Diabetes mellitus : a fundamental and clinical text PDF
Preview Diabetes mellitus : a fundamental and clinical text
Diabetes Mellitus A Fundamental and Clinical Text 3rd Edition 2004 Lippincott Williams & Wilkins Philadelphia 530 Walnut Street, Philadelphia, PA 19106 USA, http://www.lww.com/ 0-7817-4097-5 All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form or by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. Printed in the USA Library of Congress Cataloging-in-Publication Data Diabetes mellitus: a fundamental and clinical text / [edited by] Derek LeRoith, Simeon I. Taylor, Jerrold M. Olefsky.—3rd ed. p.; cm. Includes bibliographical references and index. ISBN 0-7817-4097-5 (hc) 1. Diabetes. I. LeRoith, Derek, 1945– II. Taylor, Simeon I. III. Olefsky, Jerrold M. [DNLM: 1. Diabetes Mellitus. 2. Insulin—physiology. WK 810 D536 2003] RC660.D4544 2003 616.4′62—dc21 2003051690 Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of this information in a particular situation remains the professional responsibility of the practitioner. The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug. Some drugs and medical devices presented in this publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice. 10 9 8 7 6 5 4 3 2 1 Editors Derek LeRoith Bethesda, MD Simeon I. Taylor Bristol-Myers Squibb, Princeton, NJ Jerrold M. Olefsky Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA Secondary Editors Brian Brown Acquisitions Editor Erin McMullan Developmental Editor Steven P. Martin Supervising Editor Richard Rothschild, Print Matters, Inc. Production Editor Colin J. Warnock Manufacturing Manager David Levy Cover Designer Compset, Inc. Compositor Quebecor/World Taunton Printer Contributors E. Dale Abel MD, PhD Program in Human Molecular Biology and Genetics, Division of Endocrinology, Metabolism, and Diabetes, University of Utah School of Medicine, Salt Lake City, UT Domenico Accili MD Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY Lydia Aguilar-Bryan MD, PhD Assistant Professor Department of Medicine, Baylor College of Medicine, Houston, TX Faiyaz Ahmad PhD Section on Biochemical Physiology, Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD Rodolfo Alejandro MD Professor of Medicine Diabetes Research Institute, University of Miami School of Medicine, Miami, FL Katrine Almind PhD Joslin Diabetes Center, Harvard Medical School, Boston, MA Ashish Aneja MD Department of Medicine, SUNY Downstate, UHB & Kings County Hospital, Brooklyn, NY Livia S.A. Augustin MSc Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Joseph Avruch MD Physician and Chief Diabetes Unit Massachusetts General Hospital; Professor of Medicine, Harvard Medical School, Boston, MA Jennifer M. Barker MD Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, CO Patricia Barlow RN Senior Clinical Research Associate Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, VA Andrew Becker Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA Henning Beck-Nielsen MD Chief Physician Department of Endocrinology, Odense University Hospital; Professor, Clinic Institute, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark Christine Beebe MS, RD, LD, CDE Adjunct Professor Department of Nutrition and Dietetics, University of Illinois, Chicago, IL Thomas A. Belanger MD Miller Orthopaedic Clinic, Charlotte, NC Graeme I. Bell PhD Professor Departments of Biochemistry and Molecular Biology, Medicine and Human Genetics, University of Chicago, Chicago, IL Guenther Boden MD Director Division of Endocrinology/Diabetes/Metabolism, Temple University Hospital; Professor of Medicine, Temple University School of Medicine, Philadelphia, PA Clifton Bogardus MD Chief PECRB, Clinical Diabetes and Nutrition Section, National Institutes of Health, Phoenix, AZ Susan Bonner-Weir PhD Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA Anne Brenneman MA Research Associate Biostatistics Center, George Washington University, Rockville, MD Stuart J. Brink MD Senior Endocrinologist New England Diabetes and Endocrinology Center (NEDEC), Waltham, MA; Associate Clinical Professor of Pediatrics, Tufts University School of Medicine, Boston, MA