Diabetologia 1998: Vol 41 Table of Contents

9 Pages·1998·3 MB·English

II
Copyright
Submission of a manuscript implies: that the work described has not been published before (except in the form of an abstract); that it is
not under consideration for publication elsewhere; that its publication has been approved by all coauthors, if any, as well as by the re-
sponsible authorities at the institute where the work has been carried out; that, if and when the manuscript is accepted for publication,
the authors agree to automatic transfer of the copyright to the publisher and that the manuscript will not be published elsewhere in any
language without the consent of the copyright holders.
All articles published in this journal are protected by copyright, which covers the exclusive rights to reproduce and distribute the article
(e. g., as offprints), all translation rights as well as the rights to publish the article in any electronic form. No material published in this jour-
nal may be reproduced photographically or stored on microfilm, in electronic data bases, video disks, etc., without first obtaining written
permission from the publisher.
The use of general descriptive names, trade names, trademarks, etc., in this publication, even if not specifically identified, does not imply
that these names are not protected by the relevant laws and regulations.
While the advice and information in this journal is believed to be true and accurate at the date of its going to press, neither the authors, the
editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no war-
ranty, express or implied, with respect to the material contained herein.
Special regulations for photocopies in the USA. Photocopies may be made for personal or in-house use beyond the limitations stipula-
ted under Section 107 or 108 of U.S. Copyright Law, provided a fee is paid. All fees should be paid to the Copyright Clearance Center,
Inc., 21 Congress Street, Salem, MA 01976, USA, stating the ISSN 0012-186X, the volume, and the first and last page numbers of
each article copied. The copyright owner’s consent does not include copying for general distribution, promotion, new works, or resale.
In these cases, specific written permission must first be obtained from the publisher.
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Printed in Germany by aprinta Wemding
© Springer-Verlag Berlin Heidelberg 1998
Springer-Verlag GmbH & Co.KG, D-14197 Berlin, Germany
Contents
Full instructions to authors Yki-Jarvinen H., Utriainen T.: Insulin-in- Augstein P., Elefanty A.G., Allison J.,
duced vasodilatation: physiology or Harrison L.C.: Apoptosis and beta-cell
A6o pharmacology? 369 destruction in pancreatic islets of
NOD mice with spontaneous and cy-
clophosphamide-accelerated diabetes
Editorial Originals 1381
Bakker S.J.L., Hoogeveen E. K., Nijpels
Waldhdausl W.: Where do we want Ader M., Richey J.M., Bergman R.N.: G., Kostense P.J., Dekker J.M., Gans
to go? 1 Evidence for direct action of alloxan to R.O.B., Heine R.J.: The association of
induce insulin resistance at the cellular dietary fibres with glucose tolerance is
level 1327 partly explained by concomitant in-
Review Ahrén B., Oosterwijk C., Lips C.J.M., take of thiamine: The Hoorn Study
H6ppener J. W. M.: Transgenic overex- 1168
Cherrington A. D., Edgerton D., Sindelar pression of human islet amyloid poly- Bannan S., Mansfield M. W., Grant P. J.:
D.K.: The direct and indirect effects of peptide inhibits insulin secretion and Soluble vascular cell adhesion mole-
insulin on hepatic glucose production glucose elimination after gastric glu- cule-1 and E-selectin levels in relation
in vivo 987 cose gavage in mice 1374 to vascular risk factors and to E-selec-
Efrat S.: Prospects for gene therapy of Almind K., Ambye L., Urhammer S$.A ., tin genotype in the first degree rela-
insulin-dependent diabetes mellitus Hansen T., Echwald S.M., Holst J.J., tives of NIDDM patients and in
1401 Gromada J., Thorens B., Pedersen O.: NIDDM patients 460
Parving H.-H.: Renoprotection in dia- Discovery of amino acid variants in the Barkai L., Vamosi I., Lukacs K.: Pro-
betes: genetic and non-genetic risk human glucose-dependent insulinotro- spective assessment of severe hypogly-
factors and treatment 745 pic polypeptide (GIP) receptor: the caemia in diabetic children and ado-
Porte D.Jr., Seeley R.J., Woods S.C., impact on the pancreatic beta cell re- lescents with impaired and normal
Baskin D.G., Figlewicz D. P., Schwartz sponses and functional expression stu- awareness of hypoglycaemia 898
M. W.: Obesity, diabetes and the cen- dies in Chinese hamster fibroblast Bazzan M., Gruden G., Stella S., Vaccari-
tral nervous system 863 cells 1194 no A., Tamponi G., Olivetti C., Giunti
Trovati M., Anfossi G.: Insulin, insulin Anastasiou E., Alevizaki M., Grigorakis S., Cavallo-Perin P.: Microalbuminuria
resistance and platelet function: simi- S.J., Philippou G., Kyprianou M., Sou- in IDDM is associated with increased
larities with insulin effects on cultured vatzoglou A.: Decreased stature in ge- expression of monocyte procoagulant
vascular smooth muscle cells 609 stational diabetes mellitus 997 activity 767
II
Copyright
Submission of a manuscript implies: that the work described has not been published before (except in the form of an abstract); that it is
not under consideration for publication elsewhere; that its publication has been approved by all coauthors, if any, as well as by the re-
sponsible authorities at the institute where the work has been carried out; that, if and when the manuscript is accepted for publication,
the authors agree to automatic transfer of the copyright to the publisher and that the manuscript will not be published elsewhere in any
language without the consent of the copyright holders.
All articles published in this journal are protected by copyright, which covers the exclusive rights to reproduce and distribute the article
(e. g., as offprints), all translation rights as well as the rights to publish the article in any electronic form. No material published in this jour-
nal may be reproduced photographically or stored on microfilm, in electronic data bases, video disks, etc., without first obtaining written
permission from the publisher.
The use of general descriptive names, trade names, trademarks, etc., in this publication, even if not specifically identified, does not imply
that these names are not protected by the relevant laws and regulations.
While the advice and information in this journal is believed to be true and accurate at the date of its going to press, neither the authors, the
editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no war-
ranty, express or implied, with respect to the material contained herein.
Special regulations for photocopies in the USA. Photocopies may be made for personal or in-house use beyond the limitations stipula-
ted under Section 107 or 108 of U.S. Copyright Law, provided a fee is paid. All fees should be paid to the Copyright Clearance Center,
Inc., 21 Congress Street, Salem, MA 01976, USA, stating the ISSN 0012-186X, the volume, and the first and last page numbers of
each article copied. The copyright owner’s consent does not include copying for general distribution, promotion, new works, or resale.
In these cases, specific written permission must first be obtained from the publisher.
