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DIGESTIVE DISEASES ANFormDerly P ublished Sas The CAmeriIcan JoEurnal Nof DigeCstive EDiseaseSs New Series Volume 40, Number 1 ISSN 0163-2116 62nd Year of Continuous Publication JA N UARY 1995 DDSCDJ 40(1) 1-240 (1995) |© Liver: Infectious, Inflammatory, and Metabolic Disorders ‘| 1 Nucleotide Sequence Analysis of Precore and Proximal Core Regions in Patients with Chronic Hepatitis B Treated with Interferon. T. Laskus, J. Rakela, and D.H. Persing Evidence for Hepatitis B Virus Infection in Patients with Chronic Hepatitis C with and Without Serological Markers of Hepatitis B. E. Villa, A. Grottola, P. Buttafoco, P. Trande, A. Merighi, N. Fratti, Y. Seium, G. Cioni, and F. Manenti Serial Assay of Hepatitis C Virus RNA in Serum for Predicting Response to Interferon-a Therapy. K. Hino, M. Okuda, T. Konishi, H. Ishiko, and K. Okita Serum Carboxy Terminal Propeptide of Type I Procollagen to Amino Terminal Propeptide of Type III Procollagen Ratio is a Better Indicator than Each Single Propeptide and 7S Domain Type IV Collagen for Progressive Fibrogenesis in Chronic Viral Liver Diseases. D.Y. Lin, C.M. Chu, I.S. Sheen, and Y.F. Liaw CASE REPORT: Crigler-Najjar Syndrome Type II: New Observation of Possible Autosomal Recessive Inheritance. S. Gildiituna, U. Langenbeck, K.W. Bock, A. Sieg, and U. Leuschner Hepatitis C Virus Infection as a Determinant of Behavior in Type 1 Autoimmune Hepatitis. A.J. Czaja, S. Magrin, C. Fabiano, G. Fiorentino, O. Diquattro, A. Craxi, and L. Pagliaro @ Liver: Cirrhosis, Fibrosis, Portal Hypertension, and Transplantation | 4) Use of Prostaglandin I, Analog in Treatment of Massive Hepatic Necrosis Associated with Endothelial Cell Injury and Diffuse Sinusoidal Fibrin Deposition. K. Fujiwara, S. Mochida, A. Ohno, M. Arai, A. Matsui, N. Masaki, K. Hirata, T. Tomiya, M. Yamaoka, S. Nagoshi, Y. Ohta, I. Ogata, A. Francavilla, D.H. Van Thiel, and T.E. Starzl Effects of Exercise-Induced Sympathoadrenergic Activation on Portal Blood Flow. T. Iwao, A. Toyonaga, M. Ikegami, M. Sumino, K. Oho, M. Sakaki, H. Shigemori, K. Tanikawa, and J. Iwao Use of OKT3 Monoclonal Antibody as Induction Therapy for Control of Rejection in Liver Transplantation. W.J. Wall, C.N. Ghent, A. Roy, V.C. McAlister, D.R. Grant, and P.C. Adams REVIEW ARTICLE: Immunomodulation of Transplant Rejection Using Monoclonal Antibodies and Soluble Receptors. M.-L. Alegre, D.J. Lenschow, and J.A. Bluestone REVIEW ARTICLE: Future of Monoclonal Antibodies in Solid Organ Transplantation. A.B. Cosimi LETTER: Sphincter of Oddi Dysfunction After Liver Transplantation. P.-A. Clavien, C.A. Camargo, Jr., J. Baillie, and J.G. Fitz RESPONSE: V. Douzdjian LETTER: Listeria Monocytogenes Peritonitis. E. Fricker and J.C. Yarze |@ Pancreatic and Biliary Disorders 76 Effect of Endogenous Cholecystokinin on Postprandial Gallbladder Refilling: Ultrasonographic Study in Healthy Subjects and in Gallstone Patients. M. Cicala, E. Corazziari, D. Diacinti, D. Badiali, and A. Torsoli 82 CASE REPORT: Resolution of Nonsyndromic Paucity of Intrahepatic Bile Ducts in Infancy. S. Berezin, D. Beneck, P. Altman, and S.M. Schwarz |® @ Motility, Nerve—Gut Interactions, Hormones, and Receptors 86 Effect of a Tricyclic Antidepressant on Small Intestinal Motility in Health and Diarrhea-Predominant Irritable Bowel Syndrome. D.A. Gorard, G.W. Libby, and M.J.G. Farthing 96 Effect of Capsaicin on Release of Substance P-Like Immunoreactivity from the Vascularly Perfused Rat Duodenum. M. Fujimiya and Y.N. Kwok Contents continued inside DIGESTIVE DISEASES AND SCIENCES New Series Volume 40, Number 1 January 1995 Contents continued from front cover |© Gastrointestinal Oncology 7 100 CASE REPORT: Carcinomas of the Colon with Multidirectional Differentiation: Report of Two Cases and Review of the Literature. P. Novello, P. Duvillard, S. Grandjouan, D. Elias, P. Rougier, C. Bognel, and M. Prade 107 CASE REPORT: Adenocarcinoma of the Ileum in a Patient with Cystic Fibrosis. L.E. Samuels, G. Amrom, and M.D. Kerstein |@ Esophageal, Gastric, and Duodenal Disorders 109 Determination of Helicobacter pylori Status by Reverse Transcription-Polymerase Chain Reaction: Comparison with Urea Breath Test. F.A.K. El-Zaatari, A.