DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology (Cancer Principles and Practice of Oncology) PDF
Preview DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology (Cancer Principles and Practice of Oncology)
LLWWBBKK11884444--FFMM--MMuullttii--VVooll--11__ppii--xxxxxx..iinndddd 11 2299//0077//2222 1100::4488 PPMM Editors Vincent T. DeVita Jr., MD Amy and Joseph Perella Professor of Medicine Yale Comprehensive Cancer Center and Smilow Cancer Hospital at Yale–New Haven Professor of Epidemiology and Public Health Yale University School of Public Health New Haven, Connecticut Theodore S. Lawrence, MD, PhD Isadore Lampe Professor and Chair Department of Radiation Oncology University of Michigan Ann Arbor, Michigan Steven A. Rosenberg, MD, PhD Chief, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Professor of Surgery, Uniformed Services University of the Health Sciences School of Medicine Bethesda, Maryland Professor of Surgery, George Washington University School of Medicine Washington, District of Columbia With 330 Contributing Authors LLWWBBKK11884444--FFMM--MMuullttii--VVooll--11__ppii--xxxxxx..iinndddd 22 2299//0077//2222 1100::4488 PPMM Volume 1 LLWWBBKK11884444--FFMM--MMuullttii--VVooll--11__ppii--xxxxxx..iinndddd 33 2299//0077//2222 1100::5500 PPMM Acquisitions Editor: Nicole Dernoski, Joe Cho Associate Director, Content Development: Anne Malcolm Development Editors: Thomas Celona, Kristen Baum, Ashley Fischer Editorial Coordinators: Sean Hanrahan and Marisa Solorzano-Taylor Editorial Manager: Annette Gregory Marketing Manager: Kirsten Watrud Senior Production Project Manager: Alicia Jackson Manager, Graphic Arts & Design: Stephen Druding Senior Manufacturing Coordinator: Beth Welsh Prepress Vendor: Aptara, Inc. 12th edition Copyright © 2023 Wolters Kluwer. Copyright © 2019 Wolters Kluwer. Copyright © 2015 by Wolters Kluwer Health. Copyright © 2011 by Wolters Kluwer Health / Lippincott Williams & Wilkins. Copyright © 2008 by Lippincott Williams & Wilkins, a Wolters Kluwer business. Copyright © 2005, 2001 by Lippincott Williams & Wilkins. Copyright © 1997, by Lippincott-Raven Publishers. Copyright © 1993, 1989, 1985, 1982 by J.B. Lippincott Company. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at [email protected], or via our website at shop.lww.com (products and services). 9 8 7 6 5 4 3 2 1 Printed in Mexico Library of Congress Cataloging-in-Publication Data available upon request. 978-1-9751-8468-1 This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. This work is no substitute for individual patient assessment based upon healthcare professionals’ examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments. Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturer’s package insert) accompanying each drug to verify, among other things, conditions of use, warnings, and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used, or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work. shop.lww.com LLWWBBKK11884444--FFMM--MMuullttii--VVooll--11__ppii--xxxxxx..iinndddd 44 2299//0077//2222 1100::5500 PPMM C O N T R I B U T I N G A U T H O R S Nadeem R. Abu-Rustum, MD Jon C. Aster, MD, PhD Tracy Batchelor, MD Chief, Gynecology Service Deputy Chair Chair Department of Surgery Department of Pathology Department of Neurology Memorial Sloan Kettering Cancer Center Brigham and Women’s Hospital Brigham and Women’s Hospital New York, New York Boston, Massachusetts Harvard Medical School Boston, Massachusetts Mohamed Abdelgadir Adam, MD David A. August, MD Assistant Professor of Surgery Professor of Surgery Matthew A. Beier, BS, MFE Department of Surgery, Division of Associate Director, Faculty Affairs Rutgers Robert Wood Johnson Medical