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Printed in Germany by aprinta Wemding
© Springer-Verlag Berlin Heidelberg 1998
Springer-Verlag GmbH & Co.KG, D-14197 Berlin, Germany
Contents
Full instructions to authors Yki-Jarvinen H., Utriainen T.: Insulin-in- Augstein P., Elefanty A.G., Allison J.,
duced vasodilatation: physiology or Harrison L.C.: Apoptosis and beta-cell
A6o pharmacology? 369 destruction in pancreatic islets of
NOD mice with spontaneous and cy-
clophosphamide-accelerated diabetes
Editorial Originals 1381
Bakker S.J.L., Hoogeveen E. K., Nijpels
Waldhdausl W.: Where do we want Ader M., Richey J.M., Bergman R.N.: G., Kostense P.J., Dekker J.M., Gans
to go? 1 Evidence for direct action of alloxan to R.O.B., Heine R.J.: The association of
induce insulin resistance at the cellular dietary fibres with glucose tolerance is
level 1327 partly explained by concomitant in-
Review Ahrén B., Oosterwijk C., Lips C.J.M., take of thiamine: The Hoorn Study
H6ppener J. W. M.: Transgenic overex- 1168
Cherrington A. D., Edgerton D., Sindelar pression of human islet amyloid poly- Bannan S., Mansfield M. W., Grant P. J.:
D.K.: The direct and indirect effects of peptide inhibits insulin secretion and Soluble vascular cell adhesion mole-
insulin on hepatic glucose production glucose elimination after gastric glu- cule-1 and E-selectin levels in relation
in vivo 987 cose gavage in mice 1374 to vascular risk factors and to E-selec-
Efrat S.: Prospects for gene therapy of Almind K., Ambye L., Urhammer S$.A ., tin genotype in the first degree rela-
insulin-dependent diabetes mellitus Hansen T., Echwald S.M., Holst J.J., tives of NIDDM patients and in
1401 Gromada J., Thorens B., Pedersen O.: NIDDM patients 460
Parving H.-H.: Renoprotection in dia- Discovery of amino acid variants in the Barkai L., Vamosi I., Lukacs K.: Pro-
betes: genetic and non-genetic risk human glucose-dependent insulinotro- spective assessment of severe hypogly-
factors and treatment 745 pic polypeptide (GIP) receptor: the caemia in diabetic children and ado-
Porte D.Jr., Seeley R.J., Woods S.C., impact on the pancreatic beta cell re- lescents with impaired and normal
Baskin D.G., Figlewicz D. P., Schwartz sponses and functional expression stu- awareness of hypoglycaemia 898
M. W.: Obesity, diabetes and the cen- dies in Chinese hamster fibroblast Bazzan M., Gruden G., Stella S., Vaccari-
tral nervous system 863 cells 1194 no A., Tamponi G., Olivetti C., Giunti
Trovati M., Anfossi G.: Insulin, insulin Anastasiou E., Alevizaki M., Grigorakis S., Cavallo-Perin P.: Microalbuminuria
resistance and platelet function: simi- S.J., Philippou G., Kyprianou M., Sou- in IDDM is associated with increased
larities with insulin effects on cultured vatzoglou A.: Decreased stature in ge- expression of monocyte procoagulant
vascular smooth muscle cells 609 stational diabetes mellitus 997 activity 767
Ill
Benhamou P. Y., Moriscot C., Richard Bellanné-Chantelot C., Velho G., Fro- Du X.L., Sui G. Z., Stockklauser-Farber
M.J., Beatrix O., Badet L., Pattou F, guel P.: Mutation screening in 18 Cau- K., WeiB J., Zink S., Schwippert B., Wu
Kerr-Conte J., Chroboczek J., Lemar- casian families suggest the existence of Q.X., Tschépe D., Résen P.: Induction
chand P., Halimi S.: Adenovirus-medi- other MODY genes 1017 of apoptosis by high proinsulin and
ated catalase gene transfer reduces Chico A., Pérez A., Cordoba A., Arcelti glucose in cultured human umbilical
oxidant stress in human, porcine and R., Carreras G., Leiva A de., Gonza- vein endothelial cells is mediated by
rat pancreatic islets 1093 lez-Sastre F., Blanco-Vaca F.: Plasma reactive oxygen species 249
Berg U.B., Torbjérnsdotter T. B., Jarem- homocysteine is related to albumin ex- Dufayet De La Tour D., Raccah D., Jan-
ko G., Thalme B.: Kidney morphologi- cretion rate in patients with diabetes not M.F., Coste T., Rougerie C., Vague
cal changes in relation to long-term mellitus: a new link between diabetic P.: Erythrocyte Na/K ATPase activity
renal function and metabolic control in nephropathy and cardiovascular dis- and diabetes: relationship with C-pep-
adolescents with IDDM 1047 ease? 684 tide level 1080
Bernardi M., La Rocca E., Castoldi R., Cinti S., Eberbach S., Castellucci M., Ac- Ebeling P., Essén-Gustavsson B., Tuomi-
Di Carlo V., Caldara R., Furiani S., cili D.: Lack of insulin receptors affects nen J. A., Koivisto V. A.: Intramuscular
Giudici D., Pozza G., Secchi A.: Mono- the formation of white adipose tissue triglyceride content is increased in
oligoclonal immunoglobulin abnorm- in mice. A morphometric and ultra- IDDM 111
alities in diabetic patients after kidney structural analysis 171 Enoksson S., Degerman E., Hagstrém-
transplantation: influence of simulta- Coutant R., Landais P., Rosilio M., John- Toft E., Large V., Arner P.: Various
neous pancreas graft 1176 sen C., Lahlou N., Chatelain P., Carel phosphodiesterase subtypes mediate
Bouwens L., Pipeleers D.G.: Extra-insu- J.C., Ludvigsson J., Boitard C., the in vivo antilipolytic effect of insulin
lar beta cells associated with ductules Bougnéres P. F.: Low dose linomide in on adipose tissue and skeletal muscle
are frequent in adult human pancreas Type I juvenile diabetes of recent on- in man 560
629 set: a randomised placebo-controlled Eriksson K.-F., Lindgarde F.: No excess
Brod S. A., Malone M., Darcan S., Papol- double blind trial 1040 12-year mortality in men with im-
la M., Nelson L.: Ingested interferon a Crowther N.J., Cameron N., Trusler J., paired glucose tolerance who partici-
suppresses Type I diabetes in non-ob- Gray I.P.: Association between poor pated in the Malm6 Preventive Trial
ese diabetic mice 1227 glucose tolerance and rapid post natal with diet and exercise 1010
Brown G.R., Silva M. D., Thompson weight gain in seven-year-old children Eriksson P., Reynisdottir S., Lonnqvist F.,
P.A., Beutler B.: Lymphoid Hyperpla- 1163 Stemme V., Hamsten A., Arner P.:
sia, CD45RB"*" to CD45RB'™ T-cell Dabelea D., Hanson R.L., Bennett P. H., Adipose tissue secretion of plasmino-
imbalance, and suppression of Type I Roumain J., Knowler W.C., Pettitt gen activator inhibitor-1 in non-obese
diabetes mellitus result from TNF D.J.: Increasing prevalence of Type II and obese individuals 65
blockade in NOD — NOD-scid adop- diabetes in American Indian children Fagot-Campagna A., Nelson R.G.,
tive T cell transfer 1502 904 Knowler W.C., Pettitt D. J.,R obbins
Buyken A.E., Toeller M., Heitkamp G., Darville M.1., Eizirik D.L.: Regulation D.C., Go O., Welty T.K., Lee E.T.,
Vitelli F., Stehle P., Scherbaum W.A., by cytokines of the inducible nitric Howard B. V.: Plasma lipoproteins and
Fuller J.H., EDRODIAB IDDM oxide synthase promoter in insulin- the incidence of abnormal excretion of
