Table Of Content

II Copyright Submission of a manuscript implies: that the work described has not been published before (except in the form of an abstract); that it is not under consideration for publication elsewhere; that its publication has been approved by all coauthors, if any, as well as by the re- sponsible authorities at the institute where the work has been carried out; that, if and when the manuscript is accepted for publication, the authors agree to automatic transfer of the copyright to the publisher and that the manuscript will not be published elsewhere in any language without the consent of the copyright holders. All articles published in this journal are protected by copyright, which covers the exclusive rights to reproduce and distribute the article (e. g., as offprints), as well as all translation rights. No material published in this journal my be reproduced photographically or stored on microfilm, in electronic data bases, video disks, etc., without first obtaining written permission from the publisher. The use of general descriptive names, trade names, trademarks, etc., in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. While the advice and information in this journal is believed to be true and accurate at the date of its going to press, neither the authors, the editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no war- ranty, express or implied, with respect to the material contained herein. Special regulations for photocopies in the USA. Photocopies may be made for personal or in-house use beyond the limitations stipulat- ed under Section 107 or 108 of U.S. Copyright Law, provided a fee is paid. All fees should be paid to the Copyright Clearance Center, Inc., 21 Congress Street, Salem, MA 01970, USA, stating the ISSN 0012-186X, the volume, and the first and last page numbers of each article copied. The copyright owner’s consent does not include copying for general distribution, promotion, new works, or resale. In these cases, specific written permission must first be obtained from the publisher. Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest Printed in Germany by aprinta Wemding © Springer-Verlag Berlin Heidelberg 1996 Springer-Verlag GmbH & Co.KG, D-14197 Berlin, Germany Contents Full instructions to authors Maassen, J. A., T. Kadowaki: Maternally Auer, R.N., L.G. Anderson: Hypogly- inherited diabetes and deafness: a new caemic brain damage: effect of a dihy- A5, A6 diabetes subtype 375 dropyridine calcium channel antago- Mandrup-Poulsen, T.: The role of inter- nist in rats 129 leukin-1 in the pathogenesis of IDDM Bagdade, J. D., M. Ritter, P. V. Sub- Editorial 1005 baiah: Marine lipids normalize Storlien, L.H., L.A. Baur, A. D. Kriketos, cholesteryl ester transfer in IDDM Ferrannini, E.: Concerns of an Editor for D.A. Pan, G.J. Cooney, A.B. Jenkins, 487 the Diabetologist 1 G.D. Calvert, L. V.Campbell: Dietary Bahr, M., M.Spelleken, M. Bock, M. von Zimmet, P., P. Lefebvre: The global fats and insulin action 621 Holtey, R. Kiehn, J. Eckel: Acute and NIDDM epidemic. Treating the dis- chronic effects of troglitazone (CS- ease and ignoring the symptom 1247 045) on isolated rat ventricular cardio- Originals myocytes 766 Bakillah, A., A.M. Grigorova-Borsos, Review Abe, H., A. Bandai, M. Makuuchi, R. Guillot, P. Urios, M. Sternberg: Ef- Y. Idezuki, M. Nozawa, T. Oka, J. Osu- fect of an aldose reductase inhibitor on Berger, M.: To bridge science and patient ga, Y. Watanabe, T. Inaba, N. Yamada: type IV collagen production by human care in diabetes 749 Hyperinsulinaemia accelerates accu- endothelial cells cultured in high glu- Eizirik, D. L., M.Flodstrém, A. E. Karl- mulation of cholesterol ester in aorta cose 641 sen, N. Welsh: The harmony of the of rats with transplanted pancreas Becker, D.J., B. Reul, A. T. Ozcelikay, spheres: inducible nitric oxide synthase 1276 J.P. Buchet, J.-C. Henquin, S. M. Bri- and related genes in pancreatic beta Agardh, D., L.K. Gaur, E. Agardh, chard: Oral selenate improves glucose cells 875 M. Landin-Olsson, C.-D. Agardh, homeostasis and partly reverses ab- Landgraf, R.: Impact of pancreas A. Lernmark: HLA-DQB1*0201/0302 normal expression of liver glycolytic transplantation on diabetic second- is associated with severe retinopathy in and gluconeogenic enzymes in diabetic ary complications and quality of life patients with IDDM 1313 rats 3 1415 Ahrén, B., G. Sundkvist, H. Mulder, Bianda, T. L., M.A. Hussain, A. Keller, Leibowitz, G., E.Cerasi: Sulphonylurea F Sundler: Blockade of muscarinic Y. Glatz, O. Schmitz, J.S. Christiansen, treatment of NIDDM patients with transmission increases the frequency K.G.M.M. Alberti, E.R. Froesch: In- cardiovascular disease: a mixed bles- of diabetes after low-dose alloxan sulin-like growth factor-I in man en- sing? 503 challenge in the mouse 383 hances lipid mobilization and oxida- II Copyright Submission of a manuscript implies: that the work described has not been published before (except in the form of an abstract); that it is not under consideration for publication elsewhere; that its publication has been approved by all coauthors, if any, as well as by the re- sponsible authorities at the institute where the work has been carried out; that, if and when the manuscript is accepted for publication, the authors agree to automatic transfer of the copyright to the publisher and that the manuscript will not be published elsewhere in any language without the consent of the copyright holders. All articles published in this journal are protected by copyright, which covers the exclusive rights to reproduce and distribute the article (e. g., as offprints), as well as all translation rights. No material published in this journal my be reproduced photographically or stored on microfilm, in electronic data bases, video disks, etc., without first obtaining written permission from the publisher. The use of general descriptive names, trade names, trademarks, etc., in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. While the advice and information in this journal is believed to be true and accurate at the date of its going to press, neither the authors, the editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no war- ranty, express or implied, with respect to the material contained herein. Special regulations for photocopies in the USA. Photocopies may be made for personal or in-house use beyond the limitations stipulat- ed under Section 107 or 108 of U.S. Copyright Law, provided a fee is paid. All fees should be paid to the Copyright Clearance Center, Inc., 21 Congress Street, Salem, MA 01970, USA, stating the ISSN 0012-186X, the volume, and the first and last page numbers of each article copied. The copyright owner’s consent does not include copying for general distribution, promotion, new works, or resale. In these cases, specific written permission must first be obtained from the publisher. Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest Printed in Germany by aprinta Wemding © Springer-Verlag Berlin Heidelberg 1996 Springer-Verlag GmbH & Co.KG, D-14197 Berlin, Germany Contents Full instructions to authors Maassen, J. A., T. Kadowaki: Maternally Auer, R.N., L.G. Anderson: Hypogly- inherited diabetes and deafness: a new caemic brain damage: effect of a dihy- A5, A6 diabetes subtype 375 dropyridine calcium channel antago- Mandrup-Poulsen, T.: The role of inter- nist in rats 129 leukin-1 in the pathogenesis of IDDM Bagdade, J. D., M. Ritter, P. V. Sub- Editorial 1005 baiah: Marine lipids normalize Storlien, L.H., L.A. Baur, A. D. Kriketos, cholesteryl ester transfer in IDDM Ferrannini, E.: Concerns of an Editor for D.A. Pan, G.J. Cooney, A.B. Jenkins, 487 the Diabetologist 1 G.D. Calvert, L. V.Campbell: Dietary Bahr, M., M.Spelleken, M. Bock, M. von Zimmet, P., P. Lefebvre: The global fats and insulin action 621 Holtey, R. Kiehn, J. Eckel: Acute and NIDDM epidemic. Treating the dis- chronic effects of troglitazone (CS- ease and ignoring the symptom 1247 045) on isolated rat ventricular cardio- Originals myocytes 766 Bakillah, A., A.M. Grigorova-Borsos, Review Abe, H., A. Bandai, M. Makuuchi, R. Guillot, P. Urios, M. Sternberg: Ef- Y. Idezuki, M. Nozawa, T. Oka, J. Osu- fect of an aldose reductase inhibitor on Berger, M.: To bridge science and patient ga, Y. Watanabe, T. Inaba, N. Yamada: type IV collagen production by human care in diabetes 749 Hyperinsulinaemia accelerates accu- endothelial cells cultured in high glu- Eizirik, D. L., M.Flodstrém, A. E. Karl- mulation of cholesterol ester in aorta cose 641 sen, N. Welsh: The harmony of the of rats with transplanted pancreas Becker, D.J., B. Reul, A. T. Ozcelikay, spheres: inducible nitric oxide synthase 1276 J.P. Buchet, J.-C. Henquin, S. M. Bri- and related genes in pancreatic beta Agardh, D., L.K. Gaur, E. Agardh, chard: Oral selenate improves glucose cells 875 M. Landin-Olsson, C.-D. Agardh, homeostasis and partly reverses ab- Landgraf, R.: Impact of pancreas A. Lernmark: HLA-DQB1*0201/0302 normal expression of liver glycolytic transplantation on diabetic second- is associated with severe retinopathy in and gluconeogenic enzymes in diabetic ary complications and quality of life patients with IDDM 1313 rats 3 1415 Ahrén, B., G. Sundkvist, H. Mulder, Bianda, T. L., M.A. Hussain, A. Keller, Leibowitz, G., E.Cerasi: Sulphonylurea F Sundler: Blockade of muscarinic Y. Glatz, O. Schmitz, J.S. Christiansen, treatment of NIDDM patients with transmission increases the frequency K.G.M.M. Alberti, E.R. Froesch: In- cardiovascular disease: a mixed bles- of diabetes after low-dose alloxan sulin-like growth factor-I in man en- sing? 503 challenge in the mouse 383 hances lipid mobilization and oxida- Il tion induced by a growth hormone Ceriello, A., C. Taboga, L. Tonutti, Doria, A., J. Lee, J.H. Warram, A.S. Kro- pulse 961 R. Giacomello, L. Stel, E. Motz, M. Pi- lewski: Diabetes susceptibility at Bijlstra, P.J., J. A. Lutterman, risi: Post-meal coagulation activation IDDM2 cannot be positively mapped F.G.M. Russel, T. Thien, P. Smits: In- in diabetes mellitus: the effect of acar- to the VNTR locus of the insulin gene teraction of sulphonylurea derivatives bose 469 594 with vascular ATP-sensitive potassium Chaillous, L., S. Darquy, S. Maugendre, Dorrestijn, J., D.M.Ouwens, N. Van den channels in humans 1083 A.-S. Rivereau, G. Reach, P. Sai: Xeno- Berghe, J.L. Bos, J. A. Maassen: Ex- Bolinder, J., S.Sjéberg, P. Arner: Stimu- grafts of porcine islets immunoprotec- pression of a dominant- negative Ras lation of adipose tissue lipolysis fol- ted in hollow fibres reduce the inci- mutant does not affect s:imulation of lowing insulin-induced hypoglycaemia: dence of diabetes in non-obese diabet- glucose uptake and glycogen synthesis evidence of increased beta-adrenocep- ic mice 523 by insulin 558 tor-mediated lipolytic response in Chowdhury, T. A., M.J. Dronsfield, Eaton, R.P., C. Qualls, J. Bicknell, IDDM 845 S. Kumar, S.L. C. Gough, S. P.G ibson, W.L. Sibbitt Jr, M. K.K ing, R. H. Grif- Bortoluzzi, M.-N., M.Cormont, N. Gau- A. Khatoon, F. MacDonald, fey: Structure-function relationships tier, E.V an Obberghen, Y. Le Mar- B.R. Rowe, D.B. Dunger, J.D. Dean, within peripheral nerves in diabetic chand-Brustel: GTPase activating pro- S.J. Davies, J. Webber, P.R. Smith, neuropathy: the hydration hypothesis tein activity for Rab4 is enriched in the P.M ackin, S.M. Marshall, D. Adu, 439 plasma membrane of 3T3-L1 adipo- P.J.M. Morris, J. A. Todd, A. H. Bar- Eriksson, J. W., P. Lonnroth, B.I. Posner, cytes. Possible involvement in the reg- nett, A.J.M. Boulton, S.C. Bain: A. Shaver, C. Wesslau, U. P.G. Smith: A ulation of Rab4 subcellular localiza- Examination of two genetic poly- stable peroxovanadium compound tion 899 morphisms within the renin-angioten- with insulin-like action in human fat Bowes, S. B., T.R. Hennessy, A.M. Um- sin system: no evidence for an asso- cells 235 pleby, J.J. Benn, N.C. Jackson, ciation with nephropathy in IDDM Eriksson, K.-F., F. Lindgarde: Poor physi- M. A. Boroujerdi, P.H.Sé6nksen, 1108 cal fitness, and impaired early insulin C. Lowy: Measurement of glucose me- Christie, A. W., D.K.T. McCormick, response but late hyperinsulinaemia, tabolism and insulin secretion during N.Emmison, F. B. Kraemer, as predictors of NIDDM in middle- normal pregnancy and pregnancy com- K.G.M.M. Alberti, S.J. Yeaman: Me- aged Swedish men 573 plicated by gestational diabetes 976 chanism of anti-lipolytic action of aci- Falorni, A., M. Ackefors, C. Carlberg, Brandt, R., C. Landmesser, L. Vogt, pimox in isolated rat adipocytes 45 T. Daniels, B. Persson, J. Robertson, B. Hehmke, R. Hanschke, J. Kasbohm, Clément, K., M. E. Pueyo, M. Vaxillaire, A.Lernmark: Diagnostic sensitivity K. Hartmann, B.J ager, S. Krantz, B. Rakotoambinina, F. Thuillier, of immunodominant epitopes of glu- D. Michaelis: Differential expression Ph. Passa, Ph. Froguel, J.-J. Robert, tamic acid decarboxylase (GAD65) of fructosyllysine-specific receptors on G. Velho: Assessment of insulin sensi- autoantibodies in childhood IDDM monocytes and macrophages and pos- tivity in glucokinase-deficient subjects 1091 sible pathophysiological significance 82 Ferrer, J., J. Wasson, L. Salkoff, 1140 Cohen, M.P., R.S. Clements, J. A. Cohen, M.A. Permutt: Cloning of human pan- Bressler, P., S.R. Bailey, M. Matsuda, C. W. Shearman: Prevention of decline creatic islet large conductance Ca’ * - R. A. DeFronzo: Insulin resistance and in renal function in the diabetic db/db activated K * channel (hSlo) cDNAs: coronary artery disease 1345 mouse 270 evidence for high levels of expression Burg, M. P.M. van der, O. R. Guicherit, Damert, A., B. Leibiger, I. B. Leibiger: in pancreatic islets and identification J.B.M.J. Jansen, M. Frolich, Dual function of the intron of the rat of a flanking genetic marker 891 C.B.H.W. Lamers, H.H. P. J. Lemkes, insulin I gene in regulation of gene ex- Forster, H.G., P.M.ter Wee, T. C. Hoh- J. A. Bruijn, H.G.Gooszen: Function pression 1165 man, M. Epstein: Impairment of affer- and survival of intrasplenic islet auto- Deerochanawong, C., C. Putiyanun, ent arteriolar myogenic responsiveness grafts in dogs 37 M. Wongsuryrat, S. Serirat, P. Jinayon: in the galactose-fed rat is prevented by Buschard, K., T. Horn, K. Aaen, K. Josef- Comparison of National Diabetes tolrestat 907 sen, H. Persson, P. Fredman: Presence Data Group and World Health Orga- Frittitta, L., J. Youngren, R. Vigneri, of