Developments and Applications of Calcium Phosphate Bone Cements

632 Pages·2018·26.189 MB·English

by  Changsheng Liu,Hongyan He (eds.)

Springer Series in Biomaterials Science and Engineering 9
Changsheng Liu
Hongyan He Editors
Developments
and Applications
of Calcium
Phosphate Bone
Cements
Springer Series in Biomaterials Science
and Engineering
Volume 9
Series editor
Prof. Min Wang
Department of Mechanical Engineering
The University of Hong Kong
Pokfulam Road, Hong Kong
e-mail: [email protected]
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glasses and ceramics, and composites/hybrids – and includes both biological
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Changsheng Liu • Hongyan He
Editors
Developments and
Applications of Calcium
Phosphate Bone Cements
Editors
Changsheng Liu Hongyan He
Key Laboratory for Ultrafine Materials Engineering Research Center for
of Ministry of Education Biomedical Materials of Ministry of
East China University of Science Education
and Technology East China University of Science
Shanghai, China and Technology
Shanghai, China
ISSN 2195-0644 ISSN 2195-0652 (electronic)
Springer Series in Biomaterials Science and Engineering
ISBN 978-981-10-5974-2 ISBN 978-981-10-5975-9 (eBook)
DOI 10.1007/978-981-10-5975-9
Library of Congress Control Number: 2017954397
© Springer Nature Singapore Pte Ltd. 2018
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Preface
As automobile mechanics repair damaged cars with auto parts, biomaterial research-
ers thereby endeavor to repair the damaged body tissue through the appropriate
“parts”. With the bionic concepts, they attempt to fabricate nonlife materials to par-
ticipate in the process of life for achieving tissue regeneration and functional resto-
ration. Therefore, exploring appropriate biomaterials is highly challenging and
endless.
Typically, artificial bones can be used to restore bone defects after suffering com-
minuted fracture, osteoporotic compression fractures, or bone tumors by enucleat-
ing. In the 1980s, artificial bones have been the focus of most of the research related
to biological ceramics. Although this material could imitate the composition and
strength of human bones, the low plasticity limited its wide applications. Our group
has started to study on the “biological calcium phosphate cement (CPC)” since the
early 1990s. In the following two decades, my coworkers and I have made a series
of in-depth exploration for this kind of self-setting CPCs: from powder preparation
to curing process; from the preparation mechanism to process control; from the
physicochemical properties to the biological performance; from cell experiments
in vitro to animal study/clinic research in vivo; and from material development to
enterprise establishment, clinical trial approval, clinical applications, and so on.
With the development of the novel materials and deep understanding of calcium
phosphate-based materials and their biological performance, numerous researchers
and scientists have made unremitting effort to further improve the biological perfor-
mances and extend the potentials of the CPC materials according to the feedback
from the clinical applications in recent years. By introducing functional materials
into the CPC compositions, the various shapes of CPC were designed and fabricated
for user-friendly operation and better properties according to different require-
ments. To improve the integration of artificial bone material and the bone, porous
CPCs were successfully prepared at room temperature, allowing a quick ingrowth
of cell and tissue into materials and a better degradation of the materials. Moreover,
the combination of the growth factors and the bone repair materials further enhanced
the osteoinduction activity of CPC and promoted the growth and differentiation of
the cells/tissues, speeding up the degradation of materials and new bone formation.
v
vi Preface
Advanced manufacturing technologies as 3D printings were applied for producing
the well-defined architecture, paving ways in bone tissue engineering and in person-
alized medicine of clinical orthopedic and orthodontic practices.
This book presents the state-of-the-art review of the latest advances in develop-
ing calcium phosphate bone cements and their applications. It includes 15 main
chapters and covers the synthesis methods, characterization approaches, material
modification, and novel binders, as well as the fabrication technologies of calcium
phosphate-based biomaterials in regenerative medicine and their clinical applica-
tions. Methodologies for fabricating scaffolds and biofunctional surfaces/interfaces
and subsequently modulating the host response to implantable/injectable materials
are highlighted. This book integrates a series of discussions and knowledge of the
calcium phosphate cements involving their physiochemical properties and biologi-
cal performance in vitro and in vivo. Accordingly, the book not only covers the
fundamentals but also opens new avenues for meeting future challenges in research