Complications Study Group.: Relation producing cells 1101 albumin in diabetic American Indians:
of fibre intake to HbA,, and the pre- Day C.P., Grove J., Daly A. K., Stewart The Strong Heart Study 1002
valence of severe ketoacidosis and se- M.W., Avery P.J., Walker M.: Tumour Fernyhough P., Diemel L. T., Tomlinson
vere hypoglycaemia 882 necrosis factor-alpha gene promoter D.R.: Target tissue production and ax-
Cabezas-Cerrato J for the Neuropathy polymorphism and decreased insulin onal transport of neurotrophin-3 are
Spanish Study Group of the Spanish resistance 430 reduced in streptozotocin-diabetic
Diabetes Society (S.D.S): The preva- Deacon C.F., Knudsen L. B., Madsen K., rats 300
lence of clinical diabetic polyneuropa- Wiberg F.C., Jacobsen O., Holst J. J.: Festa A., Kopp H.P., Schernthaner G.,
thy in Spain: a study in primary care Dipeptidyl peptidase IV resistant ana- Menzel E.J .: Autoantibodies to oxi-
and hospital clinic groups 1263 logues of glucagon-like peptide-1 dised low density lipoproteins in
Cameron N.E., Cotter M.A., Horrobin which have extended metabolic stabi- IDDM are inversely related to meta-
D.H., Tritschler H.J.: Effects of a-li- lity and improved biological activity bolic control and microvascular com-
poic acid on neurovascular function in 271 plications 350
diabetic rats: interaction with essential Derylo B., Babazono T., Glogowski E., Festa A., Schmdlzer B., Schernthaner G.,
fatty acids 390 Kapor-Drezgic J., Hohman T., White- Menzel E.J .: Differential expression of
Carlsson P.-O., Berne C., Jansson L.: An- side C.: High glucose-induced mesan- receptors for advanced glycation end
giotensin II and the endocrine pan- gial cell altered contractility: role of products on monocytes in patients with
creas: effects on islet blood flow and the polyol pathway 507 IDDM 674
insulin secretion in rats 127 Detaille D., Wiernsperger N., Devos P.: Fogarty D.G., Zychma M.J., Scott L.J.,
Ceriello A., Mercuri F., Fabbro D., Potentiating effect of metformin on in- Warram J. H., Krolewski A.S.: The
Giacomello R., Stel G., Taboga C., To- sulin-induced glucose uptake and gly- C825T polymorphism in the human G-
nutti L., Motz E., Damante G.: Effect cogen metabolism within Xenopus oo- protein /3 subunit gene is not associ-
of intensive glycaemic control on fibri- cytes 2 ated with diabetic nephropathy in
nogen plasma concentrations in pa- Diraison F., Large V., Brunengraber H., Type I diabetes mellitus 1304
tients with Type II diabetes mellitus. Beylot M.: Non-invasive tracing of li- Forsblom C. M., Sane T., Groop P.-H.,
Relation with /- fibrinogen genotype ver intermediary metabolism in nor- Totterman K.J., Kallio M., Saloranta
1270 mal subjects and in moderately hyper- C., Laasonen L., Summanen P., Le-
Chévre J.-C., Hani E.H., Boutin P., Va- glycaemic NIDDM subjects. Evidence pantalo M., Laatikainen L., Matikai-
xillaire M., Blanché H., Vionnet N., against increased gluconeogenesis and nen E., Teppo A.-M., Koskimies S.,
Pardini V.C., Timsit J., Larger E., hepatic fatty acid oxidation in Groop L.: Risk factors for mortality in
Charpentier G., Beckers D., Maes M., NIDDM 212 Type II (non-insulin-dependent) dia-
IV
betes: evidence of a role for neuropa- fects of streptozotocin-induced dia- Ibaiiez L., Potau N., Chacon P., Pascual
thy and a protective effect of HLA- betes 821 C., Carrascosa A.: Hyperinsulinaemia,
DR4 1253 Hallakou S., Foufelle F, Doaré L., Ker- dyslipaemia and cardiovascular risk in
Frystyk J., Skjarbek C., Zapf J., Orskov goat M., Ferré P.: Pioglitazone-induced girls with a history of premature pub-
H.: Increased levels of circulating free increase of insulin sensitivity in the arche 1057
insulin-like growth factors in patients muscles of the obese Zucker fa/fa rat Inada H., Shindo H., Tawata M., Onaya
with non-islet cell tumour hypoglycae- cannot be explained by local adipocyte T.: cAMP regulates nitric oxide pro-
mia 589 differentiation 963 duction and ouabain sensitive Na*, K*-
Fu J., Ikegami H., Kawaguchi Y., Fujisa- Hammes H.-P., Wellensiek B., Kl6ting L., ATPase activity in SH-SYSY human
wa T., Kawabata Y., Hamada Y., Ueda Sickel E., Bretzel R.G., Brownlee M.: neuroblastoma cells 1451
H., Shintani M., Nojima K., Babaya N., The relationship of glycaemic level to Ishiyama N., Kanzaki M., Seno M., Ya-
Shen Q.-J., Uchigata Y., Urakami T., advanced glycation end-product mada H., Kobayashi I., Kojima I.: Stu-
Omori Y., Shima K., Ogihara T.: Asso- (AGE) accumulation and retinal pa- dies on the betacellulin receptor in
ciation of distal chromosome 2q with thology in the spontaneous diabetic pancreatic AR42J cells 623
IDDM in Japanese subjects 228 hamster 165 Isomaa B., Henricsson M., Lehto M.,
Fiichtenbusch M., Rabl W., Grassl B., Hampson G., Evans C., Petitt R.J., Evans Forsblom C., Karanko S., Sarelin L.,
Bachmann W., Standl E., Ziegler A.- W.D., Woodhead S.J., Peters J.R., Haggblom M., Groop L.: Chronic dia-
G.: Delay of Type I diabetes in high Ralston S.H.: Bone mineral density, betic complications in patients with
risk, first degree relatives by parenter- collagen type 1 a 1 genotypes and bone MODY%3 diabetes 467
al antigen administration: the Schwa- turnover in premenopausal women Jager A., Kostense P. J., Nijpels G., Heine
bing Insulin Prophylaxis Pilot Trial 536 with diabetes mellitus 1314 R.J., Bouter L.M., Stehouwer C.D. A.:
Fujisawa T., Ikegami H., Kawaguchi Y., Hani E.H., Boutin P., Durand E., Inoue Microalbuminuria is strongly associ-
Hamada Y., Ueda H., Shintani M., Fu- H., Permutt M.A., Velho G., Froguel ated with NIDDM and hypertension,
kuda M., Ogihara T.: Meta-analysis of P.: Missense mutations in the pancrea- but not with the insulin resistance syn-
association of insertion/deletion poly- tic islet beta cell inwardly rectifying K* drome: the Hoorn Study 694
morphism of angiotensin I-converting channel gene (K/R6.2/BIR ): a meta- Jang H.C., Min H.K., Lee H.K., Cho
enzyme gene with diabetic nephropa- analysis suggests a role in the poly- N.H., Metzger B.E.: Short stature in
thy and retinopathy 47 genic basis of Type II diabetes mellitus Korean women: a contribution to the
Fujita Y., Kojima H., Hidaka H., Fuji- in Caucasians 1511 multifactorial predisposition to gesta-
miya M., Kashiwagi A., Kikkawa R.: Hirata K., Shikata K., Matsuda M.., tional diabetes mellitus 778
Increased intestinal glucose absorption Akiyama K., Sugimoto H., Kushiro M., Jones S.C., Thomas T. H., Marshall S. M.:
and postprandial hyperglycaemia at Makino H.: Increased expression of Abnormal regulation of cell mem-
the early step of glucose intolerance in selectins in kidneys of patients with brane fluidity in diabetic nephropathy
Otsuka Long-Evans Tokushima Fatty diabetic nephropathy 185 337