sulphatide (3’-sulphogalactosylcera- nization criteria for detecting gesta- B. A. Maddux, V. Trischitta, I. D. Gold- mide) in pericytes in the choroid layer tional diabetes mellitus 1070 fine: PC-1 content in skeletal muscle of of the eye: sharing of this glycolipid Dheen, S.T., K. Rajkumar, L. J. Murphy: non-obese, non-diabetic subjects: rela- autoantigen with islets of Langerhans Effects of insulin-like growth factors tionship to insulin receptor tyrosine 658 (IGF) on pancreatic islet function in kinase and whole body insulin sensi- Cameron, N.E., M. A. Cotter: Compari- IGF binding protein-1 transgenic mice tivity 1190 son of the effects of ascorbyl y -linole- 1249 Gabazza, E.C., H. Takeya, H. Deguchi, nic acid and y-linolenic acid in the Dimitriadis, E., M. Griffin, P.C ollins, Y. Sumida, O. Taguchi, K. Murata, correction of neurovascular deficits in A.J ohnson, D. Owens, G. H. Tomkin: K. Nakatani, Y. Yano, M. Mohri, diabetic rats 1047 Lipoprotein composition in NIDDM: M. Sata, T. Shima, J. Nishioka, K. Suzu- Cameron, N.E., M. A. Cotter, T. C. Hoh- effects of dietary oleic acid on the ki: Protein C activation in NIDDM man: Interactions between essential composition, oxidisability and function patients 1455 fatty acid, prostanoid, polyol pathway of low and high density lipoproteins Genovese, S., R. Bonfanti, E. Bazziga- and nitric oxide mechanisms in the 667 luppi, V. Lampasona, E. Benazzi, neurovascular deficit of diabetic rats Doi, Y., H. Yoshizumi, M. Yoshinari, E. Bosi, G. Chiumello, E. Bonifacio: 172 K. lino, M. Yamamoto, K. Ichikawa, Association of [A-2 autoantibodies Caprio, S., M. Bronson, R.S. Sherwin, M. Iwase, M. Fujishima: Association with HLA DR4 phenotypes in IDDM F. Rife, W. V. Tamborlane: Co-exis- between a polymorphism in the angio- 1223 tence of severe insulin resistance and tensin-converting enzyme gene and Goor, Y., G. Peer, A. laina, M. Blum, hyperinsulinaemia in pre-adolescent microvascular complications in Japa- Y. Wollman, T. Chernihovsky, D. Sil- obese children 1489 nese patients with NIDDM 97 verberg, S. Cabili: Nitric oxide in IV ischaemic acute renal failure of strep- Hussain, M.J .,M . Peakman, H. Gallati, mark: Association between HLA and tozotocin diabetic rats 1036 S.S.S. Lo, M. Hawa, G.C. Viberti, islet cell antibodies in diabetic patients Gregersen, S., J.L. Thomsen, B. Brock, P.J. Watkins, R. D. G. Leslie, D. Verga- with a mitochondrial DNA mutation K. Hermansen: Endothelin-1 stimu- ni: Elevated serum levels of macro- at base pair 3243 1196 lates insulin secretion by direct action phage-derived cytokines precede and Kolb, H., U. W6rz-Pagenstert, R. Klee- on the islets of Langerhans in mice accompany the onset of IDDM 60 mann, H. Rothe, P. Rowsell, F. W. Scott: 1030 Igel, M., H. Kainulainen, A. Brauers, Cytokine gene expression in the BB Gugliucci, A., M. Bendayan: Renal fate W. Becker, L. Herberg, H.-G. Joost: rat pancreas: natural course and im- of circulating advanced glycated end Long-term and rapid regulation of ob pact of bacterial vaccines 1448 products (AGE): evidence for reab- mRNA levels in adipose tissue from Kolterman, O.G., S. Schwartz, C. Corder, sorption and catabolism of AGE-pep- normal (Sprague Dawley rats) and ob- B. Levy, L. Klaff, J. Peterson, A. Gott- tides by renal proximal tubular cells ese (db/db mice, fa/fa rats) rodents lieb: Effect of 14 days’ subcutaneous 149 758 administration of the human amylin Haffner, S.M., H. Miettinen, S. P.G askill, Tino, K., M. Yoshinari, M. Yamamoto, analogue, pramlintide (AC137), on an M.P. Stern: Decreased insulin action K. Kaku, Y. Doi, K. Ichikawa, intravenous insulin challenge and re- and insulin secretion predict the de- M. Iwase, M. Fujishima: Effect of gly- sponse to a standard liquid meal in pa- velopment of impaired glucose toler- cated collagen on proliferation of hu- tients with IDDM 492 ance 1201 man smooth muscle cells in vitro 800 Koopmans, S. J., H.C. M. Sips, Hammes, H.-P., A. Weiss, D. Fiihrer, Isami, S., H. Kishikawa, E. Araki, M. Ue- H.M.J. Krans, J. K. Radder: Pulsatile H. J. Kramer, C. Papavassilis, F. Grim- hara, K. Kaneko, T. Shirotani, M. To- intravenous insulin replacement in minger: Acceleration of experimental daka, S. Ura, S. Motoyoshi, K. Matsu- streptozotocin-diabetic rats is more ef- diabetic retinopathy in the rat by ome- moto, N. Miyamura, M. Shichiri: Bra- ficient than continuous delivery: ef- ga-3 fatty acids 251 dykinin enhances GLUT4 transloca- fects on glycaemic control, insulin- Hanaire-Broutin, H., B. Sallerin-Caute, tion through the increase of insulin re- mediated glucose metabolism and li- M.F. Poncet, M.T auber, R.B astide, ceptor tyrosine kinase in primary adi- polysis 391 J.J. Chalé, R. Rosenfeld, J. P.T auber: pocytes: evidence that bradykinin sti- Kumar, S., A. J.M. Boulton, H. Beck- Effect of intraperitoneal insulin deliv- mulates the insulin signalling pathway Nielsen, F. Berthezene, M. Muggeo, ery on growth hormone binding pro- 412 B. Persson, G. A. Spinas, S. Donoghue, tein, insulin-like growth factor (IGF)- Iwahashi, H., T. Hanafusa, Y. Eguchi, S. Lettis, P. Stewart-Long, for the Tro- I, and IGF-binding protein-3 in H. Nakajima, J. Miyagawa, N. Itoh, glitazone study group: Troglitazone, an IDDM 1498 K. Tomita, M. Namba, M. Kuwajima, insulin action enhancer, improves me- Hayashi, T., M. Okamoto, Y. Yoshimasa, T. Noguchi, Y. Tsujimoto, Y. Matsuza- tabolic control in NIDDM patients G. Inoue, K. Yamada, S. Kono, M. Shi- wa: Cytokine-induced apoptotic cell 701 gemoto, J. Suga, H. Kuzuya, K. Nakao: death in a mouse pancreatic beta-cell La Selva, M., E. Beltramo, F. Pagnozzi, Insulin-induced activation of phos- line: inhibition by Bcl-2 530 E. Bena, P. A. Molinatti, G.M. Molinat- phoinositide 3-kinase in Fao cells 515 Jehle, P.M., M.P. Lutz, R. D. Fussgaen- ti, M. Porta: Thiamine corrects delayed Hellstrém, L., D. Langin, S. Reynisdottir, ger: High affinity binding sites for replication and decreases production M. Dauzats, P. Arner: Adipocyte lipo- proinsulin in human IM-9 lympho- of lactate and advanced glycation end- lysis in normal weight subjects with blasts 421 products in bovine retinal and human obesity among first-degree relatives Johansson, B.-L., K. Borg, E. Fernqvist- umbilical vein endothelial cells cul- 921 Forbes, T. Odergren, S. Remahl, tured under high glucose conditions Hoffstedt, J., H. Wahrenberg, A. Thorne, J. Wahren: C-peptide improves auto- 1263 F. Lénnqvist: The metabolic syndrome nomic nerve function in IDDM pa- Lahdenpera, S., M.Syvanne, J. Kahri, is related to 6 ;-adrenoceptor sensitiv- tients 687 M.