Michael Brownlee MD Anita and Jack Saltz Professor of Diabetes Research Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY Joseph Bryan PhD Professor Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX Thomas A. Buchanan MD Professor of Medicine Obstetrics and Gynecology, and Physiology and Biophysics, USC Keck School of Medicine; Attending Physician, LAC and USC Medical Center, General Hospital, Los Angeles, CA Mark R. Burge MD Associate Professor Department of Medicine/Endocrinology, University of New Mexico School of Medicine, Albuquerque, NM Jose F. Caro MD Vice President Endocrine Research and Clinical Investigation, Eli Lilly Research Laboratories, Indianapolis, IN Annette M. Chang MD Lecturer Department of Internal Medicine, University of Michigan, Ann Arbor, MI Aruna Chelliah MD Fellow Department of Medicine/ Endocrinology, University of New Mexico, Albuquerque, NM Alan D. Cherrington PhD Professor Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN Anthony T. Cheung PhD President enGene, Inc., Vancouver, BC Emily Y. Chew MD Deputy Director Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD Young-Hun Choi PhD Section on Biochemical Physiology, Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD Richard J. Comi MD Associate Professor of Medicine Dartmouth Medical School; Section Chief, Endocrinology and Metabolism, Dartmouth-Hitchcock Medical Center, Lebanon, NH Philip E. Cryer MD Professor of Endocrinology and Metabolism Washington University School of Medicine; Physician, Department of Medicine, Barnes-Jewish Hospital, St. Louis, MO Michael P. Czech PhD Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA Dana Dabelea MD, PhD Assistant Professor Preventive Medicine and Biometrics, University of Colorado School of Medicine, Denver, CO Mayer B. Davidson MD Professor of Medicine UCLA School of Medicine; Director, Clinical Trials Unit, Charles R. Drew University, Los Angeles, CA Eva Degerman MD, PhD Section for Molecular Signaling, Department of Cell and Molecular Biology, Lund University, Lund, Sweden George Dimitriadis MD, DPhil Associate Professor of Medicine Athens University Medical School; Research Institute and Diabetes Center, Evangelismos Hospital, Agia Paraskevi, Greece Li Ding PhD Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA Boris Draznin MD, PhD Research Service Denver Veterans Affairs Medical Center; Professor, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO Søren M. Echwald PhD Steno Diabetes Center, Copenhagen, Denmark Steven V. Edelman MD Staff Physician Diabetes/Endocrine Section, Veterans Administration San Diego Healthcare System; Professor of Medicine, University of California, San Diego, CA Shimon Efrat PhD Associate Professor Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel George S. Eisenbarth MD, PhD Executive Director Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO F. El-Atat MD Clinical Assistant Instructor of Medicine SUNY–Downstate; Fellow, County Hospital, Brooklyn, NY Sanford E. Emery MD, MBA Professor and Chairman Department of Orthopaedics, West Virginia University, Robert C. Byrd Health Sciences Center, Morgantown, WV Elizabeth D. Ennis MD, FACP Program Director Internal Medicine and Transitional Year Residency Programs, Baptist Health System, Birmingham, AL James L. Erwin Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA Garret J. Etgen PhD Head, Endocrine Research Eli Lilly and Company, Indianapolis, IN Stefan S. Fajans MD Professor Emeritus Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Michigan Health System, Ann Arbor, MI Robert V. Farese MD Research Service J.A. Haley Veterans' Hospital, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, FL Ele Ferrannini MD Professor of Medicine Department of Internal Medicine, University of Pisa, Pisa, Italy Paul J. Flakoll PhD Director Center for Designing Foods to Improve Nutrition; Professor, Food Science and Human Nutrition, Iowa State University, Ames, IA James E. Foley PhD Global Clinical Research and Medical Affairs Novartis Pharmaceutical Corporation, East Hanover, NJ Barry M. Forman MD, PhD Associate Professor Division of Molecular