Surgical Oncology Department of Surgery, Division of School University of California, San Francisco Surgical Oncology New Brunswick, New Jersey San Francisco, California Rutgers Cancer Institute of New Jersey Rutgers Robert Wood Johnson Medical Ann M. Berger, MSN, MD Narasimhan P. Agaram, MBBS School Senior Research Clinician Attending Pathologist New Brunswick, New Jersey Chief, Pain and Palliative Care Service Department of Pathology and Laboratory National Institutes of Health Clinical Medicine Itzhak Avital, Bsc MD, MBA, FACS Center Memorial Sloan Kettering Cancer Center Executive Medical Director, Chairman Bethesda, Maryland New York, New York of Surgery Legacy Heritage Oncology Center Sushil Beriwal, MD, MBA, FASTRO, Manmeet S. Ahluwalia, MD, MBA Ben Gurion University FABS Chief of Medical Oncology, Chief Beer Sheva, Israel Academic Chief Scientific Officer, Deputy Director Department of Radiation Oncology Miami Cancer Institute Joachim M. Baehring, MD, DSc Allegheny Health Network Miami, Florida Professor Pittsburgh, Pennsylvania Department of Neurology and Kaled M. Alektiar, MD Neurosurgery Ross S. Berkowitz, MD Attending Physician Yale School of Medicine Director of Gynecologic Oncology Department of Radiation Oncology New Haven, Connecticut Brigham and Women’s Hospital and Memorial Sloan Kettering Cancer Dana-Farber Cancer Institute Center Laurence Baker, DO, FACOI William H. Baker Professor of Gynecology New York, New York Collegiate Professor Harvard Medical School Department of Internal Medicine and Boston, Massachusetts Stephen Ansell, MD, PhD Pharmacology Professor of Medicine University of Michigan Jan H. Beumer, PharmD, PhD, DABT Division of Hematology Ann Arbor, Michigan Professor of Pharmaceutical Sciences Mayo Clinic and Medicine Rochester, Minnesota Ting Bao, MD, DABMA, MS UPMC Hillman Cancer Center Director, Integrative Breast Oncology University of Pittsburgh School of Pharmacy Charlotte E. Ariyan, MD, PhD Department of Medicine Pittsburgh, Pennsylvania Associate Attending Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center New York, New York Aarti Bhatia, MD, MPH New York, New York Assistant Professor Christopher A. Barker, MD Department of Internal Medicine, Alvaro Arjona-Sanchez, MD, PhD Associate Attending and Vice-Chair of Division of Oncology Consultant in Surgical Oncology Clinical Research Yale School of Medicine Unit of Surgical Oncology, Department Department of Radiation Oncology New Haven, Connecticut of Surgery Memorial Sloan Kettering Cancer Center Reina Sofia University Hospital New York, New York Leonardo Kayat Bittencourt, MD, PhD Cordoba, Spain Vice-Chair of Innovation, Associate Ronald D. Barr, CM, MB, ChB, MD Professor of Radiology Alan Ashworth, PhD, FRS Professor Emeritus Department of Radiology President, UCSF Helen Diller Family Department of Pediatrics and Medicine University Hospitals and Case Western Comprehensive Cancer Center McMaster University Reserve University University of California, San Francisco Hamilton, Ontario, Canada Cleveland, Ohio San Francisco, California v LLWWBBKK11884444--FFMM--MMuullttii--VVooll--11__ppii--xxxxxx..iinndddd 55 2299//0077//2222 1100::5500 PPMM vi Contributing Authors Elizabeth M. Blanchard, MD Justin C. Brown, PhD Sharon M. Castellino, MD, MSc Chief Director, Cancer Metabolism Program Professor of Pediatrics Department of Hematology and Oncology Pennington Biomedical Research Director, Leukemia/Lymphoma Program Southcoast Health Center Department of Pediatrics New Bedford, Massachusetts Baton Rouge, Louisiana Emory University Atlanta, Georgia Archie Bleyer, MD Harold J. Burstein, MD, PhD Clinical Research Professor Professor of Medicine Debyani Chakravarty, PhD Department