Diagnostic Issues in Dementia: Advancing the Research Agenda for DSM-V

166 Pages·2007·1.07 MB·English

by  Trey Sunderland

Diagnostic Issues in
Dementia
Advancing the Research Agenda
for DSM-V
This page intentionally left blank
Diagnostic Issues in
Dementia
Advancing the Research Agenda
for DSM-V
Edited by
Trey Sunderland, M.D.
Dilip V. Jeste, M.D.
Olusegun Baiyewu, M.D.
Paul J. Sirovatka, M.S.
Darrel A. Regier, M.D., M.P.H.
Published by the
American Psychiatric Association
Arlington, Virginia
Note: The authors have worked to ensure that all information in this book is ac-
curate at the time of publication and consistent with general psychiatric and med-
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routes of administration is accurate at the time of publication and consistent with
standards set by the U.S. Food and Drug Administration and the general medical
community. As medical research and practice continue to advance, however, ther-
apeutic standards may change. Moreover, specific situations may require a specific
therapeutic response not included in this book. For these reasons and because hu-
man and mechanical errors sometimes occur, we recommend that readers follow
the advice of physicians directly involved in their care or the care of a member of
their family.
The findings, opinions, and conclusions of this report do not necessarily represent
the views of the officers, trustees, or all members of the American Psychiatric As-
sociation. The views expressed are those of the authors of the individual chapters.
Copyright © 2007 American Psychiatric Association
ALL RIGHTS RESERVED
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Library of Congress Cataloging-in-Publication Data
Diagnostic issues in dementia : advancing the research agenda for DSM-V / edited
by Trey Sunderland ... [et al.]. — 1st ed.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-0-89042-298-4 (pbk. : alk. paper)
1. Dementia. 2. Dementia—Research. 3. Mental illness—Treatment.
I. Sunderland, Trey. II. American Psychiatric Association. [DNLM:
1. Diagnostic and statistical manual of mental disorders. 5th ed.
2. Dementia—diagnosis. WM 220 D5355 2007]
RC521.D5387 2007
616.8′30072—dc22
2007004393
British Library Cataloguing in Publication Data
A CIP record is available from the British Library.
CONTENTS
CONTRIBUTORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
DISCLOSURE STATEMENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xi
FOREWORD. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv
Darrel A. Regier, M.D., M.P.H.
PREFACE: Modern Diagnostic Approaches in Dementia:
On the Cusp of Change. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xix
Trey Sunderland, M.D.
1
ALZHEIMER’S DISEASE AND THE AGING BRAIN. . . . . . . . . . . . . . . . . .1
Robert D. Terry, M.D.
2
DEMENTIA: Epidemiological Considerations, Nomenclature,
and a Tacit Consensus Definition . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9
John C.S. Breitner, M.D., M.P.H.
3
DIAGNOSTIC CRITERIA INDEMENTIA: A Comparison of
Current Criteria, Research Challenges, and Implications for
DSM-V and ICD-11 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .27
Barry Reisberg, M.D.
Norman Sartorius, M.D., Ph.D.
4
MILD COGNITIVE IMPAIRMENT SHOULD BE CONSIDERED
FOR DSM-V. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .51
Ronald C. Petersen, Ph.D., M.D.
John O’Brien, D.M., F.R.C.Psych.
5
NEUROPSYCHOLOGICAL TESTING IN THE DIAGNOSIS OF DEMENTIA. . . 67
Mary Sano, Ph.D.
6
DIAGNOSTIC CATEGORIES AND CRITERIA FOR NEUROPSYCHIATRIC
SYNDROMES IN DEMENTIA: Research Agenda forDSM-V. . . . . . . . .77
Dilip V. Jeste, M.D.
Thomas W. Meeks, M.D.
Daniel S. Kim, M.D.
George S. Zubenko, M.D., Ph.D.
7
BIOMARKERS IN THE DIAGNOSIS OF ALZHEIMER’S DISEASE:
Are We Ready?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Trey Sunderland, M.D.
Harald Hampel, M.D.
Masatoshi Takeda, M.D., Ph.D.
