Subject Index A in renal cortex from STZ-induced rats, Angiotensin-converting enzyme [2-'*C]acetate, for measuring 826 inhibitors, effects in normotensive gluconeogenesis in vivo, limitations Aging model of diabetic nephropathy, 604 in use of, 732 effects of epinephrine in insulin Antioxidants Acetyl-L-carnitine, correction of secretion and action in humans, MDL 29,311, 1179 electroretinographic deficits in interaction with aging, 307 prevention of diabetes in nonobese experimental diabetes, 1115 ethanol and carbohydrate metabolism diabetic and multiple-low- dose Acetylcholine, abnormal in elderly and, 28 $TZ-injected mice by MDL 29,311, agonist-stimulated cardiac Ala’’®, on polyprotein of 1721 parasympathetic acetylcholine encephalomyocarditis virus, Aorta release in STZ-induced diabetes, determination of diabetogenicity effects of high glucose concentrations 141 attributable to, 435 and epalrestat on sorbitol! and Acipimox, metabolic consequences of Albuminuria myo-inositol metabolism in sustained suppression of free fatty exercise-induced, picotamide cultured rabbit aortic smooth acids by, in NIDDM, 1559 reduction of, in microalbuminuric muscle cells, 1594 Adenosine triphosphate patients with NIDDM, 178 high glucose reduction of specific impaired glucose sensitivity of impact on progression of nephropathy binding for D-a-tocopherol in ATP-sensitive K* channels in in IDDM, 715 endothelial cells of, 1138 B-cells of GK rats, 1446 Alcohol Apolipoprotein B, effects of acute sulfonylurea- binding sites and carbohydrate metabolism in elderly hyperinsulinemia on VLDL ATP-sensitive K* channels in a-TC triglyceride and VLDL ApoB and, 28 glucagonoma and B-TC impairment of glucose production in normal weight and insulinoma cells, 1760 obese individuals, 833 counterregulation by intake during Adipocytes Apolipoprotein E, polymorphism cellular insulin resistance in gestational acute insulin-induced modification of relation of hypoglycemia in, 1626 diabetes caused by multiple hyperinsulinemia to Aldose reductase, inhibition of, failure to defecis in adipocyte glucose hypertriglyceridemia, 1474 transport system, 1773 prevent retinopathy in diabetic and Appeiite, effect of galactosemic dogs, 820 metformin blockage of downregulation dehydroepiandrosterone on of cell surface GLUT4 caused by Alkylacyiglycerol, insulin-induced neurotransmitter levels and appetite chronic insulin treatment of rat generation in rat adipocytes, 988 regulation of obese Zucker rat, 663 adipocytes, 1159 ALX-induced diabetes, correction of Arginine vasopressin, effects in mouse stimulation of glucose transport, erythrocyte deformability defect in pancreatic B-cells, 914 glucose transporter translocation, ALX-induced diabetic rabbits after Arterioles, impaired myogenic reactivity and dephosphorylation in treatment with aminoguanidine, 590 in early experimental diabetes, 1226 insulin-resistant rat adipocytes in Amine oxidase, semicarbazide-sensitive, Atherogenesis, accelerated, in NIDDM, 1 vitro by glimepiride, 1852 oxidative deamination of Atrial natriuretic factor, impaired stimulation of hydrolysis of methylamine by, leading to cytotoxic vasodilator response to atrial plasmanylinositol- glycan and damage in endothelial cells, 594 natriuretic factor in IDDM, 1454 phosphatidylinosigtloylca-n in rat Amino acids, sensitivity of glucose and Autoantibodies adipocytes by insulin, 988 amino acid metabolism to insulin in association of faulty major Adipose tissue, effects of NIDDM, 1868 histocompatibility complex class II hyperinsulinemia and hyperglycemia Aminoguanidine, correction of I-E expression with autoimmunity on GLUT4 and hexokinase II MRNA erythrocyte deformability defect in in diverse strains of mice, 1166 and protein in rat skeletal muscle ALX-induced diabetic rabbits after characterization of insulin and adipose tissue, 922 treatment with, 590 autoantibodies in relatives of Adrenocorticotropic hormone, Amputations, lower- extremity, incidence, patients with IDDM, 1202 impairment of coronary vascular risk factors, and mortality in correlation of insulitis-caused reserve and ACh-induced coronary Oklahoma Indian Diabetes Study, redistribution of heat-shock protein vasodilation in ciabetic patients with 876 HSP60 inside B-cells with angiographically normal coronary Amyloid polypeptide induction of HSP60 arteries and normal left ventricular influence of islet amyloid polypeptide autoantibodies, 908 systolic function, 1017 and 8-37 fragment of islet amyloid in IDDM, primary recognition of Advanced glycation end products, polypeptide on insulin release 65,000-M, rather than 67,000M, immunochemical detection of from perfused rat islets, 330 isoform of glutamic acid in lens crystallins from STZ-induced regulation in human pancreatic islets, decarboxylase by, 631 diabetic rat, 345 1514 Autoimmune diabetes DIABETES: VOLUME 42 (1993) PAGE NUMBERS BY ISSUE January, 1-212 April, 503-636 July, 941-1098 October, 1383-1547 February, 213-366 May, 637-800 August, 1099-1218 November, 1549-1689 March, 367-502 June, 801—940 September, 1219-1382 December, 1691-1882 SUBJECT INDEX 1993 lack of role of complement lytic activity sympathovagal balance in adoptive transfer of BB rat diabetic in pathogenesis of, in NOD mice, autonomic neuropathy, 1745 syndrome and, 390 1574 Brain adoptive transfer of diabetes into prevention with lymphotoxin in NOD direction of counterregulation during immunodeficient NOD mice, 44 mice, 398 hypoglycemia by widespread simultaneous coexpression of naive revelation in adults with brain regions, 1253 and memory lymphocyte markers non-insulin- dependent onset of effect of maternal diabetes in at diagnosis of IDDM, 127 disease by antibodies to glutamic expression of genes regulating Children acid decarboxylase, 359 fetal brain glucose uptake, 1487 early exposure to dairy products Autoimmunity, association of faulty major expression of sodium channel association with increased risk of histocompatibility complex class |i a,-Subunit related to fetal brain IDDM in Finnish children, 1786 |-E expression with autoimmunity in isoform by human, rodent, and cow's milk and solid foods in infancy diverse strains of mice, 1166 canine pancreatic B-cells, 1372 and genetic predisposition and risk of IDDM, 288 Autonomic function, effects of ponalrestat on, 336 Cc obesity in, time course of increased Autonomic neuropathy Calcium lipid and decreased glucose mechanisms of arterial hypotension G-protein specificity in signaling oxidation during early phase of after therapeutic dose of pathways that mobilize calcium in childhood obesity, 1010 subcutaneous insulin in, 1055 insulin-secreting B-TC3 cells, 1878 CIKVAVS, inhibition of neurite outgrowth number of bursts of muscle normalization of glucose intolerance by nonenzymatic glycosylation of, sympathetic nerve activity in IDDM accompanying vitamin D depletion 509 as sign of, 1376 in vivo by, 35 Collagen relationship between circadian rhythms Calphostin C, sustained recovery of enhancement of glomerular collagen of blood