of Radiation Medicine Dana-Farber Cancer Institute Assistant Attending Molecular Geneticist, Oregon Health & Science University Harvard Medical School Molecular Diagnostics Service Portland, Oregon Boston, Massachusetts Department of Pathology and Laboratory Professor of Pediatrics Medicine University of Texas McGovern Medical Isabella F. Calastri, BSN Memorial Sloan Kettering Cancer Center School Department of Professional Nursing New York, New York Houston, Texas Practice Georgetown University School of Nursing Ronald Chamberlain, MD, MPA, FACS Sharon L. Bober, PhD and Health Studies Chief, Surgical Oncology and HPB Psychologist Washington, District of Columbia Surgery Director, Sexual Health Program Department of Surgery Department of Psychosocial Oncology Teresa Calimeri, MD, PhD HCA West Florida and USF Morgani and Palliative Care Physician School of Medicine Dana-Farber Cancer Institute Lymphoma Unit Tampa, Florida Harvard Medical School IRCCS San Raffaele Scientific Boston, Massachusetts Institute Richard Champlin, MD Milan, Italy Chairman, Department of Stem Cell Lawrence H. Boise, PhD Transplantation and Cellular Therapy R. Randall Rollins Professor in Cancer Robert B. Cameron, MD The University of Texas MD Anderson Research Professor of Cardiothoracic Surgery and Cancer Center Department of Hematology and Medical Surgical Oncology Houston, Texas Oncology Department of Surgery Winship Cancer Institute of Emory David Geffen School of Medicine at Étienne Chatelut, PharmD, PhD University University of California, Los Angeles Professor of Pharmacology Atlanta, Georgia Los Angeles, California Faculté de Santé, Department de Pharmacie Danielle C. Bonadies, MS, CGC Matthew T. Campbell, MD, MS Institut Universitaire du Cancer de CoFounder and Director Assistant Professor, Associate Medical Toulouse My Gene Counsel Director Genitourinary Center Toulouse, France New Haven, Connecticut Department of Genitourinary Medical Oncology Bhishamjit S. Chera, MD Steven E. Braunstein, MD, PhD The University of Texas MD Anderson Professor of Radiation Oncology and Associate Professor Cancer Center Otolaryngology, Head and Neck Department of Radiation Oncology Houston, Texas Surgery University of California San Francisco Wendy & Keith Wellin Endowed Chair San Francisco, California Michele Carbone, MD, PhD Department of Radiation Oncology William & Ellen Melohn Chair in Medical University of South Carolina Otis W. Brawley, MD Cancer Biology Charleston, South Carolina Bloomberg Distinguished Professor Director, Thoracic Oncology Department of Oncology and Epidemiology University of Hawaii Cancer Center Nathan I. Cherny, AM, MBBS, FRACP, The Johns Hopkins University School of Professor, Department of Pathology FRCP, LLD Medicine John A. Burns School of Medicine Director, Cancer Pain and Palliative Baltimore, Maryland Honolulu, Hawaii Medicine Service Department of Medical Oncology and Jonathan R. Brody, PhD Vice Chair of Research Paolo G. Casali, MD Palliative Care Department of Surgery Director of Medical Oncology Unit 2 Shaare Zedek Medical Center Associate Director of the Brenden-Colson Associate Professor Jerusalem, Israel Center for Pancreatic Care Fondazione IRCCS Istituto Nazionale Department of Surgery and Cell, dei Tumori Brooke O. Cherven, PhD, MPH, RN Development, and Cancer Biology University of Milan Assistant Professor of Pediatrics Oregon Health and Science University Milan, Italy Aflac Cancer and Blood Disorders Center Portland, Oregon Emory University Keith A. Casper, MD Atlanta, Georgia Marja Brolinson, MD Associate Professor Clinical Fellow Department of Otolaryngology—Head Lydia L. Chevalier, PhD Department of Reproductive and Neck Surgery Research Fellow, Perini