-M.H. Nguyen, R.M. Genta, P.D. Klein, and D.Y. Graham Long-Term Prospective Study of Helicobacter pylori in Nonulcer Dyspepsia. C. McCarthy, S. Patchett, R.M. Collins, S. Beattie, C. Keane, and C. O’Morain Gastric Mucosal High-Energy Phosphate Metabolism: Influence of Ethanol and PGE,. B.E. Victor, H. Taegtmeyer, and T.A. Miller Abnormalities in the Shape of the Duodenal Loop on X-Ray: Associated with Idiopathic Antral Hypomotility? J. Zighelboim, R.L. MacCarty, and N.J. Talley Effects of Nonsteroidal Antiinflammatory Drugs on Ulcerogenesis and Gastric Secretion in Pylorus-Ligated Rat. K.A. Wagner, J. Nandi, R.L. King, and R.A. Levine Gastric Emptying Response to Variable Oral Erythromycin Dosing in Diabetic Gastroparesis. S.G. Desautels, W.R. Hutson, P.E. Christian, J.G. Moore, and F.L. Datz Rabbit and Ferret Parietal Cell Inhibition by Helicobacter Species. J.S. Hoffman, W.W. King, J.G. Fox, D. Janik, and D.R. Cave CASE REPORT: Helicobacter pylori Infection: A Reversible Cause of Hypergastrinemia and Hyperchlorhydria Which May Mimic Zollinger-Ellison Syndrome. D.C. Metz, C. Weber, M. Orbuch, D.B. Strader, I.A. Lubensky, and R.T. Jensen 160 Effect of Plaunotol on Hypergastrinemia Induced by Long-Term Omeprazole Administration in Humans. H. Kaneko, T. Mitsuma, H. Nagai, M. Harada, H. Kotera, A. Furusawa, and K. Morise 166 Endoscopic, Radiographic, and Manometric Findings Associated with Cardiovascular Dysphagia. M.S. Cappell Effect of Isosorbide Dinitrate on Gastroesophageal Reflux in Healthy Volunteers and Patients with Chagas’ Disease. N.M. Matsuda, R.B. Oliveira, R.O. Dantas, and N. Iazigi 183 CASE REPORT: Bacterial Esophagitis Associated with CD4* T-Lymphocytopenia Without HIV Infection: Possible Role of Corticosteroid Treatment. S.M. Richert and J.L. Orchard 186 CASE REPORT: Cryptosporidium Gastropathy: Presentation of a Case and Review of the Literature. A.J. Massimillo, J. Chang, L. Freedman, R. Baxi, N. Kanth, and C. Pellecchia 191 LETTER: Acid-Suppression Did Not Enhance Healing of Gastric Ulcer Associated with Paraesophageal Hernia After Hernial Reduction. S. Rakic, P. Pesko, M. Dunjic, and Z. Gerzic |@ Intestinal Disorders, Inflammatory Bowel Disease, Immunology, and Microbiology 192 Alterations in Rat Peripheal Blood Neutrophil Function as a Consequence of Colitis. L. Carter and J.L. Wallace 198 Phenotypic and Functional Characterization of T-Cell Lines Generated from Colonoscopic Biopsy Specimens in Patients with Ulcerative Colitis. K. Kusugami, J.I. Haruta, M. Ieda, M. Shinoda, T. Ando, A. Kuroiwa, K. Ina, H. Ilokawa, A. Ishihara, S. Sarai, Y. Saito, M. Tanimoto, and K. Morise 211 Effect of Radiation and Radioprotection on Small Intestinal Function in Canines. J.L. Herrera, R.M. Vigneulle; T. Gage, T.J. MacVittie, J.B. Nold, and A. Dubois 219 Up-Regulation of E-Selectin and Intercellular Adhesion Molecule-1 Differs Between Crohn’s Disease and Ulcerative Colitis. N. Pooley, L. Ghosh, and P. Sharon 226 CASE REPORT: Pseudo-Crohn’s Disease with Bloody Diarrhea: A Case of Munchausen’s Syndrome. H. Klein, A. Du Vall, and S. Klein [© Editorial _| 229 Virtue and Physicians. R.A. Capone 232 ~=+|@- News and Notices a 235 Abstracts on Sensitive Gastrointestinal Disorders—Fedotozine, Versailles, France, December 5-6, 1994 DIGESTIVE DISEASES AND SCIENCES New Series Volume 40, Number 2 __ February 1995 (Supplement) Frontiers in Digestive Diseases: Omeprazole Introduction. Richard Hunt and George Sachs Pharmacological Aspects of Acid Secretion. B.I. Hirschowitz, D. Keeling, M. Lewin, S. Okabe, M. Parsons, K. Sewing, B. Wallmark, and G. Sachs Optimizing Acid Suppression for Treatment of Acid-Related Diseases. R.H. Hunt, C. Cederberg, J. Dent, F. Halter, C. Howden, I.N. Solly Marks, S. Rune, and R.P. Walt Effects of Hypochlorhydria and Hypergastrinemia on Structure and Function of Gastrointestinal Cells: A Review and Analysis. J.W. Freston, K. Borch, S.J. Brand, E. Carlsson, W. Creutzfeldt, R. Hakanson, L. Olbe, E. Solcia, J.H. Walsh, and M.M. Wolfe Safety of Acid-Suppressing