-R. Taskinen: Regulation of low- ity in visceral adipose tissue 838 Jones, D.B., I. Crosby: Proliferative lym- density lipoprotein particle size distri- Holmiang, A., E. Jennische, P. Bj6rntorp: phocyte responses to virus antigens bution in NIDDM and coronary dis- Rapid formation of capillary endothe- homologous to GAD65 in IDDM ease: importance of serum triglycer- lial cells in rat skeletal muscle after ex- 1318 ides 453 posure to insulin 206 Jérneskog, G., N. Egberg, B. Fagrell, Larsson, H., B. Ahrén: Failure to ade- Holness, M.J., M.C. Sugden: Suboptimal K. Fatah, B. Hessel, H. Johnsson, quately adapt reduced insulin sensitiv- protein nutrition in early life later in- K. Brismar, M. Blombiack: Altered ity with increased insulin secretion in fluences insulin action in pregnant rats properties of the fibrin gel structure in women with impaired glucose toler- 12 patients with IDDM 1519 ance 1099 Horowitz, M., K.M. Cunningham, Kasperska-Czyzyk, T., K. Jedynasty, Leibowitz, G., N. Weintrob, A. Pikarsky, J.M. Wishart, K. L. Jones, N. W. Read: R.R. Bowsher, D. L. Holloway, I. Stra- Z. Josefsberg, H. Landau, B. Glaser, The effect of short-term dietary sup- dowska, K.Stepien, R. Nowaczyk, C.N. Hales, E. Cerasi: Normal proinsu- plementation with glucose on gastric W.Szymezak, A. Czyzyk: Difference in lin processing despite beta-cell dys- emptying of glucose and fructose and the influence of maternal and paternal function in persistent hyperinsulinae- oral glucose tolerance in normal sub- NIDDM on pancreatic beta-cell activ- mic hypoglycaemia of infancy (nesi- jects 481 ity and blood lipids in normoglycaemic dioblastosis) 1338 Huppertz, C., C. Schwartz, W. Becker, non-diabetic adult offspring 831 Li, W., X. Liu, M. Yanoff, S. Cohen, X. Ye: F. Horn, P.C. Heinrich, H.-G. Joost: Kibenge, M.T., C. B. Chan: Effect of Cultured retinal capillary pericytes die Comparison of the effects of insulin, adrenalectomy on the development of by apoptosis after an abrupt fluctua- PDGF, interleukin-6, and interferon-y a pancreatic islet lesion in fa/fa rats tion from high to low glucose levels: a on glucose transport in 3T3-L1 cells: 190 comparative study with retinal capil- lack of cross-talk between tyrosine ki- Kobayashi, T., Y. Oka, H. Katagiri, A. Fa- lary endothelial cells 537 nase receptors and JAK/STAT path- lorni, A. Kasuga, I. Takei, K. Naka- Lindsay, R.S., R.M. Lindsay, B.J .W ad- ways 1432 nishi, T. Murase, K. Kosaka, A. Lern- dell, J.R.Seckl: Prenatal glucocorti- Vv coid exposure leads to offspring hy- chronic diabetes induced by streptozo- IDDM: effects on HbA,,, risk for se- perglycaemia in the rat: studies with tocin in rats 649 vere and mild hypoglycaemia, status of the 118-hydroxysteroid dehydrogen- Myrsén, U., B. Keymeulen, D.G. Pipe- counterregulation and awareness of ase inhibitor carbenoxolone 1299 leers, F. Sundler: Beta cells are impor- hypoglycaemia 677 Majer, M., D.M. Mott, H. Mochizuki, tant for islet innervation: evidence Pandolfi, A., L. lacoviello, F. Capani, J.C. Rowles, O. Pedersen, W. C. Know- from purified rat islet-cell grafts 54 E. Vitacolonna, M. B. Donati, A. Con- ler, C. Bogardus, M. Prochazka: Asso- Nelson, R.G., D.J. Pettitt, M. P.de Cour- soli: Glucose and insulin independent- ciation of the glycogen synthase locus ten, R.L. Hanson, W.C. Knowler, ly reduce the fibrinolytic potential of on 19q13 with NIDDM in Pima In- P.H. Bennett: Parental hypertension human vascular smooth muscle cells in dians 314 and proteinuria in Pima Indians with culture 1425 Mally, M.I., V. Cirulli, A. Hayek, NIDDM 433 Paquot, N., Ph. Schneiter, E. Jéquier, T. Otonkoski: ICA69 is expressed New, J. P., J. P.C anavan, A. Flyvbjerg, R. Gaillard, P.J .L efébvre, A. Scheen, equally in the human endocrine and G. Hamon, R. W. Bilous, S. M. Mar- L.Tappy: Effects of ingested fructose exocrine pancreas 474 shall: Renal enlargement and insulin- and infused glucagon on endogenous Markussen, J., S. Havelund, P. Kurtzhals, like growth factor-1 accumulation in glucose production in obese NIDDM A.S. Andersen, J. Halstrgm, E. Hasse- the Wistar rat model of experimental patients, obese non-diabetic subjects, lager, U. D. Larsen, U. Ribel, L. Schaf- diabetes is not prevented by angioten- and healthy subjects 580 fer, K. Vad, I. Jonassen: Soluble, fatty sin converting enzyme inhibition 166 Patterson, C.C., D.J. Carson, D.R. Had- acid acylated insulins bind to albumin Nijpels, G., C. Popp-Snijders, P.J. Kos- den on behalf of the Northern Ireland and show protracted action in pigs 281 tense, L. M. Bouter, R.J .H eine: Fasting Diabetes Study Group: Epidemiology Matsushima, M., K. Shimizu, M. Maruya- proinsulin and 2-h post-load glucose of childhood IDDM in Northern ma, R. Nishimura, R. E. LaPorte, levels predict the conversion to Ireland 1989-1994: Low incidence N.T ajima for the Diabetes Epidemiol- NIDDM in subjects with impaired glu- in areas with highest population den- ogy Research International (DERI) cose tolerance: The Hoorn Study 113 sity and most household crowding US-Japan Mortality Study Group: So- Nolan, C.J., J. Proietto: The set point for 1063 cioeconomic and behavioural risk fac- maternal glucose homeostasis is low- Pelikanova, T., I. Smrékova, J. Krizova, tors for mortality of individuals with ered during late pregnancy in the rat: J. Stiibrna, V. Lanska: Effects of insulin IDDM in Japan: population-based the role of the islet beta-cell and liver and lipid emulsion on renal haemody- case-control study 710 785 namics and renal sodium handling in McCormack, L. J., D. K. Nagi, Nyholm, B., A. Mengel, S. Nielsen, IDDM patients 1074 M.H. Stickland, M. W. Mansfield, Ch. Skjerbek, N. Mller, Petersen, J.S., T. Dyrberg, P.D, amm, V. Mohamed-Ali, J.S. Yudkin, K.G.M.M. Alberti, O. Schmitz: Insulin C. Kiihl, L. Mglsted-Pedersen, K. Bu- W.C. Knowler, P. J. Grant: Promoter resistance in relatives of NIDDM pa- schard: GAD65 autoantibodies in wo- (4G/5G) plasminogen activator inhibi- tients: the role of physical fitness and men with gestational or insulin depen- tor-1 genotype in Pima Indians: rela- muscle metabolism 813 dent diabetes mellitus diagnosed dur- tionship to plasminogen activator inhi- Odetti, P., N. Traverso, L. Cosso, G. No- ing pregnancy 1329 bitor-1 levels and features of the insu- berasco, M. A. Pronzato, U. M. Mari- Pettitt, D.J., K.M. Venkat Narayan, lin resistance syndrome 1512 nari: Good glycaemic control reduces R.L. Hanson, W.C. Knowler: Inci- McEvoy, R.C., N.M. Thomas, F. Greig, oxidation and glycation end-products dence of diabetes mellitus in women S. Larson, I. Vargas-Rodriguez, I. Felix, in collagen of diabetic rats 1440 following impaired glucose tolerance E. Wallach, P. Rubinstein, F.C. Goetz, Ohtomo, Y., A. Aperia, B. Sahlgren, in pregnancy is lower than following F Ginsberg-Fellner: Anti-islet autoan- B.-L. Johansson, J. Wahren: C-peptide impaired glucose tolerance in the non- tibodies detected by monoclonal anti- stimulates rat renal tubular Na*, K *- pregnant state 1334 body 1A2: further studies suggesting a ATPase activity in synergism with Pfeffer, F., M. A. Nauck, S. Benz, role in the pathogenesis of IDDM neuropeptide Y 199 A. Gwodzinski, R. Zink, M. Biising, 1365 Orskov, L., J.F. Bak, N. Abildgard, H.