Diabetologia 1999: Vol 42 Table of Contents

11 Pages·1999·3.2 MB·English

I]
Copyright
Submission of a manuscript implies: that the work described has not been published before (except in the form of an abstract); that it is
not under consideration for publication elsewhere; that its publication has been approved by all coauthors, if any, as well as by the re-
sponsible authorities at the institute where the work has been carried out; that, if and when the manuscript is accepted for publication,
the authors agree to automatic transfer of the copyright to the publisher and that the manuscript will not be published elsewhere in any
language without the consent of the copyright holders.
All articles published in this journal are protected by copyright, which covers the exclusive rights to reproduce and distribute the article
(e. g., as offprints), all translation rights as well as the rights to publish the article in any electronic form. No material published in this jour-
nal may be reproduced photographically or stored on microfilm, in electronic data bases, video disks, etc., without first obtaining written
permission from the publisher.
The use of general descriptive names, trade names, trademarks, etc., in this publication, even if not specifically identified, does not imply
that these names are not protected by the relevant laws and regulations.
While the advice and information in this journal is believed to be true and accurate at the date of its going to press, neither the authors, the
editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no war-
ranty, express or implied, with respect to the material contained herein.
Special regulations for photocopies in the USA. Photocopies may be made for personal or in-house use beyond the limitations stipulated
under Section 107 or 108 of U.S. Copyright Law, provided a fee is paid. All fees should be paid to the Copyright Clearance Center, Inc.,
21 Congress Street, Salem, MA 01970, USA, stating the ISSN 0012-186X, the volume, and the first and last page numbers of each article
copied. The copyright owner's consent does not include copying for general distribution, promotion, new works, or resale. In these
cases, specific written permission must first be obtained from the publisher.
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Printed in Germany by aprinta Wemding
© Springer-Verlag Berlin Heidelberg 1999
Springer-Verlag GmbH & Co.KG, D-14197 Berlin, Germany
Contents
Full Instructions to authors Leslie R.D.G., Atkinson M. A., Notkins islets of Langerhans: An immunocyto-
A.L.: Autoantigens [A-2 and GAD in chemical and confocal microscopical
A6 Type I (insulin-dependent) diabetes 13 study 978
Malaisse W.J.: Insulinotropic action of Almind K., Frederiksen S.K., Bernal D.,
monosaccharide esters: therapeutic Hansen T., Ambye L., Urhammmer S.,
Editorials perspectives 286 Ekstrgm C.T., Berglund L., Reneland
McGarry J.D., Dobbins R. L.: Fatty R., Lithell H., White M.F., Van Ob-
Hopper J.L.: Is Type II (non-insulin-de- acids, lipotoxicity and insulin secre- berghen E., Pedersen O.: Search for
pendent) diabetes mellitus not so “ge- tion 128 variants of the gene-promoter and the
netic” after all? 125 Mogensen C. E.: Microalbuminuria, blood potential phosphotyrosine encoding
Waldhausl W.: The world of Diabetologia pressure and diabetic renal disease: ori- sequence of the insulin receptor sub-
in 1999 |] gin and development of ideas 263 strate-2 gene: evaluation of their rela-
Schmetterer L., Wolzt M.: Ocular blood tion with alterations in insulin secre-
flow and associated functional devia- tion and insulin sensitivity 1244
Reviews tions in diabetic retinopathy 387 Andreelli F., Laville M., Ducluzeau P.-H.,
Sima A. A.F., Sugimoto K.: Experimen- Vega N., Vallier P., Khalfallah Y., Riou
Ashcroft F.M., Gribble F.M.: ATP-sensi- tal diabetic neuropathy: an update 773 J.-P., Vidal H.: Defective regulation of
tive K * channels and insulin secretion: Tomlinson D.R.: Mitogen-activated pro- phosphatidylinositol-3-kinase gene ex-
their role in health and disease 903 tein kinases as glucose transducers for pression in skeletal muscle and adipose
Auwerx J.: PPARy, the ultimate thrifty diabetic complications 1271 tissue of non-insulin-dependent dia-
gene 1033 Zimmet P. Z.: Diabetes epidemiology as betes mellitus patients 358
Bolli G.B., Di Marchi R.D., Park G.D., a tool to trigger diabetes research and Balkan B., Kwansnik L., Miserendino R..,
Pramming S., Koivisto V. A.: Insulin care 499 Holst J.J., Li X.: Inhibition of dipepti-
analogues and their potential in the dyl peptidase IV with NVP-DPP728
management of diabetes mellitus 1151 increases plasma GLP-1 (7-36 amide)
Coleman R.A., Herrmann T.S.: Nutri- Articles concentrations and improves oral glu-
tional regulation of leptin in humans cose tolerance in obese Zucker rats
639 Alm P., Ekstrém P., Henningsson R., 1324
Hopfner R.L., Gopalakrishnan V.: En- Lundquist I.: Morphological evidence Barazzoni R., Zanetti M., Tiengo A..,
dothelin: emerging role in diabetic for the existence of nitric oxide and Tessari P.: Protein metabolism in glu-
vascular complications 1383 carbon monoxide pathways in the rat cagonoma (Short communication) 326
I]
Copyright
Submission of a manuscript implies: that the work described has not been published before (except in the form of an abstract); that it is
not under consideration for publication elsewhere; that its publication has been approved by all coauthors, if any, as well as by the re-
sponsible authorities at the institute where the work has been carried out; that, if and when the manuscript is accepted for publication,
the authors agree to automatic transfer of the copyright to the publisher and that the manuscript will not be published elsewhere in any
language without the consent of the copyright holders.
All articles published in this journal are protected by copyright, which covers the exclusive rights to reproduce and distribute the article
(e. g., as offprints), all translation rights as well as the rights to publish the article in any electronic form. No material published in this jour-
nal may be reproduced photographically or stored on microfilm, in electronic data bases, video disks, etc., without first obtaining written
permission from the publisher.
The use of general descriptive names, trade names, trademarks, etc., in this publication, even if not specifically identified, does not imply
that these names are not protected by the relevant laws and regulations.
While the advice and information in this journal is believed to be true and accurate at the date of its going to press, neither the authors, the
editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no war-
ranty, express or implied, with respect to the material contained herein.
Special regulations for photocopies in the USA. Photocopies may be made for personal or in-house use beyond the limitations stipulated
under Section 107 or 108 of U.S. Copyright Law, provided a fee is paid. All fees should be paid to the Copyright Clearance Center, Inc.,
21 Congress Street, Salem, MA 01970, USA, stating the ISSN 0012-186X, the volume, and the first and last page numbers of each article
copied. The copyright owner's consent does not include copying for general distribution, promotion, new works, or resale. In these
cases, specific written permission must first be obtained from the publisher.
