Differential Diagnoses in Surgical Pathology: Breast PDF
Preview Differential Diagnoses in Surgical Pathology: Breast
mebooksfree.com mebooksfree.com Differential Diagnoses in Surgical Pathology: Breast mebooksfree.com mebooksfree.com Differential Diagnoses in Surgical Pathology: Breast Jean F. Simpson, MD President Breast Pathology Consultants, Inc. Nashville, Tennessee Adjunct Professor of Pathology University of South Alabama Mobile, Alabama Melinda E. Sanders, MD Professor of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center Nashville, Tennessee SERIES EDITOR Jonathan I. Epstein, MD Professor of Pathology, Urology and Oncology The Reinhard Professor of Urological Pathology Director of Surgical Pathology The Johns Hopkins Medical Institutions Baltimore, Maryland mebooksfree.com Acquisitions Editor: Ryan Shaw Product Development Editor: Kate Heaney Production Project Manager: Alicia Jackson Manufacturing Coordinator: Beth Welsh Marketing Manager: Dan Dressler Design Coordinator: Teresa Mallon Production Service: S4Carlisle Publishing Services Copyright © 2017 Wolters Kluwer All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at [email protected], or via our website at lww.com (products and services). 9 8 7 6 5 4 3 2 1 Printed in China Library of Congress Cataloging-in-Publication Data Names: Simpson, Jean F., author. | Sanders, Melinda E., author. Title: Breast/Jean F. Simpson, Melinda E. Sanders. Other titles: Differential diagnoses in surgical pathology series. Description: Philadelphia: Wolters Kluwer Health, [2017] | Series: Differential diagnoses in surgical pathology | Includes bibliographical references and index. Identifiers: LCCN 2016038688 | eISBN 9781496375391 Subjects: | MESH: Breast Neoplasms—diagnosis | Breast Neoplasms—pathology | Diagnosis, Differential | Pathology, Surgical--methods Classification: LCC RC280.B8 | NLM WP 870 | DDC 616.99/449—dc23 LC record available at https://lccn.loc.gov/2016038688 This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. This work is no substitute for individual patient assessment based upon healthcare professionals’ examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments. Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturer’s package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any mebooksfree.com injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work. LWW.com mebooksfree.com DEDICATION In memory of Lowell W. Rogers and J. Allan Tucker, gentle giants who inspired others. mebooksfree.com PREFACE Histopathology remains the cornerstone of the diagnosis and treatment of breast disease. There have been advances in breast imaging techniques, molecular analysis, and immunotherapy of breast cancer, yet the fundamental decisions regarding the need for additional surgery, chemoprevention, radiation, and/or chemotherapy are based on morphologic features. Histopathology is far from a static or “out of date” discipline. Indeed, specific histologic criteria have been defined that allow for reproducibility in diagnosis; linking these criteria to outcome data for thousands of women through long-term follow-up studies has defined the epidemiology of benign breast disease and helps identify women who may benefit from chemoprevention strategies. These studies also provide concrete evidence that merely undergoing a breast biopsy does not increase risk for later cancer development, a welcome relief for thousands of women. The widespread use of core needle biopsy has had a major impact on the practice of breast pathology, and many of the images shown in this book are from core needle biopsy specimens. Our approach to the diagnosis of core biopsy specimens is similar to a frozen section, that is, what should the next step be, specifically, should the lesion be formally excised? We are grateful for the opportunity to have learned breast pathology from Dr. David Page, whose adherence to reproducible criteria and interpretation within the clinical context guide us daily. We also are grateful to pathologists who have trusted us with their difficult cases in consultation. The vast majority of such cases come with a differential diagnosis of one or two entities, underscoring the importance of a textbook that compares and contrasts differential diagnostic partners. Jean F. Simpson Melinda E. Sanders mebooksfree.com CONTENTS Preface Chapter 1 NONPROLIFERATIVE ALTERATIONS OF ACINI Chapter 2 EPITHELIAL PROLIFERATIVE LESIONS, USUAL AND ATYPICAL DUCTAL HYPERPLASIA Chapter 3 LOBULAR NEOPLASIA AND ITS DISTINCTION FROM OTHER EPITHELIAL PROLIFERATIVE LESIONS Chapter 4 DUCTAL CARCINOMA IN SITU Chapter 5 PAPILLARY AND SCLEROSING LESIONS Chapter 6 INVASIVE CARCINOMA: SPECIAL TYPES AND IMPORTANT CONSIDERATIONS Chapter 7 FIBROEPITHELIAL LESIONS Chapter 8 BENIGN AND REACTIVE STROMAL LESIONS Chapter 9 SENTINEL LYMPH NODES Chapter 10 VASCULAR LESIONS Chapter 11 MALE BREAST Index mebooksfree.com 1 Nonproliferative Alterations of Acini 1.1 Columnar cell lesion without atypia vs. Cystically dilated lobular unit 1.2 Columnar cell lesion without atypia vs. Columnar cell lesion with atypia 1.3 Apocrine change vs. Columnar cell lesion with atypia 1.4 Secretory change vs. Columnar cell lesion with atypia 1.5 Cystically dilated lobular unit vs. Duct ectasia 1.6 Mucocele-like lesion vs. Disrupted cyst
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