-D. Becker, U.T. Hopt: Determi- Mooy, J.M., P. A. Grootenhuis, H.de O. Schmitz, F. Andreasen, E. A. Rich- nants of a normal (versus impaired) Vries, P. J. Kostense, C. Popp-Snijders, ter, C.Skjerbek, N. Mgller: Inhibition oral glucose tolerance after combined L.M. Bouter, R. J. Heine: Intra-indivi- of muscle glycogen synthase activity pancreas-kidney transplantation in dual variation of glucose, specific insu- and non-oxidative glucose disposal IDDM patients 462 lin and proinsulin concentrations mea- during hypoglycaemia in normal man Piatti, P.M., L.D. Monti, S.N. Davis, sured by two oral glucose tolerance 226 M. Conti, M. D. Brown, G. Pozza, tests in a general Caucasian popula- Orskov, L., J.J. Holst, J. Mgller, C. Ors- K.G.M.M. Alberti: Effects of an acute tion: the Hoorn Study 298 kov, N. Mgller, K.G.M.M. Alberti, decrease in non-esterified fatty acid Moriya, T., S.Ohno, K. Tanaka, Y. Fujii, O.Schmitz: GLP-1 does not acutely af- levels on muscle glucose utilization Y. Yajima: Effects of early insulin fect insulin sensitivity in healthy man and forearm indirect calorimetry in treatment on ultrastructural changes 1227 lean NIDDM patients 103 of glomeruli in diabetic rats revealed Ott, A., R. P. Stolk, A. Hofman, F. van Piddington, R., J. Joyce, P. Dhanasekaran, by the quick-freezing and deep-etching Harskamp, D.E. Grobbee, L. Baker: Diabetes mellitus affects method 632 M.M.B. Breteler: Association of dia- prostaglandin E, levels in mouse em- Mihlhauser, I., K. Prange, P. T. Sawicki, betes mellitus and dementia: The Rot- bryos during neurulation 915 R. Bender, A. Dworschak, W. Schaden, terdam Study 1392 Plater, M.E., I. Ford, M.T. Dent, M. Berger: Effects of dietary sodium Pampanelli, S., C. Fanelli, C. Lalli, FE. Preston, J.D. Ward: Elevated von on blood pressure in IDDM patients M. Ciofetta, P. Del Sindaco, M. Lepore, Willebrand factor antigen predicts de- with nephropathy 212 F. Modarelli, A.M. Rambotti, L. Epifa- terioration in diabetic peripheral nerve Mulder, H., B. Ahrén, F. Sundler: Islet no, A. Di Vincenzo, L. Bartocci, B. An- function 336 amyloid polypeptide (amylin) and in- nibale, P. Brunetti, G. B. Bolli: Long- Polderman, K.H., C.D. A.Stehouwer, sulin are differentially expressed in term intensive insulin therapy in G.J.van Kamp, L.J.G.Gooren: Effects VI of insulin infusion on endothelium-de- Mast cells and type VIII collagen in impairs receptor recycling and insulin rived vasoactive substances 1284 human diabetic nephropathy 1215 processing in cultured Epstein-Barr Pricci, F., G. Pugliese, P. Mené, G. Romeo, Russo, A., R. Fraser, M. Horowitz: The virus-transformed lymphocytes from G. Romano, G. Galli, A. Casini, effect of acute hyperglycaemia on insulin-resistant subjects 289 C.M. Rotella, V. Di Mario, F. Pugliese: small intestinal motility in normal sub- Sims, T. J., L.M. Rasmussen, H. Oxlund, Regulatory role of eicosanoids in ex- jects 984 A.J. Bailey: The role of glycation tracellular matrix overproduction in- Sagara, M., J.Satoh, R. Wada, S. Yagiha- cross-links in diabetic vascular stiffen- duced by long-term exposure to high shi, K. Takahashi, M. Fukuzawa, ing 946 glucose in cultured rat mesangial cells G. Muto, Y. Muto, T. Toyota: Inhibition Spraul, M., E. Ravussin, A. D. Baron: 1055 of development of peripheral neuro- Lack of relationship between muscle Pugliese, G., F. Pricci, N. Locuratolo, pathy in streptozotocin-induced dia- sympathetic nerve activity and skeletal G. Romeo, G. Romano, S. Giannini, betic rats with N-acetylcysteine 263 muscle vasodilation in response to in- B. Cresci, G. Galli, C.M. Rotella, Saker, P.J., A. T.H attersley, B. Barrow, sulin infusion 91 U. Di Mario: Increased activity of the M.S. Hammersley, J.-A. McLellan, Stephenson, J.M., P. Kempler, P. Cavallo insulin-like growth factor system in Y.-M. D. Lo, R.J .O lds, M. D. Gillmer, Perin, J.H. Fuller and the EURO- mesangial cells cultured in high glu- R.R. Holman, R.C. Turner: High pre- DIAB IDDM Complications Study cose conditions. Relation to glucose- valence of a missense mutation of the Group: Is autonomic neuropathy a risk enhanced extracellular matrix produc- glucokinase gene in gestational dia- factor for severe hypoglycaemia? The tion 775 betic patients due to a founder-effect EURODIAB IDDM Complications Pulido, N., A. Casla, A. Suarez, B. Casa- in a local population 1325 Study 1372 nova, F. J. Arrieta, A. Rovira: Sulpho- Sanchez-Quesada, J.L., A. Pérez, Stiimpel, F., T. Kucera, R. Bazotte, nylurea stimulates glucose uptake in A. Caixas, J. Ord6nmez-Llanos, G. Car- G. P. Piischel: Loss of regulation by rats through an ATP-sensitive K* reras, A. Payés, F. Gonzalez-Sastre, sympathetic hepatic nerves of liver channel dependent mechanism 22 A.de Leiva: Electronegative low den- metabolism and haemodynamics in Quinn, M., M.C. Angelico, J.H. Warram, sity lipoprotein subform is increased in chronically streptozotocin-diabetic A.S.Krolewski: Familial factors deter- patients with short-duration IDDM rats 161 mine the development of diabetic ne- and is closely related to glycaemic Suzuki, N., K.Svensson, U. J. Eriksson: phropathy in patients with IDDM 940 control 1469 High glucose concentration inhibits Rasmussen, L. M., T. Ledet: Aortic Sawicki, P.T., R. Dahne, R. Bender, migration of rat cranial neural crest atherosclerosis in diabetes mellitus is M. Berger: Prolonged QT interval as a cells in vitro 401 associated with an insertion/deletion predictor of mortality in diabetic ne- Tanizawa, Y., A. Matsubara, K. Ueda, polymorphism in the angiotensin I- phropathy 77 H. Katagiri, A. Kuwano, J. Ferrer, converting enzyme gene. No relation Sbraccia, P., M.D’Adamo, F. Leonetti, M.A. Permutt, Y.Oka: A human pan- between the polymorphism and aortic S. Caiola, P.lozzo, A. Giaccari, creatic islet inwardly rectifying potas- collagen content 696 A. Buongiorno, G. Tamburrano: sium channel: cDNA cloning, determi- Reichard, P., M. Pihl, U. Rosenqvist, Chronic primary hyperinsulinaemia is nation of the genomic structure and J. Sule: Complications in IDDM are associated with altered insulin recep- genetic variations in Japanese NIDDM caused by elevated blood glucose level: tor mRNA splicing in muscle of pa- patients 447 The Stockholm Diabetes Intervention tients with insulinoma 220 Taylor, R. W., R.L. Printz, M. Armstrong, Study (SDIS) at 10-year follow up Scheen, A.J., J.Sturis, K.S. Polonsky, D.K.Granner, K.G.M.M. Alberti, 1483 E. Van Cauter: Alterations in the ul- D.M. Turnbull, M. Walker: Variant se- Rewers, M., T. L. Bugawan, J. M. Norris, tradian oscillations of insulin secretion quences of the Hexokinase II gene in A. Blair, B. Beaty, M. Hoffman, and plasma glucose in aging 564 familial NIDDM 322 R.S. McDuffie, Jr., R.F Hamman, Schnell, O., D. Muhr, S. Dresel, K. Tatsch, Tesfaye, S., L.K.Stevens, J.M.Stephen- G. Klingensmith, G.S. Eisenbarth, A.G. Ziegler, M. Haslbeck, E. Stand: son, J.H. Fuller, M. Plater, C. lonescu- H.A. Erlich: Newborn screening for Autoantibodies against sympathetic Tirgoviste, A. Nuber, G. Pozza, HLA markers associated with IDDM: ganglia and evidence of cardiac sym- J.D. Ward and the EURODIAB Diabetes Autoimmunity Study in the pathetic dysinnervation in newly diag- IDDM Study Group: Prevalence of Young (DAISY) 807 nosed and long-term IDDM patients diabetic peripheral neuropathy and its Reynet, C., C.R. Kahn, M. R. Loeken: 970 relation to glycaemic control and po- Expression of the gene encoding gly- Seissler, J., N.G. Morgenthaler, P. Achen- tential risk factors: the EUJRODIAB cogen phosphorylase is elevated in bach, E. F Lampeter, D. Glawe, IDDM Complications Study 1377 diabetic rat skeletal muscle and is M. Payton, M. Christie, W. A. Scher- Tesfaye, S., R. Malik, N. Harris, J. J. Jaku- regulated by insulin and cyclic AMP baum and the DENIS Study Group: bowski, C. Mody, I.G. Rennie, 183 Combined screening