Diagnosis and Prevention of Pneumococcal Community-Acquired Pneumonia PDF
Preview Diagnosis and Prevention of Pneumococcal Community-Acquired Pneumonia
Diagnosis and Prevention of Pneumococcal Community-Acquired Pneumonia Susanne Marleen Huijts Cover design: Liesbeth de Boer Layout & print: Ridderprint, Ridderkerk, the Netherlands ISBN: 978-94-6299-113-2 © 2015 S.M. Huijts, the Netherlands All rights reserved. No part of this publication may be printed or utilised in any form without permission of the copyright holder. Printing of this thesis was financially supported by: Julius Clinical and Pfizer Nederland. Diagnosis and Prevention of Pneumococcal Community-Acquired Pneumonia Diagnose en Preventie van thuis-opgelopen pneumonie (met een samenvatting in het Nederlands) Proefschrift ter verkrijging van de graad van doctor aan de Universiteit Utrecht op gezag van de rector magnificus, prof.dr. G.J. van der Zwaan, ingevolge het besluit van het college voor promoties in het openbaar te verdedigen op dinsdag 23 juni 2015 des middags te 2.30 uur door Susanne Marleen Huijts geboren op 24 november 1981 te Rotterdam Promotor: Prof.dr. M.J.M. Bonten Beoordelingscommissie: Prof.dr. A.I.M. Hoepelman Prof.dr. P. Hermans Prof.dr. J.W.J. Lammers Prof.dr. M.J. Postma Prof.dr.ir. H.A. Smit Paranimfen: Lennie Derde Anneke Hendrix TABLE OF CONTENTS Chapter 1 General introduction 9 PART ONE Diagnosis of Pneumococcal Community-Acquired pneumonia 23 Chapter 2 Validation of an Immunodiagnostic Assay for the Detection of 13 Streptococcus 25 pneumoniae Serotype-Specific Polysaccharides in Human Urine Chapter 3 Diagnostic accuracy of a serotype specific antigen test in community-acquired 51 pneumonia Chapter 4 Predicting Pneumococcal Community-Acquired Pneumonia in the 65 Emergency Department Chapter 5 Guideline adherence for empirical treatment of pneumonia and patient outcome 79 PART TWO Prevention of Pneumococcal Community-Acquired Pneumonia 95 Chapter 6 Rationale and design of CAPITA: a RCT of 13-valent conjugated pneumococcal 97 vaccine efficacy among older adults Chapter 7 Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults 107 Chapter 8 Cost-effectiveness of adult pneumococcal conjugate vaccination in the Netherlands 137 Chapter 9 The effects of comorbidities on the efficacy of 13-valent pneumococcal conjugate 179 vaccine in elderly Chapter 10 The impact of 13-valent pneumococcal conjugate vaccination on 201 virus-associated community-acquired pneumonia in elderly Chapter 11 The impact of 13-valent pneumococcal conjugate vaccination on 215 pneumonia disease severity in elderly Chapter 12 The scrutiny of Community-Acquired Pneumonia identification in population 233 based studies and implications for health care decisions: an example from a pneumococcal vaccination trial PART THREE Summary and discussion 251 Chapter 13 Summary and general discussion 253 Nederlandse samenvatting (Dutch summary) 271 Dankwoord (Acknowlegdements) 283 Curriculum vitae 289 1 Chapter General introduction Based on: New trends in the prevention and management of community-acquired pneumonia D.F. Postma1, C.H. van Werkhoven1, S.M. Huijts1, M. Bolkenbaas1, J.J. Oosterheert2, M.J.M. Bonten1,3 1Julius Centre for Health Sciences, University Medical Centre Utrecht, the Netherlands; 2 Department of Internal Medicine and Infectious Diseases, University Medical Centre Utrecht, the Netherlands; 3 Department of Medical Microbiology, University Medical Centre Utrecht, the Netherlands Neth J Med. 2012 Oct;70(8):337-48.
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