Family Survivors’ Endocrinology and Infertility University of Michigan Center National Institute of Child Health and Ann Arbor, Michigan Dana-Farber Cancer Institute Human Development Harvard Medical School National Institutes of Health Boston, Massachusetts Bethesda, Maryland LLWWBBKK11884444--FFMM--MMuullttii--VVooll--11__ppii--xxxxxx..iinndddd 66 2299//0077//2222 1100::5500 PPMM Contributing Authors vii Lauren Chiec, MD Louis S. Constine, MD, FASTRO, FACR Catherine Hambleton Davis, MD, MPH Hematology and Oncology Fellow Professor of Radiation Oncology and Fellow, Complex General Surgical Department of Medicine Pediatrics Oncology McGaw Medical Center of Northwestern University of Rochester Medical Center Department of Surgical Oncology University Rochester, New York Rutgers Cancer Institute of New Jersey Chicago, Illinois New Brunswick, New Jersey Mehmet Sitki Copur, MD, FACP Clifford S. Cho, MD Medical Director, Morrison Cancer Lorraine T. Dean, ScD C. Gardner Child Professor of Surgery Center Medical Oncology Associate Professor Department of Surgery Morrison Cancer Center Department of Epidemiology University of Michigan Mary Lanning Healthcare, Hastings, Johns Hopkins Bloomberg School of Ann Arbor, Michigan Nebraska Public Health Professor, University of Nebraska Medical Baltimore, Maryland Edward Chow, MBBS, MSc, PhD, Center Alan H. DeCherney, MD FRCPC Department of Medicine Branch Chief, Reproductive Radiation Oncologist Division of Hematology Oncology, Endocrinology and Gynecology Department of Radiation Oncology Adjunct Faculty National Institute of Child Health and University of Toronto Omaha, Nebraska Human Development Toronto, Ontario, Canada National Institutes of Health Andres F. Correa, MD Bethesda, Maryland Sean R. Christensen, MD, PhD Assistant Professor Associate Professor Department of Urologic Oncology Angelo Paolo Dei Tos, MD Department of Dermatology Fox Chase Cancer Center Professor of Pathology Yale School of Medicine Philadelphia, Pennsylvania Chair New Haven, Connecticut Department of Integrated Diagnostics Anne M. Covey, MD, FSIR University of Padua School of Medicine Edward Chu, MD, MMS Professor of Radiology, Attending Padua, Italy Director Radiologist Vice-President of Cancer Medicine, Department of Radiology Marcos de Lima, MD Montefiore Medicine Memorial Sloan Kettering Cancer Center Professor of Medicine Montefiore Einstein Cancer Center Weill Cornell Medical Center Department of Hematology Albert Einstein College of Medicine New York, New York Ohio State University Bronx, New York Columbus, Ohio Aimee M. Crago, MD, PhD, FACS Melvin Lee Kiang Chua, MBBS, FRCR, Associate Attending Surgeon Marcello Deraco, MD PhD, FAMS Department of Gastric and Mixed Tumor Director of Peritoneal Surface Head and Senior Consultant Service Malignancies Unit Department of Head and Neck and Memorial Sloan Kettering Cancer Center Department of Surgical Oncology Thoracic Cancers New York, New York Fondazione IRCCS Istituto Nazionale dei Division of Radiation Oncology Tumori National Cancer Centre Tracy E. Crane, PhD, RDN Milan, Italy Singapore Co-lead, Cancer Control Director of Digital Health and Lifestyle Hari A. Deshpande, MD, MBChB Callisia N. Clarke, MD, MS, FACS, Medicine for Cancer Survivorship Associate Professor of Medicine FSSO Sylvester Comprehensive Cancer Center Department of Medical Oncology Assistant Professor of Surgery University of Miami, Leonard M. Miller Yale Cancer Center Department of Surgery, Division of School of Medicine Yale School of Medicine Surgical Oncology Miami, Florida New Haven, Connecticut Medical College of Wisconsin Frank C. Detterbeck, MD Milwaukee, Wisconsin Brian G. Czito, MD Professor and Chief, Thoracic