Drugs. R.A. Smallwood, R.G. Berlin, N. Castagnoli, H.P.M. Festen, C.J. Hawkey, S.K. Lam, M.J.S. Langman, P. Lundborg, and A. Parkinson Effects of Acid Suppression on Microbial Flora of Upper Gut. N.D. Yeomans, R.W. Brimblecombe, J. Elder, R.V. Heatley, J.J. Misiewicz, T.C. Northfield, and A. Pottage Pathophysiological Effects of Long-Term Acid Suppression in Man. R.F. McCloy, R. Arnold, K.D. Bardhan, D. Cattan, E. Klinkenberg-Knol, P.N. Maton, R.H. Riddell, P. Sipponen, and A. Walan Acid Suppression and Gastric Mucosal Cell Biology. G. Delle Fave, H. Helander, S. Hold, I.M. Modlin, R. Powers, E. Solcia, A. Soll, Y. Tielemans, and N.A. Wright DIGESTIVE DISEASES ANFormDerly P ublished Sas The CAmeriIcan JoEurnal Nof DigeCstive EDiseaseSs New Series Volume 40, Number 2 ISSN 0163-2116 62nd Year of Continuous Publication FEBRUARY 1995 DDSEDJ .40(2) 241-480 (1995) |@ Esophageal, Gastric, and Duodenal Disorders | 241 Human Proximal Duodenal Ion and Water Transport: Role of Enteric Nervous System and Carbonic Anhydrase. T.W. Knutson, L.F. Knutson, D.L. Hogan, M.A. Koss, and J.I. Isenberg 247 Effect of Repeated Boluses of Intravenous Omeprazole and Primed Infusionso f Ranitidine on 24-Hour Intragastric pH in Healthy Human Subjects. S. Teyssen, S.T. Chari, J.S cheid, and M.V. Singer 256 Increased Mortality of Acute Upper Gastrointestinal Bleeding in Patients with Chronic Obstructive Pulmonary Disease: A Case Controlled, Multiyear Study of 53 Consecutive Patients. M.S. Cappell and S.C. Nadler 263 Regional Distribution of Transforming Growth Factor-Alpha and Epidermal Growth Factor in Normal and Portal Hypertensive Gastric Mucosa in Humans. M. Romano, K.S. Meise, R. Suozzo, G. Sessa, M. Persico, and R.J. Coffey 268 Products of Neutrophil Metabolism Increase Ammonia-Induced Gastric Mucosal Damage. M. Murakami, K. Asagoe, H. Dekigai, S. Kusaka, H. Saita, and T. Kita 274 Irritant and Protective Action of Urea—-Urease Ammonia in Rat Gastric Mucosa: Different Effects of Ammonia and Ammonium Ion. K. Takeuchi, T. Ohuchi, H. Harada, and S. Okabe 282 Spontaneous Swallowing Rate and Emotional State: Possible Mechanism for Stress-Related Gastrointestinal Disorders. J.L. Cuevas, E.W. Cook III, J.E. Richter, M. McCutcheon, and E. Taub 287 CASE REPORT: Endoscopic Detection of Ectopic Multiple Minute Sebaceous Glands in the Esophagus: Report of a Case and Review of the Literature. K. Hoshika, S. Inoue, M. Mizuno, M. lida, and M Shimizu @ Intestinal Disorders, Inflammatory Bowel Disease, Immunology, and Microbiology 291 Interleukin-2 Receptor a and B Chain Expression by Circulating af and yd T Cells in Inflammatory Bowel Disease. I. Kirman, O.H. Nielsen, E. Kjaersgaard, and J. Brynskov 296 Safety and Efficacy of Controlled-Release Mesalamine for Maintenance of Remission in Ulcerative Colitis. P. Miner, S. Hanauer, M. Robinson, J. Schwartz, S. Arora, and Pentasa UC Maintenance Study Group 305 Topical Treatment of Refractory Distal Ulcerative Colitis with 5-ASA and Sodium Butyrate. P. Vernia, M. Cittadini, R. Caprilli, and A. Torsoli 308 CASE REPORT: Eosinophilic Gastroenteritis Presenting with Colitis and Cholangitis. D. Schoonbroodt, Y. Horsmans, A. Laka, A.P. Geubel, and P. Hoang 315 CASE REPORT: Nonsteroidal Antiinflammatory Drug-Induced Colonic Stricture: An Unusual Cause of Large Bowel Obstruction and Perforation. M.H.E. Robinson, T. Wheatley, and I.H. Leach 320 Colonic Lactate Metabolism and p-Lactic Acidosis. H. Hove and P. Brgbech Mortensen 331 Role of T Lymphocytes in Secretory Response to an Enteric Nematode Parasite: Studies in Athymic Rats. D.M. McKay, M. Benjamin, M. Baca-Estrada, R. D’Inca, K. Croitoru, and M.H. Perdue 338 Influence of Heated and Nonheated Partially Hydrogenated Dietary Fats on Ileal Chyme Fat and Fatty Acid Composition of Ileal Mucosa in Pigs. S. Biihner, E. Nagel, H. Stockhorst, J. Kérber, A.N. Sagredos, and R. Pichlmayr 346 CASE REPORT: Abnormal Abdominal CT Findings in a Patient with Giardiasis: Resolution After Treatment. J. Orchard and V. Petorak ®@ Motility, Nerve—Gut Interactions, Hormones, and Receptors | 349 Effect of Wheat Bran in Treatment of Chronic Nonorganic Constipation: A Double-Blind