Rats 1459 Holl R. W., Grabert M., Sorgo W., Heinze Jérneskog G., Brismar K., Fagrell B.:
Fiirnsinn C., Brunmair B., Furtmiiller R., E., Debatin K. M.: Contributions of Pronounced skin capillary ischemia in
Roden M., Englisch R., Waldhausl W.: age, gender and insulin administration the feet of diabetic patients with bad
Failure of leptin to affect basal and in- to weight gain in subjects with IDDM metabolic control 410
sulin-stimulated glucose metabolism 542 Jude E.B., Abbott C.A., Young M.J .,
of rat skeletal muscle in vitro 524 Hopfner R.L., Misurski D., Wilson T. W., Anderson S.G., Douglas J. T., Boulton
Garofano A., Czernichow P., Bréant B.: McNeill J.R., Gopalakrishnan V.: In- A.J.M.: The potential role of cell ad-
Beta-cell mass and proliferation fol- sulin and vanadate restore decreased hesion molecules in the pathogenesis
lowing late fetal and early postnatal plasma endothelin concentrations and of diabetic neuropathy 330
malnutrition in the rat 1114 exaggerated vascular responses to nor- Kanc K., Janssen M.M.J., Keulen E. T.P.,
Giaccari A., Morviducci L., Pastore L., mal in the streptozotocin diabetic rat Jacobs M. A.J.M., Popp-Snijders C.,
Zorretta D., Sbraccia P., Maroccia E., 1233 Snoek F.J., Heine R.J.: Substitution of
Buongiorno A., Tamburrano G.: Rela- Hovorka R., Koukkou E., Southerden night-time continuous subcutaneous
tive contribution of glycogenolysis and D., Powrie J.K., Young M. A.: Measur- insulin infusion therapy for bedtime
gluconeogenesis to hepatic glucose ing prehepatic insulin secretion using a NPH insulin in a multiple injection re-
production in control and diabetic rats. population model of C-peptide kinet- gimen improves counterregulatory
A re-examination in the presence of ics: accuracy and required sampling hormonal responses and warning
euglycaemia 307 schedule 548 symptoms of hypoglycaemia in IDDM
Gibbins R.L., Owens D.R., Allen J.C., Hudson C., Flanagan J.G., Turner G.S., 322
Eastman L.: Practical application of Chen H.C., Young L.B., McLeod D.: Kawamura T., Umemura T., Kanai A.,
the European Field Guide in screening Influence of laser photocoagulation Uno T., Matsumae H., Sano T., Saka-
for diabetic retinopathy by using oph- for clinically significant diabetic macu- moto N., Sakakibara T., Nakamura J.,
thalmoscopy and 35 mm retinal slides lar oedema (DMO) on short-wave- Hotta N.: The incidence and charac-
59 length and conventional automated teristics of silent cerebral infarction in
Guenifi A., Abdel-Halim S.M., Efendic perimetry 1283 elderly diabetic patients: association
S., Ostenson C.-G.: Preserved initia- Hudson C., Flanagan J.G., Turner G.S., with serum-soluble adhesion mole-
tory and potentiatory effect of a-ke- Chen H.C., Young L.B., McLeod D.: cules 911
toisocaproate on insulin release in is- Short-wavelength sensitive visual field Keymeulen B., Ling Z., Gorus F. K., Del-
lets of glucose intolerant rats 1368 loss in patients with clinically signifi- vaux G., Bouwens L., Grupping A.,
Hahl J., Simell T., Ilonen J., Knip M., Si- cant diabetic macular oedema 918 Hendrieckx C., Pipeleers-Marichal M.,
mell O.: Costs of predicting IDDM 79 Hussain M.J., Maher J., Warnock T., Vats Van Schravendijk C., Salmela K., Pip-
Hajduch E., Darakhshan F., Hundal A., Peakman M., Vergani D.: Cytokine eleers D.G.: Implantation of standar-
H.S.: Fructose uptake in rat adipo- overproduction in healthy first degree dized beta-cell grafts in a liver segment
cytes: GLUTS expression and the ef- relatives of patients with IDDM 343 of IDDM patients: graft and recipient
characteristics in two cases of insulin- Ling Z.-C., Khan A., Delauny F., Davani with Type I (insulin-dependent) dia-
independence under maintenance im- B., Ostenson C.-G., Gustafsson J.-A., betes mellitus — a population-based
munosuppression for prior kidney Okret S., Landau B.R., Efendic S.: In- study 1139
graft 452 creased glucocorticoid sensitivity in is- Murase K., Odaka H., Suzuki M., Tayuki
Klannemark M., Orho M., Langin D., let beta-cells: effects on glucose 6- N., Ikeda H.: Pioglitazone time-de-
Laurell H., Holm C., Reynisdottir S., phosphatase, glucose cycling and insu- pendently reduces tumour necrosis
Arner P., Groop L.: The putative role lin release 634 factor-a level in muscle and improves
of the hormone-sensitive lipase gene in Lorenzen T., Pociot F., Stilgren L., Kris- metabolic abnormalities in Wistar fat-
the pathogenesis of Type II diabetes tiansen O.P., Johannesen J., Olsen ty rats 257
mellitus and abdominal obesity 1516 P.B., Walmar A., Larsen A., Albrecht- Murata T., Hoffmann §S., Ishibashi T.,
Kong M.-F, King P., Macdonald I. A., sen N.C., Eskildsen P.C., Andersen Spee C., Gordon E.M., Anderson
Blackshaw P.E., Perkins A.C., Arm- O.0., Nerup J and the Danish IDDM W.F., Hinton D.R., Ryan S.J.: Retro-
strong E., Buchanan K.D., Tattersall Epidemiology and Genetics Group.: virus-mediated gene transfer targeted
R.B.: Effect of euglycaemic hyperin- Predictors of IDDM recurrence risk in to retinal photocoagulation sites 500
sulinaemia on gastric emptying and offspring of Danish IDDM patients Nakazaki M., Ishihara H., Kakei M., In-
gastrointestinal hormone responses in 666 ukai K., Asano T., Miyazaki J.-I., Ta-
normal subjects 474 Makino A., Kamata K.: Possible modu- naka H., Kikuchi M., Yada T., Oka Y.:
Kong M.-F, Stubbs T. A., King P., lation by endothelin-1, nitric oxide, Repetitive mitochondrial Ca’* signals
Macdonald I. A., Lambourne J.E., prostaglandin I, and thromboxane A, synchronize with cytosolic Ca* oscil-
Blackshaw P.E., Perkins A.C., Tatter- of vasoconstriction induced by an a- lations in the pancreatic beta-cell line,
sall R.B.: The effect of single doses agonist in mesenteric arterial bed from MIN6 279
of pramlintide on gastric emptying diabetic rats 1410 Naserke H.E., Dozio N., Ziegler A.-G.,
of two meals in men with IDDM Malkki M., Laakso M., Neeb S.S.: Func- Bonifacio E.: Comparison of a novel
577 tional consequences of naturally oc- micro-assay for insulin autoantibodies
Koopmans S. J., Leighton B., DeFronzo curring variants of human hexokinase with the conventional radiobinding as-
R.A.: Neonatal de-afferentation of II 1205 say 681
capsaicin-sensitive sensory nerves in- Mari A.: Assessment of insulin sensitivity New J. P., Marshall S.M., Bilous R. W.:
creases in vivo insulin sensitivity in and secretion with the labelled intra- Renal autoregulation is normal in
conscious adult rats 813 venous glucose tolerance test: im- newly diagnosed, normotensive,
Koren W., Koldanov R., Pronin V.S., proved modelling analysis 1029 NIDDM patients 206
Postnov I. Y., Peleg E., Rosenthal T., Martin S., Heidenthal E., Schulte B., Ng L.L., Ngkeekwong F.C., Quinn P.A.,
Berezin M., Postnov Y. V.: Enhanced Rothe H., Kolb H.: Soluble forms of Davies J. E.: Uptake mechanisms for