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Printed in Germany by aprinta Wemding
© Springer-Verlag Berlin Heidelberg 1999
Springer-Verlag GmbH & Co.KG, D-14197 Berlin, Germany
Contents
Full Instructions to authors Leslie R.D.G., Atkinson M. A., Notkins islets of Langerhans: An immunocyto-
A.L.: Autoantigens [A-2 and GAD in chemical and confocal microscopical
A6 Type I (insulin-dependent) diabetes 13 study 978
Malaisse W.J.: Insulinotropic action of Almind K., Frederiksen S.K., Bernal D.,
monosaccharide esters: therapeutic Hansen T., Ambye L., Urhammmer S.,
Editorials perspectives 286 Ekstrgm C.T., Berglund L., Reneland
McGarry J.D., Dobbins R. L.: Fatty R., Lithell H., White M.F., Van Ob-
Hopper J.L.: Is Type II (non-insulin-de- acids, lipotoxicity and insulin secre- berghen E., Pedersen O.: Search for
pendent) diabetes mellitus not so “ge- tion 128 variants of the gene-promoter and the
netic” after all? 125 Mogensen C. E.: Microalbuminuria, blood potential phosphotyrosine encoding
Waldhausl W.: The world of Diabetologia pressure and diabetic renal disease: ori- sequence of the insulin receptor sub-
in 1999 |] gin and development of ideas 263 strate-2 gene: evaluation of their rela-
Schmetterer L., Wolzt M.: Ocular blood tion with alterations in insulin secre-
flow and associated functional devia- tion and insulin sensitivity 1244
Reviews tions in diabetic retinopathy 387 Andreelli F., Laville M., Ducluzeau P.-H.,
Sima A. A.F., Sugimoto K.: Experimen- Vega N., Vallier P., Khalfallah Y., Riou
Ashcroft F.M., Gribble F.M.: ATP-sensi- tal diabetic neuropathy: an update 773 J.-P., Vidal H.: Defective regulation of
tive K * channels and insulin secretion: Tomlinson D.R.: Mitogen-activated pro- phosphatidylinositol-3-kinase gene ex-
their role in health and disease 903 tein kinases as glucose transducers for pression in skeletal muscle and adipose
Auwerx J.: PPARy, the ultimate thrifty diabetic complications 1271 tissue of non-insulin-dependent dia-
gene 1033 Zimmet P. Z.: Diabetes epidemiology as betes mellitus patients 358
Bolli G.B., Di Marchi R.D., Park G.D., a tool to trigger diabetes research and Balkan B., Kwansnik L., Miserendino R..,
Pramming S., Koivisto V. A.: Insulin care 499 Holst J.J., Li X.: Inhibition of dipepti-
analogues and their potential in the dyl peptidase IV with NVP-DPP728
management of diabetes mellitus 1151 increases plasma GLP-1 (7-36 amide)
Coleman R.A., Herrmann T.S.: Nutri- Articles concentrations and improves oral glu-
tional regulation of leptin in humans cose tolerance in obese Zucker rats
639 Alm P., Ekstrém P., Henningsson R., 1324
Hopfner R.L., Gopalakrishnan V.: En- Lundquist I.: Morphological evidence Barazzoni R., Zanetti M., Tiengo A..,
dothelin: emerging role in diabetic for the existence of nitric oxide and Tessari P.: Protein metabolism in glu-
vascular complications 1383 carbon monoxide pathways in the rat cagonoma (Short communication) 326
Boni-Schnetzler M., Hauri C., Zapf J.: Chen M.-C., Schuit F., Eizirik D.L.: In- Dupont S., Vionnet N., Chévre J.C.,
Leptin is suppressed during infusion of dentification of [L-16-induced mes- Gallina S., Dina C., Seino Y., Yamada
recombinant human insulin-like growth senger RNAs in rat pancreatic beta Y., Froguel P.: No evidence of linkage
factor I (rhIGF I) in normal rats 160 cells by differential display of messen- or diabetes-associated mutations in the
Boomsma F., Meiracker AH van den, ger RNA 1199 transcription factors BETA2/NEU-
Winkel S., Aanstoot H.J., Batstra Cherubini V., Carle F., Gesuita R., Ian- ROD1 and PAX4 in Type II diabetes
M.R., Man in ’t Veld A.J., Bruining nilli A., Tuomilehto J., Prisco F., Iafus- in France (Short communication) 480
G.J.: Circulating semicarbazide-sensi- co D., Altobelli E., Chiarelli F., De Ebeling P., Teppo A.-M., Koistinen
tive amine oxidase is raised both in Giorgi G., Falorni A.: Large incidence H.A., Viikari J., Ronnemaa T., Nissén
Type I (insulin-dependent), in Type II variation of Type I diabetes in central- M., Bergkulla S., Salmela P., Saltevo J.,
(non-insulin-dependent) diabetes mel- southern Italy 1990-1995: lower risk in Veikko, Koivisto A.: Troglitazone re-
litus and even in childhood Type I dia- rural areas (Short communication) duces hyperglycaemia and selectively
betes at first clinical diagnosis 233 789 acute-phase serum proteins in patients
Bosi E., Garancini M. P., Poggiali F., Bo- Chowdhury T.A., Dyer P.H., Mijovic with Type II diabetes 1433
nifacio E., Gallus G.: Low prevalence C.H., Dunger D.B., Barnett A.H., Ek J., Urhammer S. A., Sgrensen T.1.A.,
of islet autoimmunity in adult diabetes Bain S.C.: Human leucocyte antigen Andersen T., Auwerx J., Pedersen O.:
and low predictive value of islet auto- and insulin gene regions and nephro- Homozygosity of the Pro]2Ala variant
antibodies in the general adult popula- pathy in Type I diabetes (Short com- of the peroxisome proliferation-acti-
tion of northern Italy (Short commu- munication) 1017 vated receptor-y 2 (PPAR-y2 ): diver-
nication) 840 Dalgaard L.T ., Sgrensen T.I.A., Ander- gent modulating effects on body mass
Brock B., Gregersen S., Kristensen K., sen T., Hansen T., Pedersen O.: An index in obese and lean Caucasian men
Thomsen J.L., Buschard K., Kofod H., untranslated insertion variant in the (Short communication) 892
Hermansen K..: The insulinotropic ef- uncoupling protein 2 gene is not relat- Elliott R.B., Harris D.P., Hill J.P., Bibby
fect of endothelin-1 is mediated by ed to body mass index and changes in N.J., Wasmuth H.E.: Type I (insulin
glucagon release from the islet alpha body weight during a 26-year follow- dependent) diabetes mellitus and
cells 1302 up in Danish Caucasian men 1413 cow milk: casein variant consumption
Bruno G., Merletti F., Boffetta P., Caval- Davis E. A., Cuesta-Mufioz A., Raoul 292
lo-Perin P., Bargero G., Gallone G., M., Buettger C., Sweet I., Moates M., Eriksson J., Lindstrém J., Valle T., Au-
Pagano G.: Impact of glycaemic con- Magnuson M.A., Matschinsky F. M.: nola S., Hamalainen H., Ilanne-Parik-
trol, hypertension and insulin treat- Mutants of glucokinase cause hypo- ka P., Keinaénen-Kiukaanniemi S.,
ment on general and cause-specific glycaemia- and hyperglycaemia syn- Laakso M., Lauhkonen M., Lehto P.,
mortality: an Italian population-based dromes and their analysis illuminates Lehtonen A., Louheranta A., Manne-
cohort of Type II (non-insulin-depen- fundamental quantitative concepts of lin M., Martikkala V., Rastas M.,
dent) diabetes mellitus (Short commu- glucose homeostasis 1175 Sundvall J., Turpeinen A., Viljanen T.,
nication) 297 De Mattia G., Bravi M.C., Costanzo A.., Uusitupa M., Tuomilehto J on behalf
Buschard K., Schloot N.C., Kaas A., Laurenti O., Cassone Faldetta M., Ar- of the Finnish Diabetes Prevention
Bock T., Horn T., Fredman P., Roep miento A., De Luca O., Ferri C.: Ef- Study Group: Prevention of Type II
B.O.: Inhibition of insulin-specific au- fects of insulin on in vitro vascular cell diabetes in subjects with impaired glu-
toreactive T-cells by sulphatide which adhesion molecule-1 expression and in cose tolerance: the Diabetes Preven-
is variably expressed in beta cells 1212 vivo soluble VCAM-1 release (Short tion Study (DPS) in Finland. Study
Buteau J., Roduit R., Susini S., Prentki communication) 1235 design and 1-year interim report on the
M.: Glucagon-like peptide-1 promotes de Vegt F., Dekker J.M., Ruhé H.G., feasibility of the lifestyle intervention
DNA synthesis, activates phosphati- Stehouwer C.D. A., Nijpels G., Bouter programme 793
dylinositol 3-kinase and increases L.M., Heine R.J.: Hyperglycaemia is Esterbauer H., Oberkofler H., Dallinger
transcription factor pancreatic and associated with all-cause and cardio- G., Breban D., Hell E., Krempler F..