Controlled Trial. D. Badiali, E. Corazziari, F.1. Habib, E. Tomei, G. Bausano, P. Magrini, F. Anzini, and A. Torsoli 357 Distribution of Mast Cells in Human Ileocecal Region. S. Bacci, M.S. Faussone-Pellegrini, B. Mayer, and P. Romagnoli Contents continued inside DIGESTIVE DISEASES AND SCIENCES New Series Volume 40, Number 2 February 1995 Contents continued from front cover 366 Changes of Protein Gene Product 9.5 (PGP 9.5) Immunoreactive Nerves in Inflamed Appendix. P. Di Sebastiano, T. Fink, E. Weihe, H. Friess, H.G. Beger, and M. Biichler |© Gastrointestinal Oncology | 373 Microvascular Structure of Benign and Malignant Tumors of the Celon in Humans. S.A. Skinner, G.M. Frydman, and P.E. O’Brien 385 Ecological Study of Association Between Heliobacter pylori Infection and Gastric Cancer in Taiwan. J.-T. Lin, L.-Y. Wang, J.-T. Wang, T.-H. Wang, and C.-J. Chen 389 Autoantibodies Specific for Villin Found in Patients with Colon Cancer and Other Colitides. D.L. Rimm, T.E. Holland, J.S. Morrow, and J.M. Anderson 396 Aging: Increased Responsiveness of Colorectal Mucosa to Carcinogen Stimulation and Protective Role of Folic Acid. Y.M. Nensey, F.L. Arlow, and A.P.N. Majumdar 402 Familial Adenomatous Polyposis and Inflammatory Bowel Disease Associated in Two Kindreds. C. Brignola, C. Belloli, G. De Simone, L. Varesco, P. Walger, A. Areni, C. Calabrese, G. Di Febo, and L. Barbara | © Pancreatic and Biliary Disorders 406 Cholecystokinin and Pancreatic Polypeptide Release in Diabetic Patients with and Without Autonomic Neuropathy. B. Glasbrenner, E. Dominguez-Munoz, R.L. Riepl, A. Vetsi, and P. Malfertheiner 412 Human Polymorphonuclear Leukocyte Phagocytosis of Crystalline Cholesterol, Bilirubin, and Calcium Hydroxyapatite in Vitro. J.B. Prystowsky, J.S. Huprikar, A.W. Rademaker, and R.V. Rege 419 Toxic Effects of Cholelitholytic Solvents on Gallbladder and Liver: A Piglet Model Study. C.-Y. Chen, K.-K. Chang, N.-H. Chow, T.-C. Leow, T.-C. Chou, and X.-Z. Lin 427 LETTER: Cholecystokinin-Induced Gallbladder Contraction and Muscarinic Blockade with Pirenzepine in Man. N.B. Ulusoy, S. Oktay, B.C. Yegen, E. Tankurt, and N. Gurmen 428 Gallbladder Emptying, Plasma Levels of Estradiol and Progesterone, and Cholecystokinin Secretion in Liver Cirrhosis. M. Pompili, G.L. Rapaccini, E. Caturelli, D. Curr6, P. Montuschi, M. D’Amato, A. Aliotta, A. Grattagliano, A. Cedrone, M. Anti, V. Sciamanna, and E. Menini |© Liver: Infectious, Inflammatory, and Metabolic Disorders 435 REVIEW ARTICLE: Autoimmune Hepatitis: Evolving Concepts and Treatment Strategies. A.J. Czaja 457 Clinical Study of IgA Antibody Against Hepatitis C Virus Core Antigen in Patients with Type C Chronic Liver Disease. M. Tanaka, S. Sato, S. Fujiyama, S.-I. Kawano, Y. Taura, H. Chikazawa, Y. Honda, J. Shibata, and T. Sato 465 A Retrospective Study of Hepatitis C Virus Carriers in a Local Endemic Town in Japan: A Possible Presence of Asymptomatic Carrier. S. Ohkoshi, H. Tawaraya, K. Kuwana, T. Harada, M. Watanabe, S. Higuchi, H. Kojima, T. Kamimura, and H. Asakura |© Diagnostic and Interventional Techniques 472 Multicenter, Multiyear Study of Safety and Efficacy of Flexible Sigmoidoscopy During Pregnancy in 24 Females with Follow-up of Fetal Outcome. M. Cappell and O. Sidhom 480 | @ News and Notices DIGESTIVE DISEASES ANFormeDrly Pu blished asS The CAmericIan JouErnal Nof DigeCstive EDiseaseSs New Series Volume 40, Number 3 ISSN 0163-2116 62nd Year of Continuous Publication MARCH 1995 DDSCDJ 40(3) 481-708 (1995) je Intestinal Disorders, Inflammatory Bowel Disease, Immunology, and Microbiology CASE REPORT: Small Bowel Perforation due to Cholesterol Atheromatous Embolism. J.A. Jimenez-Heffernan, C.M. Martinez-Garcia, M.A. Sanchez, C. Jimenez, C. Perna, and E. Burgos Expression of Growth Factor Receptor-Encoded mRNA by Colonic Epithelial Cells Is Altered in Inflammatory Bowel Disease. R.J. Alexander, A. Panja, E. Kaplan-Liss, L. Mayer, and R.F. Raicht Endotoxin-Resistant Mice Are Protected from PAF-Induced Bowel Injury and Death: Role of TNF, Complement Activation, and Endogenous PAF Production. X. Sun, M.S. Caplan, Y. Liu, and W. Hsueh Ketotifen Ameliorates Capsaicin-Augmented Acetic Acid-Induced Colitis. R. Eliakim, F. Karmeli, E. Okon, and D. Rachmilewitz Polarized Caco-2 Cells: Effect of Reactive Oxygen Metabolites on Enterocyte Barrier Function. R.D. Baker, S.S. Baker, and K. LaRosa Immunocytochemical Localization of Pancreatitis-Associated Protein in Human Small Intestine. L. Masciotra, P. Lechéne de la Porte, J.