pressure and Na*-K*-ATPase activity in mouse synthesis in diabetic rats by sympathovagal balance in, 1745 sciatic nerve and, 257 transforming growth factor-B,, Autoreactive cells, in IDDM, transcription Carbohydrates 1673 facior jun-B as target of, 626 enhancement of intestinal sugar type IV, effect of high glucose on transport in diabetic mice, 1579 production by cultured glomerular metabolism in elderly, effects of epithelial, endothelia!, and B ethanol on, 28 mesangial cells, 170 BB rat Cardiovascular risk factors, relationship Complement lytic activity, lack of role in adoptive transfer of diabetic syndrome Of proinsulin and insulin to, in pathogenesis of autoimmune in, CD8* T-cells and, 390 nondiabetic subjects, 1297 diabetes in NOD mice, 1574 decreased catecholamine secretion Cartilage, insulinlike growth factor Coronary arteries, impairment of from adrenal medullae of l-resistant state in cartilage of coronary vascular reserve and chronically diabetic BB-Wistar diabetic rats ameliorated by ACh-induced coronary vasodilation rats, 862 hypophysectomy, role of metabolism in diabetic patients with pancreatic islet function in nondiabetic and, 463 angiographically normal coronary and diabetic BB rats, 1310 Cataracts arteries and normal left ventricular spontaneously diabetic, enhanced immunochemical detection of systolic function, 1017 glucose metabolism and advanced glycation end products Cyclophosphamide, reversal of tolerance respiratory burst in peritoneal in lens crystallins from to IDDM induced by CD4 antibodies macrophages from, 520 $TZ-induced diabetic rat, 345 in nonobese diabetic mice by, 1601 transcription and translation of RT6? mechanisms for D-glucose inhibition of Cyclosporin A, metabolic effects in liver gene in lymphopenic myo-inositol influx into rat lens, transplant recipients, 1753 diabetes- prone BB rats, 688 1737 Benfluorex Cathepsin, decreased activity of D amelioration of insulin resistance in rat glomerular cathepsin and Dairy products, early exposure to by, 457 metalloprotease in STZ-induced association with increased risk of normalization of hyperglycemia and diabetes in rats, 1425 IDDM in Finnish children, 1786 reversal of hepatic insulin CD4* T-cells cow's milk and solid foods in infancy resistance in STZ-induced aberrant distribution in recent- onset and genetic predisposition and diabetic rats by, 564 IDDM patients, 862 risk of IDDM, 288 Blacks, with NIDDM, insulin resistance adoptive transfer of diabetes into Deferoxamine, lack of effect on glucose syndrome and, 444 immunodeficient NOD mice, 44 homeostasis and insulin secretion in Blood pressure. See also Hypertension reversal of tolerance to IDDM induced individuals with NIDDM and elevated arterial by CD4 antibodies in nonobese serum ferritin, 544 impact on progression of diabetic mice by Dehydroepiandrosterone, effects on nephropathy in IDDM, 715 cyclophosphamide, 1601 neurotransmitter levels and appetite mechanisms of hypotension after simultaneous coexpression of naive regulation of cbese Zucker rat, 663 therapeutic dose of and memory lymphocyte markers Diabetes Contro! and Complications subcutaneous insulin in diabetic at diagnosis of IDDM, 127 Trial, 1549 autonomic neuropathy, 1055 CD8* T-cells implications of, 1555 relationship between circadian rhythms aberrant distribution in recent- onset Diabetic complications. See specific of blood pressure and IDDM patients, 862 disorders DIABETES: VOLUME 42 (1993) PAGE NUMBERS BY ISSUE January, 1-212 April, 503-636 July, 941-1098 October, 1383-1547 February, 213-366 May, 637—800 August, 1099-1218 November, 1549-1689 March, 367-502 June, 801-940 September, 1219-1382 December, 1691-1882 SUBJECT INDEX 1993 Diacylglycerol, insulin-induced malformations of, role of substrate acute insulin-induced generation in rat adipocytes, 988 free-oxygen radical production for hypoglycemia in, 1626 Didecanoyl-L-a- phosphatidylcholine, dysmorphogenesis in cultured rat Ethnicity. See also Race; specific groups insulin transport across rabbit nasal embryos, 411 association of ethnicity and polycystic mucosa in vitro induced by, 1032 Encephalomyocarditis virus, Ala’”® on ovary syndrome with independent Diet polyprotein of, determination of and additive decreases in insulin carbohydrate enhancement of diabetogenicity attributable to, 435 action in Caribbean-Hispanic intestinal sugar transport in Endocytosis, inhibition in hepatocytes women, 1462 diabetic mice, 1579 from diabetic rats, 1303 Exendin, cloning and functional early exposure to dairy products Endothelial barrier, microdialysis expression of human islet GLP-1 association with increased risk of measurement of insulin receptor, exendin-4 and IDDM in Finnish children, 1786 concentration in subcutaneous exendin-(9-39) and, 1678 cow's milk and solid foods in infancy interstitial fluid, 1469 Exercise, reversal of defect in and genetic predisposition and Endothelial cells mitrochondrial energy production in risk of IDDM and, 288 aortic, high glucose reduction of heart of chronically diabetic rat by fiber in management of diabetes, 503 specific binding for D-a-tocopherol physical training, 682 inducement of insulin resistance in rat in, 1138 Experimental diabetes by, 457 endothelial cell-binding properties of correction of electroretinographic reduced motor nerve conduction lymphocytes infiltrated into human deficits in, 1115 velocity and Na*-K*-ATPase diabetic pancreas, 1656 impaired arteriolar myogenic reactivity activity in rats maintained on glomerular, effect of high glucose on in early experimental diabetes, L-fucose diet, reversal by type IV collagen production by, 1226 myo-inositol supplementation, 170 Extracellular matrix 1401 modulation of vascular endothelial cell extracellular matrix-containing giant DNA vasodilatory response by elevated perivascular spaces in thymus of characterization of CDNA, gene, and D-glucose concentrations, 1497 NOD mouse, 134 chromosomal localization of oxidative deamination of methylamine induction of increased expression of human skeletal muscle insulin by semicarbazide-sensitive amine extracellular matrix components in receptor substrate-1, 1041 oxidase leading to cytotoxic rat embryos by maternal diabetes, islet cell, as target of inflammatory damage in, 594 975 attack by nitric acid, 496 vascular, regulation of glucose localization of human glucagonlike transport and transporters by F peptide-1 receptor gene to glucose in, 80 Factor Xla-a,-antitrypsin complex, chromosome band 6p21 by Endothelin, insulin stimulation of elevation in NIDDM patients with fluorescence in situ hybridization production and secretion from diabetic nephropathy, 233 and linkage of highly polymorphic bovine endothelial cells, 351 Fasting, insulin-stimulated glucose simple tandem repeat DNA Endothelium, vascular relaxation uptake and intracellular glucose polymorphism to other markers on dependent on, in IDDM, 148 metabolism in conscious rats and, chromosome 6, 1215 Energy production, reversal of defect in 757 simple tandem repeat DNA