and clinical applications.
I believe this book will be useful to current bone material developers who wish
to have a complete view of the field, to newcomers who attempt to make the best
choice between different technologies, and to academic researchers who engage in
technology transfer activities and need to evaluate the hurdles from material devel-
opment to clinic trials. I am especially grateful to the authors, my colleagues, who
kindly accepted to undertake the absorbing task of writing a chapter. And, of course,
the organizational support from Springer in the production of this book is gratefully
acknowledged.
Shanghai, P.R. China Changsheng Liu
Contents
1 Calcium Phosphate Bone Cements: Their Development
and Clinical Applications........................................................................ 1
Fangping Chen, Xiaoyu Ma, Yuanman Yu, and Changsheng Liu
2 Self-Setting Calcium Orthophosphate (CaPO)
4
Formulations............................................................................................ 41
Sergey V. Dorozhkin
3 Injectable Calcium Phosphate Cements for Hard
Tissue Repair ........................................................................................... 147
Fangping Chen, Yuanman Yu, Xiaoyu Ma, and Changsheng Liu
4 Calcium Phosphate Composite Cement ................................................ 187
Jing Wang and Changsheng Liu
5 Accelerating Biodegradation of Calcium Phosphate Cement ............. 227
Hongyan He, Zhongqian Qiao, and Changsheng Liu
6 Bioactivation of Calcium Phosphate Cement by Growth
Factors and Their Applications.............................................................. 257
Yifan Ma, Baolin Huang, Dan Lin, Yuan Yuan, and Changsheng Liu
7 Drug-Loading Calcium Phosphate Cements for Medical
Applications ............................................................................................. 299
Shuxin Qu, Jie Weng, Ke Duan, and Yumei Liu
8 Biomimetic Ion-Substituted Calcium Phosphates................................ 333
Jun Ma, Shenglong Tan, and Shengmin Zhang
9 N anodimensional and Nanocrystalline Calcium
Orthophosphates ..................................................................................... 355
Sergey V. Dorozhkin
vii
viii Contents
10 Calcium Phosphate-Silk Fibroin Composites: Bone
Cement and Beyond ................................................................................ 449
Fengxuan Han, Chen Shi, Huilin Yang, and Bin Li
11 Importance of Biomaterials In Vivo Microenvironment
pH (μe-pH) in the Regeneration Process of Osteoporotic
Bone Defects ............................................................................................ 473
Wenlong Liu, Xiuli Dan, William Weijia Lu, and Haobo Pan
12 3D Printing of Calcium Phosphate Bio- scaffolds
for Bone Therapy and Regeneration ..................................................... 497
Hongshi Ma, Jiang Chang, and Chengtie Wu
13 Development of Biodegradable Bone Graft Substitutes
Using 3D Printing .................................................................................... 517
Zhidao Xia, Yunsong Shi, Hongyan He, Yuanzhong Pan,
and Changsheng Liu
14 Preparation of Collagen/Calcium Phosphate Coatings
and Evaluation of Their Biological Performances ............................... 547
Cheng Kui, Jun Lin, and Wenjian Weng
15 Preclinical and Clinical Assessments of Calcium
Phosphate Bone Cements ....................................................................... 597
Lingyan Cao, Deliang Zeng, Shuxian Lin, Xiao Wang,
Xiangkai Zhang, Ao Zheng, Jie Wang, and Xinquan Jiang
Contributors
Lingyan Cao Department of Prosthodontics, Ninth People’s Hospital, Shanghai
JiaoTong University School of Medicine, Shanghai, China
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of
Stomatology, National Clinical Research Center of Stomatology, Shanghai, China
Jiang Chang State Key Laboratory of High Performance Ceramics and Superfine
Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences,
Shanghai, China
Fangping  Chen Engineering Research Center for Biomedical Materials of
Ministry of Education, East China University of Science and Technology, Shanghai,
China
Xiuli Dan School of Biomedical Sciences, Faculty of Medicine, The Chinese
University of Hong Kong, Shatin, Hong Kong
Sergey V. Dorozhkin Kudrinskaja sq. 1-155, Moscow, Russia
Ke Duan Key Lab of Advanced Technologies of Materials, Ministry of Education,
School of Materials Science and Engineering, Southwest Jiaotong University,
Chengdu, China
Fengxuan  Han Orthopedic Institute, Soochow University (South Campus),
Suzhou, Jiangsu, China
Department of Orthopaedics, The First Affiliated Hospital of Soochow University,
Suzhou, Jiangsu, China
Hongyan He Engineering Research Center for Biomedical Materials of Ministry
of Education, East China University of Science and Technology, Shanghai, China
Baolin Huang Engineering Research Center for Biomedical Materials of Ministry
of Education, East China University of Science and Technology, Shanghai, China
ix