duodenal homeobox gene | (PDX-1) vascular mortality in the Hoorn popu- Patsch W.: Uncoupling protein-3 gene
DNA binding activity in beta (INS-1)- lation: the Hoorn Study 926 expression: reduced skeletal muscle
cells (Rapid communication) 856 Deinum J., Rgnn B., Mathiesen E., mRNA in obese humans during pro-
Cameron N.E., Cotter M.A., Jack A. M., Derkx F.H.M., Hop W.C.J., Schale- nounced weight loss 302
Basso M.D., Hohman TC: Protein ki- kamp MA.D.H.: Increase in serum Fagerudd J. A., Pettersson-Fernholm
nase C effects on nerve function, per- prorenin precedes onset of microalbu- K.J., Grénhagen-Riska C., Groop P.-
fusion, Na*, K*-ATPase activity and minuria in patients with insulin-de- H.: The impact of a family history of
glutathione content in diabetic rats pendent diabetes mellitus 1006 Type II (non-insulin-dependent) dia-
1120 Deng D., Evans T., Mukherjee K., betes mellitus on the risk of diabetic
Cassell P.G., Neverova M., Janmohamed Downey D., Chakrabarti S.: Diabetes- nephropathy in patients with Type I
S., Uwakwe N., Qureshi A., McCarthy induced vascular dysfunction in the re- (insulin-dependent) diabetes mellitus
M.I., Saker P.J., Albon L., Kopelman tina: role of endothelins 1228 519
P., Noonan K., Easlick J., Ramachan- Di Luca M., Ruts L., Gardoni F., Catta- Fernandez-Real J.-M., Ricart W.: Insulin
dran A., Snehalatha C., Pecqueur C., beni F., Biessels G.J., Gispen W. H.: resistance and inflammation in an evo-
Ricquier D., Warden C., Hitman G. A..: NMDA receptor subunits are modi- lutionary perspective: the contribution
An uncoupling protein 2 gene variant fied transcriptionally and post-transla- of cytokine genotype/phenotype to
is associated with a raised body mass tionally in the brain of streptozotocin- thriftiness 1367
index but not Type II diabetes 688 diabetic rats 693 Fliick C.E., Kuhlmann B. V., Mullis P. E.:
Chang S.L., Lin J.G., Chi T.C., Liu I. M., Douglas Petersen L., van der Keur M., de Insulin increases serum leptin concen-
Chen J.T.: An insulin-dependent hy- Vries R.R.P., Roep B.O.: Autoreac- trations in children and adolescents
poglycaemia induced by electroacu- tive and immunoregulatory T-cell sub- with newly diagnosed Type I diabetes
puncture at the Zhongwan (CV12) sets in insulin-dependent diabetes mellitus with and without ketoacidosis
acupoint in diabetic rats 250 mellitus 443 (Short communication) 1067
IV
Forouhi N.G., Jenkinson G., Thomas Ivy J.L., Moller D. E., Draznin B.: In- J., Tritschler H., Ritz E., Wahl P.,
E.L., Mullick S., Mierisova S., Bhonsle creased amounts of farnesylated Ziegler R., Bierhaus A., Nawroth P. P:
U., McKeigue P.M ., Bell J. D.: Rela- p21Ras in tissues of hyperinsulinaemic Peripheral blood mononuclear cells
tion of triglyceride stores in skeletal animals 310 isolated from patients with diabetic
muscle cells to central obesity and in- Greig N.H., Holloway H. W., De Ore nephropathy show increased activa-
sulin sensitivity in European and South K.A., Jani D., Wang Y., Zhou J., Ga- tion of the oxidative-stress sensitive
Asian men (Short communication) rant M.J., Egan J.M.: Once daily in- transcription factor NF-KB 222
932 jection of exendin-4 to diabetic mice Holemans K., Gerber R.T., Meurrens K.,
Forsblom C. M., Kanninen T., Lehtovirta achieves long-term beneficial effects De Clerck F., Poston L., Van Assche
M., Saloranta C., Groop L. C.: Heri- on blood glucose concentrations 45 F.A.: Streptozotocin diabetes in the
tability of albumin excretion rate in Gribble F.M., Ashcroft F.M.: Differen- pregnant rat induces cardiovascular
families of patients with Type II dia- tial sensitivity of beta-cell and extra- dysfunction in adult offspring 81
betes 1359 pancreatic Kp channels to gliclazide Holness M.J., Sugden M.C.: In late
Forsén L., Meyer H.E., Midthjell K., (Rapid communication) 845 pregnancy insulin-dependent glucose
Edna T.-H.: Diabetes mellitus and the Grill V., Persson G., Carlsson S., Norman transport/phosphorylation is selective-
incidence of hip fracture: results from A., Alvarsson M., Ostensson C.-G., ly impaired and activation of glycogen
the Nord-Tr@ndelag Health Survey Svanstr6m L., Efendic S.: Family his- synthase by insulin facilitated in skele-
920 tory of diabetes in middle-aged Swed- tal muscles of 24-h starved rats 802
Furukawa M., Zhang Y.O., Nie L., Shi- ish men is a gender unrelated factor Holzapfel A., Festa A., Stacher-Janotta
bata H., Kojima I.: Role of mitogen- which associates with insulinopenia in G., Bergmann H., Shnawa N., Bran-
activated protein kinase and phos- newly diagnosed diabetic subjects 15 nath W., Schernthaner G., Stacher G.:
phoinositide 3-kinase in the differen- Hamilton-Wessler M., Ader M., Dea M., Gastric emptying in non-insulin-de-
tiation of rat pancreatic AR42J cells Moore D., Jorgensen P.N., Markussen pendent diabetes before and after ther-
induced by hepatocyte growth factor J., Bergmann R.N.: Mechanism of apy readjustment: no influence of ac-
450 } protracted metabolic effects of fatty tual blood-glucose concentration 1383
Garofano A., Czernichow P., Bréant B.: acid acylated insulin, NN304, in dogs: Hoorens A., Pipeleers D.: Nicotinamide
Effect of ageing on beta-cell mass and retention of NN304 by albumin 1254 protects human beta cells against che-
function in rats malnourished during Hammes H.-P., Alt A., Niwa T., Clausen mically-induced necrosis, but not
the perinatal period 711 J.T., Bretzel R.G., Brownlee M., against cytokine-induced apoptosis 55
Gautier J.-F., Milner M.R., Elam E., Schleicher E. D.: Differential accumu- Hoppener J. W. M., Oosterwijk C., Nieu-
Chen K., Ravussin E., Pratley R.E.: lation of advanced glycation end pro- wenhuis M.G., Posthuma G., Thijssen
Visceral adipose tissue is not increased ducts in the course of diabetic retino- J.H.H., Vroom ThM, Ahrén B., Lips
in Pima Indians compared with equally pathy 728 C.J.M.: Extensive islet amyloid for-
obese Caucasians and is not related to Hammes H.-P., Brownlee M., Lin J., mation is induced by development of
insulin action or secretion 28 Schleicher E., Bretzel R.G.: Diabetic Type II diabetes mellitus and contri-
Ghosh S., Langefeld C. D., Ally D., Wa- retinopathy risk correlates with intra- butes to its progression: pathogenesis
tanabe R.M., Hauser E.R., Magnuson cellular concentrations of the glycoxi- of diabetes in a mouse model 427
V.L., Nylund S.J., Valle T., Eriksson J., dation product N‘ -(carboxymethyl) Horton V., Stratton I., Bottazzo G.F,,
Bergman R.N., Tuomilehto J., Coilins lysine independently of glycohaemo- Shattock M., Mackay I., Zimmet P.,
F.S., Boehnke M.: The W64R variant globin concentrations (Short commu- Manley S., Holman R., Turner R., for
of the / ;-adrenergic receptor is not as- nication) 603 the UK Prospective Diabetes Study
sociated with Type II diabetes or obe- ‘t Hart L.M., de Knijff P., Dekker J.M.., (UKPDS) Group: Genetic heteroge-