mitrochondrial energy production in Fatty acids polymorphism in human glycogen heart of chronically diabetic rat by abnormality of postprandial free fatty synthase gene, linkage to five physical training, 682 acid kinetics in upper body markers in chromosome 19q, 930 Epalrestat, effects of high glucose obesity, 1567 DNA damage-inducible genes, increase concentrations and epalrestat on effects of insulin on fatty acid of expression by genotoxic agents, sorbitol and myo-inositol metabolism reesterification in healthy subjects, in rat pancreatic islets, 738 in cultured rabbit aortic smooth 1588 Driving, decrements in IDDM during muscle cells, 1594 impairment of glucose moderate hypoglycemia, 239 Epinephrine, effects on insulin secretion counterregulation by alcohol Dysmorphogenesis, role of substrate and action in humans, interaction intake during acute free-oxygen radical production for with aging, 307 insulin-induced hypoglycemia in dysmorphogenesis in cultured rat Epithelial cells, glomerular, effect of high IDDM, 1626 embryos, 411 glucose on type IV collagen metabolic consequences of sustained production by, 170 suppression of free fatty acids by E Erythrocytes, correction of erythrocyte acipimox in NIDDM, 1559 Elderly, carbohydrate metabolism in, deformability defect in ALX-induced Ferritin, lack of effect of deferoxamine effects of ethanol on, 28 diabetic rabbits after treatment with therapy on glucose homeostasis and Electroretinography, correction of aminoguanidine, 590 insulin secretion in individuals with electroretinographic deficits in Escherichia coli, effects of ponalrestat on NIDDM and elevated serum ferritin, experimental diabetes by neutrophil killing of Escherichia coli 544 acetyl-L-carnitine, 1115 and autonomic function, 336 Fibrinolysis, attenuated, in NIDDM, 1 Embryo Ethanol Fibroblasts, abnormal activation of induction of increased expression of carbohydrate metabolism in elderly glycogen synthesis in fibroblasts extracellular matrix components in and, 28 from subjects with NIDDM, evidence rat embryos by maternal diabetes, impairment of glucose for abnormality specific to glucose 975 counterregulation by intake during metabolism, 583 DIABETES: VOLUME 42 (1993) PAGE NUMBERS BY ISSUE January, 1-212 April, 503-636 July, 941-1098 October, 1383-1547 February, 213-366 May, 637-800 August, 1099-1218 November, 1549-1689 March, 367-502 June, 801-940 September, 1219-1382 December, 1691-1882 SUBJECT INDEX 1993 Fibronectin simple tandem repeat DNA transforming growth factor-B,, accumulation by mesangial cells polymorphism to other markers on 1673 grown in high- glucose medium, chromosome 6 and, 1215 Glucagon, loss of potentiating effect of mediation by protein kinase C, increase of expression of growth arrest hypoglycemia on glucagon 118 and DNA damage-inducible response to hyperaminoacidemia in mesangial cell prostaglandin release genes gadd 153 and gadd 45 by IDDM, 550 induced by, hyperglycemia and genoioxic agents in rat pancreatic Glucagonlike peptides PKC inhibition and, 183 islets, 738 cloning and functional expression of plasma, functional activity in diabetes linkage analysis and molecular human islet GLP-1 receptor, mellitus, 1606 scanning of glucokinase gene in exendin-4 and exendin-(9-39) Finnish children, early introduction of NIDDM families, 1238 and, 1678 dairy products associated with linkage of chromosomal marker on 4q glucagonlike peptide-1 and control of increased risk of IDDM in, 1786 with putative gene determining insulin secretion in normal state FK 506, metabolic effects in liver maximal insulin action in Pima and NIDDM, 1219 transplant recipients, 1753 Indians, 514 indistinguishable effects of Free-oxygen radicals, role of substrate localization of IDDM susceptibility glucagonlike peptide-1 7-36 free-oxygen radical production for locus to variable tandem repeat amide and glucagonlike peptide-1 dysmorphogenesis in cultured rat region flanking insulin gene, 1708 7-37 in healthy subjects, 658 embryos, 411 localization of glucagonlike peptide-1 organization of human GLUT2 glucose Fructose-1,6-biphosphatase, hepatic, transporter gene, 773 receptor gene to chromosome impaired regulation in New Zealand band 6p21 by fluorescence in situ risk to IDDM conferred by 5’ insulin obese mouse model of NIDDM, hybridization and linkage of highly 1731 gene polymorphism independently polymorphic simple tandem of HLA class II susceptibility, 851 repeat DNA polymorphism to sequence variations of glucokinase G other markers on chromosome 6, gene in Japanese subjects with Galactosemia, failure of aldose 1215 NIDDM, 1133 reductase inhibition to prevent Glucagonoma, sulfonylurea- binding sites retinopathy in dogs, 820 simple tandem repeat DNA and ATP-sensitive K* channels in Galanin, high-affinity GTPase activity in polymorphism in human glycogen a-TC glucagonoma and B-TC plasma membranes from RINmM5F synthase gene, linkage to five insulinoma cells, 1760 cells stimulated by, 74 markers in chromosome 19q, 930 Glucocorticoids, effect of glucocorticoid Gamma- aminobutyric acid, production in Genotoxic agents, increase of and growth hormone on proinsulin rat islets, 1506 expression of growth arrest and levels in humans, 1082 Genetic factors DNA damage-inducible genes gadd Glucokinase availability of NIDDM diabetic families 153 and gadd 45 by, in rat glucose modulation of activity in rat for detection of diabetes pancreatic islets, 738 pancreatic B-cells, 199 susceptibility genes, 1536 Gestational diabetes mellitus inhibition of glucose-induced insulin characterization of cDNA, gene, and cellular insulin resistance caused by secretion through inactivation of chromosomal localization of multiple defects in adipocyte glucokinase by glyceraldehyde, human skeletal muscle insulin glucose transport system in, 1773 1003 receptor substrate-1, 1041 glucokinase mutations in, 933 mutations in gestational diabetes characterization of insulin GK rat mellitus, 933 autoantibodies in relatives of GLUT2 expression and function in Glucokinase gene patients with IDDM, 1202 B-cells of GK rats with NIDDM, association of polymorphic decreased risk of IDDM in offspring of dissociation between reductions in microsatellite repeat markers at mothers who acquire diabetes glucose transport and glucokinase gene locus with during adrenarchy, 1433 glucose-stimulated insulin NIDDM in Japanese, 1147 distribution of NIDDM in nuclear secretion and, 1065 linkage analysis and molecular families and, 106 impaired glucose sensitivity of scanning of, in NIDDM families, early exposure to cow's milk and solid ATP-sensitive K* channels in 1238 foods in infancy and genetic B-cells of, 1446 sequence variations in Japanese predisposition and risk of IDDM Glimepiride, stimulation of glucose subjects with NIDDM, 1133 and, 288 transport, glucose transporter variants in common form of NIDDM, effect of maternal diabetes in translocation, and dephosphorylation 579 expression of genes regulating in insulin-resistant rat adipocytes in Gluconeogenesis fetal brain glucose