erythrocyte Na*/H* exchange predicts intercellular adhesion molecule-1 inhi- ascorbate and dehydroascorbate in
diabetic nephropathy in patients with bit insulitis and onset of autoimmune lymphoblasts from diabetic nephropa-
IDDM 201 diabetes 1298 thy and hypertensive patients 435
Kuzuya M., Satake S., Ai S., Asai T., McKeigue P.M., Lithell H.O., Leon Niculescu L., Van Schaftingen E.: Man-
Kanda S., Ramos M.A., Miura H.., D.A.: Glucose tolerance and resis- nitol 1-phosphate mediates an inhibi-
Ueda M., Iguchi A.: Inhibition of an- tance to insulin-stimulated glucose up- tory effect of mannitol on the activity
giogenesis on glycated collagen latti- take in men aged 70 years in relation to and the translocation of glucokinase in
ces 49] size at birth 1133 isolated rat hepatocytes 947
Lam K.S.L., Ma O.C.K., Bourke C., Morgan D.G., Kulkarni R.N., Hurley Nielsen M.F., Dinneen S., Basu A., Basu
Chan L.C., Janus E. D.: Genetic influ- J.D., Wang Z.L., Wang R.M., Ghatei R., Alzaid A., Rizza R.R.: Failure of
ence of the R/Q353 genotype on fac- M.A., Karlsen A.E., Bloom S.R., nocturnal changes in growth hormone
tor VII activity is overwhelmed by en- Smith D.M.: Inhibition of glucose sti- to alter carbohydrate tolerance the
vironmental factors in Chinese pa- mulated insulin secretion by neuro- following morning 1064
tients with Type II (non-insulin-de- peptide Y is mediated via the Y1 re- Niklasson M., Holmang A., Lonnroth P.:
pendent) diabetes mellitus 760 ceptor and inhibition of adenylyl cy- Induction of rat muscle insulin resis-
Lamhamedi-Cherradi S.-E., Luan J.-J., clase in RIN 5AH rat insulinoma cells tance by epinephrine is accompanied
Eloy L., Fluteau G., Bach J.-F, Gar- 1482 by increased interstitial glucose and
chon H.-J.: Resistance of T-cells to Motoyoshi S., Shirotani T., Araki E., Sa- lactate concentrations 1467
apoptosis in autoimmune diabetic kai K., Kaneko K., Motoshima H., Nordfors L., Hoffstedt J., Nyberg B.,
(NOD) mice is increased early in life Yoshizato K., Shirakami A., Kishika- Thorne A., Arner P., Schalling M.,
and is associated with dysregulated wa H., Shichiri M.: Cellular character- Lonngqvist F.: Reduced gene expres-
expression of Bcl-x 178 ization of pituitary adenoma cell line sion of UCP2 but not UCP3 in skeletal
Larsson H., Ahrén B.: Glucose-depen- (AtT20 cell) transfected with insulin, muscle of human obese subjects 935
dent arginine stimulation test for char- glucose transporter type 2 (GLUT2) Oberkofler H., Liu Y.M., Esterbauer H.,
acterization of islet function: studies and glucokinase genes: insulin secre- Hell E., Krempler F., Patsch W.: Un-
on reproducibility and priming effect tion in response to physiological con- coupling protein-2 gene: reduced
of arginine 772 centrations of glucose 1492 mRNA expression in intraperitoneal
LeBras S., Czernichow P., Scharfmann Mihlhauser I., Overmann H., Bender R., adipose tissue of obese humans 940
R.: A search for tyrosine kinase recep- Bott U., Berger M.: Risk factors of se- Obrosova I., Cao X., Greene D.A., Ste-
tors expressed in the rat embryonic vere hypoglycaemia in adult patients vens M.J.: Diabetes-induced changes
pancreas 1474 with Type I diabetes — a prospective in lens antioxidant status, glucose utili-
Lindsay R.M., Jamieson N.S. D., Walker population based study 1274 zation and energy metabolism: effect
S.A., McGuigan C.C., Smith W., Baird Miihlhauser I., Overmann H., Bender R., of DL-a-lipoic acid 1442
J.D.: Tissue ascorbic acid and polyol Bott U., Jorgens V., Trautner Ch., O’Harte F. P.M., Abdel-Wahab Y.H.A.,
pathway metabolism in experimental Siegrist J., Berger M.: Social status and Conlon J.M., Flatt P.R.: Glycation of
diabetes 516 the quality of care for adult people glucagon-like peptide-1(7—36)amide:
VI
characterization and impaired action Pietruck F,, Spleiter S., Daul A., Philipp vascular outcomes in the JCR:LA-cp
on rat insulin secreting cells 1187 T., Derwahl M., Schatz H., Siffert W.: rat by p-fenfluramine 380
Ohtomo Y., Bergman T., Johansson B.- Enhanced G protein activation in Sackmann H., Tran-Van T., Tack I., Ha-
L., Jornvall H., Wahren J.: Differential IDDM patients with diabetic nephro- naire-Broutin H., Tauber J.-P., Ader J.-
effects of proinsulin C-peptide frag- pathy 94 L.: Renal functional reserve in IDDM
ments on Na*, K*-ATPase activity of Pijl JW van der., Daha M.R., Born J van patients 86
renal tubule segments 287 den., Verhagen N. A.M., Lemkes Sakura H., Ashcroft S.J.H., Terauchi Y.,
Ono Y., Umeda F., Kunisaki M., Sekigu- H.H.P.J., Bucala R., Berden J.H.M., Kadowaki T., Ashcroft F. M.: Glucose
chi N., Hashimoto T., Nawata H.: Ef- Zwinderman A.H., Bruijn J.A., Es LA modulation of ATP-sensitive K-cur-
fect of high glucose concentrations on van., Woude FJ van der.: Extracellular rents in wild-type, homozygous and
prostacyclin-stimulating factor mRNA matrix in human diabetic nephropathy: heterozygous glucokinase knock-out
expression in cultured aortic smooth reduced expression of heparan sul- mice 654
muscle cells 134 phate in skin basement membrane 791 Salbe A. D., Fontvieille A.M., Pettitt
Ozanne S.E., Martensz N.D., Petry C.J., Poulsen P.L., Bek T., Ebbehgj E., Hansen D.J., Ravussin E.: Maternal diabetes
Loizou C.L., Hales C.N.: Maternal K. W., Mogensen C.E.: 24-h ambula- status does not influence energy ex-
low protein diet in rats programmes tory blood pressure and retinopathy in penditure or physical activity in 5-year-
fatty acid desaturase activities in the normoalbuminuric IDDM patients old Pima Indian children 1157
offspring 1337 105 Sano T., Umeda F., Hashimoto T., Nawa-
Pagano P. J.,G riswold M.C., Ravel D., Poulton J., Scott-Brown M., Cooper A., ta H., Utsumi H.: Oxidative stress
Cohen R.A.: Vascular action of the Marchington D.R., Phillips D.I.W.: A measurement by in vivo electron spin
hypoglycaemic agent gliclazide in dia- common mitochondrial DNA variant resonance spectroscopy in rats with
betic rabbits 9 is associated with insulin resistance in streptozotocin-induced diabetes 1355
Palmer A.M., Gopaul N., Dhir S., Tho- adult life 54 Saukkonen T., Virtanen S.M., Karppinen
mas C.R., Poston L., Tribe R. M.: En- Qiang X., Satoh J., Sagara M., Fukuzawa M., Reijonen H., [lonen J., Rasanen L.,
dothelial dysfunction in streptozoto- M., Masuda T., Sakata Y., Muto G., Akerblom H.K., Savilahti E., and the
cin-diabetic rats is not reversed by Muto Y., Takahashi K., Toyota T.: In- Childhood Diabetes in Finland Study
dietary probucol or simvastatin sup- hibitory effect of troglitazone on dia- Group.: Significance of cow’s milk
plementation 157 betic neuropathy in streptozotocin-in- protein antibodies as risk factor for