sity in a large Finnish sample 238 Stolk R.P., Nijpels G., van der Does neity of autoimmune diabetes: age of
Giannattasio C., Failla M., Piperno A., F.E.E., Ruige J.B., Grobbee D.E., presentation in adults is influenced by
Grappiolo A., Gamba P., Paleari F., Heine R.J., Maassen J. A.: Variants in HLA DRBI and DQBI genotypes
Mancia G.: Early impairment of large the sulphonylurea receptor gene: asso- (UKPDS 43) 608
artery structure and function in Type I ciation of the exon 16-3 ¢ variant with Hou X., Ling Z., Quartier E., Foriers A.,
diabetes mellitus 987 Type II diabetes mellitus in Dutch Schuit F., Pipeleers D., Van Schraven-
Giltay E.J., Lambert J., Elbers J.M.H., Caucasians (Short communication) dijk C.: Prolonged exposure of pan-
Gooren L.J.G., Asscheman H., Ste- 617 creatic beta cells to raised glucose
houwerx C.D.A.: Arterial compliance Hermans M.P., Levy J.C., Morris R.J., concentrations results in increased cel-
and distensibility are modulated by Turner R.C.: Comparison of insulin lular content of islet amyloid polypep-
body composition in both men and sensitivity tests across a range of glu- tide precursors 188
women but by insulin sensitivity only cose tolerance from normal to dia- Ibrahim S., Harris N.D., Radatz M., Sel-
in women 214 betes 678 mi F., Rajbhandari S., Brady L., Jaku-
Giroix M.-H., Saulnier C., Portha B.: Hinokio Y., Suzuki S., Hirai M., Chiba bowski J., Ward J.D.: A new minimally
Decreased pancreatic islet response to M., Hirai A., Toyota T.: Oxidative invasive technique to show nerve
.-leucine in the spontaneously diabetic DNA damage in diabetes mellitus: its ischaemia in diabetic neuropathy 737
GK rat: enzymatic, metabolic and se- association with diabetic complica- Imagawa A., Hanafusa T., Itoh N., Wa-
cretory data 965 tions (Short communication) 995 guri M., Yamamoto K., Miyagawa J.,
Gleeson A., Anderton K., Owens D., Hjeltnes N., Fernstrém M., Zierath J.R., Moriwaki M., Yamagata K., Iwahashi
Bennett A., Collins P., Johnson A., Krook A.: Regulation of UCP2 and H., Sada M., Tsuji T., Tamura S., Ka-
White D., Tomkin G.H.: The Role of UCP3 by muscle disuse and physical wata S., Kuwajima M., Nakajima H.,
microsomal triglyceride transfer pro- activity in tetraplegic subjects 826 Namba M., Matsuzawa Y.: Immunolo-
tein and dietary cholesterol in chylo- Hofmann M. A., Schiekofer S., Isermann gical abnormalities in islets at diagno-
micron production in diabetes 944 B., Kanitz M., Henkels M., Joswig M., sis paralleled further deterioration of
Goalstone M.L., Wail K., Leitner J. W., Treusch A., Morcos M., Weiss T., Bor- glycaemic control in patients with re-
Kurowski T., Ruderman N., Pan S.J., cea V., Abdel Khalek A. K.M., Amiral cent-onset Type I (insulin-dependent)
diabetes mellitus (Short communica- mori T., Naruse K., Nakashima E., yer J., Forst T.: The effect of human
tion) 574 Kato K., Koh N., Hotta N.: An aldose proinsulin C-peptide on erythrocyte
Imanishi M., Yoshioka K., Konishi Y., redutase inhibitor prevents the intimal deformability in patients with Type I
Okumura M., Okada N.., Sato T., Ta- thickening in coronary arteries of ga- diabetes mellitus 465
naka S., Fujii S., Kimura G.: Glomeru- lactose-fed beagle dogs 1404 Lalain S., Chaillous L., Gouin E., Sai P.:
lar hypertension as one cause of albu- Kawano Y., Rincon J., Soler A., Ryder Intensity and mechanisms of in vitro
minuria in Type II diabetic patients J.W., Nolte L.A., Zierath J.R., Wall- xenorecognition of adult pig pancrea-
999 berg-Heriksson H.: Changes in glucose tic islet cells by CD,* and CD,* lym-
Inoue S., Fukuda K., Kudara T., Igura T., transport and protein kinase Cf, in rat phocytes from Type I diabetic or heal-
Inui Y., Tamura S., Hanafusa T., Ka- skeletal muscle induced by hypergly- thy subjects (Short communication)
wata S., Matsuzawa Y.: Augmented caemia 1071 330
growth response to IGF-1 via in- Keegan A., Cotter M.A., Cameron N.E.: Lam K.S.L., Ma O.C.K., Wat N.M.S.,
creased IRS-1 in Chinese hamster Effects of diabetes and treatment with Chan L.C., Janus E. D.: f-fibrinogen
ovary cells expressing kinase-negative the antioxidant a-lipoic acid on endo- gene G/A-455 polymorphism in rela-
insulin receptors 763 thelial and neurogenic responses of tion to fibrinogen concentrations and
Ishiyama-Shigemoto S., Yamada K.., corpus cavernosum in rats 343 ischaemic heart disease in Chinese pa-
Yuan X., Ichikawa F., Nonaka K.: As- Kim A., Jun H.-S., Wong L., Stephure D., tients with Type II diabetes (Short
sociation of polymorphisms in the /2- Pacaud D., Trussell R.A., Yoon J.-W.: communication) 1250
adrenergic receptor gene with obesity, Human endogenous retrovirus with a Lampasona V., Bonfanti R., Bazzigaluppi
hypertriglyceridaemia, and diabetes high genomic sequence homology with E., Venerando A., Chiumello G., Bosi
mellitus (Short Communication) 98 IDDMK,»2 2 is not specific for Type I E., Bonifacio E.: Antibodies to tissue
Jacob S., Hauer B., Becker R., Artzner (insulin-dependent) diabetic patients transglutaminase C in Type I diabetes
S., Grauer P., Loblein K., Nielsen M., but ubiquitous (Rapid communica- (Short communication) 1195
Renn W., Rett K., Wahl H.-G., Stum- tion) 413 Larsen J.J.S., Dela F, Madsbad S., Gal-
voll M., Haring H.-U.: Lipolysis in Klein H.H., Miiller R., Vestergaard H., bo H.: The effect of intense exercise on
skeletal muscle is rapidly regulated by Pedersen O.: Implications of com- postprandial glucose homeostasis in
low physiological doses of insulin pound heterozygous insulin receptor Type II diabetic patients 1282
(Short communicaton) 1171 mutations in congenital muscle fibre Larsson H., Ahrén B.: Insulin resistant
Jones S.C., Saunders H.J., Qi W., Pol- type disproportion myopathy for the subjects lack islet adaptation to short-
lock C. A.: Intermittent high glucose receptor kinase activation (Short com- term dexamethasone-induced reduc-
enhances cell growth and collagen munication) 245 tion in insulin sensitivity 936
synthesis in cultured human tubuloin- Knott R.M., Robertson M., Muckersie Lefrandt J.D., Hoogenberg K., van Roon
terstitial ceils 1113 E., Folefac V. A., Fairhurst F. E., Wile- A.M., Dullaart R.P.F., Gans R.O.B.,
Jénsson B., Cook J.R., Pedersen T.R.: man S.M., Forrester J. V.: A model Smit A.J.: Baroreflex sensitivity is de-
The cost-effectiveness of lipid lower- system for the study of human retinal pressed in microalbuminuric Type I
ing in patients with diabetes: results angiogenesis: activation of monocytes diabetic patients at rest and during
from the 4S trial 1293 and endothelial cells and the associa- sympathetic manoeuvres 1345
Josefsen K., Sgrensen L. R., Buschard K., tion with the expression of the mono- Lehto M., Wipemo C., Ivarsson S.-A.,
Birkenbach M.: Glucose induces early carboxylate transporter type 1 (MCT- Lindgren C., Lipsanen-Nyman M.,
growth response gene (Egr-1) expres- 1) 870 Weng J., Wirbell L., Widén E., Tuomi