-M. Frigerio, N.J. Dusetti, J.-C. Dagorn, and J.L. lovanna LETTER: Aseptic Systemic Abscesses Preceding the Diagnosis of Crohn’s Disease by Three Years. M. Andre, O. Aumaitre, J.-C. Marcheix, and J.-C. Piette LETTER: Fatal Invasive Aspergillosis During Cyclosporine and Steroids Treatment for Crohn’s Disease. A. Scalzini, C. Barni, R. Stelini, and L. Sueri |e Pancreatic and Biliary Disorders a 529 Role of Nutrient Fat and Cholecystokinin in Regulation of Gallbladder Emptying in Man. F. Froehlich, J.J. Gonvers, and M. Fried 534 Black Pigment Gallstones with Cholesterol Gallstones in the Same Gallbladder: 13 Cases in a Surgical Series of 1226 Patients with Gallbladder Stones. F. Cetta, F. Lombardo, and P.F. Malet 539 LETTER: Intraoperative Cholangiogram-Induced Bradycardia—Another Indication for Common Bile Duct Exploration. Y. Kluger, O. Jurim, and Z. Gimmon 540 Nonesterified Fatty Acids in Acute Cerulein-Induced Pancreatitis in the Rat: Are They Really Deleterious in Vivo? F. Paye, J. Chariot, G. Molas, J. Benessiano, and C. Rozé 546 LETTER: Beneficial Effects of Preventive Oral Administration of Camostate on Cerulein-Induced Pancreatitis in Rats. K. Kisfalvi, M. Papp, H. Friess, M. Biichler, and U.G. Goracz |e Liver: Cirrhosis, Fibrosis, Portal Hypertension, and Transplantation | 548 Recipient Kupffer Cell Influx into Xenografted Liver. Y. Yamaguchi, E.C. Halperin, K. Mori, R.R. Bollinger, and M. Ogawa 552 Prefused Kupffer Cell Mass: Correlation with Histology and Severity of Chronic Liver Disease. J. Hoefs, K. Chang, F. Wang, G. Kanel, T. Morgan, and P. Braunstein 561 Prevalence and Prognostic Significance of Bacterascites in Cirrhosis with Ascites. C.-M. Chu, K.-Y. Chang, and Y.-F. Liaw 566 Glycine-to-Arginine Substitution at Codon 145 of HBsAg in Two Infants Born to Hepatitis B e Antigen-Positive Carrier. K. Hino, M. Okuda, O. Hashimoto, H. Ishiko, M. Okazaki, K. Fujii, H. Hanada, and K. Okita 571 CASE REPORT: Primary Biliary Cirrhosis Diagnosed During Pregnancy: Does It Have a Different Outcome? M. Rabinovitz, R. Appasamy, and S. Finkelstein 575 LETTER: Treatment of Crigler-Najjar Type II with Small-Dose Phenobarbital. Z.M. Younossi and P. Foroozan Contents continued inside DIGESTIVE DISEASES AND SCIENCES New Series Volume 40, Number 3 March 1995 Contents continued from front cover © Esophageal, Gastric, and Duodenal Disorders 576 Chili—Protective Factor Against Peptic Ulcer? J.Y. Kang; K.G. Yeoh, H.P. Chia, H.P. Lee, Y.W. Chia, R. Guan, and I. Yap 580 Chilli Protects Against Aspirin-Induced Gastroduodenal Mucosal Injury in Humans. K.G. Yeoh, J.Y. Kang, I. Yap, R. Guan, C.C. Tan, A. Wee, and C.H. Teng 584 Impact of Functional Dyspepsia on Quality of Life. N.J. Talley, A.L. Weaver, and A.R. Zinsmeister 590 Treatment of Erosive Reflux Esophagitis Resistant to H,-Receptor Antagonist Therapy: Lansoprazole, a New Proton Pump Inhibitor. M. Robinson, D.R. Campbell, S. Sontag, and S.M. Sabesin 598 Endoscopic Ultrasonographic Abnormalities and Lower Esophageal Sphincter Function in Reflux Esophagitis. O. Kawamura, T. Sekiguchi, M. Kusano, T. Horikoshi, K. Kikuchi, M. Miyazaki, T. Yamada, and T. Ohwada 606 CASE REPORT: Cytomegalovirus Infection of Esophagus in Immunocompetent Adult. C. Altman, P. Bedossa, E. Dussaix, and C. Buffet 609 Serological Parameters in Assessment of Degree of Gastritis in Healthy Volunteers. J. Kreuning, J. Lindeman, I. Biemond, and C.B.H.W. Lamers 615 Helicobacter pylori Infection and Gastric Juice Vitamin C Levels: Impact of Eradication. T. Rokkas, G. Papatheodorou, A. Karameris, A. Mavrogeorgis,N . Kalogeropoulos, and N. Giannikos 622 LETTER: Effect of Upper Gastrointestinal Endoscopy on Serum Gastrin Levels: Does Presence of H. pylori Make a Difference? J.S. Mathews, H.M. El-Newihi, J.L. Achord, and A.A. Mihas 