uptake, 1487 vitro by, 1852 decrease from lactate but not fasting HLA-DQA1 and DQB1 gene Glomeruli hyperglycemia cr total hepatic polymorphisms in IDDM patients from diabetic rats, MRNA expression glucose production by inhibition of from central Italy and their use for of growth factors in, 450 lipolysis in NIDDM, 1694 risk prediction, 1173 effect of high glucose on type IV limitations in use of [2-'*C]acetate for human glucagonlike peptide-1 collagen production by cultured measuring in vivo, 732 receptor gene, localization to glomerular epithelial, endothelial, Glucose chromosome band 6p21 by and mesangial celis, 170 amplitude regulation of pulsatile insulin fluorescence in situ hybridization enhancement of glomerular collagen secretion from individual and linkage of highly polymorphic synthesis in diabetic rats by pancreatic islets induced by, 670 DIABETES: VOLUME 42 (1993) PAGE NUMBERS BY ISSUE January, 1-212 April, 503-636 July, 941-1098 October, 1383-1547 February, 213-366 May, 637-800 August, 1099-1218 November, 1549-1689 March, 367—502 June, 801-940 September, 1219-1382 December, 1691-1882 SUBJECT INDEX 1993 calcium channel MRNA expression in reduced sample number for differential regulation by glucose in rat pancreatic islets, calculation of insulin sensitivity vascular endothelial cells and downregulation after glucose and glucose effectiveness from smooth muscle cells, 80 infusion and, 948 minimal model, 250, 1635 GLUT2 expression and function in in children, 1010 role of glucose-6- phosphatase in B-cells of GK rats with NIDDM, decrease of lipid oxidation and action of insulin on hepatic dissociation between reductions in gluconeogenesis from lactate but glucose production in rat, 1614 glucose transport and not fasting hyperglycemia or total upreguiation of myo-inositol transport, glucose-stimulated insulin hepatic glucose production by compensation for competitive secretion and, 1065 inhibition of lipolysis in NIDDM, inhibition by glucose and, 1119 in human skeletal muscle, in vivo 1694 in vascular endothelial and smooth response to insulin and, 191 effect of elevated concentration on muscle cells, differential regulation induction of insulin resistance of membrane voltage regulation in of glucose transport and glucose transport and glycogen retinal capillary pericytes, 1347 transporters by, 80 synthesis in isolated rat skeletal effect of high glucose on type IV Glucose metabolism muscles by pre-exposure to collagen production by cultured abnormal activation of glycogen glucosamine, 1333 glomerular epithelial, endothelial, synthesis in fibroblasts from reduction of Na*-dependent glucose and mesangial cells, 170 subjects with NIDDM, evidence for transport in rat small intestine by effect on proteoglycans produced by abnormality specific to glucose oral vanadate, 1126 cultured mesangial cells, 1815 metabolism, 583 stimulation by glimepiride in effects of high concentrations on effect of maternal diabetes in insulin-resistant rat adipocytes in sorbitol and myo-inositol expression of genes regulating vitro, 1852 metabolism in cultured rabbit fetal brain glucose uptake, 1487 Glucose transporters. See also specific aortic smooth muscle cells, 1594 enhanced glucose metabolism and transporters effects on insulin secretion from respiratory burst in peritoneal cellular insulin resistance in gestational perfused rat islets, 843 macrophages from spontaneously diabetes caused by multiple fluorescence digital image analysis of diabetic BB rats, 520 defects in adipocyte glucose glucose-induced [Ca?*]; insulin-stimulated glucose uptake and transport system, 1773 oscillations in mouse islets, 1210 intracellular glucose metabolism in differential regulation by glucose in impaired glucose sensitivity of conscious rats, fasting and, 757 vascular endothelial cells and ATP-sensitive K* channels in regulation of glucose uptake and smooth muscle cells, 80 B-cells of GK rats, 1446 metabolism by working muscle, differential regulation of GLUT1 and impairment of effectiveness by 956 GLUT4 in skeletal muscle of new repeated low doses of sensitivity to insulin in NIDDM, 1868 model of NIDDM, 1195 streptozocin in dogs, 475 signals derived from glucose glucose modulation of glucose inhibition of glucose-induced insulin metabolism required for glucose transporter affinity in rat secretion through inactivation of regulation of pancreatic islet pancreatic B-cells, 199 glucokinase by glyceraldehyde, GLUT2 mRNA and protein, 1273 organization of human GLUT2 glucose 1003 in vivo transporter gene, 773 insulin response to intravenous glucose utilization by individual stimulation of translocation of, by glucose load during development tissues in virgin and pregnant glimepiride in insulin-resistant rat of obesity in gold offspring of severely diabetic adipocytes in vitro, 1852 thioglucose-injected mice, 1153 rats, 530 GLUT1, differential regulation in skeletal lack of effect of deferoxamine therapy in obese and NIDDM subjects with muscle of new model of NIDDM, on glucose homeostasis and or without hypertension, 764 1195 insulin secretion in individuals with Glucose-6- phosphatase, role in action of GLUT2 NIDDM and elevated serum insulin on hepatic glucose organization of human GLUT2 glucose ferritin, 544 production in rat, 1614 transporter gene, 773 MDL 29,311 and, 1179 Glucose tolerance signals derived from glucose mechanisms for D-glucose inhibition of impaired metabolism required for glucose myo-inositol influx into rat lens, incidence in hypertensive subjects, regulation of pancreatic islet 1737 154 GLUT2 mRNA and protein, 1273 modulation of glucose transporter risk of progression to NIDDM in GLUT4 affinity, glucokinase activity, and South-African Indians with, 556 cellular insulin resistance in gestational secretory response in rat vitamin D depletion in vivo and, diabetes caused by multiple pancreatic B-cells, 199 normalization by calcium, 35 defects in adipocyte glucose modulation of vascular endothelial cell insulin resistance and insulin secretion transport system, 1773 vasodilatory response by elevated as determinant of oral glucose differential regulation in skeletal D-glucose concentrations, 1497 tolerance in normal individuals, muscle of new model of NIDDM, normal proinsulin responses, in mild 1324 1195 NIDDM subjects with subnormal Glucose transport effects of hyperinsulinemia and insulin response, 162 in adipocytes, cellular insulin hyperglycemia on GLUT4 and prevention of STZ-induced diabetes by resistance in gestational diabetes hexokinase Il mRNA and protein D-glucose and 5-thio-D- glucose, caused by multiple defects in, in rat skeletal muscle and adipose 420 1773 tissue, 922 DIABETES: VOLUME 42 (1993) PAGE NUMBERS BY ISSUE January, 1-212 April, 503-636 July, 941-1098 October, 1383-1547 February, 213-366 May, 637—800 August, 1099-1218 November, 1549-1689 March, 367-502 June, 801-940 September, 1219-1382 December, 1691-1882 SUBJECT INDEX 1993 metformin blockage of downregulation B-cell lines and fetal rat islets in direction