sion in pancreatic beta cells 195 Koch M., Rett K., Maerker E., Volk A.., T., Groop L.: High frequency of muta-
Jude E.B., Boulton A.J.M., Ferguson Haist K., Deninger M., Renn W., Har- tions in MODY and mitochondrial
M.W.J., Appleton I.: The role of nitric ing H.U.: The PPARy2 amino acid genes in Scandinavian patients with
oxide synthase isoforms and arginase polymorphism Pro 12 Ala is prevalent familial early-onset diabetes 1131
in the pathogenesis of diabetic foot ul- in offspring of Type II diabetic patients Lenhard J.M., Lancaster M.E., Paulik
cers: possible modulatory effects by and is associated to increased insulin M.A., Weiel J.E., Binz J.G., Sundseth
transforming growth factor beta 1 748 sensitivity in a subgroup of obese sub- S.S., Gaskill B. A., Lightfoot R.M..,
Kajimoto Y., Matsuoka T., Kaneto H., jects (Rapid communication) 758 Brown H.R.: The RXR agonist
Watada H., Fujitani Y., Kishimoto M., Kohner E.M., Stratton I.M., Aldington LG100268 causes hepatomegaly, im-
Sakamoto K., Matsuhisa M., Kawa- S.J., Turner R.C., Matthews D.R.: proves glycaemic control and decrea-
mori R., Yamasaki Y., Hori M.: Induc- Microaneurysms in the development ses cardiovascular risk and cachexia in
tion of glycation suppresses glucoki- of diabetic retinopathy (UKPDS 42) diabetic mice suffering from pancrea-
nase gene expression in HIT-T15 cells 1107 tic beta-cell dysfunction 545
1417 Kong M.-F, King P., Macdonald 1. A., Li L., Oshida Y., Kusunoki M., Yama-
Kallmann B.A., Lampeter E. F., Hanifi- Blackshaw P.E., Horowitz M., Perkins nouchi K., Johansson B.-L., Wahren J.,
Moghaddam P., Hawa M.., Leslie A.C., Armstrong E., Buchanan K.D.., Sato Y: Rat C peptide I and II stimu-
R.D.G., Kolb H.: Cytokine secretion Tattersall R. B.: Euglycaemic hyperin- late glucose utilization in STZ-induced
patterns in twins discordant for Type I sulinaemia does not affect gastric diabetic rats 958
diabetes (Rapid communication) 1080 emptying in Type I and Type II dia- Lindberg B., Ivarsson S.-A., Landin-Ols-
Kaneto H., Kajimoto Y., Fujitani Y., betes mellitus 365 son M., Sundkvist G., Svanberg L.,
Matsuoka T., Sakamoto K., Matsuhisa Kronenberg F., Auinger M., Trenkwalder Lernmark A: Islet autoantibodies in
M., Yamasaki Y., Hori M.: Oxidative E., Irsigler K., Utermann G., Dieplin- cord blood from children who devel-
stress induces p21 expression in pan- ger H.: Is apolipoprotein(a) a suscept- oped Type I (insulin-dependent) dia-
creatic islet cells: possible implication ibility gene for Type I diabetes mellitus betes mellitus before 15 years of age
in beta-cell dysfunction (Rapid com- and related to long-term survival? 181
munication) 1093 1021 Lindblad P., Chow W.H., Chan J., Berg-
Kasuya Y., Ito M., Nakamura J., Hama- Kunt T., Schneider S., Pfiitzner A., Goi- strom A., Wolk A., Gridley G.,
da Y., Nakayama M., Chaya S., Ko- tum K., Engelbach M., Schauf B., Be- McLaughlin J.K., Nyrén O., Adami
VI
H.O.: The role of diabetes mellitus in Moller A.M., Ek J., Durviaux S.M., Ur- M.: Reduced prevalence of diabetes
the aetiology of renal cell cancer 107 hammer S. A., Clausen J.O., Eiberg according to 1997 American Diabetes
Linderkamp O., Ruef P., Zilow E.P., H., Hansen T., Rousseau G.G., Le- Association criteria (Short communi-
Hoffmann G. F.: Impaired deformabil- maigre F. P., Pedersen O.: Hepatocyte cation) 1168
ity of erythrocytes and neutrophils in nuclear factor-6: associations beween Onkamo P., Vaananen S., Karvonen M.,
children with newly diagnosed insulin- genetic variability and Type II diabetes Tuomilehto J.: Worldwide increase in
dependent diabetes mellitus 865 and between genetic variability and incidence of Type I diabetes — the ana-
MacArthur D.L.A., de Koning E.J.P., estimates of insulin secretion 1011 lysis of the data on published incidence
Verbeek J.S., Morris J.F., Clark A.: Moriwaki M., Itoh N., Miyagawa J., Ya- trends 1395
Amyloid fibril formation is progressive mamoto K., Imagawa A., Yamagata Orho-Melander M., Almgren P., Kanni-
and correlates with beta-cell secretion K., Iwahashi H., Nakajima H., Namba nen T., Forsblom C., Groop L.C.: A
in transgenic mouse isolated islets M., Nagata S., Hanafusa T., Matsuza- paired-sibling analysis of the Xbal
1219 wa Y.: Fas and Fas ligand expression in polymorphism in the muscle glycogen
Maegawa H., Obata T., Shibata T., Fujita inflamed islets in pancreas sections of synthase gene 1138
T., Ugi S., Morino K., Nishio Y., Koji- patients with recent-onset Type I dia- Pieper G.M.: Enhanced, unaltered and
ma H., Hidaka H., Haneda M., Yasuda betes mellitus 1332 impaired nitric oxide-mediated endo-
H., Kikkawa R., Kashiwagi A.: A new Morrissette D.L., Goldstein M. K., Ra- thelium-dependent relaxation in ex-
antidiabetic agent (JTT-501) rapidly skin D.B., Rowland D.L.: Finger and perimental diabetes mellitus: impor-
stimulates glucose disposal rates by penile tactile sensitivity in sexually tance of disease duration 204
enhancing insulin signal transduction functional and dysfunctional diabetic Poulsen P., Kyvik K.O., Vaag A., Beck-
in skeletal muscle 151 men 336 Nielsen H.: Heritability of Type II
Maggi D., Barbetti F., Cordera R.: Role Movassat J., Portha B.: Beta-cell growth (non-insulin-dependent) diabetes mel-
of proline 193 in the insulin receptor in the neonatal Goto-Kakisaki rat and litus and abnormal glucose tolerance —
post-translational processing 435 regeneration after treatment with a population-based twin study 139
Makimattila S., Nikkila K., Yki-Jarvinen streptozotocin at birth 1098 Reed M.J., Meszaros K., Entes L.J.,
H.: Causes of weight gain during insu- Mykkanen L., Zaccaro D.J., Hales C.N., Claypool M.D.., Pinkett J.G., Brignetti
lin therapy with and without metfor- Festa A., Haffner S.M.: The relation of D., Luo J., Khandwala A., Reaven
min in patients with Type II diabetes proinsulin and insulin to insulin sensi- G.M.: Effect of masoprocol on carbo-
mellitus 406 tivity and acute insulin response in hydrate and lipid metabolism in a rat
Mathews C.E., McGraw R.A., Dean R., subjects with newly diagnosed Type II model of Type II diabetes 102
Berdanier C. D.: Inheritance of a mi- diabetes: the Insulin Resistance Riaz S., Malcangio M., Miller M., Tom-
tochondrial DNA defect and impaired Atherosclerosis Study 1060 linson D.R.: A vitamin D, derivative
glucose tolerance in BHE/Cdb rats 35 Neele D.M., de Wit E.C.M., Princen (CB1093) induces nerve growth factor
McKenna K., Morris A.D., Azam H., H.M.G.: Insulin suppresses apolipo- and prevents neurotrophic deficits in
Newton R. W., Baylis P.H., Thompson protein(a) synthesis by primary cul- streptozotocin-diabetic rats 1308
C. J.: Exaggerated vasopressin secre- tures of cynomolgus monkey hepato- Rolandsson O., Hagg E., Hampe C., Sul-
tion and attenuated osmoregulated cytes (Short Communication) 41 livan Jr E.P., Nilsson M., Jansson G.,