Surgery Professor Department of Surgery Erin F. Cobain, MD Department of Radiation Oncology Yale School of Medicine Assistant Professor Duke University Medical Center New Haven, Connecticut Department of Internal Medicine Durham, North Carolina University of Michigan Siddhartha Devarakonda, MD Ann Arbor, Michigan Douglas M. Dahl, MD Assistant Professor of Medicine Chief, Division of Urologic Oncology Department of Internal Medicine Robert E. Coleman, MBBS, MD, FRCP Department of Urology Washington University School of Medicine Emeritus Professor of Medical Oncology Massachusetts General Hospital St. Louis, Missouri Department of Oncology and Metabolism Boston, Massachusetts University of Sheffield Vincent T. DeVita Jr., MD Sheffield, United Kingdom Sandra P. D’Angelo, MD Amy and Joseph Perella Professor of Research Director, Attending Physician Medicine Annette Compter, MD, PhD Department of Medicine Yale Comprehensive Cancer Center and Neuro-Oncologist Memorial Sloan Kettering Cancer Center Smilow Cancer Department of Neurology New York, New York Hospital at Yale–New Haven Antoni van Leeuwenhoek Professor of Epidemiology and Public Health Amsterdam, Netherlands Yale University School of Public Health New Haven, Connecticut LLWWBBKK11884444--FFMM--MMuullttii--VVooll--11__ppii--xxxxxx..iinndddd 77 2299//0077//2222 1100::5500 PPMM viii Contributing Authors Khanh T. Do, MD Matthew J. Ehrhardt, MD, MS Adam S. Feldman, MD, MPH Director, Clinical Development Assistant Member Assistant Professor of Surgery Department of Oncology Department of Oncology Department of Urology Division of Cancer Treatment and Department of Epidemiology and Cancer Massachusetts General Hospital Diagnosis Control Harvard Medical School National Cancer Institute St. Jude Children’s Research Hospital Boston, Massachusetts National Institutes of Health Memphis, Tennessee Moderna, Incorporated Mary Feng, MD Cambridge, Massachusetts Kevin M. Elias, MD, FACOG Professor Director of the Gynecologic Oncology Department of Radiation Oncology Ahmet Dogan, MD, PhD Laboratory University of California, San Francisco Chief, Department of Pathology Division of Gynecologic Oncology San Francisco, California Memorial Sloan Kettering Cancer Department of Obstetrics and Center Gynecology and Reproductive Biology Andrea Ferrari, MD New York, New York Brigham and Women’s Hospital Pediatric Oncology Unit Dana-Farber Cancer Institute Fondazione IRCCS Istituto Nazionale dei Jessica S. Donington, MD, MSCr Assistant Professor Tumori Professor and Chief of Thoracic Surgery Harvard Medical School Milan, Italy Department of Surgery, Section of Boston, Massachusetts Renata Ferrarotto, MD Thoracic Surgery Associate Professor University of Chicago Medicine Tobias Else, MD Department of Thoracic Head and Neck Chicago, Illinois Associate Professor Medical Oncology Department of Internal Medicine The University of Texas MD Anderson Benjamin J. Drapkin, MD, PhD Division of Metabolism, Endocrinology Cancer Center Assistant Professor and Diabetes Houston, Texas Department of Internal Medicine University of Michigan University of Texas Southwestern Medical Ann Arbor, Michigan Andrés José María Ferreri, MD Center Doctor Dallas, Texas Cathy Eng, MD, FACP, FASCO Lymphoma Unit David H. Johnson Endowed Chair in IRCCS San Raffaele Scientific Institute Alexander Drilon, MD Surgical and Medical Oncology Milano, Italy Chief, Early Drug Development Professor of Medicine, Hematology and Memorial Sloan Kettering Cancer Oncology Paul T. Finger, MD, FACS Center Co-Director, GI Oncology Director, The New York Eye Cancer New York, New York Co-Leader, Gastrointestinal Cancer Center Research Program Clinical Professor of Ophthalmology Steven