Medicine, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA Sarah F. Fowler PhD Research Professor Epidemiology and Biostatistics, George Washington University, Bethesda, MD Jian Fu Department of Medicine, University of Illinois, Chicago, IL Alan J. Garber MD, PhD Department of Medicine, Baylor College of Medicine, Houston TX Sanford Garfield PhD Senior Advisor, Biometry and Behavioral Research National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD Saul Genuth MD Professor of Medicine Case Western Reserve University; Physician, Medicine-Endocrinology, University Hospitals of Cleveland, Cleveland, OH Michael German MD Associate Professor Hormone Research Institute, University of California, San Francisco, CA Marvin C. Gershengorn MD, PhD Scientific Director National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD Soumitra Ghosh MD, PhD Department of Pediatrics, Medical College of Wisconsin, Children's Hospital of Wisconsin, Max McGee National Research Center for Juvenile Diabetes, Milwaukee, WI Lisa K. Gilliam MD, PhD Senior Fellow Department of Medicine, University of Washington, Seattle, WA Luigi Gnudi MD, PhD Consultant Department of Diabetes, Endocrinology and Internal Medicine, Guy's and St. Thomas Hospital; Senior Lecturer, Diabetes, Endocrinology and Internal Medicine, King's College, London, United Kingdom Marc L. Goalstone PhD Research Service Denver Veterans Affairs Medical Center, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO Barry J. Goldstein MD, PhD Director Division of Endocrinology, Diabetes and Metabolism; Professor, Thomas Jefferson University, Philadelphia, PA Olga Göransson MS Section for Molecular Signaling, Department of Cell and Molecular Biology, Lund University, Lund, Sweden Daryl K. Granner MD Professor Department of Molecular Physiology and Biophysics, Vanderbilt University; Director, Vanderbilt Diabetes Center, Nashville, TN Dale L. Greiner PhD Professor Department of Medicine, University of Massachusetts Medical School, Worcester, MA Gabriella Gruden MD, PhD Research Associate Internal Medicine, University of Turin, Turin, Italy Angelika C. Gruessner MD, PhD Department of Surgery, University of Minnesota, Minneapolis, MN Rainer W. G. Gruessner MD Department of Surgery, University of Minnesota, Fairview-University Medical Center, Minneapolis, MN Joel F. Habener MD Professor of Medicine Harvard Medical School; Chief, Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA Jeffrey B. Halter MD University of Michigan, Ann Arbor, MI Richard F. Hamman MD, DrPH Professor and Chair Department of Preventive Medicine and Biometrics, University of Colorado School of Medicine, Denver, CO Barbara C. Hansen PhD Obesity and Diabetes Research Center, University of Maryland School of Medicine, Baltimore, MD Anandwardhan A. Hardikar PhD National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD Jamie Susan Harmon PhD Staff Scientist Pacific Northwest Research Institute, Seattle, WA Linda Härndahl Section for Molecular Signaling, Department of Cell and Molecular Biology, Lund University, Lund, Sweden Maureen I. Harris PhD, MPH Director National Diabetes Data Group, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD Leonard C. Harrison MD, DSc Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Melbourne, Victoria, Australia Martin Hessner PhD Department of Pediatrics, Medical College of Wisconsin, Children's Hospital of Wisconsin, Milwaukee, WI Boaz Hirshberg MD Senior Research Fellow Transplantation and Autoimmunity Branch, National Institute of Diabetes, Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD Susanna Hofmann MD Research Associate Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY Edward S. Horton MD Section Head, Clinical Research Joslin Diabetes Center; Professor of Medicine, Harvard Medical School, Boston, MA Gökhan S. Hotamisligil MD, PhD Professor and Chair Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA Ole Hother-Nielsen MD, DSc Associate Professor Department of Endocrinology; Chief Physician, Department of Endocrinology, Odense University Hospital, Odense, Denmark June Chunqiu Hou MD Department of Pharmacological