(Digital Academic Repository) Functional consequences of inborn and acquired errors in ...

214 Pages·2017·9.97 MB·English

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Functional consequences of inborn and acquired errors in endothelial glycocalyx
heparan sulfates
Mooij, H.L.
Publication date
2015
Document Version
Final published version
Link to publication
Citation for published version (APA):
Mooij, H. L. (2015). Functional consequences of inborn and acquired errors in endothelial
glycocalyx heparan sulfates. [Thesis, fully internal, Universiteit van Amsterdam].
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Hans Leonard Mooij
H
.L
. M
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ij
Functional consequences oF inborn
and acquired errors in endothelial
glycocalyx heparan sulFates
Functional consequences of inborn and acquired errors in endothelial
glycocalyx heparan sulfates, Academic thesis, University of Amsterdam,
Amsterdam, the Netherlands
ISBN: 978-94-6182-547-6
Author: H.L. Mooij
Printed & Lay Out by: Off Page
Published by:
© H.L. Mooij, Amsterdam 2015
All rights reserved. No part of this publication may be reproduced,
stored or transmitted in any form or by any means, without written
permission of the author.
Printing of this thesis was financially supported by: Stichting AMSTOL,
Universiteit van Amsterdam, Stichting tot Steun Promovendi Vasculaire
Geneeskunde and ChipSoft BV.
Functional consequences oF inborn
and acquired errors in endothelial
glycocalyx heparan sulFates
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus
prof. dr. D.C. van den Boom
ten overstaan van een door het College voor Promoties ingestelde commissie,
in het openbaar te verdedigen in de Agnietenkapel
op dinsdag 7 april 2015, te 10:00 uur
door
Hans Leonard Mooij
geboren te Bedum
promotiecommissie
Promotores: Prof. dr. E.S.G. Stroes
Prof. dr. H. Vink
Co-promotores: Dr. M. Nieuwdorp
Dr. G.M. Dallinga-Thie
Overige leden: Prof. dr. H.P. Sauerwein
Prof. dr. R.J.A. Wanders
Prof. dr. M.J.A.P. Daemen
Prof. dr. J.B.L. Hoekstra
Prof. dr. J.M.F.G. Aerts
Prof. dr. E.J.G. Sijbrands
Faculteit der Geneeskunde
Financial support by the Dutch Heart Foundation for the publication of this thesis is
gratefully acknowledged
table oF contents
chapter 1 General introduction and outline of the thesis 9
part i endothelial glycocalx in health and disease
chapter 2 Endothelial glycocalyx damage coincides with 19
microalbuminuria in type 1 diabetes mellitus
chapter 3 Effect of Sulodexide on endothelial glycocalyx 35
and vascular permeability in patients with
type 2 diabetes mellitus
chapter 4 Tumor Necrosis Factor-α inhibition protects 51
against endotoxin-induced endothelial
glycocalyx perturbation
chapter 5 Partial recovery of the endothelial glycocalyx 69
upon rosuvastatin therapy in patients with
heterozygous Familial Hypercholesterolemia
part ii inborn hspg synthesis deFects
and cardiometabolic disease
chapter 6 Loss of function in heparan sulfate elongation 83
genes EXT1 and EXT2 results in improved nitric
oxide bioavailability and endothelial function
chapter 7 Carriers of loss-of-function mutations in EXT 103
display impaired pancreatic β-cell reserve
due to smaller pancreas volume
chapter 8 Inhibition of hepatic Sulf2 in vivo: a novel 121
strategy to correct diabetic dyslipidemia
chapter 9 SULF2 Strongly Prediposes to Fasting and 135
Postprandial Triglyceride-rich Lipoprotein Levels
in Patients with Obesity and Type 2 Diabetes Mellitus
chapter 10 Genetic variation in heparan sulfate is associated 153
with postprandial lipid clearance in humans
chapter 11 Summary and future perspectives 175
appendices Nederlandse samenvatting 191
List of abbreviations 195
Authors and affiliations 199
List of Publications 205
About the author 207
Curriculum Vitae 209
Dankwoord 211