624 Gastric Emptying in Mexican Americans Compared to Non-Hispanic Whites. J.G. Schwartz, C.:A. McMahan, G.M. Green, and W.T. Phillips 631 Recent Trends in Mortality from Peptic Ulcer Disease in Finland. H. Paimela, T. Joutsi, T. Kiviluoto, and E. Kivilaakso 636 Antral Emptying of Semisolid Meal Measured by Real-Time Ultrasonography in Chronic Renal Failure. D.L. Dumitrascu, J. Barnert, T. Kirschner, and M. Wienbeck 645 Effect of Ranitidine on Intragastric pH and Stress-Related Upper Gastrointestinal Bleeding in Patients with Severe Head Injury. P. Burgess, G.M. Larson, P. Davidson, J. Brown, and C.A. Metz 651 Cholecystokinin Is a Potent Protective Agent Against Alcohol-Induced Gastric Injury in the Rat: Role of Endogenous Prostaglandins. D.W. Mercer, J.M. Cross, J.C. Barreto, N.H.P. Strobel, D.H. Russell, and T.A. Miller 661 Relationship Between Gastroprotective Effect of Locally Acting Antiulcer Agent Ecabet Sodium and Its Binding to Gastric Mucosa in Rats: Comparison with Sucralfate. M. Kinoshita, K. Yamasaki, Y. Kokusenya, and H. Tamaki 668 LETTER: Effect of Aging on Gastric Mucosal Proliferation in Rats Treated with Aspirin. Y. Twersky, M. Blumstein, S. Bank, and V. Kranz 670 Effects of Nitric Oxide Synthase Inhibitor N°-Nitro-L-Arginine Methyl Ester on Duodenal Alkaline Secretory and Ulcerogenic Responses Induced by Mepirizole in Rats. K. Takeuchi, T. Ohuchi, and S. Okabe 678 Effect of Somatostatin-14 on Duodenal Mucosal Bicarbonate Secretion in Guinea Pigs. H.S. Odes, R. Muallem, R. Reimer, S. Ioffe, W. Beil, M. Schwenk, and K.-F. Sewing |© G astrointestinal Oncology 685 Transglutaminase in Azoxymethane-Induced Colon Cancer in the Rat. G. D’Argenio, P. Iovino, V. Cosenza, I. Sorrentini, F. De Ritis, M. Delle Cave, F.P. D’Armiento, and G. Mazzacca 696 Endoscopic Ultrasonography in Diagnosis and Staging of Pancreatic Cancer. A. Nakaizumi, H. Uehara, H. Iishi, M. Tatsuta, T. Kitamura, C. Kuroda, H. Ohigashi, O. Ishikawa, and S. Okuda 701 Nonsurgical Management of Primary Cholangiocarcinoma: Retrospective Analysis of 40 Cases. B. Banerjee and S.K. Teplick 706 LETTER: Screening of Hepatocellular Carcinoma in French Patients. F. Durand, C. Buffet, G. Pelletier, H. Hagege, O. Ink, and J.P. Etienne 708 | @ News and Notices DIGESTIVE DISEASES | ANFormeDrly Pu blished asS The CAmericIan JouErnal Nof DigeCstive EDiseaseSs New Series Volume 40, Number 4 ISSN 0163-2116 62nd Year of Continuous Publication AP RIL 1995 DDSCDJ 40(4) 709-930 (1995) @ Ischemia—Reperfusion e 709 Current Theories of Pathogenesis and Treatment of Nonocclusive Mesenteric Ischemia. M.G. Wilcox, T.J. Howard, L.A. Plaskon, J.L. Unthank, and J.A. Madura 717 Newly Synthesized Histamine Accelerates Ornithine Decarboxylase Activity in Rat Intestinal Mucosa After Ischemia—Reperfusion. K. Fujimoto, Y. Sakata, S. Tsunada, T. Koyama, H. Morita, S.-I. Ogata, C. Matsunaga, Y. Gotoh, and R. Iwakiri @ Pancreatic and Biliary Disorders 722 Evaluation of Gallbladder Function Before and After Gastrectomy Using a Double-Isotope Method. T. Hamasaki, Y. Hamanaka, A. Adachi, and T. Suzuki Increased Turnover of Intrahepatic Bile Ducts Induced by Bromobenzene. G. Zajicek, R. Shamir, J. Nordenberg, Y. Sidi, and N. Arber REVIEW ARTICLE: Effectiveness of Gabexate Mesilate in Acute Pancreatitis: A Metaanalysis. A. Messori, R. Rampazzo, G. Scroccaro, R. Olivato, C. Bassi, M. Falconi, P. Pederzoli, and N. Martini Preduodenal Mechanisms Compensate Completely for Absent Pancreatic Enzymes to Stimulate Gallbladder After Meals. J.H. Meyer, M. Hlinka, D. Jehn, and Y.G. Gu Effect of Gastric Distension and Duodenal Fat Infusion on Biliary Sphincter of Oddi Motility in Healthy Volunteers. A.N. Kalloo and P.J. Pasricha 749 LETTER: A Case of Pancreatic Ascites in Which Endoscopic Retrograde Pancreatography (ERP) Was Used to Confirm a Leaking Pancreatic Duct. R.E. Davis 749 RESPONSE: Y.-C. Kuo 750 LETTER: Schonlein-Henoch Purpura and Pancreatitis. C.F. Diaz @ Liver: Infectious, Inflammatory, and Metabolic Disorders s 752 CASE REPORT: Regression of Inflammatory Pseudotumor of the Liver Under Conservative Therapy. P. Jais, J.