Sciences, State University of New York, Stony Brook, NY Khaled Houamed PhD Departments of Anesthesia and Critical Care, University of Chicago, Chicago, IL Barbara V. Howard PhD President MedStar Research Institute, Hyattsville, MD Stanley H. Hsia MD Assistant Professor Department of Medicine, Charles R. Drew University of Medicine and Science; Attending Staff, Division of Endocrinology and Metabolism, Martin Luther King Jr./Charles R. Drew Medical Center, Los Angeles, CA Milagros G. Huerta MD Assistant Professor of Pediatrics University of Virginia, Charlottesville, VA Christopher Hug MD, PhD Whitehead Institute for Biomedical Research, Cambridge, MA, Division of Respiratory Diseases, Children's Hospital, Boston, MA Rebecca L. Hull PhD Senior Research Fellow Department of Medicine, VA Puget Sound Health Care System, Seattle, WA Alexandra L. Jenkins BSc, RD, CDE Research Associate Risk Factor Modification Center, St. Michael's Hospital, Toronto, Ontario, Canada David J.A. Jenkins MD, PhD, DSc Director Risk Factor Modification Center, St. Michael's Hospital; Professor, Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada Michael D. Jensen MD Professor of Medicine Department of Endocrinology, Mayo Foundation, Rochester, MN Guoqiang Jiang PhD Research Fellow Merck & Co., Rahway, NJ Hee-Sook Jun PhD Julia McFarlane Diabetes Research Centre, Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada Barbara B. Kahn MD Professor of Medicine Harvard Medical School; Chief, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Hospital, Boston, MA C. Ronald Kahn MD Joslin Diabetes Center, Harvard Medical School, Boston, MA Steven E. Kahn MB, ChB Professor Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington; Associate Chief of Staff, Veterans Administration Puget Sound Health Care System, Seattle, WA Thomas W. H. Kay MD St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia David E. Kelley MD Professor of Medicine, Endocrinology Fellow Department of Medicine, University of Pittsburgh, Pittsburgh, PA Daniel M. Kemp PhD Research Fellow Medicine, Harvard Medical School; Research Associate, Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston, MA Cyril W. C. Kendall PhD Research Scientist Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Norma S. Kenyon PhD Professor Surgery, Medicine, Microbiology, & Immunology, University of Miami, Miami, FL Lajwanti S. Khemlani PhD Global Clinical Research and Medical Affairs, Novartis Pharmaceutical Corporation, East Hanover, NJ Timothy J. Kieffer PhD Associate Professor Departments of Physiology and Surgery, University of British Columbia, Vancouver, British Columbia, Canada William C. Knowler MD, DrPH Chief Diabetes and Arthritis Epidemiology Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD Robert A. Kreisberg MD Vice-President for Medical Affairs, Dean College of Medicine, University of South Alabama, Mobile, AL Anjli Kukreja PhD Department of Pediatrics, Cornell Juvenile Diabetes Program, Weill Medical College of Cornell University, New York, NY P. Kumar MD SUNY Downstate, Kings County Hospital, Brooklyn VA Medical Center, Brooklyn, NY Jonathan R. T. Lakey PhD Assistant Professor Department of Surgery, University of Alberta; Director, Clinical Islet Isolation Laboratory, Edmonton, Alberta, Canada Tova Rahn Landström PhD Section for Molecular Signaling, Department of Cell and Molecular Biology, Lund University, Lund, Sweden Jack L. Leahy MD Professor Department of Medicine; Chief, Division of Endocrinology, Diabetes and Metabolism, University of Vermont, Burlington, VT Harold E. Lebovitz MD Department of Medicine, State University of New York, Health Science Center, Brooklyn, NY Åke Lernmark PhD Professor of Medicine University of Washington, Seattle, WA Robert S. Lindsay MB, PhD Senior Scientist MedStar Research Institute, Hyattsville, MD Hanguan Liu MD, PhD Section on Biochemical Physiology, Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD Harvey F. Lodish PhD Whitehead Institute for Biomedical Research, Cambridge, MA, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA Constantine Londos DDS, PhD
The list of books you might like
