Detoxification and Substance Abuse Treatment A Treatment Improvement Protocol TIP 45 U.S. DEPARTMENT OFHEALTH AND HUMAN SERVICES Substance Abuse and Mental Health Services Administration Center for Substance Abuse Treatment www.samhsa.gov DETOXIFICATION Detoxification and Substance Abuse Treatment Norman S. Miller, M.D., FASAM Consensus Panel Chair Steven S. Kipnis, M.D., FACP Consensus Panel Co-Chair A Treatment Improvement Protocol TIP 45 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Substance Abuse and Mental Health Services Administration Center for Substance Abuse Treatment 1 Choke Cherry Road Rockville, MD 20857 Acknowledgments Public Domain Notice Numerous people contributed to the develop- All materials appearing in this volume except ment of this TIP (see pp. ix–xii and appendices those taken directly from copyrighted sources D and E). This publication was produced by are in the public domain and may be repro- The CDM Group, Inc. (CDM) under the duced or copied without permission from Knowledge Application Program (KAP) con- SAMHSA/CSAT or the authors. Do not repro- tract numbers 270-99-7072 and 270-04-7049 duce or distribute this publication for a fee with the Substance Abuse and Mental Health without specific, written authorization from Services Administration (SAMHSA), U.S. SAMHSA’s Office of Communications. Department of Health and Human Services (DHHS). Andrea Kopstein, Ph.D., M.P.H., Electronic Access and Copies Karl D. White, Ed.D., and Christina Currier of Publication served as the Center for Substance Abuse Treatment (CSAT) Government Project Copies may be obtained free of charge from Officers. Rose M. Urban, M.S.W., J.D., SAMHSA’s National Clearinghouse for Alcohol LCSW, CCAC, CSAC, served as the KAP and Drug Information (NCADI), (800) 729- Executive Project Co-Director. Elizabeth 6686 or (301) 468-2600; TDD (for hearing Marsh Cupino served as CDM KAP Managing impaired), (800) 487-4889, or electronically Project Co-Director. Sheldon Weinberg, through the following Internet World Wide Ph.D., served as KAP Senior Web site: www.ncadi.samhsa.gov. Researcher/Applied Psychologist. Other KAP personnel included Raquel Witkin, M.S., Deputy Project Manager; Susan Kimner, Recommended Citation Editorial Director; Jonathan Max Gilbert. Center for Substance Abuse Treatment. M.A., Editor/Writer; Deborah Steinbach, Detoxification and Substance Abuse M.A., Editor/Writer; James M. Girsch, Ph.D., Treatment. Treatment Improvement Protocol Editor/Writer; Michelle Myers, Quality (TIP) Series 45. DHHS Publication No. Assurance Editor; and Sonja Easley and (SMA) 06-4131. Rockville, MD: Substance Elizabeth Plevyak, Editorial Assistants. In Abuse and Mental Health Services addition, Sandra Clunies, M.S., ICADC, Administration, 2006. served as Content Advisor. Jonathan Max Gilbert, M.A. served as a writer. Special thanks go to Suzanne Gelber, Ph.D., for her Originating Office contributions to chapter 6, and Joan Practice Improvement Branch, Division of Dilonardo, Ph.D., for her input on the TIP. Services Improvement, Center for Substance Abuse Treatment, Substance Abuse and Mental Disclaimer Health Services Administration, 1 Choke Cherry Road, Rockville, MD 20857. The opinions expressed herein are the views of the consensus panel members and do not neces- DHHS Publication No. (SMA) 06-4131 sarily reflect the official position of CSAT, Printed 2006 SAMHSA, or DHHS. No official support of or endorsement by CSAT, SAMHSA, or DHHS for these opinions or for particular instru- ments, software, or resources described in this document are intended or should be inferred. The guidelines in this document should not be considered substitutes for individualized client care and treatment decisions. ii Acknowledgments Contents What Is a TIP?........................................................................................................vii Consensus Panel ......................................................................................................ix KAP Expert Panel and Federal Government Participants................................................xi Foreword..............................................................................................................xiii Executive Summary.................................................................................................xv Chapter 1—Overview, Essential Concepts, and Definitions in Detoxification........................1 Purpose of the TIP.....................................................................................................1 Audience..................................................................................................................2 Scope......................................................................................................................2 History of Detoxification Services...................................................................................2 Definitions................................................................................................................3 Guiding Principles in Detoxification and Substance Abuse Treatment.....................................7 Challenges to Providing Effective Detoxification................................................................8 Chapter 2—Settings, Levels of Care, and Patient Placement...........................................11 Role of Various Settings in the Delivery of Services...........................................................11 Other Concerns Regarding Levels of Care and Placement...................................................20 Chapter 3—An Overview of Psychosocial and Biomedical Issues During Detoxification.......23 Evaluating and Addressing Psychosocial and Biomedical Issues...........................................24 Strategies for Engaging and Retaining Patients in Detoxification..........................................33 Referrals and Linkages ..............................................................................................38 Chapter 