G. DuBois, MD, MS Director, Young Adult Cancers Program Department of Ophthalmology Associate Professor Co-Chair, NCI Gastrointestinal Steering NYU Grossman School of Medicine Department of Pediatrics Committee New York, New York Harvard Medical School Vanderbilt-Ingram Cancer Center Dana-Farber Cancer Institute Nashville, Tennessee Joel A. Finkelstein, MD, MSc, FRCSC Boston, Massachusetts Associate Professor Douglas B. Evans, MD Department of Surgery Lara A. Dunn, MD Donald C. Ausman Family Foundation University of Toronto Assistant Attending Physician Professor of Surgery Toronto, Ontario, Canada Department of Medicine Chair, Department of Surgery Memorial Sloan Kettering Cancer Medical College of Wisconsin Allison Fitzgerald, PhD Center Milwaukee, Wisconsin Department of Oncology New York, New York Georgetown University Joseph R. Evans, MD, PhD Washington, District of Columbia Peter T. Dziegielewski, MD, FRCSC Assistant Professor Chief of Head and Neck Surgical Department of Radiation Oncology Yuman Fong, MD Oncology and Microvascular University of Michigan Sangiacomo Chair and Chairman Reconstructive Surgery Ann Arbor, Michigan Department of Surgery Department of Otolaryngology City of Hope National Medical Center College of Medicine Jane M. Fall-Dickson, PhD, MSN, RN Duarte, California University of Florida Associate Professor Gainesville, Florida Assistant Chair, Research Francine M. Foss, MD Department of Professional Nursing Professor of Medicine Jason A. Efstathiou, MD, DPhil, Practice Department of Hematology and Stem FASTRO, FACRO Georgetown University School of Nursing Cell Transplantation Professor, Harvard Medical School and Health Studies Yale School of Medicine Director, Genitourinary Division Washington, District of Columbia New Haven, Connecticut Department of Radiation Oncology Massachusetts General Hospital Meagan B. Farmer, MS, MBA, LCGC Deshka Foster, MD, PhD Boston, Massachusetts Director, Genetic Clinical Operations Department of Surgery Department of Genetics Stanford University School of Medicine My Gene Counsel, LLC Stanford, California New Haven, Connecticut LLWWBBKK11884444--FFMM--MMuullttii--VVooll--11__ppii--xxxxxx..iinndddd 88 2299//0077//2222 1100::5500 PPMM Contributing Authors ix Steven J. Frank, MD Matthew P. Goetz, MD Stephanie Halene, MD The Bessie McGoldrick Professorship in Erivan K. Haub Family Professor Associate Professor Clinical Cancer Research Professor of Oncology and Pharmacology Chief, Section of Hematology Executive Director, Particle Therapy Department of Medical Oncology Yale Cancer Center Institute Mayo Clinic Yale School of Medicine Deputy Head, Strategic Programs Rochester, Minnesota New Haven, Connecticut Division of Radiation Oncology The University of Texas MD Anderson Stephanie L. Goff, MD, FACS Meera Hameed, MD Cancer Center Associate Research Physician Attending Pathologist, Chief of Service, Houston, Texas Center for Cancer Research/Surgery Surgical Pathology Branch Department of Pathology and Laboratory Arnold S. Freedman, MD National Cancer Institute Medicine Professor of Medicine National Institutes of Health Memorial Sloan Kettering Cancer Center Department of Medical Oncology Bethesda, Maryland New York, New York Dana-Farber Cancer Institute Harvard Medical School Sara B. Goldberg, MD, MPH Gary D. Hammer, MD, PhD Boston, Massachusetts Associate Professor Millie Schembechler Professor of Adrenal Department of Medicine, Division of Cancer Scott Nicholas Furlan, MD Medical Oncology Director, Endocrine Oncology Program Assistant Professor Yale School of Medicine Department of Internal Medicine/MEND Clinical Research Division New Haven, Connecticut University of Michigan Fred Hutchinson Cancer Research Ann