Differential Diagnoses in Surgical Pathology: Genitourinary System PDF
Preview Differential Diagnoses in Surgical Pathology: Genitourinary System
Epstein_FM.indd 1 12/13/2013 5:59:37 PM Differential Diagnoses in Surgical Pathology: Genitourinary System Epstein_FM.indd 1 12/13/2013 5:59:37 PM Differential DiaGnoSeS in SurGical PatholoGy SerieS Series Editor: Jonathan I. Epstein Differential Diagnoses in Surgical Pathology: Genitourinary System Jonathan I. Epstein and George J. Netto, 2014 Differential Diagnoses in Surgical Pathology: Gastrointestinal System Elizabeth Montgomery and Whitney Green, 2014 Epstein_FM.indd 2 12/13/2013 5:59:37 PM Differential Diagnoses in Surgical Pathology: Genitourinary System Jonathan i. epstein, MD Professor of Pathology, Urology and Oncology The Reinhard Professor of Urological Pathology Director of Surgical Pathology The Johns Hopkins Medical Institutions Baltimore, Maryland George J. netto, MD Professor of Pathology, Urology and Oncology Director of Surgical Pathology Molecular Diagnostics Johns Hopkins University Baltimore, Maryland SerieS eDitor Jonathan i. epstein, MD Professor of Pathology, Urology and Oncology The Reinhard Professor of Urological Pathology Director of Surgical Pathology The Johns Hopkins Medical Institutions Baltimore, Maryland Epstein_FM.indd 3 12/13/2013 5:59:44 PM Acquisitions Editor : Ryan Shaw Product Development Editor : Kate Marshall Production Project Manager: David Saltzberg Senior Manufacturing Coordinator : Beth Welsh Designer : Stephen Druding Production Service : SPi Global Copyright © 2014 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business Two Commerce Square 2001 Market Street Philadelphia, PA 19103 USA LWW.com All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above- mentioned copyright. Printed in China library of congress cataloging-in-Publication Data Epstein, Jonathan I., author. Differential diagnoses in surgical pathology: genitourinary system / Jonathan I. Epstein, George J. Netto. p. ; cm. Includes bibliographical references and index. ISBN 978-1-4511-8958-2 (hardback : alk. paper) I. Netto, George J., author. II. Title. [DNLM: 1. Male Urogenital Diseases—diagnosis. 2. Diagnosis, Differential. 3. Male Urogenital Diseases—surgery. 4. Pathology, Surgical—methods. 5. Urologic Diseases—diagnosis. 6. Urologic Diseases—surgery. WJ 141] RC900.9 616.6'075—dc23 2013041073 Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, com- pleteness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. 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Lippincott Williams & Wilkins customer service repre- sentatives are available from 8:30 am to 6 pm, EST. 10 9 8 7 6 5 4 3 2 1 Epstein_FM.indd 4 12/13/2013 5:59:44 PM Preface How often in surgical pathology, when confronted with a dif- This book hopes to fill this niche in urologic pathology. By ficult case, do we arrive at a differential diagnosis between arranging the book according to differential diagnoses, the two or three entities? After turning to one of the many excel- text and illustrations have been specifically tailored to help- lent general surgical pathology books or specialty texts, we ing the pathologist differentiate between entities that are read about each entity and still are unsure of the diagnosis. commonly confused with each other. In addition to illustrat- In part, this situation arises from these books' all encompass- ing and discussing the “classical” features of these entities, ing nature. By having to include both the very common “clas- atypical features, which can “sandbag” the pathologist have sic” lesions which pose no diagnostic difficulty, as well as been stressed. rare entities which are unlikely to be seen by most patholo- It is hoped that this book will supplement existing general gists, these books devote less text and photographs to spe- and subspecialty books, and provide diagnostic aid for patholo- cific differential diagnoses. Also, because these books are gists who must contend with an ever increasing number of uro- arranged in a standard format where each entity is discussed logic pathology specimens. and illustrated in its own section, the text and photographs are not directed toward differentiating between entities. v Epstein_FM.indd 5 12/13/2013 5:59:44 PM Epstein_FM.indd 6 12/13/2013 5:59:44 PM acknowleDGMentS Dr. epstein’s acknowledgment who provide a local’s view of their country. How else would I With great affection, I dedicate this book to my former and have been able to see a Sumo match in Japan, visit an Eastern current Genitourinary Pathology Fellows spanning the last 21 Medicine Pharmacy in China, or attend the Camel Market in years. It is a life cycle event when each academic year brings Saudi Arabia? a new group of enthusiastic pathologists eager to tackle It also gives me great pleasure to see my former fellows our challenging consult service and participate in multiple thrive in their subsequent practice. Many of the fellows have research projects. Without the fellows, I would not be able risen over the years to leadership positions in academics, private to handle the heavy consult load nor would I be able to be practice, or laboratories. However, what unifies them is that they as productive academically. Although initially, they often dread all provide the best and most up-to-date knowledge of Urological the “unknowns” portion of my teaching sessions, they soon Pathology in helping patients, which ultimately is what is most appreciate its value. Knowledge of which lesions cause the important. Our GU fellows and faculty are truly a big family fellows difficulty is a major source of the differential diagnoses that gathers together every year for a lively dinner at USCAP. that comprises this book. Everyone gets to know the new fellows and has fun catching up But it is not just about the Pathology! The fellows have been with former ones. My fellows are not just my mentees but are a fantastic group of very diverse individuals from the United friends who I feel incredibly fortunate to have had the opportu- States and over 10 countries. They bring their unique personal- nity to know and keep up with over the ensuing years. Not only ities to each daily sign-out making the review of approximately do all the fellows and I share a common strong bond but we also 50 cases an experience that I look forward to each day. Each have our own unique language. “Backslash flyaway time.” year, one of the four fellows is sponsored from an institution from another country. Having these fellows from around the Dr. netto’s acknowledgment world has expanded all of our cultural horizons. I thoroughly I would like to acknowledge the great efforts contributed by enjoy subsequently lecturing at their institutions and seeing his two Urologic Pathology Fellows, Dr. Sheila Friedrich Faraj how they have become leaders in Genitourinary (GU) Pathology and Dr. Enrico Munari in obtaining some of the photomicro- in their country. As a bonus, I am hosted by my former fellows graphs and references. vii Epstein_FM.indd 7 12/13/2013 5:59:44 PM Epstein_FM.indd 8 12/13/2013 5:59:44 PM contentS Preface v Acknowledgments vii chapter 1 ProState 1 chapter 2 kiDney 177 chapter 3 BlaDDer 263 chapter 4 teStiS 387 chapter 5 PeniS/ScrotuM 493 Index 521 ix Epstein_FM.indd 9 12/13/2013 5:59:45 PM
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