4—Physical Detoxification Services for Withdrawal From Specific Substances .......47 Psychosocial and Biomedical Screening and Assessment.....................................................47 Alcohol Intoxication and Withdrawal.............................................................................52 Opioids ..................................................................................................................66 Benzodiazepines and Other Sedative-Hypnotics...............................................................74 Stimulants...............................................................................................................76 Inhalants/Solvents.....................................................................................................82 Nicotine..................................................................................................................84 Marijuana and Other Drugs Containing THC..................................................................95 Anabolic Steroids......................................................................................................96 Club Drugs..............................................................................................................97 Management of Polydrug Abuse: An Integrated Approach.................................................101 Alternative Approaches ............................................................................................103 Considerations for Specific Populations........................................................................105 iii Chapter 5—Co-Occurring Medical and Psychiatric Conditions.......................................121 General Principles of Care for Patients With Co-Occurring Medical Conditions .....................122 Treatment of Co-Occurring Psychiatric Conditions..........................................................136 Standard of Care for Co-Occurring Psychiatric Conditions...............................................138 Chapter 6—Financing and Organizational Issues.........................................................145 Preparing and Developing a Program...........................................................................145 Working in Today’s Managed Care Environment.............................................................157 Preparing for the Future...........................................................................................168 Appendix A—Bibliography......................................................................................169 Appendix B—Common Drug Intoxication Signs and Withdrawal Symptoms.....................223 Appendix C—Screening and Assessment Instruments...................................................225 Section I: Screening and Assessment for Alcohol Abuse ....................................................225 Section II: Screening and Assessment for Alcohol and Other Drug Abuse..............................228 Appendix D—Resource Panel..................................................................................231 Appendix E—Field Reviewers..................................................................................233 Index..................................................................................................................237 CSAT TIPs and Publications....................................................................................243 Figures Figure 1-1 DSM-IV-TR Definitions of Terms.....................................................................6 Figure 1-2 Guiding Principles Recognized by the Consensus Panel.........................................7 Figure 2-1 Issues To Consider in Determining Whether Inpatient or Outpatient Detoxification Is Preferred.......................................................................................21 Figure 3-1 Initial Biomedical and Psychosocial Evaluation Domains......................................25 Figure 3-2 Symptoms and Signs of Conditions That Require Immediate Medical Attention..........26 Figure 3-3 Strategies for De-escalating Aggressive Behaviors ...............................................28 Figure 3-4 Questions To Guide Practitioners To Better Understand the Patient’s Cultural Framework...........................................................................................................32 Figure 3-5 The Transtheoretical Model (Stages of Change)..................................................36 Figure 3-6 Clinician’s Characteristics Most Important to the Therapeutic Alliance....................38 Figure 3-7 Recommended Areas for Assessment To Determine Appropriate Rehabilitation Plans...............................................................................................40 Figure 3-8 Strategies To Promote Initiation of Treatment and Maintenance Activities................42 Figure 4-1 Assessment Instruments for Dependence and Withdrawal From Alcohol and Specific Illicit Drugs................................................................................................49 Figure 4-2 Symptoms of Alcohol Intoxication...................................................................53 Figure 4-3 Potential Contraindications To Using Benzodiazepines To Treat Alcohol Withdrawal..61 Figure 4-4 Signs and Symptoms of Opioid Intoxication and Withdrawal.................................67 Figure 4-5 Benzodiazepines and Their Phenobarbital Withdrawal Equivalents........................77 iv Contents Figure 4-6 Other Sedative-Hypnotics and Their Phenobarbital Withdrawal Equivalents............78 Figure 4-7 Stimulant Withdrawal Symptoms....................................................................79 Figure 4-8 Commonly Abused Inhalants/Solvents..............................................................83 Figure 4-9 DSM-IV-TR on Nicotine Withdrawal ...............................................................86 Figure 4-10 Items and Scoring for the Fagerstrom Test for Nicotine Dependence......................87 Figure 