of counterregulation during of cell surface GLUT4 caused by primary culture, 1829 hypoglycemia by widespread chronic insulin treatment of rat in glomeruli from diabetic rats, MRNA brain regions, 1253 adipocytes, 1159 expression of, 450 impairment of glucose Glutamic acid decarboxylase insulinlike growth factor I-resistant counterregulation by alcohol antibodies to, revelation of latent state in cartilage of diabetic rats intake during acute autoimmune diabetes mellitus in ameliorated by hypophysectomy, insulin-induced hypoglycemia in adults with non-insulin- dependent role of metabolism and, 463 IDDM, 1626 onset of disease, 359 transforming growth factor synthesis inhibitory effect of pregnancy on differential expression of and expression in endocrine and counterregulatory hormone of GAD, and GADg; in human, rat, exocrine pancreas, 746 responses to hypoglycemia in and mouse pancreatic islets, Growth hormone, effect of on proinsulin awake rat, 1440 1799 levels in humans, 1082 Human leukocyte antigens in rat and human islets, 485 Guanidines, prevention of diabetic association of HLA-A24 with complete primary recognition of 65,000-M, rather vascular dysfunction by, inhibition of B-cell destruction in IDDM, 1086 than 67,000M, isoform of glutamic nitric oxide synthase versus class |, detection of insulin receptor acid decarboxylase by advanced glycation end- product association with, 619 autoantibodies in IDDM, 631 formation and, 221 Hyperaminoacidemia, loss of potentiating Glyceraldehyde, inhibition of Guanosine triphosphatase, effect of hypoglycemia on giucagon glucose-induced insulin secretion galanin-stimulated high- affinity response to, in IDDM, 550 through inactivation of glucokinase GTPase activity in plasma Hypercapnia, progressive, lack of effect by, 1003 membranes from RINMS5F cells, 74 of naloxone on ventilatory response Glycogen to, in IDDM, 282 abnormal activation of synthesis in Hyperglycemia fibroblasts from subjects with H antihyperglycemic effect of NIDDM, evidence for abnormality H7, sustained recovery of dehydroepiandrosterone analogue specific to glucose metabolism, 583 Na*-K*-ATPase activity in mouse 16a-fluoro-5-androsten-17-one in structure and segmental localization in sciatic nerve and, 257 diabetic mice, 1105 diabetic rat kidney, 891 Heart decrease of lipid oxidation and Glycogen synthase, regulation of impairment of coronary vascular gluconeogenesis from lactate but reserve and ACh-induced not fasting hyperglycemia or total insulin-stimulated glycogen synthase activity by overexpression of coronary vasodilation in diabetic hepatic glucose production by glutamine: fructose-6 - phosphate patients with angiographically inhibition of lipolysis in NIDDM, amidotransferase in rat-1 fibroblasts, normal coronary arteries and 1694 1289 normal left ventricular systolic effects in liver glycogen synthase Glycogen synthase gene, simple tandem function, 1017 phosphatase activity in diabetic repeat DNA polymorphism in, reversal of defect in mitrochondrial rat, 363 linkage to five markers in energy production in heart of effects on GLUT4 and hexokinase II chromosome 19q, 930 chronically diabetic rat by mRNA and protein in rat skeletal Glycolysis, resistance to hypoxia and physical training, 682 muscle and adipose tissue, 922 liability to hypoxic damage in Heat-shock protein, correlation of fibronectin-induced increase in hypoglycemic peripheral nerves insulitis-caused redistribution of mesangial cell prostaglandin and, 981 heat-shock protein HSP60 inside release and, 183 Glycosylation, requirement of Asn*9” or B-cells with induction of HSP60 hypoxia-induced sympathetic inhibition Asn *'® for normal biosynthesis and autoantibodies, 908 of fetal plasma insulin response processing of insulin receptors, 966 Hepatocytes to, 1621 Gold thioglucose, insulin response to inhibition of endocytosis in increased proinsulin/insulin ration in intravenous glucose load during hepatocytes from diabetic rats, pancreas extracts of development of obesity in gold 1303 hyperglycemic rats, 22 thioglucose-injected mice, 1153 organization of human GLUT2 glucose normalization by benfluorex, in Granulocyte-colony stimulating factor, transporter gene, 773 STZ-induced diabetic, 564 improvement of impaired Hispanics, association of ethnicity and pseudohypoxia and, diabetic bactericidal function in neutrophils polycystic ovary syndrome with complications and, 801 from STZ-induced rats by, 470 independent and additive decreases Hyperinsulinemia Growth arrest-genes, increase of in insulin action in acute, effects on VLDL triglyceride and expression by genotoxic agents, in Caribbean-Hispanic women, 1462 VLDL ApoB production in normal rat pancreatic islets, 738 Histocompatibility antigens, isolated islet weight and obese individuals, 833 Growth factors of Langerhans transplantation in rat apolipoprotein E polymorphism enhancement of glomerular collagen and, 90 modification of relation of synthesis in diabetic rats by Hormonal counterregulation hyperinsulinemia to transforming growth factor-B,, compromised, after recurrent hypertriglyceridemia, 1474 1673 short-term episodes of effects on GLUT4 and hexokinase II expression of functional nerve growth insulin-induced hypoglycemia in mRNA and protein in rat skeletal factor receptors in pancreatic IDDM, 610 muscle and adipose tissue, 922 DIABETES: VOLUME 42 (1993) PAGE NUMBERS BY ISSUE January, 1-212 April, 503-636 July, 941-1098 October, 1383-1547 February, 213-366 May, 637—800 August, 1099-1218 November, 1549-1689 March, 367—502 June, 801-940 September, 1219-1382 December, 1691-1882 SUBJECT INDEX 1993 effects on muscle fiber composition insulin in diabetic autonomic nephropathy in, impact of arterial and capillarization in rats, 1073 neuropathy, 1055 blood pressure and albuminuria in Hypertension Hypoxia progression of, 715 incidence of NIDDM and impaired hyperglycemia pseudohypoxia and normalization of neuroendocrine glucose tolerance in, 154 diabetic complications, 801 responses to, symptoms of, and insulin resistance in spontaneously insulin secretion by isolated rat and cognitive function during hypertensive rats, 1364 canine islets of Langerhans, 12 hypoglycemia in short-term IDDM, in vivo glucose metabolism in obese resistance to, liability to hypoxic by prevention of hypoglycemia, and NIDDM subjects with or damage in hypoglycemic 1683 without hypertension, 764 peripheral nerves and, glycolysis North-American twins with, genetic, Hypertriglyceridemia, apolipoprotein E and, 981 etiological, and clinical polymorphism modification of sympathetic inhibition of fetal plasma significance of disease relation of hyperinsulinemia to insulin response to hyperglycemia concordance according to age, hypertriglyceridemia, 1474 induced by, 1621 zygosity, and interval after diagnosis in first twin, 1351 Hypoglycemia awareness of. See Symptom number of bursts of muscle awareness I sympathetic nerve activity in IDDM direction of counterregulation during IDDM as sign of autonomic neuropathy, aberrant