Arbor, Michigan Center Leonard G. Gomella, MD, FACS Department of Pediatrics Professor and Chairman Christine L. Hann, MD, PhD University of Washington Department of Urology Associate Professor of Oncology Seattle, Washington Thomas Jefferson University The Johns Hopkins University School Philadelphia, Pennsylvania of Medicine Nicolette M. Gabel, PhD Baltimore, Maryland Associate Professor Karyn A. Goodman, MD, MS Department of Physical Medicine and Professor Ehab Y. Hanna, MD, FACS Rehabilitation Department of Radiation Oncology Professor and Vice Chairman University of Michigan Icahn School of Medicine at Mount Sinai Department of Head and Neck Surgery Ann Arbor, Michigan New York, New York The University of Texas MD Anderson Cancer Center Carlo Gambacorti-Passerini, MD Ramaswamy Govindan, MD Houston, Texas Director, Department of Hematology Professor of Medicine University of Milano Bicocca Department of Medicine Glenn J. Hanna, MD San Gerardo Hospital Washington University School of Medicine Medical Oncologist, Assistant Professor of Monza, Italy St. Louis, Missouri Medicine Center for Salivary and Rare Head and Nasrin Ghalyaie, MD, FACS, FASCRS Jennifer J. Griggs, MD, MPH Neck Cancers Colon and Rectal Surgeon Professor Center for Head and Neck Oncology HCA Affiliated Hospitals Department of Internal Medicine, Dana-Farber Cancer Institute Tampa, Florida Division of Hematology/Oncology Harvard Medical School University of Michigan Boston, Massachusetts Nicolas Girard, MD, PhD Ann Arbor, Michigan Head, Thorax Institute Curie-Montsouris Aphrothiti J. Hanrahan, PhD Institute Curie Alessandro Gronchi, MD Assistant Lab Member Paris, France Chair, Sarcoma Service Department of Human Oncology and Department of Surgery Pathogenesis Program (HOPP) Michael Girardi, MD Fondazione IRCCS Istituto Nazionale dei Memorial Sloan Kettering Cancer Center Professor and Vice Chair Tumori New York, New York Department of Dermatology Milan, Italy Yale School of Medicine Roy S. Herbst, MD, PhD New Haven, Connecticut Vikas A. Gupta, MD, PhD Chief of Medical Oncology and Deputy Assistant Professor Director for Clinical Affairs Olivier Glehen, MD, PhD Department of Hematology and Medical Yale Cancer Center Professor of Surgery Oncology Assistant Dean for Translational Research Department of Surgical Oncology Winship Cancer Institute of Emory Yale School of Medicine Centre Hospitalo-Universitaire Lyon Sud University New Haven, Connecticut Pierre-Bénite, France Atlanta, Georgia James G. Herman, MD Diane Goéré, MD, PhD Daphne A. Haas-Kogan, MD Professor Professor Chair Department of Medicine, Hematology Department of Digestive Surgery Department of Radiation Oncology Oncology Hôpital Saint Louis Brigham and Women’s Hospital UPMC Hillman Cancer Center Université Paris Diderot Dana-Farber Cancer Institute University of Pittsburgh School of Medicine Paris, France Boston Children’s Hospital Pittsburgh, Pennsylvania Boston, Massachusetts LLWWBBKK11884444--FFMM--MMuullttii--VVooll--11__ppii--xxxxxx..iinndddd 99 2299//0077//2222 1100::5500 PPMM x Contributing Authors Paul J. Hesketh, MD, FASCO Caron A. Jacobson, MD Matthew F. Kalady, MD Director, Lahey Health Cancer Institute Assistant Professor of Medicine Professor of Surgery Lahey Hospital and Medical Center Department of Medical Oncology Director, Division of Colon and Rectal Burlington, Massachusetts Dana-Farber Cancer Institute Surgery Harvard Medical School Department of Surgery Geoffrey R. Hill, MD Boston, Massachusetts The Ohio State Wexner Medical Center Director of Hematopoietic Stem Cell The James Comprehensive Cancer Transplantation Michael Jaglal, MD, MS Center Clinical Research Division Associate Professor Columbus, Ohio Fred Hutchinson