
in health and disease. Innovative strategies are considered for standardisation of
healthcare services. New guidelines are proposed for medical ethics, treatment of
rare diseases, innovative approaches to early and predictive diagnostics, patient
stratification and targeted prevention in healthy individuals, persons at risk,
individual patient groups, subpopulations, institutions, healthcare economy and
marketing.
About the Book Series Editor
Prof.Dr.OlgaGolubnitschaja
Dr. Golubnitschaja, Department of Radiology, Medical Faculty, Rheinische
Friedrich-Wilhelms-Universität in Bonn, Germany, has studied journalism,
biotechnology and medicine and has been awarded research fellowships in
Austria, Russia, the UK, Germany, the Netherlands and Switzerland (early and
predictive diagnostics in paediatrics, neurosciences and cancer). She is the author
of more than 400 well-cited international publications (research and review
articles, position papers, books and book contributions) in the innovative field
ofpredictive,preventiveandpersonalisedmedicine(PPPM)withthemainresearch
focusesonpre-andperinataldiagnostics,diagnosticsofcardiovasculardiseaseand
neurodegenerativepathologies,predictivediagnosticsincanceranddiabetes.
She has been awarded National and International Fellowship of the Alexander
von Humboldt Foundation and Highest Prize in Medicine and Eiselsberg Prize in
Austria.
Since2009Dr.Golubnitschaja isthesecretarygeneral ofthe“European Asso-
ciation for Predictive, Preventive and Personalised Medicine” (EPMA, Brussels)
networking over 50 countries worldwide (www.epmanet.eu), book series editor
of “Advances in Predictive, Preventive and Personalised Medicine” (Springer
Nature)bookeditorofPredictiveDiagnosticsandPersonalisedTreatment:Dream
viii AbouttheBookSeriesEditor
or Reality (Nova Science Publishers, New York 2009) and book coeditor of
PersonalisierteMedizin(HealthAcademy,Dresden2010).
SheistheEuropeanrepresentativeintheEDRNetworkattheNationalInstitutes
ofHealth,USA(http://edrn.nci.nih.gov/).
Sheisaregularreviewerforover30clinicalandscientificjournalsandservesas
agrantreviewerforthenational(MinistriesofHealthinseveralEuropeancountries)
andinternationalfundingbodies.
Since2007untilthepresent,sheworksastheEuropeanCommissionevaluation
expertforFP7,Horizon2020,IMI-1(InnovativeMedicalInitiatives)andIMI-2.In
years 2010–2013, she was involved in creating the PPPM-related contents of the
EuropeanProgramme“Horizon2020”.
Currently, she is vice-chair of the Evaluation Panel for Marie Curie Mobility
ActionsattheEuropeanCommissioninBrussels.
Preface
This volume contains the papers presented at ICDHT 2018: International Confer-
enceonDigitalHealthTechnologiesheldonOctober15–16,2018,inSfax.
Therewere12submissions.Eachsubmissionwasreviewedbyatleasttwo,and
ontheaverage2.4,programcommitteemembers.Thecommitteedecidedtoaccept
ninepapers.Theprogramalsoincludesoneinvitedtalk.
This first edition of the ICDHT conference has gathered authors from five
countriesandfourcontinents.ItwashostedbytheDigitalResearchCentreofSfax
and organized in collaboration with the Higher Institute of Computer Science and
MultimediaofSfax,theFacultyofMedicineofSfax,andtheMIRACLLaboratory.
Theconferencewasalsosupportedbyanumberofindustrialpartners,allactivein
digitalhealth.
The general chair of the ICDHT 2018 conference (Lotfi Chaari) would like to
thankallthecommitteemembers,keynotespeakers,authors,andattendees.
AcademicSponsors:DigitalResearchCentreofSfax,UniversityofSfax,Higher
InstituteofComputerScienceandMultimediaofSfax,FacultyofMedicineofSfax,
MIRACLLaboratory
Industrial Sponsors: Sfax HealthTech Cluster, Technopark of Sfax, IAT,
MedikaTech,IIT,DHCsys
TheconferencecommitteeisgratefultoEasyChairforprovidingthemaccessto
theconferencemanagementplatform.
Sfax,Tunisia LotfiChaari
October24,2018
ix