distribution of CD4 and CD8 1376 by widespread brain regions, 1253 lymphocyte subsets in pancreatic B-cell repair in early IDDM, recent-onset IDDM patients, 862 1383 effects of differing insulin levels on association of HLA-A24 with complete prediction of, 213 thoo,r mino nnaolr maaln d hummeatanbso,l ic2 63r esponse B-cell destruction in, 1086 recognition of distinct islet antigens by autoantibodies in, primary recognition cytoplasmic islet cell antibodies iatrogenic, in IDDM, 1691 of 65,000-M, rather than 67,000M, in, 1642 impairment of glucose isoform of glutamic acid recurrent short-term episodes of counterregulation by alcohol decarboxylase by, 631 insulin-induced hypoglycemia in, intake during acute characterization of insulin compromised hormonal insulin-induced hypoglycemia in autoantibodies in relatives of counterregulation, symptom IDDM, 1626 patients with, 1202 awareness, and induction of hypoglycemia decreased risk of IDDM in offspring of neurophysiological function after, unawareness by asymptomatic mothers who acquire diabetes 610 nocturnal hypoglycemia, 1233 during adrenarchy, 1433 regulation of apolipoprotein inhibitory effect of pregnancy on design of trails for prevention of, 941 A-l-containing lipoproteins in, counterregulatory hormone driving decrements in IDDM during 1281 responses to, in awake rat, 1440 moderate hypoglycemia, 239 reversal of tolerance to IDDM induced liability to hypoxic damage in early introduction of dairy products by CD4 antibodies in nonobese peripheral nerves, glycolysis and, associated with increased risk of, diabetic mice by 981 in Finnish children, 1786 cyclophosphamide, 1601 loss of potentiating effect on glucagon endothelium-dependent vascular risk of, conferred by 5’ insulin gene response to hyperaminoacidemia relaxation in, 148 polymorphism independently of in IDDM and, 550 genetic predisposition and risk of, HLA class II susceptibility, 851 moderate, driving decrements in IDDM early exposure to cow's milk and simultaneous coexpression of naive during, 239 solid foods in infancy and, 288 and memory lymphocyte markers normalization of neuroendocrine HLA-DQA1 and DQB1 gene at diagnosis of, 127 responses to, symptoms of, and polymorphisms in IDDM patients transcription factor jun-B as target of cognitive function during from central Italy and their use for autoreactive cells in, 626 hypoglycemia in short-term IDDM, risk prediction, 1173 ventilatory response to progressive by prevention of hypoglycemia iatrogenic hypoglycemia in, 1691 hypercapnia in, lack of effect of 1683 impaired vasodilator response to atrial naloxone on, 282 recurrent short-term episodes of natriuretic factor in, 1454 weight gain in, intensive insulin insulin-induced hypoglycemia in impairment of glucose therapy and, 1700 IDDM, compromised hormonal counterregulation by alcohol Immunodeficiency, adoptive transfer of counterregulation, symptom intake during acute diabetes into immunodeficient NOD awareness, and insulin-induced hypoglycemia in, mice, 44 neurophysiological function after, 1626 Inositol 610 induced by thymectomy and antagonism of glucagon activation of severe, in adult patients with irradiation, in rats, 571 glycogen phosphorylase by insulin-treated diabetes, 341 loss of potentiating effect of inositol glycan phosphate derived Hypophysectomy, insulinlike growth hypoglycemia on glucagon from human erythrocyte factor I-resistant state in cartilage of response to hyperaminoacidemia acetylcholinesterase glycolipid diabetic rats ameliorated by, role of in, 550 anchor and inositol cyclic metabolism and, 463 muscie sympathetic nerve activity in, 1,2-phosphate, 1318 Hypotension, arterial, mechanisms after reduction before overt neuropathy, effects of high glucose concentrations therapeutic dose of subcutaneous 375 and epalrestat on sorbitol and DIABETES: VOLUME 42 (1993) PAGE NUMBERS BY ISSUE January, 1-212 April, 503-636 July, 941-1098 October, 1383-1547 February, 213-366 May, 637-800 August, 1099-1218 November, 1549-1689 March, 367-502 June, 801-940 September, 1219-1382 December, 1691-1882 SUBJECT INDEX 1993 myo-inositol metabolism in localization of IDDM susceptibility role of glucose-6- phosphatase in cultured rabbit aortic smooth locus to variable tandem repeat action on hepatic glucose muscle cells, 1594 region flanking insulin gene, 1708 production in rat, 1614 mechanisms for D-glucose inhibition of mechanisms of arterial hypotension Insulin-dependent diabetes. See IDDM myo-inositol influx into rat lens, after therapeutic dose of Insulin gene 1737 subcutaneous insulin in diabetic localization of IDDM susceptibility myo-inositol transport in autonomic neuropathy, 1055 locus to variable tandem repeat region flanking, 1708 glucose- desensitized rat islets, microdialysis measurement of 1392 concentration in subcutaneous risk to IDDM conferred by 5’ insulin gene polymorphism independently reduced motor nerve conduction interstitial fluid, endothelial barrier of HLA class II susceptibility, 851 velocity and Na*-K*-ATPase and, 1469 somatostatin inhibition of gene activity in rats maintained on microtiter well assay system to expression through L-fucose diet, reversal by measure insulin activation of posttranscriptional mechanism in myo-inositol supplementation, insulin receptor kinase in intact hamster islet cell line, 244 1401 human mononuclear cells, 883 Insulinlike growth factor | upregulation of myo-inositol transport, normal proinsulin responses to in extreme insulin resistance compensation for competitive glucose in mild NIDDM subjects syndromes, 696 inhibition by glucose and, 1119 with subnormal insulin response, resistant state in cartilage of diabetic Inositol glycan, insulin-induced 162 rats ameliorated by generation in rat adipocytes, 988 proteolytic processing of proinsulin to, hypophysectomy, role of Insulin metabolism of des(64,65)-human metabolism and, 463 action of, effects of epinephrine on, proinsulin in rat and, 1407 Insulinoma interaction with aging, 307 regulation of insulin-stimulated murine insulinoma cell line with normal altered distribution between glycogen synthase activity by glucose-regulated insulin intravascular and interstitial overexpression of secretion, 901 compartments in STZ-induced glutamine:fructose- 6 - phosphate sulfonylurea- binding sites and diabetic rats, 1528 amidotransferase in rat-1 ATP-sensitive K* channels in a-TC characterization of insulin fibroblasts, 1289 glucagonoma and B-TC autoantibodies in relatives of relationship to cardiovascular risk insulinoma cells, 1760 patients with IDDM, 1202 factors in nondiabetic subjects, Insulin-receptor promotor region, deficiency of, effects in liver glycogen 1297 GC-rich, nuclear- protein binding synthase phosphatase activity in sensitivity of glucose and amino acid analysis of, 66 diabetic rat, 363 metabolism to, in NIDDM, 1868 Insulin receptors dynamics of hepatic and peripheral severe hypoglycemia and intelligence characterization of cDNA, gene, and effects of, common rate-limiting in adult patients