thirst in human survivors of hyperos- Nelson R.G., Tan M., Beck G.J., Ben- Hallmans G., Lernmark A: Glutamate
molar coma (Short communication) nett P.H., Knowler W.C., Mitch W.E., decarboxylase (GAD65) and tyrosine
534 Blouch K., Myers B. D.: Changing glo- phosphatase-like protein (IA-2) auto-
Medici F., Hawa M., Ianari A., Pyke merular filtration with progression antibodies index in a regional popula-
D.A., Leslie R.D.G.: Concordance from impaired glucose tolerance to tion is related to glucose intolerance
rate for Type II diabetes mellitus in Type II diabetes mellitus (Short Com- and body mass index (Short communi-
monozygotic twins: actuarial analysis munication) 90 cation) 555
146 Nielsen S., Schmitz A., Bacher T., Reh- Rondinone C.M., Carvalho E., Wesslau
Meyer T. W., Bennett P.H., Nelson R.G.: ling M., Ingerslev J., Mogensen C.E.: C., Smith U.P.: Impaired glucose
Podocyte number predicts long-term Transcapillary escape rate and albumi- transport and protein kinase B activa-
urinary albumin excretion in Pima In- nuria in Type II diabetes. Effects of tion by insulin, but not okadaic acid, in
dians with Type II diabetes and micro- short-term treatment with low-mole- adipocytes from subjects with Type II
albuminuria (Short communication) cular weight heparin (Short Commu- diabetes mellitus (Rapid communica-
1341 nication) 60 tion) 819
Moczulski D.K., Burak W., Doria A., Nyholm B., Walker M., Gravholt C.H., Rosenbauer J., Herzig P., von Kries R.,
Zychma M., Zukowska-Szczechowska Shearing P.A., Sturis J., Alberti Neu A., Giani G.: Temporal, seasonal,
E., Warram J.H., Grzeszczak W.: The KG.M.M.., Holst J.J., Schmitz O.: and geographical incidence patterns of
role of aldose reductase gene in the Twenty-four-hour insulin secretion Type I diabetes mellitus in children
susceptibility to diabetic nephropathy rates, circulating concentrations of under 5 years of age in Germany
in Type II (non-insulin-dependent) fuel substrates and gut incretin hor- (Short communication) 1055
diabetes mellitus (Short Communica- mones in healthy offspring of Type II Rudberg S., Osterby R., Bangstad H.-J.,
tion) 94 (non-insulin-dependent) diabetic par- Dahlquist G., Persson B.: Effect of an-
Mgller A. M., Ek J., Durviaux S.M., Ur- ents: evidence of several aberrations giotensin converting enzyme inhibitor
hammer S.A., Clausen J.O., Eiberg 1314 or beta blocker on glomerular struc-
H., Hansen T., Rousseau G.G., Le- Obrosova I.G., Fathallah L., Lang H.J., tural changes in young microalbumi-
maigre F. P., Pedersen O.: Hepatocyte Greene D.A.: Evaluation of a sorbitol nuric patients with Type I (insulin-de-
nuclear factor-6: associations between dehydrogenase inhibitor on diabetic pendent) diabetes mellitus 589
genetic variability and Type II diabetes peripheral nerve metabolism: a pre- Rudich A., Tirosh A., Potashnik R.,
and between genetic variability and vention study 1187 Khamaisi M., Bashan N.: Lipoic acid
estimates of insulin secretion (Short Okubo M., Watanabe H., Fujikawa R.., protects against oxidative stress in-
communication) 896 Kawamura T., Egusa G., Yamakido duced impairment in insulin stimula-
Vil
tion of protein kinase B und glucose Soulis T., Sastra S., Thallas V., Mortensen childhood and risk for Type I (insulin-
transport in 3T3-L1 adipocytes 949 S.B., Wilken M., Clausen J. T., Bjer- dependent) diabetes mellitus 51
Ruige J.B., Dekker J.M., Nijpels G., rum O.J., Petersen H., Lau J., Jerums Thorburn A. W., Baldwin M.E., Rosella
Popp-Snijders C., Stehouwer C.D.A., G., Boel E., Cooper M.E.: A novel in- G., Zajac J.D., Fabris S., Song S..,
Kostense P. J., Bouter L.M., Heine hibitor of advanced glycation end-pro- Proietto J.: Features of syndrome X
R.J.: Hyperproinsulinaemia in im- duct formation inhibits mesenteric develop in transgenic rats expressing a
paired glucose tolerance is associated vascular hypertrophy in experimental non-insulin responsive phosphoenol-
with a delayed insulin response to glu- diabetes 472 pyruvate carboxykinase gene 419
cose (Short communication) 177 Strebelow M., Schlosser M., Ziegler B., Tiedge M., Lortz S., Munday R., Lenzen
Salas A., Panés J., Rosenbloom C.L., Rjasanowski I., Ziegler M.: Karlsburg S.: Protection against the co-operative
Elizalde J.1., Anderson D.C., Granger Type I diabetes risk study of a general toxicity of nitric oxide and oxygen free
D.N., Piqué J.M.: Differential effects population: frequencies and interac- radicals by overexpression of antioxi-
of a nitric oxide donor on reperfusion- tions of the four major Type I diabetes- dant enzymes in bioengineered insu-
induced microvascular dysfunction in associated autoantibodies studied in lin-producing RINmSF cells 849
diabetic and non-diabetic rats 1350 9419 schoolchildren 661 Trovati M., Massucco P., Mattiello L.,
Sanchez-Margalet V.: Modulation of in- Strobel A., Siquier K., Zilberfarb V., Costamagna C., Aldieri E., Cavalot F.,
sulin receptor signalling by pancreast- Strosberg A. D., Issad T.: Effect of Anfossi G., Bosia A., Ghigo D.: Human
atin in HTC hepatoma cells 317 thiazolidinediones on expression of vascular smooth muscle cells express a
Sanchez-Soto M.C., Larrieta M.E., Vi- UCP2 and adipocyte markers in hu- constitutive nitric oxide synthase that
daltamayo R., Hiriart M.: Heteroge- man PAZ6 adipocytes 527 insulin rapidly activates, thus increasing
neity in glutamic acid decarboxylase Sugimoto H., Shikata K., Wada J., Ho- guanosine 3’ : 5’-cyclic monophosphate
expression among single rat pancreatic riuchi S., Makino H.: Advanced glyca- and adenosine 3’ : 5’-cyclic monopho-
beta cells 1086 tion end products-cytokine-nitric sphate concentrations 831
Sato A., Tarnow L., Parving H.-H.: Pre- oxide sequence pathway in the devel- Tsuchida K., Makita Z., Yamagishi S.,
valence of left ventricular hypertrophy opment of diabetic nephropathy: ami- Atsumi T., Miyoshi H., Obara S., Ishi-
in Type I diabetic patients with diabet- noguanidine ameliorates the overex- da M., Ishikawa S., Yasumura K.,
ic nephropathy 76 pression of tumour necrosis factor-a Koike T.: Suppression of transforming
Schaeffer G., Wascher T.C., Kostner and inducible nitric oxide synthase in growth factor beta and vascular endo-
G.M., Graier W.F.: Alterations in pla- diabetic rat glomeruli 878 thelial growth factor in diabetic ne-
telet Ca** signalling in diabetic pa- Suschek C. V., Bonmann E., Kolb-Ba- phropathy in rats by a novel advanced
tients is due to increased formation of chofen V.: A regulatory defect of con- glycation end product inhibitor, OPB-
superoxide anions and reduced nitric stitutive no-synthase in islet endothe- 9195 579
oxide production 167 lial cells correlates with probability of Tuomilehto J., Karvonen M., Pitkaniemi
Schalkwijk C.G., Poland D.C. W., Dijk disease manifestation in BBdp rats J., Virtala E., Kohtamaki K., Toivanen
W van, Kok A., Emeis J.J., Drager 457 L., Tuomilehto-Wolf E., The Finnish
