Differential Diagnosis in Surgical Pathology

1085 Pages·2015·99.682 MB·English

by  Paolo Gattuso, Vijaya B. Reddy, Odile David, Daniel J. Spitz, Meryl H. Haber

Differential Diagnosis
in Surgical Pathology
THIRD EDITION
Differential
Diagnosis
in Surgical
Pathology
Paolo Gattuso, MD Daniel j. sPitz, MD
The Otho S.A. Sprague Professor of Chief Medical Examiner
Pathology Macomb and St. Clair Counties, Michigan
Director of Anatomic Pathology Clinical Assistant Professor of Pathology
Rush Medical College of Rush University Wayne State University School of
Chicago, Illinois Medicine
Detroit, Michigan
Vijaya B. ReDDy, MD, MBa
Professor and Associate Chair MeRyl H. HaBeR, MD
Department of Pathology Borland Professor and Chairman of
Rush Medical College of Rush University Pathology, Emeritus
Chicago, Illinois Rush Medical College of Rush University
Chicago, Illinois
oDile DaViD, MD
Associate Professor and Director of
Cytopathology
University of Illinois at Chicago
Chicago, Illinois
1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
DIFFERENTIAL DIAGNOSIS IN SURGICAL PATHOLOGY, THIRD EDITION ISBN: 978-1-4557-7013-7
Copyright © 2015, 2010, 2002 by Saunders, an imprint of Elsevier Inc.
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Library of Congress Cataloging-in-Publication Data
Differential diagnosis in surgical pathology. – Third edition / [edited by] Paolo Gattuso, Vijaya B. Reddy, Odile David,
Daniel J. Spitz, Meryl H. Haber.
p.; cm.
Includes bibliographical references and index.
ISBN 978-1-4557-7013-7 (hardcover : alk. paper)
I. Gattuso, Paolo, editor of compilation. II. Reddy, Vijaya B., editor of compilation. III. David, Odile, editor of
compilation. IV. Spitz, Daniel J., editor of compilation. V. Haber, Meryl H., 1934- editor of compilation.
[DNLM: 1. Neoplasms–pathology. 2. Neoplasms–surgery. 3. Diagnosis, Differential. 4. Pathology, Surgical.
QZ 268]
RD57
617ʹ.075–dc23
2013046614
Content Strategist: William Schmitt
Content Development Specialist: Janice M. Gaillard
Publishing Services Manager: Anne Altepeter
Project Manager: Ted Rodgers
Designer: Ellen Zanolle
Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
To my wife, Nancy, and my children Vincent and Francesca
PAOLO GATTUSO
To my son Vikram, for the nineteen years of life, love, and memories
VIJAYA B. REDDY
For my family, to whom I owe my appreciation of life and learning
ODILE DAVID
To my parents, for setting me on the right track, and to my wife, Jodi, for her continuous
support and encouragement
DANIEL J. SPITZ
To all of my former students, residents, fellows, and physician associates
from whom I have always learned more than I have been able to teach
MERYL H. HABER
Contributors
SYLVIA L. ASA, MD, PhD ADEL K. EL-NAGGAR, MD, PhD
Pathologist-in-Chief Professor of Pathology and Head and Neck Surgery
Laboratory Medicine Program Program Director, Head and Neck Pathology Fellowship
University Health Network The University of Texas MD Anderson Cancer Center
Professor Houston, Texas
Department of Laboratory Medicine and Pathobiology
University of Toronto MARK F. EVANS, PhD
Toronto, Ontario, Canada Research Assistant Professor
Department of Pathology
LAURA BARISONI, MD University of Vermont College of Medicine
Professor of Pathology Burlington, Vermont
University of Miami Miller School of Medicine
Miami, Florida SANDRA E. FISCHER, MD
Consultant Pathologist
PINCAS BITTERMAN, MD Laboratory Medicine Program
Professor of Pathology University Health Network
Rush University Medical Center Assistant Professor
Chicago, Illinois University of Toronto
Toronto, Ontario, Canada
ELIZABETH J. COCHRAN, MD
Professor of Pathology JULIA TURBINER GEYER, MD
Medical College of Wisconsin Assistant Professor of Pathology and Laboratory
Milwaukee, Wisconsin Medicine
Weill Cornell Medical College
KUMARASEN COOPER, MBChB, FRCPath, DPhil New York, New York
Professor of Pathology and Laboratory Medicine
Director of Anatomic Pathology RICHARD J. GROSTERN, MD
Department of Pathology and Laboratory Medicine Assistant Professor of Pathology and Ophthalmology
Perelman School of Medicine at the University of Rush University Medical Center
Pennsylvania Chicago, Illinois
Philadelphia, Pennsylvania
RALPH H. HRUBAN, MD
BYRON E. CRAWFORD, MD Professor of Pathology
Professor of Pathology Johns Hopkins Hospital
Director of Anatomic Pathology Baltimore, Maryland
Tulane University School of Medicine
New Orleans, Louisiana ALIYA N. HUSAIN, MD
Professor of Pathology
MICHAEL CRUISE, MD, PhD University of Chicago
Assistant Professor of Pathology Chicago, Illinois
Johns Hopkins Hospital
Baltimore, Maryland ALEXANDRA N. KALOF, MD
Associate Professor of Pathology
KOSSIVI DANTEY, MD University of Vermont College of Medicine
Clinical Instructor of Pathology Attending Physician, Department of Pathology
University of Vermont College of Medicine and Fletcher Fletcher Allen Health Care
Allen Health Care Burlington, Vermont
Burlington, Vermont
vi
Contributors vii
ROBIN D. LEGALLO, MD VIJAYA B. REDDY, MD, MBA
Assistant Professor of Pathology Professor and Associate Chair
University of Virginia School of Medicine Department of Pathology
Charlottesville, Virginia Rush Medical College of Rush University
Chicago, Illinois
CRISTINA MAGI-GALLUZZI, MD, PhD
Professor of Pathology E RENE RODRIGUEZ, MD
Lerner College of Medicine of Case Western Section of Cardiovascular Pathology
Reserve University Department of Anatomic Pathology
Director of Genitourinary Pathology The Cleveland Clinic
The Cleveland Clinic Cleveland, Ohio
Cleveland, Ohio
JOHN J. SCHMIEG, MD, PhD
MARIA J. MERINO-NEUMANN, MD Assistant Professor of Pathology
