DIABETES MELLITUS AND HUMAN HEALTH CARE A Holistic Approach to Diagnosis and Treatment TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk DIABETES MELLITUS AND HUMAN HEALTH CARE A Holistic Approach to Diagnosis and Treatment Edited by Anne George, Robin Augustine, and Mathew Sebastian Apple Academic Press TORONTO NEW JERSEY CRC Press Apple Academic Press, Inc Taylor & Francis Group 3333 Mistwell Crescent 6000 Broken Sound Parkway NW, Suite 300 Oakville, ON L6L 0A2 Boca Raton, FL 33487-2742 Canada © 2014 by Apple Academic Press, Inc. Exclusive worldwide distribution by CRC Press an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Version Date: 20131218 International Standard Book Number-13: 978-1-4822-2451-1 (eBook - PDF) This book contains information obtained from authentic and highly regarded sources. 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She did her MBBS (Bachelor of Medicine, Bachelor of Surgery) at Trivandrum Medical College, University of Kerala, India. She ac- quired a DGO (Diploma in Obstetrics and Gynaecology) from the University of Vienna, Austria; Diploma Acupuncture from the University of Vienna; and an MD from Kottayam Medical College, Mahatma Gandhi University, Kerala, India. She has organized several international conferences, is a fellow of the American Medical Society, and is a member of many international organizations. She has five publications to her name and has presented 25 papers. Robin Augustine Mr. Robin Augustine is a research fellow working at International and Interuniver- sity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala, India. He received a bachelor’s degree in botany from the Uni- versity of Calicut, Kerala, India, and a master’s degree in bioengineering from Madurai Kamaraj University, Tamil Nadu, India. He is experienced in develop- ing smart biomaterials such as wound dressings, tissue engineering scaffolds, and suture matrials. Presently he is engaged in the design and development of nano- technology-based smart wound dressing materials for chronic diabetic wounds. He has publications in international journals and conference proceedings in his credit. Mathew Sebastian Mathew Sebastian, MD, has a degree in surgery (1976) with specialization in Ayurveda. He holds several diplomas in acupuncture, neural therapy (pain therapy), manual therapy, and vascular diseases. He was a missionary doctor in Mugana Hospital, Bukoba in Tansania, Africa (1976–1978), and underwent surgi- cal training in different hospitals in Austria, Germany, and India for more than vi About the Editors 10 years. Since 2000 he is the doctor in charge of the Ayurveda and Vein Clinic in Klagenfurt, Austria. At present he is a Consultant Surgeon at Privatclinic Maria Hilf, Klagenfurt. He is a member of the scientific advisory committee of the European Academy for Ayurveda, Birstein, Germany, and the TAM advisory com- mittee (Traditional Asian Medicine, Sector Ayurveda) of the Austrian Ministry for Health, Vienna. He conducted an International Ayurveda Congress in Klagenfurt, Austria, in 2010. He has several publications to his name. CONTENTS List of Contributors ....................................................................................ix List of Abbreviations ................................................................................xiii Preface ...................................................................................................xxiii 1. Diabetes and Health Care: An Overview .................................................1 M. Abhilash and Robin Augustine 2. Withania coagulans Dunal: An Overview on Its Up to Date Antidiabetic Investigations ....................................................................131 S. Hemalatha, Satyendra K. Prasad, Manish Kumar, and S. D. Dubey 3. Evaluation of Total Phenolics and Free Radical Quenching Activity of Glycosmis pentaphylla (Retz.) A. DC. .................................169 Rahul Chandran and Thangaraj Parimelazhagan 4. Antioxidant, Antidiabetic, and Chemical Composition of Syzygium aqueum Leaf Extracts .............................................................................187 Uma D. Palanisamy and Thamilvaani Manaharan 5. Review on Novel 2,4-Thiazolidinedione Derivatives as Potential Therapeutic Agents for Type II Diabetes ..............................................229 Gangadhara Angajala and Radhakrishnan Subashini 6. Molecular Mechanism of S-Oxidation of Anti-Diabetic Thiazolidinedione Class of Drugs: Computational Approaches to Drug Metabolism ................................................................................247 Nikhil Taxak and P. V. Bharatam 7. Role of Wound Dressings in the Management of Chronic and Acute Diabetic Wounds ..........................................................................273 Robin Augustine, Nandakumar Kalarikkal, and Sabu Thomas 8. Recent Advances in Diabetic Foot Care: The Role of Footwear and Orthosis ............................................................................................315 G. Saraswathy, Gautham Gopalakrishna, B. N. Das, and Vijay Viswanathan 9. Temporal Effect of Repeated Stress on Type-2 Experimental Diabetes ...................................................................................................357 Debapriya Garabadu and Sairam Krishnamurthy viii Contents 10. Sugar Rich Diet Induced Insulin Resistance and Alteration in Gut Microflora ................................................................................................393 Prasant Kumar Jena, Shilpa Singh, and Sriram Seshadri 11. Prevalence of Diabetes Mellitus in Patients Presenting With Acute Myocardial Infarction .................................................................431 Meeakshi Narkhede, Satyanarayan Durgam, Harshal Bhitkar, Swapnil Yadav, and Dilip Mhaisekar 12. Development of Therapeutic Strategy to Restore Coronary Microcirculation and VEGF Signaling Cascade in Diabetes: A Novel Approach to Prevent Cardiac Complication in Diabetes .........447 Subrina Jesmin, Arifur Rahman, Abdullah Al Mamun, Farzana Sohael, Shamima Akter, Yoshio Iwashima, Nobutake Shimojo, Naoto Yamaguchi, Michiaki Hiroe, Taro Mizutani, and Masao Moroi Index ........................................................................................................479 LIST OF CONTRIBUTORS M. Abhilash School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam–686560, Kerala, India. Shamima Akter Health and Disease Research Center for Rural Peoples (HDRCRP), Dhaka–1207, Bangladesh. Gangadhara Angajala Chemistry Research Laboratory, School of Advanced Sciences, VIT University, Vellore–632014, Tamil Nadu, India. Robin Augustine International and Interuniversity Centre for Nanoscience and Nanotechnology, Mahatma Gandhi University, Priyadarshini Hills, Kottayam–686560, Kerala, India. P. V. Bharatam Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S. A. S. Nagar, Mohali–160062, Punjab, India. Harshal Bhitkar Department of Medicine, Dr. S. C. Government Medical College, Nanded–431601, Maharashtra, India. Rahul Chandran Bioprospecting Laboratory, Department of Botany, Bharathiar University, Coimbatore–641046, Tamil Nadu, India. B. N. Das Shoe Design and Development Centre, Council of Scientific and Industrial Research–Central Leather Research Institute, Adyar, Chennai–600020, Tamil Nadu, India. S. D. Dubey Department of Dravaguna, Institute of Medical Sciences, Banaras Hindu University, Varanasi–221005, India. Satyanarayan Durgam Department of Medicine, Dr. S. C. Government Medical College, Nanded–431601, Maharashtra, India. Debapriya Garabadu Neurotherapeutics Lab, Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi–221005, India. Gautham Gopalakrishna Shoe Design and Development Centre, Council of Scientific and Industrial Research–Central Leather Research Institute, Adyar, Chennai–600020, Tamil Nadu, India.
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