Diagnosis and Treatment of Parkinson's Disease

273 Pages·2011·5.872 MB·English

by  A. Rana

DIAGNOSIS AND
TREATMENT OF
PARKINSON’S DISEASE

Edited by Abdul Qayyum Rana
Diagnosis and Treatment of Parkinson’s Disease
Edited by Abdul Qayyum Rana

Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia

Copyright © 2011 InTech
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Technical Editor Teodora Smiljanic
Cover Designer Jan Hyrat
Image Copyright Supri Suharjoto, 2011. Used under license from Shutterstock.com

First published September, 2011
Printed in Croatia

A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]

Diagnosis and Treatment of Parkinson’s Disease, Edited by Abdul Qayyum Rana
p. cm.
ISBN 978-953-307-465-8
free online editions of InTech
Books and Journals can be found at
www.intechopen.com

Contents

Preface IX
Chapter 1 Diagnosis and Differential Diagnosis
of Parkinson’s Disease 1
Paul Lingor, Jan Liman, Kai Kallenberg,
Carsten-Oliver Sahlmann and Mathias Bähr
Chapter 2 Impact of Dopamine Transporter Scan
in Parkinson´s Disease 21
Jörg Spiegel
Chapter 3 CFS Biomarkers in Parkinson’s Disease 29
Lucilla Parnetti, Anna Castrioto, Claudia De Carlo,
Davide Chiasserini, Nicola Tambasco, Aroldo Rossi,
Chiara Balducci, Tommaso Beccari and Paolo Calabresi
Chapter 4 Neuropsychological Functions
and SPECT Neuroimaging in Parkinson’s Disease 49
Lambros Messinis, Athanasios Papathanasiou, Epameinondas Lyros,
George Gatzounis and Panagiotis Papathanasopoulos
Chapter 5 Imaging Dyskinesias in Parkinson’s Disease 69
Marios Politis and Clare Loane
Chapter 6 Combinations of Markers Provide Clues
to the Underlying Neurodegenerative Disorder
in REM Sleep Behavior Disorder 89
Tomoyuki Miyamoto and Masayuki Miyamoto
Chapter 7 Advances in Drug Therapy:
Alternative Treatments for the Control
of Motor Fluctuations and Dyskinesias 105
José Matías Arbelo González and Rocío Malo de Molina Zamora
Chapter 8 The Role of Feedback in Decision Making 117
Magda Osman
VI Contents

Chapter 9 Balance and Gait Rehabilitation
in Patients with Parkinson’s Disease 141
Nicola Smania, Alessandro Picelli, Christian Geroin, Patrizia Ianes,
Elisabetta La Marchina, Andrea Zenorini and Marialuisa Gandolfi
Chapter 10 How to Stay Active with Parkinson’s Disease 183
Abu Qutubuddin
Chapter 11 Invasive and Non-Invasive Stimulation
in Parkinson’s Disease 189
Caspar Stephani
Chapter 12 Mechanisms of High Frequency Stimulation
of the Subthalamic Nucleus in Parkinson's Disease: From
Local to Distal Effects on the Basal Ganglia Network 211
Marc Savasta, Carole Carcenac and Sabrina Boulet
Chapter 13 Thalamic Deep Brain Stimulation
for Parkinson’s Disease 233
Ryoma Morigaki, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto
Chapter 14 Post-Operative Management of Parkinson Patients
with Deep Brain Stimulation 253
Niels Allert and Volker Arnd Coenen

Preface

Diagnosis of Parkinson’s disease at times could be challenging even for the expert
clinicians. Currently there are no laboratory investigations available for the definite
diagnosis of this complicated condition; however some progress is being made to
develop tools which may aid in the diagnosis of Parkinson’s disease. A summary of
current knowledge about biomarkers and various imaging techniques which may be
helpful in diagnosis of Parkinson’s disease is given in various chapters of this book. A
discussion about the differential diagnosis of Parkinson’s disease has been generated.
As Parkinson’s disease advances, both motor and non-motor symptoms also progress,
the management of which becomes challenging for the treating physician. This book
provides an up to date account of all available treatments of Parkinson’s disease.
Various modes of treatment such as pharmacotherapy, physical therapy have
discussed in detail in addition to the latest developments on the surgical treatments of
Parkinson’s disease. A chapter on postoperative care of patients has also been
included in this text. Not only clinicians dealing with day to day problems caused by
Parkinson’s disease can use this book as a guideline, but other health care workers
may find useful information in this book.
Clinical information presented in this book is considered generally accepted practice;
however the authors, editor, and publisher are not responsible for any errors,
omissions, or consequences from the application of this information. Every effort has
been made to present correct and up to date information in this book but medicine is a
field with ongoing research and development, therefore readers may use other sources
if the content of this book is found to be insufficient.

Dr. Abdul Qayyum Rana
Parkinson's Clinic of Eastern Toronto & Movement Disorders Center
Toronto, Canada