Palmer A.M., Thomas C.R., Gopaul N., duced diabetic rats 1321 childhood IDDM: interactions with
Dhir S., Anggard E.E., Poston L., Raabe H.-M., Hépner J.-H., Notbohm dietary cow’s milk intake and HLA-
Tribe R.M.: Dietary antioxidant sup- H., Sinnecker G.H.G., Kruse K., Miil- DQBI genotype 72
plementation reduces lipid peroxida- ler P.K.: Biochemical and biophysical Savola K., Bonifacio E., Sabbah E., Kul-
tion but impairs vascular function in alterations of the 7S and NCI domain mala P., Vahasalo P., Karjalainen J.,
small mesenteric arteries of the strep- of collagen IV from human diabetic Tuomilehto-Wolf E., Merilainen J.,
tozotocin-diabetic rat 148 kidneys 1073 Akerblom H.K., Knip M and the
Paolisso G., Tagliamonte M.R., Rizzo Rabini R.A., Staffolani R., Fumelli P., Childhood Diabetes in Finland Study
M.R., Gualdiero P., Saccomanno F., Mutus B., Curatola G., Mazzanti L.: Group.: IA-2 antibodies — a sensitive
Gambardella A., Giugliano D., Decreased nitric oxide synthase activ- marker of IDDM with clinical onset in
D’Onofrio F., Howard B. V.: Lowering ity in platelets from IDDM and childhood and adolescence 424
fatty acids potentiates acute insulin re- NIDDM patients 101 Savola K., Sabbah E., Kulmala P., Vaha-
sponse in first degree relatives of peo- Ranganath L., Sedgwick I., Morgan L., salo P., Ilonen J., Knip M.: Autoanti-
ple with Type II diabetes 1127 Wright J., Marks V.: The ageing en- bodies associated with Type I diabetes
Peak M., Rochford J. J., Borthwick A.C., tero-insular axis 1309 mellitus persist after diagnosis in chil-
Yeaman S.J., Agius L.: Signalling Renaudin C., Michoud E., Rapin J.R., dren 1293
pathways involved in the stimulation Lagarde M., Wiernsperger N.: Hyper- Schneider D.J., Absher P.M., Neimane
of glycogen synthesis by insulin in rat glycaemia modifies the reaction of mi- D., Russell J.C., Sobel B. E.: Fibrinoly-
hepatocytes 16 crovessels to insulin in rat skeletal sis and atherogenesis in the JCR:LA-
Peschke E., Peschke D.: Evidence for a muscle 26 cp rat in relation to insulin and trigly-
circadian rhythm of insulin release from Riemens S.C., van Tol A., Sluiter W.J., ceride concentrations in blood 141
perifused rat pancreatic islets 1085 Dullaart R. P.F.: Plasma phospholipid Seissler J., de Sonnaville J.J. J., Morgen-
Petersen J.S., Rimvall K., Jorgensen transfer protein activity is related to thaler N.G., Steinbrenner H., Glawe
P.N., Hasselager E., Moody A., Hej- insulin resistance: impaired acute low- D., Khoo-Morgenthaler U. Y., Lan
nes K., Clausen J.T., Dyrberg T.: Reg- ering by insulin in obese Type II dia- M.S., Notkins A. L., Heine R.J.,
ulation of GAD expression in rat pan- betic patients 929 Scherbaum W. A.: Immunological het-
creatic islets and brain by y- vinyl- Romano G., Tilly-Kiesi M.K., Patti L., erogeneity in Type I diabetes: presence
GABA and glucose 530 Taskinen M.-R., Pacioni D., Cassader of distinct autoantibody patterns in
Pieper G.M., Dembny K., Siebeneich W.: M., Riccardi G., Rivellese A. A.: Ef- patients with acute onset and slowly
Long-term treatment in vivo with fects of dietary cholesterol on plasma progressive disease 891
NOX-101, a scavenger of nitric oxide, lipoproteins and their subclasses in Sener A., Kadiata M. M., Olivares E.,
prevents diabetes-induced endothelial IDDM patients 193 Malaisse W. J.: Comparison of the ef-
dysfunction 1220 Roufail E., Soulis T., Boel E., Cooper fects of D-mannoheptulose and its
Pieper G.M., Dondlinger L. A.: Antioxi- M.E., Rees S.: Depletion of nitric hexaacetate ester on D-glucose meta-
dant pyrrolidine dithiocarbamate pre- oxide synthase-containing neurons in bolism and insulinotropic action in rat
vents defective bradykinin-stimulated the diabetic retina: reversal by amino- pancreatic islets 1109
calcium accumulation and nitric oxide guanidine 1419 Serino R., Ueta Y., Tokunaga M., Hara
activity following exposure of endo- Russell J.C., Dolphin P. J.,G raham S.E., Y., Nomura M., Kabashima N., Shi-
thelial cells to elevated glucose con- Amy R.M., Brindley D.N.: Improve- buya I., Hattori Y., Yamashita H.: Up-
centration 806 ment of insulin sensitivity and cardio- regulation of hypothalamic nitric oxide
Vil
synthase gene expression in streptozo- new insulin sensitiser, in restoring im- diabetes mellitus: the homologous do-
tocin-induced diabetic rats 640 paired GLUT4 translocation in adipo- main in coxsackie B virus protein 2C
Sharpe P.C., Yue K.K.M., Catherwood cytes of rats fed a high fat diet 400 and islet autoantigen GAD,, is highly
M.A., McMaster D., Trimble E. R.: The Diabetes Control and Complication conserved in the coxsackie B-like en-
The effects of glucose-induced oxida- Trial Research Group.: The effect of teroviruses and binds to the diabetes
tive stress on growth and extracellular intensive diabetes therapy on mea- associated HLA-DR3 molecule 40
matrix gene expression of vascular sures of autonomic nervous system Wu S.Q., Kwan C. Y., Tang F.: Streptozo-
smooth muscle cells 1210 function in the Diabetes Control and tocin-induced diabetes has differential
Songini M., Bernardinelli L., Clayton D., Complications Trial (DCCT) 416 effects on atrial natriuretic peptide
Montomoli C., Pascutto C., Ghislandi The Eurodiab Ace Study Group and The synthesis in the rat atrium and ventri-
M., Fadda D., Bottazzo GF and the Eurodiab Ace Substudy 2 Study cle: a study by solution-hybridization-
Sardinian IDDM Study Group.: The Group.: Familial Risk of Type I Dia- RNase protection assay 660
Sardinian IDDM Study: 1. Epidemiol- betes in European Children 1151 Yagui K., Shimada F., Mimura M.,
ogy and geographical distribution of Toft-Nielsen M., Madsbad S., Holst J. J.: Hashimoto N., Suzuki Y., Tokuyama
IDDM in Sardinia during 1989 to 1994 Exaggerated secretion of glucagon- Y., Nata K., Tohgo A., [kehata F.,,
221 like peptide-1 (GLP-1) could cause re- Takasawa S., Okamoto H., Makino H.,
Spinas G. A., Laffranchi R., Francoys [., active hypoglycaemia 1180 Saito Y., Kanatsuka A.: A missense
David I., Richter C., Reinecke M.: The Traverso N., Menini S., Cosso L., Odetti mutation in the CD38 gene, a novel
early phase of glucose-stimulated in- P., Albano E., Pronzato M. A., Mari- factor for insulin secretion: association
sulin secretion requires nitric oxide nari U.M.: Immunological evidence with Type II diabetes mellitus in Japa-
292 for increased oxidative stress in diabet- nese subjects and evidence of abnor-
Sugimoto H., Shikata K., Matsuda M.., ic rats 265 mal function when expressed in vitro
Kushiro M., Hayashi Y., Hiragushi K., Tribe R.M., Thomas C.R., Poston L.: 1024
Wada J., Makino H.: Increased expres- Flow-induced dilatation in isolated re- Yamagishi S., Fujimori H., Yonekura H.,
sion of endothelial cell nitric oxide sistance arteries from control and Yamamoto Y., Yamamoto H.: Ad-