-C. Berger, C. Vissuzaine, O. Paramelle, E. Clays-Schouman, F. Potet, and M. Mignon 757 A Lectin Histochemical Study of Intrahepatic Ducts in Patients with Hepatolithiasis. K.-T. Lee and P.-C. Sheen 763 CASE REPORT: Posttransfusional, LKM-1-Autoantibody-Positive Hepatitis C Virus Infection, Cryoglobulinemia, and Aplastic Anemia. M. Peters, M. Trippler, H. Lohr, W. Gédderz, W. Herr, S. Stérkel, K.-H. Meyer zum Biischenfelde, and G. Gerken |e Motility, Nerve—Gut Interactions, Hormones, and Receptors cs 774 Na*/H* Exchange Mediates Postprandial Ileal Water and Electrolyte Transport. O.J. Hines, A.J. Bilchik, D.W. McFadden, P.J. Rodgers, N. Bautista, M.J. Zinner, and S.W. Ashley 781 Colocalization of NADPH-Diaphorase Staining and VIP Immunoreactivity in Neurons in Opossum Internal Anal Sphincter. R.B. Lynn, S.L. Sankey, S. Chakder, and S. Rattan 792 LETTER: Should Interdigestive Motility of Small Intestine Be Recorded by Long-Term Ambulatory or Short-Term Stationary Manometry? E. Husebye le Intestinal Disorders, Inflammatory Bowel Disease, Immunology and Microbiology | 793 Serum Concentrations of von Willebrand Factor and Soluble Thrombomodulin Indicate Alteration of Endothelial Function in Inflammatory Bowel Diseases. A.M. Sawyerr, M.S. Smith, A. Hall, M. Hudson, C.R. Hay, A.J. Wakefield, M.G. Brook, H. Tomura, and R.E. Pounder Contents continued inside DIGESTIVE DISEASES AND SCIENCES New Series Volume 40, Number 4 April 1995 Contents continued from front cover 800 Prospective Evaluation of Interferon-a in Treatment of Chronic Active Crohn’s Disease C. Gasché, W. Reinisch, H. Vogelsang, R. P6étzi, E. Markis, M. Micksche, H.P. Wirth, A. Gangl, and H. Lochs 805 Decreased Mucosal IgA Levels in Ileum of Patients with Chronic Ulcerative Colitis. L. Cicalese, R.H. Duerr, M.A. Nalesnik, P.F. Heeckt, K.K.W. Lee, and W.H. Schraut 812 LETTER: Ileal Intussusception and Obstruction as Presentation of Inflammatory Fibroid Polyp. B. Bradley, P.J Molloy, K. Glick, and R.J. Kania 814 HLA-DRB1* 1502 Allele, Subtype of DR15, Is Associated with Susceptibility to Ulcerative Colitis and Its Progression. S. Futami, N. Aoyama, Y. Honsako, T. Tamura, S$. Morimoto, T. Nakashima, A. Ohmoto, H. Okano, M. Miyamoto, H. Inaba, T. Naruse, Y. Nose, and M. Kasuga 819 Visceral Perception in Irritable Bowel Syndrome: Rectal and Gastric Responses to Distension and Serotonin Type 3 Antagonism. J. Zighelboim, N.J. Talley, S.F. Phillips, W.S. Harmsen, and A.R Zinsmeister 828 Effect of Streptozotocin-Induced Diabetes Mellitus on Release of Vasoactive Intestinal Polypeptide from Rodent Small Intestine. T.V. Nowak, W.W. Chey, T.M. Chang, J.P. Weisbruch, and G. Fouquet 837 LETTER: Esophageal Crohn’s Disease: Treat the Inflammation, Not Just the Symptoms. P ©. Beck, T.E. Lay, and P.K. Blustein 837 RESPONSE: A.S. Mee and R. Przemioslo 839 Nonhereditary Colonic Angiodysplasias: Histomorphometric Approach to Their Pathogenesis. S. Naveau, M.B. Leger-Ravet, C. Houdayer, P. Bedossa, G. Lemaigre, and J.C. Chaput 843 REVIEW ARTICLE: Intense Nutritional Support in Inflammatory Bowel Disease. S. Wu and R.M. Craig @ Esophageal, Gastric, and Duodenal Disorders 853 In Vitro Free Radical Production in Rat Esophageal Mucosa Induced by Nicotine. G.J. Wetscher, D. Bagchi, G. Perdikis, M. Bagchi, E.J. Redmond, P.R. Hinder, K. Glaser, and R.A. Hinder 859 Are Human Herpes Viruses or Measles Virus Associated with Esophageal Achalasia? H. Niwamoto, E. Okamoto, J. Fujimoto, M. Takeuchi, J.-I. Furuyama, and Y. Yamamoto 865 Mechanism of Gastric Alkaline Response in the Stomach After Damage: Roles of Nitric Oxide and Prostaglandins. K. Takeuchi and S. Okabe 872 Adaptive Cytoprotection in Cultured Rat Gastric Mucus-Producing Cells: Role of Mucus and Prostaglandin Synthesis. H. Mutoh, S. Ota, H. Hiraishi, K.J. Ivey, A. Terano, and T. Sugimoto 879 Protection of Cultured Rat Gastric Cells Against Oxidant Stress by Iron Chelation: Role of Lipid Peroxidation. N. Yajima, H. Hiraishi, and T. Harada 887 Duodenal Ulcer: Calcium Status in Isolated Parietal Cells. U. Kaur, N. Agnihotri, S. Kaur, M. Khullar, P. Bambery, G. Sood, and K. Singh 893 Electrogastrography Prior to and Following Total Gastrectomy, Subtotal