Cancer Research Moffitt Cancer Center Center Tampa, Florida Arif H. Kamal, MD, MBA, MHS Seattle, Washington Associate Professor Reshma Jagsi, MD, DPhil Division of Medical Oncology and Christopher J. Hoimes, DO Newman Family Professor, Department Section of Palliative Care Associate Professor of Radiation Oncology Duke Cancer Institute Genitourinary Oncology Director, Center for Bioethics and Social Durham, North Carolina Associate Director for Developmental Sciences in Medicine Therapeutics, Center for Cancer University of Michigan Jose A. Karam, MD, FACS Immunotherapy Ann Arbor, Michigan Associate Professor Department of Medicine, Genitourinary Department of Urology and Translational Oncology Ahmedin Jemal, DVM, PhD Molecular Pathology Duke Cancer Institute, Duke University Senior Vice President The University of Texas MD Anderson School of Medicine Surveillance and Health Equity Science Cancer Center Durham, North Carolina American Cancer Society Houston, Texas Atlanta, Georgia Neil S. Horowitz, MD Philipp Karschnia, MD Assistant Professor of Obstetrics, Erel Joffe, MD, MSc Department of Neurosurgery Gynecology, and Reproductive Medicine Attending Ludwig-Maximilians-University Harvard Medical School Department of Medicine, Lymphoma Munich, Germany Co-Director, New England Trophoblastic Service Disease Center Memorial Sloan Kettering Cancer Center Partow Kebriaei, MD Division of Gynecologic Oncology New York, New York Professor Brigham and Women’s Hospital Department of Stem Cell Transplant and Dana-Farber Cancer Institute Douglas B. Johnson, MD, MSCI Cellular Therapy Boston, Massachusetts Assistant Professor of Medicine The University of Texas MD Anderson Vanderbilt University School of Medicine Cancer Center Christina Huang, MD, MS Nashville, Tennessee Houston, Texas Department of Radiation Oncology Duke University School of Medicine Peter W.M. Johnson, MD, FRCP, Jacqueline R. Kelly, MD, MSc Durham, North Carolina FMedSci Radiation Oncologist Professor of Medical Oncology Morrison Cancer Center Mark D. Hurwitz, MD School of Cancer Sciences, Faculty of Mary Lanning Healthcare, Hastings, Chair and Director, Department of Medicine Nebraska Radiation Medicine University of Southampton Adjunct Professor in the College of New York Medical College, Westchester Southampton, United Kingdom Allied Health Professions, Division of Medical Center Radiation Therapy Program Valhalla, New York Shruti Jolly, MD University of Nebraska Medical Center Professor Omaha, Nebraska David H. Ilson, MD, PhD Department of Radiation Oncology Professor University of Michigan W. Kevin Kelly, DO Gastrointestinal Oncology Service Ann Arbor, Michigan Professor Department of Medicine Department of Medical Oncology and Memorial Sloan Kettering Cancer Center Kirsten Jorgensen, MD Urology Weill Cornell Medical College Gynecologic Oncology Fellow Thomas Jefferson University New York, New York Department of Gynecologic Oncology Philadelphia, Pennsylvania and Reproductive Medicine Gopa Iyer, MD The University of Texas MD Anderson Michelle M. Kim, MD Associate Attending Physician Cancer Center Associate Professor Department of Medicine Houston, Texas Department of Radiation Oncology Memorial Sloan Kettering Cancer Center University of Michigan New York, New York Nisha S. Joseph, MD Ann Arbor, Michigan Assistant Professor William C. Jackson, MD Department of Hematology and Medical Assistant Professor Oncology Department of Radiation Oncology Winship Cancer Institute, Emory Michigan Medicine University Ann Arbor, Michigan Atlanta, Georgia LLWWBBKK11884444--FFMM--MMuullttii--VVooll--11__ppii--xxxxxx..iinndddd 1100 2299//0077//2222 1100::5500 PPMM
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