synthase (ecNOS) in afferent and glo- streptozotocin-diabetic rats 34 vanced glycation endproducts inhibit
merular endothelial cells is involved in Tuomilehto J., Borch-Johnsen K., Mola- prostacyclin production and induce
glomerular hyperfiltration of diabetic rius A., Forsén T., Rastenyte D., Sarti plasminogen activator inhibitor-1 in
nephropathy 1426 C., Reunanen A.: Incidence of cardio- human microvascular endothelial cells
Suzuki S., Hinokio Y., Ohtomo M., Hirai vascular disease in Type 1| (insulin-de- 1435
M., Hirai A., Chiba M., Kasuga S., Sa- pendent) diabetic subjects with and You S., Gouin E., Sai P.: Spleen cells of
toh Y., Akai H., Toyota T.: The effects without diabetic nephropathy in Fin- non-obese diabetic mice fed with pig
of coenzyme Q,, treatment on mater- land 784 splenocytes display modified prolif-
nally inherited diabetes mellitus and Ueda K., Tanizawa Y., Ishihara H., Kizu- eration and reduced aggressiveness in
deafness, and mitochondrial DNA ki N., Ohta Y., Matsutani A., Oka Y.: vitro against pig islet cells 955
3243 (A to G) mutation 584 Overexpression of mitochondrial Zhu M., Mizuno A., Kuwajima M., Ogi-
Sweeney G., Somwar R., Ramlal T., FAD-linked glycerol-3-phosphate de- no T., Murakami T., Noma Y., Sano T.,
Martin-Vasallo P., Klip A.: Insulin sti- hydrogenase does not correct glucose- Shima K.: Ovarian hormone-induced
mulation of K* uptake in 3T3-L] fi- stimulated insulin secretion from dia- beta-cell hypertrophy contributes to
broblasts involves phosphatidylinositol betic GK rat pancreatic islets 649 the homeostatic control of beta-cell
3-kinase and protein kinase C-zeta Utriainen T., Takala T., Luotolahti M., mass in OLETF female rat, a model of
1199 R6nnemaa T., Laine H., Ruotsalainen Type II diabetes 799
Tack C.J. J.,O ng M.K.E., Lutterman U., Haaparanta M., Nuutila P., Yki- Ziegler D., Weise F., Langen K.-J., Piolot
J.A., Smits P.: Insulin-induced vasodi- Jarvinen H.: Insulin resistance charac- R., Boy C., Hiibinger A., Miiller-Gart-
latation and endothelial function in terizes glucose uptake in skeletal mus- ner H.-W., Gries F. A.: Effect of gly-
obesity/insulin resistance. Effects of cle but not in the heart in NIDDM 555 caemic control on myocardial sympa-
troglitazone 569 Utsunomiya N., Ohagi S., Sanke T., Tat- thetic innervation assessed by
Takeda Y., Gotoh M., Dono K., Nishi- suta H., Hanabusa T., Nanjo K.: Orga- ['I]metaiodobenzylguanidine scinti-
hara M., Grochowiecki T., Kimura F., nization of the human carboxypepti- graphy: a 4-year prospective study in
Yoshida T., Ohta Y., Ota H., Ohzato dase E gene and molecular scanning IDDM patients 443
H., Umeshita K., Takeda T., Matsuura for mutations in Japanese subjects with Zierath J.R., Livingston J.N., Thorne A.,
N., Sakon M., Kayagaki N., Yagita H., NIDDM or obesity 701 Bolinder J., Reynisdottir S., Lonnqvist
Okumura K., Miyasaka M., Monden Valve R., Heikkinen S., Rissanen A., F., Arner P.: Regional difference in in-
M.: Protection of islet allografts trans- Laakso M., Uusitupa M.: Synergistic sulin inhibition of non-esterified fatty
planted together with Fas ligand ex- effect of polymorphisms in uncoupling acid release from human adipocytes:
pressing testicular allografts 315 protein 1 and /-adrenergic receptor relation to insulin receptor phosphory-
Temelkova-Kurktschiev T., Koehler C., genes on basal metabolic rate in obese lation and intracellular signalling
Schaper F., Henkel E., Hahnefeld A., Finns 357 through the insulin receptor substrate-
Fuecker K., Siegert G., Hanefeld M.: Vettor R., Pagano C., Granzotto M., 1 pathway 1343
Relationship between fasting plasma Englaro P., Angeli P., Blum W.F., Fe-
glucose, atherosclerosis risk factors derspil G., Rohner-Jeanrenaud F.,
and carotid intima media thickness in Jeanrenaud B.: Effects of intravenous Rapid communications
non-diabetic individuals 706 neuropeptide Y on insulin secretion
Terasaki J., Anai M., Funaki M., Shibata and insulin sensitivity in skeletal mus- Almind K., Frederiksen S.K., Ahlgren
T., Inukai K., Ogihara T., Ishihara H., cle in normal rats 1361 M.G., Urhammer S., Hansen T., Clau-
Katagiri H., Onishi Y., Sakoda H., Fu- Vreugdenhil G.R., Geluk A., Ottenhoff sen J.O., Pedersen O.: Common amino
kushima Y., Yazaki Y., Kikuchi M., T.H.M., Melchers W.J.G., Roep B.O., acid substitutions in insulin receptor
Oka Y., Asano T.: Role of JTT-501, a Galama J.M.D.: Molecular mimicry in substrate-4 are not associated with
Vill
Type II diabetes mellitus or insulin re- induces regulatory tolerance to insulin Heinemann L., Schmelzeisen-Redeker G
sistance 969 in pre-diabetic mice 237 on behalf of the Non-invasive task
Bédard S., Marcotte B., Marette A.: In- Urhammer S.A., Dalgaard L.T., Sgren- force (N.I.T. F): Non-invasive contin-
sulin inhibits inducible nitric oxide sen T.I. A., Tybjerg-Hansen A., Ech- uous glucose monitoring in Type I dia-
synthase in skeletal muscle cells 1523 wald S.M., Andersen T., Clausen J. O., betic patients with optical glucose sen-
Bellmann K., Kolb H., Rastegar S., Jee P., Pedersen O.: Organisation of the sors 848
Scott F. W.: Potential risk of oral insulin coding exons and mutational screening Leahy J.L., Chen Ch., Rhodes Ch. J.:
with adjuvant for the prevention of of the uncoupling protein 3 gene in How is the insulin content regulated in
Type I diabetes: a protocol effective in subjects with juvenile-onset obesity nondiabetic hyperinsulinaemic, insulin
NOD mice may exacerbate disease in 241 resistant states? Study of spontaneous-
BB rats 844 Urrutia I., Calvo B., Bilbao J.R., the ly hypertensive rats 855
Boeri D., Derchi L. E., Martinoli C., Si- GEPV-N Group., Gastafio L.: Ano- Ozanne S.E., Hales C.N.: Thrifty yes, ge-
moni G., Sampietro L., Storace D., malous behaviour of the 5’ insulin netic no 485
Ponte L., Calvi C., Repetto M., Ro- gene polymorphism allele 814: lack of Pickup J.C., Crook M.A.: Is Type II dia-
baudo C., Maiello M.: Intrarenal arte- association with Type I diabetes in betes mellitus a disease of the innate
riosclerosis and impairment of kidney Basques 1121 immune system? 1241
function in NIDDM subjects 121 Yamada K., Yuan X., Ishiyama S., Ichi- Reaven G.M.: Hypothesis: muscle insu-
Ellis T.M., Ottendorfer E., Jodoin E., kawa F., Kohno S., Shoji S., Hayashi H., lin resistance is the (“not-so”) thrifty
Salisbury P.J., She J. X., Schatz D.A., Nonaka K.: Identification of a single genotype 482
Atkinson M. A.: Cellular immune re- nucleotide insertion polymorphism in Sawicki P.T .: Do ACE inhibitors offer
sponses to f casein: elevated in but not the upstream region of the insulin pro- specific benefits in the antihyperten-
specific for individuals with Type I moter factor-1 gene: an association sive treatment of diabetic patients?