for autoantibo- J.D. Ward: Arterio-venous shunting Rice, T., A. Nadeau, L. Pérusse, C. Bou- dies to [A-2 and antibodies to glutamic and proliferating new vessels in acute chard, D.C. Rao: Familial correlations acid decarboxylase in first degree rela- painful neuropathy of rapid glycaemic in the Québec family study: cross-trait tives of patients with IDDM 1351 control (insulin neuritis) 329 familial resemblance for body fat with Sellins, K.S., D.P. Gold, D. Bellgrau: Re- Thaiss, F., G. Wolf, N. Assad, G. Zahner, plasma glucose and insulin 1357 sistance to tolerance induction in the R.A.K. Stahl: Angiotensinase A gene Rosenberg, L., A. I. Vinik, G. L. Pitten- diabetes-prone Biobreeding rat as one expression and enzyme activity in iso- ger, R. Rafaeloff, W. P. Duguid: Islet- manifestation of abnormal responses lated glomeruli of diabetic rats 275 cell regeneration in the diabetic ham- to superantigens 28 The Microalbuminuria Captopril Study ster pancreas with restoration of nor- Sesti, G., R. D’Alfonso, M. D. Vargas Group: Captopril reduces the risk of moglycaemia can be induced by a local Punti, A.N. Tullio, Y. Y. Liu, M. Federi- nephropathy in IDDM patients with growth factor(s) 256 ci, P. Borboni, M. A. Marini, R. Lauro, microalbuminuria 587 Riiger, B. M., Q. Hasan, N.S. Greenhill, A. Fusco: Delayed intracellular disso- Toeller, M., A. Klischan, G. Heitkamp, P. F. Davis, P.R. Dunbar, T. J. Neale: ciation of the insulin-receptor complex W. Schumacher, R. Milne, A. Buyken, Vil B. Karamanos, F. A. Gries and the Viana, M., E. Herrera, B. Bonet: Terato- nergic-receptor mutations to insulin EURODIAB IDDM Complications genic effects of diabetes mellitus in the resistance and obesity respectively Study Group: Nutritional intake of rat. Prevention by vitamin E 1041 with no evidence for glycogen synthase 2868 IDDM patients from 30 centres Vincent, M.F., M.D. Erion, H. E. Gruber, gene mutations 1505 in Europe 929 G. Van den Berghe: Hypoglycaemic Ziegler, D., P.Schadewaldt, A. Pour Mir- Tomonari, A., K. Yoshimoto, M. Tanaka, effect of AICAriboside in mice 1148 za, R. Piolot, B.Schommartz, M. Rein- H. Iwahana, J. Miyazaki, M. Itakura: Virsolvy-Vergine, A., G. Salazar, R. Sil- hardt, H. Vosberg, H. Brésicke, GGAAAT motifs play a major role in lard, L. Denoroy, V. Mutt, D. Bataille: F.A..Gries: ['C]Octanoic acid breath transcriptional activity of the human Endosulfine, endogenous ligand for test for non-invasive assessment of insulin gene in a pancreatic islet beta- the sulphonylurea receptor: isolation gastric emptying in diabetic patients: cell line MIN6 1462 from porcine brain and partial struc- validation and relationship to gastric Tosaki, A., T. Pali, M.-T. Droy-Lefaix: tural determination of the a form 135 symptoms and cardiovascular auto- Effects of Ginkgo biloba extract and Wang, R.N., L. Bouwens, G. Kléppel: nomic function 823 preconditioning on the diabetic rat Beta-cell growth in adolescent and Zierath, J.R., A. Handberg, M. Tally, myocardium 1255 adult rats treated with streptozotocin H. Wallberg-Henriksson: C-peptide Trevisan, R., M.R. Cipollina, E. Duner, during the neonatal period 548 stimulates glucose transport in isolated M. Trevisan, R. Nosadini: Abnormal Weston, P.J., R.B. Panerai, A. McCul- human skeletal muscle independent of Na*/H* antiport activity in cultured lough, P.G. McNally, M. A. James, insulin receptor and tyrosine kinase fibroblasts from NIDDM patients with J.F. Potter, H. Thurston, J.D. Swales: activation 306 hypertension and microalbuminuria Assessment of baroreceptor-cardiac Zierath, J.R., L.He, A.Guma, E. Ode- 717 reflex sensitivity using time domain gaard Wahlstrém, A. Klip, H. Wall- Trovati, M., P. Massucco, L. Mattiello, analysis in patients with IDDM and berg-Henriksson: Insulin action on F Cavalot, E.M. Mularoni, the relation to left ventricular mass in- glucose transport and plasma mem- A. W. Hahn, G. Anfossi: Studies on the dex 1385 brane GLUT4 content in skeletal influence of insulin on cyclic adenosine Winlove, C. P., K.H. Parker, N.C. Avery, muscle from patients with NIDDM monophosphate in human vascular A.J. Bailey: Interactions of elastin and 1180 smooth muscle cells: dependence on aorta with sugars in vitro and their ef- Ziv, E., R. Kalman, K. Hershkop, V. Bar- cyclic guanosine monophosphate and fects on biochemical and physical ash, E. Shafrir, H. Bar-On: Insulin re- modulation of catecholamine effects properties 1131 sistance in the NIDDM model 1156 Worm, D., A. Handberg, E. Hoppe, Psammomys obesus in the normogly- Ura, S., E. Araki, H. Kishikawa, T. Shiro- J. Vinten, H. Beck-Nielsen: Decreased caemic, normoinsulinaemic state 1269 tani, M. Todaka, S. Isami, S. Shimoda, skeletal muscle phosphotyrosine phos- R. Yoshimura, K. Matsuda, S. Mo- phatase (PTPase) activity towards in- toyoshi, N. Miyamura, C.R. Kahn, sulin receptors in insulin-resistant Rapid communications M. Shichiri: Molecular scanning of the Zucker rats measured by delayed insulin receptor substrate-1 (IRS-1) Europium fluorescence 142 Earle, K.A., M. Mishra, A. Morocutti, gene in Japanese patients with Worm, D., J. Vinten, P.S taehr, J. E. Hen- D. Barnes, E. Stephens, J. Chambers, NIDDM: identification of five novel riksen, A. Handberg, H. Beck-Nielsen: G.C. Viberti: Microalbuminuria as a polymorphisms 600 Altered basal and insulin-stimulated marker of silent myocardial ischaemia Utriainen, T., S. Makimattila, A. Virka- phosphotyrosine phosphatase in IDDM patients 854 maki, R. Bergholm, H. Yki-Jarvinen: (PTPase) activity in skeletal muscle Fonteles, M.C., L.C. Huang, J. Larner: Dissociation between insulin sensitiv- from NIDDM patients compared with Infusion of pH 2.0 p-chiro-inositol gly- ity of glucose uptake and endothelial control subjects 1208 can insulin putative mediator normali- function in normal subjects 1477 Yagihashi, N., N. Nishida, H. Geuk Seo, zes plasma glucose in streptozotocin Vaccaro, O., G. Imperatore, V. Iovino, N. Taniguchi, S. Yagihashi: Expression diabetic rats at a dose equivalent to in- C. Iovine, A. A. Rivellese, G. Riccardi: of nitric oxide synthase in macula den- sulin without inducing hypoglycaemia Does impaired glucose tolerance pre- sa in streptozotocin diabetic rats 793 731 dict hypertension? A prospective ana- Yamada, K., N. Takane-Gyotoku, Fujisawa, T., H. Ikegami, E. Yamato, lysis 70 X. Yuan, F. Ichikawa, C. Inada, K. Non- K. Takekawa, Y. Nakagawa, Y. Hama- Valensise, H., Y. Y. Liu, M. Federici, aka: Mouse islet cell lysis mediated by da, T. Oga, H. Ueda, M. Shintani, D. Lauro, D. Dell’anna, C. Romanini, interleukin-1-induced Fas 1306 M. Fukuda, T. Ogihara: Association of G. Sesti: Increased expression of low- Yamagata, K., J. Takeda, S. Menzel, Trp64Arg mutation of the 63-adrener- affinity insulin receptor isoform and X. Chen, S. Eng, L.R. Lim, P. Concan- gic-receptor with NIDDM and body insulin/insulin-like growth factor-I hy- non, C. L. Hanis, R.S. Spielman, weight gain 349 brid receptors in term placenta from N.J .C ox, G.I. Bell: Searching for Koefoed Theil, P., T. Hansen, M. Larsen, insulin-resistant women with gesta- NIDDM susceptibility genes: studies O. Pedersen, H. Lund-Andersen: Lens tional hypertension 952 of genes with triplet repeats expressed autofluorescence in increased in newly Veiga-da-Cunha, M., L. Z. Xu, Y.