Gastrectomy, and Gastric Tube Formation. S. Homma, N. Shimakage, M. Yagi, J. Hasegawa, K. Sato, H. Matsuo, Y. Tamiya, T. Muto, and K. Hatakeyama 901 Effect of Cisapride on Myoelectrical and Motor Responses of Antropyloroduodenal Region During Intraduodenal Lipid and Antral Tachygastria in Conscious Dog. M. Edelbroek, J. Schuurkes, W. de Ridder, M. Horowitz, J. Dent, and L. Akkermans 912 CASE REPORT: Helicobacter pylori Gastritis Therapy with Omeprazole and Clarithromycin Increases serum Carbamazepine Levels. D.C. Metz and H.D. Getz 916 CASE REPORT: Diffuse Muscular Thickening of Esophagus Associated with Multiple Leiomyomas Diagnosed by Endoscopic Ultrasonagraphy. M. Ikeda, M. Ochiai, T. Nakamura, Y. Kojima, T. Sato, A. Morozumi, and M.A. Fujino 920 LETTER: Consequences of Percutaneous Endoscopic Gastrostomy (PEG) Tubes in Nursing Home Patients. J. Hall 921 RESPONSE: M. Kaw and G. Sekas 922 | @ Book Reviews ese 930 | @ News and Notices e DIGESTIVE DISEASES | ANFormeDrly Pu blished asS The CAmericIan JouErnal Nof DigeCstive EDiseaseSs New Series Volume 40, Number 5 ISSN 0163-2116 62nd Year of Continuous Publication MAY 1995 DDSCDJ 40(5) 931-1166 (1995) |e Intestinal Disorders, Inflammatory Bowel Disease, Immunology, and Microbiology 931 Quality-of-Life Results of Double-Blind, Placebo-Controlled Trial of Mesalamine in Patients with Crohn’s Disease. J.W. Singleton, S. Hanauer, and M. Robinson 936 Topical Nicotine Protects Rat Gastric Mucosa Against ASA-Induced Damage: A Role for Mucosal Fluid Secretion in Cytoprotection. C.A. Fallone and G.P. Morris Effect of Olsalazine on Sodium-Dependent Bile Acid Transport in Rat Ileum. A. Chawla, P.I. Karl, R.N. Reich, G. Narasimhan, G.A. Michaud, S.E. Fisher, and B.L. Schneider Elevation of Interleukin-6 in Inflammatory Bowel Disease Is Macrophage- and Epithelial Cell-Dependent. K. Kusugami, A. Fukatsu, M. Tanimoto, M. Shinoda, J.-I. Haruta, A. Kuroiwa, K. Ina, K. Kanayama, T. Ando, T. Matsuura, T. Yamaguchi, K. Morise, M. Ieda, H. Ilokawa, A. Ishihara, and S. Sarai Changes in Intestinal Tunica Muscularis Following Dietary Fiber Feeding in Rats: A Morphometric Study Using Image Analysis. A. Stark, A. Nyska, A. Zuckerman, and Z. Madar Uptake and Translocation of Microparticles in Small Intestine: Morphology and Quantification of Particle Distribution. G.M. Hodges, E.A. Carr, R.A. Hazzard, and K.E. Carr Passive Elastic Wall Properties in Isolated Guinea Pig Small Intestine. J.H. Storkholm, G.E. Villadsen, S.L. Jensen, and H. Gregersen A Study of Irritable Bowel Syndrome Diagnosed by Manning Criteria in an African Population. I.O. Olubuyide, F. Olawuyi, and A.A. Fasanmade Functional Bowel Disorders: A Multicenter Comparison of Health Status and Development of Illness Severity Index. D.A. Drossman, Z. Li, B.B. Toner, N.E. Diamant, F.H. Creed, D. Thompson, N.W. Read, C. Babbs, M. Barreiro, L. Bank, W.E. Whitehead, M.M. Schuster, and E.A. Guthrie |© Gastrointestinal Oncology 996 DNA Ploidy and Proliferating Cell Nuclear Antigen in Colonic Adenomas and Adenocarcinomas. T. Tomita 1005 Role of SPan-1 Antigen in Adhesion of Human Colon Cancer Cells to Vascular Endothelium. N. Yamada, Y.-S. Chung, T. Sawada, M. Okuno, and M. Sowa 1013. LETTER: “Helicobacter heilmannii” Infection in a Patient with Gastric Cancer. H. Yang, X. Li, Z. Xu, and D. Zhou C Motility, Nerve—-Gut Interactions, Hormones, and Receptors 1015 Cecum of Guinea Pig Is a Reservoir and Sigmoid Is a High-Resistance Conduit. W. Lange, K. Schulze-Delrieu, H. Lange, S. Shirazi, and G. Lepsien 1024 Effects of Enteral Feedback Inhibition on Motility, Luminal Flow, and Absorption of Nutrients in Proximal Gut of Minipigs. A. Huge, E. Weber, and H.-J. Ehrlein Postischemic Intestinal Motility in Rat Is Inversely Correlated to Length of Ischemia: An in Vivo Animal Model. R. Udassin, D. Eimer], J. Schiffman, and Y. Haskel LETTER: Gastrointestinal Bleeding and Intestinal Ischemia Associated with Anticardiolipin Antibodies. A.A. Mihas LETTER: Gastrointestinal Hemmorrhage and Anticardiolipin Antibodies. M.S. Cappell and N. Mikhail Contents continued inside

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