4-11 The Glover-Nilsson Smoking Behavioral Questionnaire (GN-SBQ) ........................88 Figure 4-12 Some Examples of Nicotine Withdrawal Symptoms That Can Be Confused With Other Psychiatric Conditions....................................................................................89 Figure 4-13 Effects of Abstinence From Smoking on Blood Levels of Psychiatric Medications......90 Figure 4-14 The “5 A’s” for Brief Intervention.................................................................91 Figure 4-15 Some Definitions Regarding Disabilities ........................................................111 Figure 4-16 Impairment and Disability Chart.................................................................112 Figure 4-17 Locating Expert Assistance.........................................................................114 Figure 6-1 Financial Arrangements for Providers............................................................162 Contents v What Is a TIP? Treatment Improvement Protocols (TIPs), developed by the Center for Substance Abuse Treatment (CSAT), part of the Substance Abuse and Mental Health Services Administration (SAMHSA) within the U.S. Department of Health and Human Services (DHHS), are best-practice guidelines for the treatment of substance use disorders. CSAT draws on the experience and knowledge of clinical, research, and administrative experts to produce the TIPs, which are distributed to facilities and indi- viduals across the country. The audience for the TIPs is expanding beyond public and private treatment facilities to include practitioners in mental health, criminal justice, primary care, and other healthcare and social service settings. CSAT’s Knowledge Application Program (KAP) Expert Panel, a distin- guished group of experts on substance use disorders and professionals in such related fields as primary care, mental health, and social services, works with the State Alcohol and Drug Abuse Directors to generate topics for the TIPs. Topics are based on the field’s current needs for information and guidance. After selecting a topic, CSAT invites staff from pertinent Federal agencies and national organizations to be members of a resource panel that recom- mends specific areas of focus as well as resources that should be consid- ered in developing the content for the TIP. Then recommendations are communicated to a consensus panel composed of experts on the topic who have been nominated by their peers. This consensus panel participates in a series of discussions. The information and recommendations on which they reach consensus form the foundation of the TIP. The members of each consensus panel represent substance abuse treatment programs, hos- pitals, community health centers, counseling programs, criminal justice and child welfare agencies, and private practitioners. A panel chair (or co-chairs) ensures that the guidelines mirror the results of the group’s collaboration. vii A large and diverse group of experts closely “front-line” information quickly but responsi- reviews the draft document. Once the changes bly. For this reason, recommendations prof- recommended by these field reviewers have fered in the TIP are attributed to either pan- been incorporated, the TIP is prepared for elists’ clinical experience or the literature. If publication, in print and online. The TIPs research supports a particular approach, cita- can be accessed via the Internet at tions are provided. www.kap.samhsa.gov. The online TIPs are This TIP, Detoxification and Substance consistently updated and provide the field Abuse Treatment, revises TIP 19, with state-of-the-art information. Detoxification From Alcohol and Other While each TIP strives to include an evidence Drugs. The revised TIP provides the clinical base for the practices it recommends, CSAT evidence-based guidelines, tools, and recognizes that the field of substance abuse resources necessary to help substance abuse treatment is evolving, and research frequently counselors and clinicians treat clients who are lags behind the innovations pioneered in the dependent on substances of abuse. field. A major goal of each TIP is to convey viii What Is a TIP? Consensus Panel Chair Anthony Radcliffe, M.D., FASAM Chief of Addiction Medicine Norman S. Miller, M.D., FASAM Kaiser Permanente Professor and Director of Addiction Medicine Southern California Permanente Medical Department of Psychiatry Group Michigan State University Fontana, California East Lansing, Michigan Carl Rollynn Sullivan, III, M.D. Co-Chair Professor Steven S. Kipnis, M.D., FACP Director of Addiction Program Medical Director Department of Behavioral Medicine and Russell E. Blaisdell Addiction Treatment Psychiatry Center School of Medicine New York State Office of Alcoholism and West Virginia University Substance Abuse Services Morgantown, West Virginia Orangeburg, New York Nancy R. VanDeMark, M.S.W. Workgroup Managers and Director of Colorado Social Research Co-Managers Associates Arapahoe House, Inc. Anne M. Herron, M.S. Thornton, Colorado Director Division of State and Community Assistance Panelists Center for Substance Abuse Treatment Substance Abuse and Mental Health Services Louis E. Baxter, Sr., M.D., FASAM Administration Executive Director Rockville, Maryland Physicians Health Program Medical Society of New Jersey Ronald J. Hunsicker, D.Min., FACATA Lawrenceville, New Jersey President/Chief Executive Officer National Association of Addiction Treatment Kenneth O. Carter, M.D., M.P.H., Dipl.Ac. Providers Psychiatrist Lancaster, Pennsylvania Acupuncture Detoxification Specialist Carolinas Medical Center Robert J. Malcolm, Jr., M.D. Charlotte, North Carolina Professor of Psychiatry, Family Medicine, and Pediatrics Jean Lau Chin, M.A., Ed.D., ABPP Associate Dean for Continuing Medical President Education CEO Services Center for Drug and Alcohol Programs Alameda, California Institute of Psychiatry Medical University of South Carolina Charleston, South Carolina ix
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