-H. Lee, in skeletal muscle 725 diagnosed patients with NIDDM 1524 D. Marotta, S. J. Pilkis, E. Van Schaftin- Yamato, E., H. Ikegami, J.-I. Miyazaki, Li, L.S., F Lénnqvist, H. Luthman, P. Ar- gen: Effect of mutations on the sensi- T. Ogihara: Identification of genes ner: Phenotypic characterization of the tivity of human beta-cell glucokinase regulated by glucose in a pancreatic Trp64Arg polymorphism in the beta,- to liver regulatory protein 1173 beta-cell line by a new method for adrenergic receptor gene in normal Veves, A., V.M. Donaghue, M. R. Sar- subtraction of mRNA 1293 weight and obese subjects 857 now, J.M. Giurini, D.R. Campbell, Zhang, Y., N. Wat, I.M. Stratton, Malaisse, W.J., L. Ladriére, T.-M. Zhang, F. W. LoGerfo: The impact of reversal M.G. Warren-Perry, M. Orho, I. Verbruggen, R. Willem: Enzyme-to- of hypoxia by revascularization on the L.Groop, R.C. Turner: UKPDS 19: enzyme channelling of symmetric peripheral nerve function of diabetic Heterogeneity in NIDDM: separate Krebs cycle intermediates in pancrea- patients 344 contributions of IRS-1 and £3-adre- tic islet cells 990 Vill Malmstrém, R., M.-R. Taskinen, Paolisso, G., D. Giugliano: Oxidative Dahlquist, G., L.Gothefors: Response S.-L. Karonen, H. Yki-Jarvinen: Insulin stress and insulin action: is there a re- from the authors 502 increases plasma leptin concentrations lationship? 357 DeSilva, M.G., H.-S. Jun, J.-W. Yoon, in normal subjects and patients with Phillips, D.I. W.: Insulin resistance as a A.L. Notkins, M.S. Lan: Autoantibo- NIDDM 993 programmed response to fetal under- dies to IA-2 not detected in NOD mice Rothe, H., V. Burkart, A. Faust, H. Kolb: nutrition 1119 or BB rats 1237 Interleukin-12 gene expression is asso- Pickkers, P., M.Schachter, A. D. Hughes, Ebeling, P., J. A. Tuominen, V. A. Koivis- ciated with rapid development of dia- M.D. Feher, P.S. Sever: Thiazide-in- to: Insulin analogues and carcinoma of betes mellitus in non-obese diabetic duced hyperglycaemia: a role for cal- the breast 124 mice 119 cium-activated potassium channels? Fasching, P., W. Waldhausl, O. F. Wagner: Roy, S., M. Lorenzi: Early biosynthetic 861 Elevated circulating adhesion mole- changes in the diabetic-like retinopa- Porta, M.: Endothelium: the main actor cules in NIDDM - potential mediators thy of galactose-fed rats 735 in the remodelling of the retinal mi- in diabetic macroangiopathy 1242 Sainsbury, A., I. Cusin, P. Doyle, F. Roh- crovasculature in diabetes 739 Foulis, A. K.: Interferon-alpha and ner-Jeanrenaud, B. Jeanrenaud: Intra- Purdy, L. P., B. E. Metzger: Influences of IDDM: comment 127 cerebroventricular administration of the intrauterine metabolic environ- Fujisawa, T., H. Ikegami, E. Yamato, neuropeptide Y to normal rats increa- ment on adult disease: what may we T. Ogihara: Response from the au- ses obese gene expression in white adi- infer from size at birth? 1126 thors 1410 pose tissue 353 Smits, P.: Role of potassium channels in Fujisawa, T., H. Ikegami, Y. Kawaguchi, Sakura, H., N. Wat, V. Horton, H. Millns, the modulation of insulin release 865 T. Ogihara: Response from the au- R.C. Turner, F.M. Ashcroft: Sequence Sternberg, F., C. Meyerhoff, F. J. Mennel, thors 1412 variations in the human Kir6.2 gene, a H. Mayer, F. Bischof, E. F. Pfeiffer: Ilonen, J., H. Reijonen, M. Knip, O. Si- subunit of the beta-cell ATP-sensitive Does fall in tissue glucose precede fall mell: Population-based genetic screen- K-channel: no association with in blood glucose? 609 ing for IDDM susceptibility as a source NIDDM in white Caucasian subjects Tooke, J. E.: Endothelium: the main actor of HLA-genotyped control subjects or evidence of abnormal function or choreographer in the remodelling of 123 when expressed in vitro 1233 the retinal microvasculature in dia- Imagawa, A., N. Itoh, T. Hanafusa, Shintani, M., H. Ikegami, E. Yamato, betes? 745 M. Waguri, M. Kuwajima, Y. Matsuza- Y. Kawaguchi, T. Fujisawa, Y. Nakaga- Yudkin, J.S.: Assessing the evidence on wa: Antibodies to glutamic acid de- wa, Y. Hamada, H. Ueda, T. Miki, aspirin in diabetes mellitus. Gemini or carboxylase induced by interferon- T. Ogihara: A novel microsatellite Libra; lumping or splitting; surrogate alpha therapy for chronic viral hepa- polymorphism in the human OB gene: or hard; low or high; interventionist or titis 126 a highly polymorphic marker for link- nihilist 1407 Jaksch, M., S. Hofmann, K. D. Gerbitz: age analysis 1398 Glucagon receptor gene mutation in Suzuki, Y., T. Muramatsu, M. Taniyama, NIDDM 248 Y. Atsumi, R. Kawaguchi, S. Higuchi, Letters to the editors Kiln, M.R.: Treatment of patients with K. Hosokawa, T. Asahina, C. Murata, human insulin 248 K. Matsuoka: Association of aldehyde Awata, T., T. Izumida, C. Kikuchi, S. Ka- Klein, H.H.: Response from the authors dehydrogenase with inheritance of tayama: Response from the authors 249 NIDDM 1115 373 Knowler, W.C.: Association of Trp64Arg Barthelow Classen, J., D.C. Classen: Vac- mutation of the 63-adrenergic recep- cines modulate IDDM 500 tor gene with NIDDM 1411 For debates Baum, H., M. Peakman, M.N. Norazmi, Lam, K.S.L.: Response from the authors D. Vergani: Molecular mimicry and the 368 Bouchard, C.: The causes of obesity: ad- T-cell repertoire 246 Lam, K.S.L., I. J. Lauder: Response from vances in molecular biology but stag- Bender, R.: The effect of cholesterol- the authors 369 nation on the genetic front 1532 lowering therapy on the progression Lan, M.S., W.S. Modi, H. Xie, A. L.N ot- Caumo, A., P.V icini, C. Cobelli: Is the of diabetic nephropathy is unproved kins: Assignment of the IA-2 gene en- minimal model too minimal? 997 368 coding an autoantigen in IDDM to Ceriello, A., E. Motz: Prevention of vas- Berlini, C., M. Maioli, P. Fresu, G. Tonolo, chromosome 2q35 1001 cular events in diabetes mellitus: which M. Pirastu, M. Maioli: A new missense Lanne, T., A.Rydén Ahlgren: Increased “antithrombotic” therapy? 1405 mutation in the glucokinase gene in an arterial stiffness in IDDM women -— Cimminiello, C., M. Milani: Diabetes Italian Mody family 1413 methodological considerations 871 mellitus and peripheral vascular dis- Bognetti, E., A. Zoja, F Meschi, Lehmann, E. D., K.D. Hopkins, ease: is aspirin effective in preventing P. L. Paesano, G. Chiumello: Relation- R.G. Gosling: Increased aortic stiff- vascular events? 1402 ship between kidney volume, microal- ness in women with NIDDM 870 Cominacini, L., U. Garbin, V. Lo Cascio: buminuria and duration of diabetes Lithner, F.:: Diabetes mellitus and Alz- The need for a ‘free radical initiative’ mellitus 1409 heimer’s disease 1242 364 Ceriello, A., M. Pirisi: Response from the Lorini, R., M. Vanelli: Normal values of Eriksson, U.J.: Lifelong consequences of authors 1003 first-phase insulin response to intrave- metabolic adaptations in utero? 1123 Cominacini, L., A. Fratta Pasini, U. Gar- nous glucose in healthy Italian chil- Guerre-Millo, M., B. Staels, J. Auwerx: bin, V. Lo Cascio: Response from the dren and adolescents 370 New insights into obesity genes 1528 authors 869 Martin, S., V. Lampasona, M. Dosch, Lénnroth, P.: Can hypoglycaemia be pre- Cominacini, L., U.Garbin, A. Fratta Pa- M. Pietropaolo: Islet cell autoantigen dicted before its onset? 