A.M., Doni A., Hinsbergh VWM van, Suzuki M., Fujikura K., Kotake K., Ina- Childhood Type I Diabetes Registry
Stehouwer C. D. A.: Plasma concen- gaki N., Seino S., Takata K.: Immuno- Group: Record-high incidence of
tration of C-reactive protein is in- localization of sulphonylurea receptor Type I (insulin-dependent) diabetes
creased in Type I diabetic patients lin rat pancreas 1204 mellitus in Finnish children 655
without clinical macroangiopathy and Tanaka T., Itoh H., Doi K., Fukunaga Y., van den Ouweland J.M. W., Maechler P.,
correlates with markers of endothelial Hosoda K., Shintani M., Yamashita J., Wollheim C.B., Attardi G., Maassen
dysfunction: evidence for chronic in- Chun T.-H., Inoue M., Masatsugu K., J.A.: Functional and morphological
flammation 351 Sawada N., Saito T., Inoue G., Nishi- abnormalities of mitochondria har-
Schenker M., Hummel M., Ferber K., mura H., Yoshimasa Y., Nakao K..: bouring the tRNA*"UR) mutation in
Walter M., Keller E., Albert E.D., Down regulation of peroxisome pro- mitochondrial DNA derived from pa-
Janka H.-U., Kastendiek C., Sorger liferator-activated receptory expres- tients with maternally inherited dia-
M., Louwen F., Ziegler A.-G.: Early sion by inflammatory cytokines and its betes and deafness (MIDD) and pro-
expression and high prevalence of islet reversal by thiazolidinediones 702 gressive kidney disease 485
autoantibodies for DR3/4 heterozy- Tanizawa Y., Ohta Y., Nomiyama J., Varadi A., Lebel L., Hashim Y., Metha
gous and DR4/4 homozygous offspring Matsuda K., Tanabe K., Inoue H., Z., Ashcroft S.J.H., Turner R.: Se-
of parents with Type I diabetes: The Matsutani A., Okuya S., Oka Y.: quence variants of the sarco(endo)-
German BABYDIAB study 671 Overexpression of dominant negative plasmic reticulum Ca**-transport AT-
Schlingemann R.O., Hofman P., Vrensen mutant hepatocyte nuclear factor Pase 3 gene (SERCA3) in Caucasian
GF.J.M., Blaauwgeers H.G.T.: In- (HNF)-1a inhibits arginine-induced Type II diabetic patients (UK Pro-
creased expression of endothelial anti- insulin secretion in MIN6 cells (Short spective Diabetes Study 48) (Short
gen PAL-E in human diabetic retino- communication) 887 communication) 1240
pathy correlates with microvascular Tannous M., Rabini R.A., Vignini A., Veglio M., Borra M., Stevens L. K., Ful-
leakage 596 Moretti N., Fumelli P., Zielinski B., ler J.H., Perin PC and the EURO-
Shaw J.E., Hodge A.M., de Courten M., Mazzanti L., Mutus B.: Evidence for DIAB IDDM Complications Study
Chitson P., Zimmet P. Z.: Isolated post- iNOS-dependent peroxynitrite pro- Group: The relation between QTc in-
challenge hyperglycaemia confirmed duction in diabetic platelets 539 terval prolongation and diabetic com-
as a risk factor for mortality 1050 The DECODE-study group on behalf of plications. The EURODIAB IDDM
Shaw J.T.E., Purdie D.M., Neil H. A. W., the European Diabetes Epidemiology Complication Study Group 68
Levy J.C., Turner R.C.: The relative Group: Is fasting glucose sufficient to Wada R., Sugo M., Nakano M., Yagiha-
risks of hyperglycaemia, obesity and define diabetes? Epidemiological data shi S.: Only limited effects of amino-
dyslipidaemia in the relatives of pa- from 20 European studies 647 guanidine treatment on peripheral
tients with Type II diabetes mellitus The EURODIAB Substudy 2 Study nerve function, (Na*,K*)-ATPase ac-
(Short Communication) 24 Group: Vitamin D supplement in early tivity and thrombomodulin expression
Vill
in streptozotocin-induced diabetic Asano T., Tsukuda K., Katagiri H., Hanaire-Broutin H., Melki V., Tauber
rats 743 Onishi Y., Sakoda H., Ono H., Ogiliara J.P.: Treatment of acquired immune
Wahren J., Ekberg K., Fernqvist-Forbes T., Funaki M., Anai M., Inukai K., Fu- insulin resistance with i. v. immuno-
E., Nair S.: Brain substrate utilisation jishiro Y.M., Fukushima, Yamasoba globulins 1378
during acute hypoglycaemia 812 T., Oka T., Kikuchi M., Oka Y.: Clini- Holmes-Walker D.J., Boyages S.C.: Pre-
Wolf G., Wenzel U., Ziyadeh F.N., Stahl cal relevance of heteroplasmic con- valence of maternally inherited dia-
R.A.K.: Agiotensin converting-en- centration of mitochondrial A3243G betes and deafness in Australian dia-
zyme inhibitor treatment reduces glo- mutation in leucocytes 1439 betic subjects 1028
merular p16'N** and p27*""! expression Beales P.E., Pozzilli P.: Caution is re- Isotani H., Kameoka K., Nagano Y., Ki-
in diabetic BBdp rats 1425 quired with Interferon a as a potential taoka H., Ohsawa N.: Characteristic
Xu X.-J., Gearon C., Stevens E., Vergani treatment for Type I diabetes 385 neuroimaging findings in patients with
D., Baum H., Peakman M.: Sponta- Bhonde R.R., Parab P.B.: Muscle insulin diabetes and the 8296 mitochondrial
neous T-cell proliferation in the non- resistance: a probable case of disuse of tRNA’ 1266
obese diabetic mouse to a peptide skeletal muscles. Lamarckism revis- Karlsson S., Ahrén B.: Capsaicin-in-
from the unique class II MHC mole- ited 257 duced sensory denervation increases
cule, I-A®’, which is also protective Bloom S.R., Edwards C.M.B.: The in- glucose elimination in rodents 260
against the development of autoim- cretins — outdated terminology in Koehler C., Temelkova-Kurktschiev T.,
mune diabetes 560 man? 1048 Henkel E., Schaper F., Fuecker K.,
Yamaoka T., Yano M., Idehara C., Ya- Boutin P., Gresh L., Cisse A., Hara M., Hanefeld M.: Is the newly suggested
mada T., Tomonari S., Moritani M., [i Bell G., Babu S., Eisenbarth G., Fro- fasting plasma glucose cut-off point for
S., Yoshimoto K., Hata J., Itakura M.: guel P.: Missense mutation Gly574Ser the diagnosis of diabetes the right
Apoptosis and remodelling of beta in the transcription factor HNF-1a is a one? 635
cells by paracrine interferon-y without marker of atypical diabetes mellitus in Krssak M., Falk Petersen K., Dresner A.,
insulitis in transgenic mice 566 African-American children 380 DiPietro L., Vogel S.M., Rothman
Yoshiuchi I., Yamagata K., Yang Q., Bring J., Wernroth L.: Inefficient analysis D.L., Shulman G.I., Roden M.: Intra-
Iwahashi H., Okita K., Yamamoto K.., of twin data: is there an association myocellular lipid concentrations are
Oue T., Imagawa A., Hamaguchi T., between diabetes and birth weight? correlated with insulin sensitivity in
Yamasaki T., Horikawa Y., Satoh T., 898 humans: a 'H NMR spectroscopy study
Nakajima H., Miyazaki J., Higashiya- Chico A., Pérez A., Cérdoba A., Arcelus (Rapid communication) 1269
ma S., Miyagawa J., Namba M., Hana- R., Carreras G., Leiva A de, Gonzalez Lauro D., Kido Y., Hayashi H., Ebina Y.,
fusa T., Matsuzawa Y.: Three new mu- Sastre F., Blanco-Vaca F. 383 Accili D.: Expression of kinase-inac-
tations in the hepatocyte nuclear fac- Cordain L., Miller J., Mann N.: Scant tive mutant insulin receptors does not
tor-1 a gene in Japanese subjects with evidence of periodic starvation among rescue insulin receptor-deficient mice