diabetes mellitus 731 study with diabetes mellitus 603 598
Fioretto P., Stehouwer C.D. A., Mauer Zierler K.: Does insulin-induced increase
M., Chiesura-Corona M., Brocco E., in the amount of plasma membrane
Carraro A., Bortoloso E., Hinsbergh Short communications GLUTs quantitatively account for in-
VWM van., Crepaldi G., Nosadini R.: sulin-induced increase in glucose up-
Heterogeneous nature of microalbu- De Mattia G., Bravi M.C., Laurenti O., take? 724
minuria in NIDDM: studies of endo- Cassone-Faldetta M., Proietti A., De
thelial function and renal structure Luca O., Armiento A., Ferri C.: Re-
233 duction of oxidative stress by oral N- Letters to the editors
Hounsom L., Horrobin D.F., Tritschler acetyl-L-cysteine treatment decreases
H., Corder R., Tomlinson D.R.: A li- plasma soluble vascular cell adhesion Baba T., Drenckhan M., Neugebauer S.,
poic acid-gamma linolenic acid conju- molecule-1 concentrations in non-ob- Klein H.: Effect of angiotensin IT and
gate is effective against multiple indi- ese, non-dyslipidaemic, normotensive, bradykinin on insulin-stimulated tyro-
ces of experimental diabetic neuropa- patients with non-insulin-dependent sine kinase activity of insulin receptor
thy 839 diabetes 1392 741
Ishii H., Tada H., Isogai S.: An aldose re- Kalidas K., Wasson J., Glaser B., Meyer Bakker S.J.L., Dekker J.M., Heine R.J.:
ductase inhibitor prevents glucose-in- J.M., Duprat L.J., White M.F,, Per- Association between HbA,, and HDL-
duced increase in transforming growth mutt M. A.: Mapping of the human in- cholesterol independent of fasting tri-
factor-£ and protein kinase C activity sulin receptor substrate-2 gene, identi- glycerides in a Caucasian population:
in cultured human mesangial cells 362 fication of a linked polymorphic mar- evidence for enhanced cholesterol es-
Ju Q., Edelstein D., Brendel M.D., ker and linkage analysis in families ter transfer induced by in vivo glyca-
Brandhorst D., Brandhorst H., Bretzel with Type II diabetes: no evidence for tion 1249
R.G., Brownlee M.: Transduction of a major susceptibility role 1389 Bartsocas C.S., Dacou-Voutetakis C.,
non-dividing adult human pancreatic Mller A.M., Dalgaard L.T., Pociot F., Damianaki D., Karayanni C. H., Kas-
beta cells by an integrating lentiviral Nerup J., Hansen T., Pedersen O.: Mu- siou C., Qadreh A., Theodoridis C. H.,
vector 736 tations in the hepatocyte nuclear fac- Tsoka H., Green A., for the Eurodiab
Kellerer M., Mushack J., Seffer E., Mis- tor-l1a gene in Caucasian families ori- ACE G1 Group.: Epidemiology of
chak H., Ullrich A., Haring H. U.: Pro- ginally classified as having Type I dia- childhood IDDM in Athens: trends
tein kinase C isoforms a, 6 and 6 re- betes 1528 in incidence for the years 1989-1995
quire insulin receptor substrate-1 to 245
inhibit the tyrosine kinase activity of Berger M., Mihlhauser I., Sawicki P.T .:
the insulin receptor in human kidney For debates Possible risk of sulphonylureas in the
embryonic cells (HEK 293 cells) 833 treatment of non-insulin-dependent
Millet L., Vidal H., Larrouy D., Andreelli Amiel S. A.: Cognitive function testing in diabetes mellitus and coronary artery
F., Laville M., Langin D.: mRNA ex- studies of acute hypoglycaemia: rights disease 744
pression of the long and short forms of and wrongs? 713 Braun J., Donner H., Plock K., Rau H.,
uncoupling protein-3 in obese and lean Fanelli C.G., Pampanelli S., Porcellati F, Usadel K.H., Badenhoop K.: Heredi-
humans 829 Bolli G.B.: Shift of glycaemic thresh- tary hemochromatosis mutations
Radziuk J., Pye S., Bradley B., Braaten J., olds for cognitive function in hypogly- (HFE) in patients with Type IT dia-
Vignati L., Roach P., Bowsher R., Di- caemia unawareness in humans 720 betes mellitus 983
Marchi R., Chance R.: Basal activity Gambaro G., Skrha J., Ceriello A.: Gly- Chuang L.-M., Lee K.-C., Huang C.-N.,
profiles of NPH and [N‘-palmitoyl Lys cosaminoglycan therapy for long-term Wu H.-P., Tai T.-Y., Lin B.J.: Role of
(B29) |h uman insulins in subjects with diabetic complications? 975 S20G mutation of amylin gene in insu-
IDDM 116 Gazis A., Page S.R., Cockcroft J. R.: lin secretion, insulin sensitivity, and
Tian J., Chan C., Kaufman D.L.: Insulin ACE inhibitors, diabetes and cardio- Type II diabetes mellitus in Taiwanese
selectively primes Th2 responses and vascular disease 595 patients 1250
IX
Fasching P.: Possible risk of sulphonyl- Murakami K., Ishibashi S., Yoshida Y., Wilson C., Nelson R., Nicolson M., Prat-
ureas in the treatment of non-insulin- Yamada N., Akanuma Y.: Lipopro- ley R.: Plasma leptin concentrations:
dependent diabetes mellitus and cor- tein(a) as a coronary risk factor in Ja- no difference between diabetic Pima
onary artery disease 743 panese patients with Type II (non-in- Indians with and without nephropathy
Gasic S., Wagner O.F., Fasching P., Lud- sulin-dependent) diabetes mellitus. 861
wig C., Veitl M., Kapiotis S., Jilma B.: Relation with apolipoprotein(a) phe- Winkler G., Dworak O., Salamon F., Sal-
Fosinopril decreases levels of soluble notypes 1397 amon D., Speer G., Cseh K.: Increased
vascular cell adhesion molecule-1 in Odawara M.., Sasaki K., Tachi Y., Yama- interleukin-12 plasma concentrations
Type II diabetic patients suffering shita K.: Endothelial nitric oxide syn- in both, insulin-dependent and non-in-
from microalbuminuria 980 thase gene polymorphism and coro- sulin-dependent diabetes mellitus 488
Hirai M., Suzuki S., Hinokio Y., Chiba M., nary heart disease in Japanese Winkler G., Salamon F., Salamon D.,
Kasuga S., Hirai A., Toyota T.: Group NIDDM 365 Speer G., Simon K., Cseh K.: Elevated
specific component protein genotype is Paquis-Flucklinger V., Vialettes B., Va- serum tumour necrosis factor-alpha le-
associated with NIDDM in Japan 742 gue P., Canivet B., Hieronimus S., Oli- vels can contribute to the insulin resis-
Kaneto H., Ikeda M., Kishimoto M., lida ver C., Pellissier J.F., Sauniéres A., tance in Type II (non-insulin-depen-
M., Hoshi A., Watarai T., Kubota M., Desnuelle C.: Importance of searching dent) diabetes and in obesity 860
Kajimoto Y., Yamasaki Y., Hori M.: for mtDNA defects in patients with Yamada K., Yuan X., Ishiyama S., Nona-
Dramatic recovery of counter-regula- diabetes and hearing deficit 740 ka K.: Glucose tolerance in Japanese
tory hormone response to hypoglycae- Rumberger J., Gottschalk W., Yarnall D., subjects with S20G mutation of the
mia after intensive insulin therapy in Nguyen Q., Burns D., Durcan M.: amylin gene 125
poorly controlled Type I diabetes mel- Identification of genetic markers to
litus 982 20 NIDDM candidate genes by radia-
Katsilambros., Tentolouris N., Linos A., tion hybrid analysis 366 EASD News section
Stambulis E., Papageorgiou K.: Blood Sakane N., Yoshida T., Yoshioka K., Na-
pressure and heart rate changes during kamura Y., Umekawa T., Kogure A.., Fh 2 25, 2b 29 ot 4a
leaning forward in normal and in Takakura Y., Kondo M.: Trp64Arg
NIDDM subjects 126 mutation of / ,-adrenoceptor gene is
Kogure A., Yoshida T., Sakane N., Ume- associated with diabetic nephropathy Erratum
kawa T., Takakura Y., Kondo M.: Sy- in Type II diabetes mellitus 1533
nergic effect of polymorphisms in un- Sharp P.S., Al-Mrayat M., Valabhji J., 489, 608
coupling protein 1 and /,-adrenergic Kearney T. M., Wright D.: Serum levels
receptor genes on weight loss in obese of vascular endothelial growth factor
Japanese 1399 in diabetic subjects: the relationship Author index
Larsson H., Berglund G., Lindgarde F.,, with blood pressure 984
Ahrén B.: Comparison of ADA and Sgvik O., Njglstad P., Fglling I., Sagen J., 1540
WHO criteria for diagnosis of diabetes Cockburn B.N., Bell G.1I.: Hyperexcit-
and glucose intolerance 1124 ability to sulphonylurea in MODY 3
Lobefalo L., Verrotti A., Mastropasqua 607 Subject index
L., Chiarelli F., Della Loggia G., Sundkvist G., Tydén G., Karlsson F.A.,
Morgese G., Galienga P. E.: Colour and Bolinder J.: Islet autoimmunity before 1545
achromatic perimetry in diabetic chil- and after pancreas transplantation in
dren without retinopathy 247 patients with Type I diabetes mellitus
Meynial-Denis D., Foucat L., Mignon M., 1532 Contents of Volume 41
Chavaroux A., Prugnand J., Bayle G., Wasada T., Katsumori K., Watanabe C.,
Ronou J. P., Arnal M.: Despite similar Kawahara R., Iwamoto Y.: Insulin I-IX
rates of alanine release, fasting and sensitivity is inversely correlated with
diabetes affect de novo alanine syn- plasma cholesteryl ester transfer pro-
thesis differently 606 tein (CETP) 1251