613 sini, V. Lo Cascio: Increased levels of 69 antibodies in IDDM 747 Maggs, D.: Can hypoglycaemia be pre- plasma ELAM-1, ICAM-1 and Mizota, M., Y. Uchigata, S. Moriyama, dicted before its onset? (Comment) VCAM-1 in NIDDM: possible role of K. Tokunaga, N. Matsuura, J. Miura, 615 oxidized LDL 1244 T. Juji, Y. Omori: Age-dependent asso- IX ciation of HLA-A24 in Japanese for quantitative analysis of mRNA by in patients with NIDDM: the Munich IDDM patients 371 reverse transcriptase-polymerase chain General Practitioner Project 1540 Meller, N., J. Frystyk, C. Skjerbek, reaction in pancreatic beta cells 747 Vedel, P., J. Obel, F.S. Nielsen, L. E. Bang, H.B. Pedersen, C. Christensen, Yoshioka, K., T. Yoshida, N.Sakane, T. L. Svendsen, O.B. Pedersen, O.Schmitz, A. Gee, A. Gjedde, J. Zapf, T. Umekawa, T. Takahashi, Y. Sakai, H.-H. Parving: Glomerular hyperfil- H. @rskov: Systemic and regional tu- M. Kondo: Association of Trp64Arg tration in microalbuminuric NIDDM mour metabolism in a patient with mutation of the #3-adrenergic recep- patients 1584 non-islet cell tumour hypoglycaemia: tor gene with NIDDM, current and Vestbo, E., E.M. Damsgaard, A. Fr¢land, role of increased levels of free insulin- maximal body mass index 1410 C.E. Mogensen: Birth weight and car- like growth factors 1534 diovascular risk factors in an epide- Momiyama, Y., Y. Suzuki, F Ohsuzu, miological study 1598 Y. Atsumi, K. Matsuoka, M. Kimura: Clinical trial design Subclinical cardiac abnormality in mitochondrial diabetes mellitus, detected Passa, Ph., G. Chatellier on behalf of the Preface by '3I-BMIPP scintigraphy 1412 Diab-Hycar Study Group: The DIAB- Nakagawa, Y., K. Kawai, H. Suzuki, HYCAR study 1662 Mogensen, C.E., R. Turner, C. Berne, S. Ohashi, K. Yamashita: Glucagon- Schrier, R. W., R.O. Estacio, B.J effers: R. Bilous: Improving prognosis in like peptide-1 (7-36) amide and glyco- Appropriate Blood Pressure Control NIDDM patients 1539 gen synthesis in the liver 1241 in NIDDM (ABCD) Trial 1646 Parving, H.-H.: Cholesterol-lowering Steiner for the DAIS Project Group, therapy may retard the progression of Prepared by G.: The Diabetes Athero- Reports diabetic nephropathy 367 sclerosis Intervention Study (DAIS): a Podar, T., A. Solntsev, M. Rahu, M. Lein- study conducted in cooperation with Bertani, T., V.Gambara, G. Remuzzi: salu, J. Tuomilehto, R. E. LaPorte: the World Health Organization 1655 Structural basis of diabetic nephropa- Mortality of childhood-onset IDDM thy in microalbuminuric NIDDM pa- patients in Estonia 1238 tients: a light microscopy study 1625 Purrello, F.: Response from the authors Original studies Birkeland, K.I., U. Rishaug, K. F. Hans- 244 sen, S. Vaaler: NIDDM: a rapid pro- Scott, F. W., X.-B. Li, Y. H. Park, Bijlstra, P.J., J.A.C.J.den Arend, gressive disease. Results from a long- J.-W. Yoon: Response from the J. A. Lutterman, F.G.M. Russel, term, randomised, comparative study authors 619 Th. Thien, P. Smits: Blockade of vascu- of insulin or sulphonylurea treatment Shimada, F., N. Hashimoto, A. Kanatsu- lar ATP-sensitive potassium channels 1629 ka, R.L . Printz, D. K. Granner, H. Ma- reduces the vasodilator response to Ebskov, B., L. Ebskov: Major lower limb kino: Identification of the aminoacid ischaemia in humans 1562 amputation in diabetic patients: devel- polymorphisms in hexokinase II in Ja- Fioretto, P., M. Mauer, E. Brocco, M. Ve- opment during 1982 to 1993 1607 panese subjects 123 lussi, F. Frigato, B. Muollo, M. Samba- Lind, L., C. Berne, B. Andrén, H. Lithell: Sjéholm, A.: Interleukin-1f and GTP- taro, C. Abaterusso, B. Baggio, G. Cre- Relationship between diastolic hyper- binding proteins 243 paldi, R. Nosadini: Patterns of renal tension and myocardial morphology Smith, M.A., L.M. Sayre, G. Perry: Dia- injury in NIDDM patients with micro- and function in elderly males with diabetes mellitus and Alzheimer’s disease: albuminuria 1569 betes mellitus 1603 glycation as a biochemical link 247 Hanefeld, M.., S. Fischer, U. Julius, Nyengaard, J.R., T. F Bendtsen, Steiner, M., K.M. Reinhardt, J. Schulze, U. Schwanebeck, H. Schme- C.E. Mogensen: Low birth weight — is A.D.Blann: Soluble adhesion mole- chel, H.J .Z iegelasch, J. Lindner, The it associated with few and small glo- cules in NIDDM: increased concen- DIS Group: Risk factors for myocar- meruli in normal subjects and NIDDM tration, relation to glycometabolic dial infarction and death in newly de- patients? 1634 control and possible pathophysiologi- tected NIDDM: the Diabetes Inter- Olsen, S., C.E. Mogensen: How often is cal significance 868 vention Study, 11-year follow-up 1577 NIDDM complicated with non-dia- Storlien, L.H., A.B. Jenkins: Laboratory Hypertension in Diabetes Study Group: betic renal disease? An analysis of re- chow-induced insulin resistance: a Hypertension in Diabetes Study IV. nal biopsies and the literature 1638 possible contributor to autoimmune Therapeutic requirements to maintain Rosenkranz, B., V. Profozic, Z. Metelko, type 1 diabetes in rodents 618 tight blood pressure control 1554 V. Mrzljak, C. Lange, V. Malerczyk: Uchigata, Y., M. Mizota, K. Yanagisawa, Nauck, M.A., D. Wollschlager, J. Werner, Pharmacokinetics and safety of glime- Y. Nakagawa, T. Otani, H. Ikegami, J.J. Holst, C. Orskov, W. Creutzfeldt, piride at clinically effective doses in H. Yamada, J. Miura, T. Ogihara, B. Willms: Effects of subcutaneous diabetic patients with renal impair- N. Matsuura, Y. Omori: Large-scale glucagon-like peptide 1 (GLP-1 [7- ment 1617 study of an A-to-G transition at posi- 36 amide]) in patients with NIDDM Schnack, Ch., W. Hoffmann, P. Hopmei- tion 3243 of the mitochondrial gene 1546 er, G.Schernthaner: Renal and meta- and IDDM in Japanese patients 245 Parving, H.-H., F.S. Nielsen, L. E. Bang, bolic effects of 1-year treatment with Vendemiale, G., I. Grattagliano, T. Micel- U.M. Smidt, T. L. Svendsen, ramipril or atenolol in NIDDM pali-Ferrari, L. Cardia, E. Altomare: Ab- J.-W. Chen, M.-A. Gall, P. Rossing: tients with microalbuminuria 1611 normal protein redox status in the lens Macro-microangiopathy and endothe- and vitreous of diabetic subjects 1239 lial dysfunction in NIDDM patients Wittmann, I., J. Nagy: Are insulin resis- with and without diabetic nephropa- Short reviews tance and atherosclerosis the conse- thy 1590 quences of oxidative stress? 1002 Standl, E., B. Balletshofer, B. Dahl, Raine, A.E.G., R. W. Bilous: End-stage Yamato, E., H. Ikegami, K. Takekawa, B. Weichenhain, H. Stiegler, A. H6r- renal disease in NIDDM: a conse- T. Fujisawa, Y. Nakagawa, Y. Hamada, mann, R. Holle: Predictors of 10-year quence of microangiopathy alone? H. Ueda, T. Ogihara: Internal marker macro-vascular and overall mortality 1673 X Rosskamp, R.: Safety aspects of oral hy- Book review Subject index poglycaemic agents 1668 Ward, J. D.: Diabetic neuropathy in 502 1689 NIDDM 1676 Errata Contents of Volume 39 Workshop Report 1004, 1130, 1245, 1414 I Berger, M., J. Kobberling, J. Windeler: Appraisal of effectiveness and potential therapeutic benefit of acar- List of referees bose: a non-consensus conference 873 1679 EASD News Section Author index P29 21, 27. 31, 335.352 48; 67, 73 1684