with chromosomal localization of step in vivo suggested by, 296 insulin-treated diabetes, 341 human skeletal muscle insulin effect of fasting on insulin-stimulated stimulation of hydrolysis of receptor substrate-1, 1041 defective kinase activity and insulin glucose uptake and intracellular plasmanylinositgloylc-an and resistance caused by Ala’ glucose metabolism in conscious phosphatidylinosigtloylca-n in rat rats, 757 adipocytes by, 988 mutation in kinase domain of, 1837 effect on tissue kallikrein and tonin stimulation of production and secretion levels in submandibular glands of of endothelin from bovine detection of association with class | human leukocyte antigen STZ-induced diabetic rats, 113 endothelial cells by, 351 molecules in cell surfaces, 619 effects of differing levels on hormonal thoracic duct lymph and dynamics of, differences in ratio of RNA encoding of and metabolic response to splanchnic and muscle tissue isoforms between control and hypoglycemia in normal humans, and, 720 NIDDM patients, 675 263 transport across rabbit nasal mucosa induction of insulin resistance of effects of physiological increments in in vitro induced by glucose transport and glycogen plasma concentrations on didecanoyl-L-a- synthesis in isolated rat skeletal synthesis of hepatic proteins in phosphatidylcholine, 1032 muscles by pre-exposure to normal humans, 995 Insulin actions glucosamine, 1333 effects on fatty acid reesterification in association of ethnicity and polycystic insulin receptor substrate-1 and insulin healthy subjects, 1588 ovary syndrome with independent signaling, 643 enhancement of lipolysis and and additive decreases in, in methionine for valine substitution in activation of partially purified Caribbean-Hispanic women, 1462 exon 17 of insulin receptor gene hormone-sensitive lipase by impact of obesity on, in NIDDM, 405 in pedigree with familial NIDDM, chronic exposure of rat fat cells linkage of chromosomal marker on 4q 429 to, 1415 with putative gene determining microtiter well assay system to failure to induce hydrolysis of glycosyl maximal action in Pima Indians, measure insulin activation of phosphatidylinositol in rat fetal 514 insulin receptor kinase in intact hepatocytes, 1262 pharmacodynamics and activity of human mononuclear cells, 883 glucose transport in human skeletal intranasally administered insulin in muscle-specific expression in muscle and, 191 healthy male volunteers, 1649 transgenic mice, 206 DIABETES: VOLUME 42 (1993) PAGE NUMBERS BY ISSUE January, 1-212 April, 503-636 July, 941-1098 October, 1383-1547 February, 213-366 May, 637-800 August, 1099-1218 November, 1549-1689 March, 367-502 June, 801-940 September, 1219-1382 December, 1691-1882 SUBJECT INDEX 1993 requirement of Asn°9’ or Asn 4'® for inhibition of glucose-induced secretion calcium channel mRNA expression in normal biosynthesis and through inactivation of glucokinase rat, downregulation after glucose processing of, 966 by glyceraldehyde, 1003 infusion and, 948 Insulin resistance by isolated rat and canine islets of differential expression of GAD,. and in aging, relationship to abdominal Langerhans, effect of hypoxia on, GADg; in human, rat, and mouse obesity, 273 12 islets, 1799 in blacks with NIDDM, 444 lack of effect of deferoxamine therapy differential expression of glutamic acid caused by Ala'°48—> mutation in kinase on, in individuals with NIDDM and decarboxylase in rat and human domain of insulin receptor, 1837 elevated serum ferritin, 544 islets, 485 murine insulinoma cell line with normal effect of STZ administration on islet cellular, in gestational diabetes caused glucose-regulated insulin allograft and allograft survival in by multiple defects in adipocyte secretion, 901 NOD mice, 324 glucose transport system, 1773 oscillatory, after pancreas transplant, effects of monomethylsuccinate and as determinant of oral glucose 855 glucose on insulin secretion from tolerance in normal individuals, reduction by repeated low doses of perfused rat islets, 843 1324 streptozocin, impairment of fluorescence digital image analysis of hepatic, reversal by benfluorex, in glucose effectiveness and lack of glucose-induced [Ca?*], STZ-induced diabetic rats, 564 induction of insulin resistance in oscillations in mouse islets, 1210 inducement by diet and amelioration dogs and, 475 function in nondiabetic and diabetic with benfluorex in rat, 457 retinoic acid receptor, cytosolic BB rats, 1310 induction of insulin resistance of retinol-binding and retinoic GABA production in rat islets, 1506 glucose transport and glycogen acid-binding protein mRNA glucose-induced amplitude regulation synthesis in isolated rat skeletal transcripts and proteins in rat of pulsatile insulin secretion from muscles by pre-exposure to insulin-secretion cells, 1109 individual islets, 670 glucosamine, 1333 Insulin sensitivity increase of expression of growth arrest insulinlike growth factor | therapy for quantification of relationship between and DNA damage-inducible patients with extreme insulin insulin sensitivity and B-cell genes gadd 153 and gadd 45 by resistance syndromes, 696 function in human subjects, 1663 genotoxic agents in, 738 in spontaneously hypertensive rats, reduced sample number for influence of islet amyloid polypeptide 1364 calculation of insulin sensitivity and 8-37 fragment of islet amyloid stimulation of glucose transport, and glucose effectiveness from polypeptide on insulin release glucose transporter translocation, minimal model, 250, 1635 from perfused rat islets, 330 and dephosphorylation in Insulin signaling insulin secretion, myo-inositol insulin-resistant rat adipocytes in G-protein specificity in signaling transport, and Na*-K*-ATPase in vitro by glimepiride, 1852 pathways that mobilize calcium in glucose- desensitized rat islets, Insulin secretion insulin-secreting B-TC3 cells, 1878 1392 amplification by lipid messengers, 367 insulin receptor substrate-1 and insulin secretion by isolated rat and arginine vasopressin and oxytocin proteins with SH2 domains and, canine islets, effect of hypoxia on, 643 12 effects in mouse pancreatic B-cells, 914 Insulin therapy interleukin-1 interaction with B-cells of, intensive, weight gain in IDDM and, 56 as determinant of oral glucose 1700 islet cell DNA as target of inflammatory tolerance in normal individuals, 1324 pharmacodynamics and activity of attack by nitric acid, 496 intranasally administered insulin in prevention of rejection of islet effects of epinephrine on, interaction healthy male volunteers, 1649 xenografts (rat to mouse) by tumor with aging, 307 Insulitis, association of faulty major necrosis factor-a, 651 effects of monomethylsuccinate and histocompatibility complex class II proinsulin conversion in, kinetics of, glucose on secretion from I-E expression with autoimmunity in 933 perfused rat islets, 843 diverse strains of mice, 1166 prolongation of islet allograft survival glucagonlike peptide-1 and control of Intelligence, in adult patients with by MHC class | deficiency, 1520 