Karen T. Putnam, M.S.
Robert M. Cohen, M.D., Ph.D.
8
NEUROIMAGING AS A SURROGATE MARKER OF DISEASE . . . . . . . 117
Gary W. Small, M.D.
9
GENETICS AND DEMENTIA NOSOLOGY . . . . . . . . . . . . . . . . . . . . . 127
Deborah Blacker, M.D., Sc.D.
Simon Lovestone, Ph.D., M.R.C.Psych.
INDEX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
CONTRIBUTORS
Olusegun Baiyewu, M.D.
Professor of Psychiatry, Department of Psychiatry, College of Medicine, University
of Ibadan, Ibadan, Nigeria
Deborah Blacker, M.D., Sc.D.
Director, Gerontology Research Unit, Assistant Vice Chair for Research, Depart-
ment of Psychiatry, Mass General Hospital/Harvard Medical School; Department
of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
John C.S. Breitner, M.D., M.P.H.
Director, Geriatric Research Education and Clinical Center, VA Puget Sound
Health Care System; Division of Geriatric Psychiatry, University of Washington
School of Medicine, Seattle, Washington
Robert M. Cohen, M.D., Ph.D.
Department of Psychiatry, Cedars-Sinai Medical Center, Los Angeles, California
Harald Hampel, M.D.
Professor of Psychiatry and Director, Alzheimer Memorial Center, Department of
Psychiatry, University of Munich, Munich, Germany
Dilip V. Jeste, M.D.
Estelle and Edgar Levi Chair in Aging; Director, Sam and Rose Stein Institute for
Research on Aging; Distinguished Professor of Psychiatry and Neurosciences, Uni-
versity of California, San Diego
Daniel S. Kim, M.D.
Geriatric Psychiatry Postdoctoral Fellow, Division of Geriatric Psychiatry, Depart-
ment of Psychiatry, University of California, San Diego
Simon Lovestone, Ph.D., M.R.C.Psych.
Professor of Old Age Psychiatry, MRC Centre for Neurodegeneration Research,
Institute of Psychiatry, Kings College London, London, UK
vii
viii Diagnostic Issues in Dementia: Advancing the Research Agenda for DSM-V
Thomas W. Meeks, M.D.
Postdoctoral Fellow, Division of Geriatric Psychiatry, Department of Psychiatry,
University of California, San Diego
John O’Brien, D.M., M.R.C.Psych.
Wolfson Research Centre, Institute for Ageing and Health, Newcastle General
Hospital, Newcastle upon Tyne, UK
Ronald C. Petersen, Ph.D., M.D.
Mayo Clinic College of Medicine, Rochester, Minnesota
Karen T. Putnam, M.S.
Litwin-Zucker Research Center, North Shore–LIJ Health System, Great Neck,
New York
Darrel A. Regier, M.D., M.P.H.
Executive Director, American Psychiatric Institute for Research and Education
(APIRE), American Psychiatric Association, Arlington, Virginia
Barry Reisberg, M.D.
Professor, Department of Psychiatry and Clinical Director, Silberstein Aging and
Dementia Research Center, New York University School of Medicine, New York,
New York
Mary Sano, Ph.D.
Alzheimer Disease Research Center of Mount Sinai School of Medicine, New
York, New York; James J. Peters VAMC, Bronx, New York
Norman Sartorius, M.D., Ph.D.
Adjunct Professor of Psychiatry, Washington University, St. Louis, Missouri; Vis-
iting Professor, University of London, Prague, Beijing, and Zagreb
Paul J. Sirovatka, M.S.
Associate Director for Research Policy Analysis, Division of Research/American
Psychiatric Institute for Research and Education (APIRE), Arlington, Virginia
Gary W. Small, M.D.
Parlow-Solomon Professor on Aging; Professor of Psychiatry & Biobehavioral Sci-
ences; Director, UCLA Center on Aging; Director, Memory & Aging Research
Center, University of California, Los Angeles, California
Contributors ix
Trey Sunderland, M.D.
National Institute of Mental Health, Bethesda, Maryland
Masatoshi Takeda, M.D., Ph.D.
Chairman and Professor, Department of Clinical Neuroscience, Osaka University
Graduate School of Medicine, Osaka, Japan
Robert D. Terry, M.D.
Professor Emeritus, Department of Neurosciences, University of California, San
Diego, California
George S. Zubenko, M.D., Ph.D.
Professor, Department of Psychiatry, University of Pittsburgh, Pittsburgh, Penn-
sylvania