Chief of Translational Surgical Pathology Department of Pathology and Laboratory Medicine
National Institutes of Health Tulane University School of Medicine
National Cancer Institute New Orleans, Louisiana
Bethesda, Maryland
SAUL SUSTER, MD
CESAR A. MORAN, MD Chairman and Professor
Professor and Deputy Chair Department of Pathology and Laboratory Medicine
Department of Pathology Medical College of Wisconsin
The University of Texas MD Anderson Cancer Center Milwaukee, Wisconsin
Houston, Texas
PAUL E. SWANSON, MD
ATTILIO ORAZI, MD Professor of Pathology
Director of Hematopathology Division University of Washington School of Medicine
Department of Pathology and Laboratory Medicine Seattle, Washington
Weill Cornell Medical College
New York, New York CARMELA D. TAN, MD
Section of Cardiovascular Pathology
HREEM N. PATEL, MD Department of Anatomic Pathology
Resident Physician The Cleveland Clinic
Ophthalmology Cleveland, Ohio
Rush University Medical Center
Chicago, Illinois MARK R. WICK, MD
Associate Director of Surgical Pathology
ROBERT E. PETRAS, MD University of Virginia Health System
Associate Clinical Professor of Pathology Charlottesville, Virginia
Northeastern Ohio Medical University
Rootstown, Ohio MICHELLE D. WILLIAMS, MD
AmeriPath Institute of Gastrointestinal Pathology and Associate Professor of Pathology
Digestive Disease Director, Surgical Pathology Fellowship Program, Head
Oakwood Village, Ohio and Neck Section
The University of Texas MD Anderson Cancer Center
MICHAEL R. PINS, MD Houston, Texas
Chairman and Professor
Department of Pathology MATTHEW M. YEH, MD, PhD
Chicago Medical School of Rosalind Franklin University Associate Professor
of Medicine and Science Director of Gastrointestinal and Hepatic Pathology
Chairman, Department of Pathology University of Washington School of Medicine
Advocate Lutheran General Hospital Seattle, Washington
Park Ridge, Illinois
MING ZHOU, MD, PhD
SONAM PRAKASH, MD Professor of Pathology and Urology
Health Sciences Associate Clinical Professor Director of Surgical Pathology and Urological Pathology
UCSF School of Medicine NYU Medical Center Tisch Hospital
University of California, San Francisco New York, New York
San Francisco, California
Preface
I find it hard to believe that more than a decade has passed Dr. Vijaya Reddy spearheaded the writing and produc-
since the initial concept of writing a “new” textbook of tion of the third edition. In this edition, new authors have
pathology was proposed by a few residents and an attend- been added; some former authors no longer appear. New
ing pathologist in the Department of Pathology at Rush photographs and photomicrographs facilitate the text, and
Medical College. The concept was for a different type of references for each section have been updated. Biomarkers,
pathology textbook—simple in design, not encyclopedic, which are assuming an evermore significant importance
and one that would be useful for students, residents, and in pathologic diagnosis, have taken a prominent place in
pathologists. To achieve these ends, the text would have sections of the text. Medical diseases of the kidney have
to be limited, with a relatively simple format—a succinct been added. But, as in previous editions, the book is or-
outline-type style with a focus on more frequently seen ganized by systems, and within each disease category spe-
conditions. Additionally, to be really useful, hundreds cific entities are discussed using an outline approach that
of photographs and photomicrographs inserted in par- begins with clinical features and then goes on to explore
allel along with text descriptions would be required. To the pathologic hallmarks, criteria for diagnosis, including
achieve these ends, considerable time, effort, and exper- pertinent laboratory findings, and differential diagnosis.
tise would be demanded. After three years of develop- Selected references are appended. The photographs con-
ment and the finding of a publisher, the first edition of tinue to be reproduced in the highest quality of color. We
Differential Diagnosis in Surgical Pathology was published believe that this is the best and most complete edition of
in 2002. Its success immediately became evident. Now, this textbook yet, but, more important, it continues to
some 14 years after the original concept for this textbook achieve our most important goal—to be a useful diagnos-
was approved, Differential Diagnosis in Surgical Pathology tic aid for practicing pathologists and a valuable teaching
has been translated into other languages and is widely adjunct for resident pathologists and students of medicine
accepted as a useful addition to the pathologist’s library— and the health sciences.
both for teaching pathology to students and residents,
and for assisting in the diagnosis of a variety of pathologic
Meryl H. Haber, MD
conditions.
March 26, 2014
viii
Acknowledgments
We thank all our contributors for their expertise, knowledge, and encouragement in the production of a third edition.
and invaluable role in the continued success of this book. A special thanks to Janice M. Gaillard, senior content
The editors also gratefully acknowledge the work of au- development specialist at Elsevier, for her patience and
thors who have contributed to this book in its previous competence in keeping the book on course over the past
editions. year, and to Ted Rodgers, production editor at Elsevier,
We thank Irma Parker and Mira Davis for their secre- for overseeing the final stages of the publication process.
tarial assistance. We are thankful to our publisher, Elsevier,
and William R. Schmitt, executive editor, for his support Vijaya B. Reddy, MD
ix