secretion in normal state and insulin-treated diabetes, 341 recognition of distinct islet antigens by NIDDM, 1219 Interleukin-1 cytoplasmic islet cell antibodies in in glucose- desensitized rat islets, 1392 interaction with islet B-cells, 56 IDDM but not in stiff man glucose-induced amplitude regulation prolongation of mouse islet allograft syndrome, 1642 of pulsatile secretion from survival by treatment with regulation of amyloid polypeptide in individual pancreatic islets, 670 interleukin-1 receptor antagonist, human islets, 1514 GLUT2 expression and function in 1845 signals derived from glucose B-cells of GK rats with NIDDM, selective pancreatic B-cell production metabolism required for glucose dissociation between reductions in of tumor necrosis factor-a induced regulation of islet GLUT2 mRNA glucose transport and by, 1026 and protein, 1273 glucose-stimulated insulin International International Immunology somatostatin inhibition of insulin- gene secretion and, 1065 and Diabetes Workshop, 1099 expression through G-protein specificity in signaling Irradiation, IDDM induced by, in rats, posttranscriptional mechanism in pathways that mobilize calcium in 571 hamster islet cell line, 244 insulin-secreting B-TC3 cells, 1878 Islets of Langerhans transplantation of, in rat DIABETES: VOLUME 42 (1993) PAGE NUMBERS BY ISSUE January, 1-212 April, 503-636 July, 941-1098 October, 1383-1547 February, 213-366 May, 637-800 August, 1099-1218 November, 1549-1689 March, 367-502 June, 801-940 September, 1219-1382 December, 1691-1882 SUBJECT INDEX 1993 histocompatibility antigens in, 90 Lipoprotein(s), apolipoprotein fibronectin-induced increase in insulin secretory function in relation A-l-containing, regulation in IDDM, prostaglandin release by, to transplanted islet mass and, 1281 hyperglycemia and PKC inhibition 98 Liver and, 183 ecrease of lipid oxidation and grown in high- glucose medium, gluconeogenesis from lactate but accumulation of fibronectin by, J not fasting hyperglycemia or total mediation by protein kinase C, Japanese association of polymorphic hepatic glucose production by 118 microsatellite repeat markers at inhibition of lipolysis in NIDDM, mediation of increased fibronectin glucokinase gene locus with 1694 accumulation by mesangial cells NIDDM in, 1147 effects of physiological increments in grown in high- glucose medium by sequence variations of glucokinase plasma insulin concentrations on protein C, 118 gene in Japanese subjects with synthesis of hepatic proteins in proteoglycans produced by, effect of NIDDM, 1133 normal humans, 995 glucose on, 1815 jun-B transcription factor, as target of failure of insulin to induce hydrolysis of Metalloprotease, decreased activity in autoreactive cells in IDDM, 626 glycosy! phosphatidylinositol in rat STZ-induced diabetes in rats, 1425 fetal hepatocytes, 1262 Metformin, blockage of downregulation impaired regulation of hepatic of cell surface GLUT4 caused by fructose-1,6-biphosphatase in chronic insulin treatment of rat Kallikrein, in submandibular glands of New Zealand obese mouse model adipocytes by, 1159 $TZ-induced diabetic rats, effects of of NIDDM, 1731 Methionine, for valine substitution in exon insulin and, 113 inhibition of endocytosis in 17 of insulin receptor gene in Kidney. See also Glomeruli; Nephropathy hepatocytes from diabetic rats, pedigree with familial NIDDM, 429 decreased activity of glomerular 1303 Methylamine, oxidative deamination by cathepsin and metalloprotease in role of glucose-6-phosphatase in semicarbazide-sensitive amine STZ-induced diabetes in rats, action of insulin on hepatic oxidase leading to cytotoxic damage 1425 glucose production in rat, 1614 in endothelial cells, 594 enhancement of glomerular collagen transplantation of, metabolic effects of Methylguanine, repair of synthesis in diabetic rats by cyclosporin A and FK 506 in O®-methylguanine in rat B-cells after transforming growth factor-B,, transplant recipients, 1753 exposure to N-methyl-N-nitrosourea, 1673 Liver glycogen synthase phosphatase, 1187 glycogen structure and segmental opposite effects of hyperglycemia Mitochondria, reversal of defect in localization in diabetic rat kidney, and insulin deficiency on, in diabetic mitrochondrial energy production in 891 rat, 363 heart of chronically diabetic rat by neuropathy following successful Lymphocytes. See also CD8* T-cells; physical training, 682 pancreas and kidney CD4* T-cells Monomethylsuccinate, effects on insulin transplantation, 1482 endothelial cell-binding properties of secretion frorn perfused rat islets, Kinase, defective kinase activity and iymphocytes infiltrated into human 843 insulin resistance caused by diabetic pancreas, 1656 mRNA Ala'°4®-s mutation in kinase domain Lymphopenia, transcription and calcium channel mRNA expression in of insulin receptor, 1837 translation of RT6* gene in rat pancreatic islets, lymphopenic diabetes- prone BB downregulation after glucose rats, 688 infusion and, 948 Laminin, inhibition of neurite outgrowth Lymphotoxin, prevention of autoimmune effects of hyperinsulinemia and by nonenzymatic glycosylation of, diabetes in NOD mice by, 398 hyperglycemia on GLUT4 and 509 hexokinase Il mRNA and protein Lipase, enhancement of lipolysis and M in rat skeletal muscle and adipose activation of partially purified Major histocompatibility complex tissue, 922 hormone-sensitive lipase by chronic association of faulty major expression of growth factors in exposure of rat fat cells to insulin, histocompatibility complex class II glomeruli from diabetic rats, 450 1415 |-E expression with autoimmunity retinoic acid receptor, cytosolic Lipid(s) in diverse strains of mice, 1166 retinol- binding and retinoic in children, 1010 prolongation of islet allograft survival acid-binding protein MRNA decrease of lipid oxidation and by MHC class | deficiency, 1520 transcripts and proteins in rat gluconeogenesis from lactate but MDL 29,311, 1179 insulin-secretion cells, 1109 not fasting hyperglycemia or total prevention of diabetes in nonobese signals derived from glucose hepatic glucose production by diabetic and multiple-lodwo-se metabolism required for glucose inhibition of lipolysis in NIDDM, STZ-injected mice by, 1721 regulation of pancreatic islet 1694 Memory lymphocyte markers, GLUT2 mRNA and protein, 1273 MDL 29,311 and, 1179 simuitaneous expression with naive Muscle Lipid messengers, amplification of insulin lymphocyte markers at diagnosis of effects of hyperinsulinemia on muscle secretion by, 367 IDDM, 127 fiber composition and Lipolysis, enhancement by chronic Mesangial cells capillarization in rats, 1073 exposure of rat fat cells to insulin, effect of high glucose on type IV number of bursts of muscle 1415 collagen production by, 170 sympathetic nerve activity in IDDM DIABETES: VOLUME 42 (1993) PAGE NUMBERS 8Y ISSUE January, 1-212 April, 503-636 July, 941-1098 October, 1383-1547 February, 213-366 May, 637—800 August, 1099-1218 November, 1549-1689 March, 367-502 June, 801-940 September, 1219-1382 December, 1691-1882