diabetes mellitus: clinical features and hunter-gatherers 383 from perinatal death 1441
functional characterization (Short Cox R.D., Southam L., Hashim Y., Hor- Lernmark A, Kolb H., Mire-Sluis T.: To-
communication) 621 ton V., Mehta Z., Taghavi J., Lathrop wards a World Health Organisation
Zhang Y.-Q., Kanzaki M., Furukawa M.., M., Turner R.: UKPDS 31: Hepatocyte (WHO) approved standard sample for
Shibata H., Ozeki M., Kojima I.: In- nuclear factor-lalpha (the MODY3 islet cell antibodies, GAD65 and IA-2
volvement of Smad proteins in the dif- gene) mutations in late onset Type II autoantibodies 381
ferentiation of pancreatic AR42J cells diabetic patients in the United King- Lindberg B., Ivarsson S.-A., Lernmark
induced by activin A 719 dom 120 : A: Influence of heredity on the ap-
Cseh K., Baranyi E, Winkler G.: The role pearance of islet autoantibodies in
of cytokines of the innate and adaptive cordblood from children developing
Rapid communication immune system in the regulation of in- Type I diabetes before 15 years of age
sulin resistance 497 896
Krssak M., Falk Petersen K., Dresner A.., Dabelea D., Palmer J.P., Bennett P.H., Lindberg B., Ivarsson S.-A., Lernmark
DiPietro L., Vogel S.M., Rothman Pettitt D.J., Knowler W.C.: Absence A: Islet autoantibodies in cord blood
D.L., Roden M., Shulman G.I.: Intra- of glutamic acid decarboxylase antibo- could be a risk factor for future dia-
myocellular lipid concentrations are dies in Pima Indian children with dia- betes 1375
correlated with insulin sensitivity in betes mellitus 1265 Lindner T.H., Cockburn B.N., Bell G.L:
humans: a 'H NMR spectroscopy Dyer P.H., Chowdhury T. A., Dronsfield Molecular genetics of MODY in Ger-
study 113 M.J., Dunger D., Barnett A.H., Bain many 121
S.C.: The 5’-end polymorphism of the Malaisse W.J.: p-glucose transport and
aldose reductase gene is not associated utilization in pituitary adenoma cells
For debates with diabetic nephropathy in Cauca- transfected with glucokinase gene 498
sian Type I diabetic patients 1030 Mauricio D.: Islet autoantibodies at birth
Gerbitz K.-D.: Reflexions on a newly Faehling M., Fussgaenger R. D., Jehle in children later developing Type I
discovered diabetogenic gene, wolfra- P.M.: High affinity binding sites for diabetes mellitus 896
min (WFS/) 627 proinsulin on human umbilical vein McShane P.:: Confidence intervals for
Nauck M.A.: Is glucagon-like peptide 1 endothelial cells (HUVEC) 259 frequencies of rare alleles 635
an incretin hormone? 373 Grzeszczak W., Saucha W., Zychma M.J., Naserke H.E., Schenker M., Ziegler A.-
Zukowska-Szczechowska E., Labuz G.: Frequency of islet autoantibodies
B., Lacka B., Szydlowska I.: Is in relatives of patients with Type II
Letters Trp64Arg polymorphism of f ;-adre- diabetes or gestational diabetes 1377
nergic receptor a clinically useful mar- Nauck M.: Response to: “The incretins —
Arya S.C.: Temperature loggers are to be ker for the predisposition to diabetic outdated terminology in man? By
used to guarantee quality of insulin nephropathy in Type II diabetic pa- C.M.B. Edwards and S.R. Bloom,
preparations 257 tients? 632 London UK” 1049
IX
Nisoli E., Vettor R., Tonello C., Macor C., Seissler J., Schott M., Boms S., Wohlrab Zerbini G., Meregalli G., Cornaghi L.,
Federspil G., Carruba M. O.: Nutrient U., Ostendorf B., Morgenthater N.G., Mangili R., Pozza G.: Tetraploid cells
channelling-regulated peroxisome Scherbaum W. A.: Autoantibodies to and diabetic nephropathy 118
proliferator-activated receptor-y-2 human tissue transgiutaminase identi- Zozulinska D., Majchrzak A., Sobieska
(PPARy-2) and leptin gene expression fy silent coeliac disease Type I dia- M., Wiktorowicz K., Wierusz-
in human subcutaneous fat 495 betes 1440 Wysocka B.: Serum interleukin-8
Odawara M., Yamashita K.: A common Smith S.R., Lovejoy J.C., DeLaney J.P., level is increased in diabetic patients
mutation of the methylenetetrahydro- Ruyter I., McNeil M.: The inhibition of 117
folate reductase gene as a risk factor glycogen synthesis by fatty acids is not
for diabetic nephropathy 631 mediated by inhibition of extracellular
Panarotto D., Maheux P.: Reduction of signal-regulated kinase 1/2 1031 Abstracts
plasma leptin during a short-term fast, Smulders Y.M., Brouwer C.B., Silber-
an oral glucose tolerance or a meal test busch J.: Is plasma homocysteine All
can be a misleading bias in clinical stu- related to albumin excretion rate in
dies 634 patients with diabetes mellitus? 382
Pérez de Nanclares G., Bilbao J.R., Nis- Steinberg H.O., Baron A. D.: Insulin- Organisation Section
ticd L., Buzzetti R., Larsen Z. M., Po- mediated vasodilation: why one’s phy-
ciot F., Castafio L.: No evidence of as- siology could be the other’s pharma- A355
sociation of chromosome 2q with cology 493
Type I diabetes in the Basque popula- Stobbe I., Duinkerken G., van Rood J.J.,
tion 119 Lernmark A, Keymeulen B., Pipeleers Book review
Petrie J.R., Cleland S.J., Ueda S., Elliott D., De Vries R.R.P., Claas F.H.J.,
H.L., Connell J.M.C.: Insulin-medi- Roep B.: Tolerance to kidney allograf 901
ated vasodilation and forearm plethys- transplanted into Type I diabetic pa-
mography: physiology not pharmacol- tients persists after in vivo challenge
ogy 1376 with pancreatic islet allografts that ex- EASD News Section
Poulsen P., Vaag A. A., Kyvik K.O., Mgl- press repeated mismatches 1379
ler Jensen D., Beck-Nielsen H.: Evi- Wasada T., Katsumori K., Kuroki H., 15; 25. 23-27, 29, 33-4 5
dence for an association between dia- Iwamoto Y.: Insulin resistance facili-
betes and birth weight still exists 899 tates the development of coronary ar-
Princen H.M.G.: Insulin suppresses apo- tery disease in Japanese Type II dia- Erratum
lipoprotein(a) synthesis in cultures cy- betic patients: a single hospital-based
nomolgus monkey hepatocytes 897 follow-up study 1264 262, 386, 498, 1032, 1269, 1444
Rathmann W., Giani G., Mielck A.: Car- Weitgasser R., Davalli A.M., Weir G.C.:
diovascular risk factors in newly diag- Measurement of glucose concentra-
nosed abnormal glucose tolerance: tions in rats: differences between glu- Author index
comparison of 1997 ADA and 1985 cose meter and plasma laboratory re-
WHO criteria 1268 sults 256 1453
Reaven G.M.: Insulin resistance, the key Worm D., Vinten J., Beck-Nielsen H.:
to survival: a rose by any other name The significance of phosphotyrosine
384 phosphatase (PTPase) 1B in insulin Subject index
Riemens S.C., Dullaart R. P. F.: Effect of signalling 1046
insulin on apolipoprotein(a) synthesis Yki-Jarvinen H., Utriainen T.: Insulin- 1458
897 mediated vasodilation: the authors’ re-
Roep B.O., on behalf of the Immunology ply 494
of Diabetes Society T-cell Committee: Young A., Kolterman O., Hall J.: Amylin Contents of Volume 42
Standardization of T-cell assays in innocent in essential hypertension?
Type I diabetes 636 1029 I-IX