Table Of Content

Woodhead Publishing Series in Biomaterials Design and Applications of Theranostic Nanomedicines Edited by Somasree Ray Professor, Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, West Bengal, India Amit Kumar Nayak Professor, Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj, Odisha, India WoodheadPublishingisanimprintofElsevier 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates TheBoulevard,LangfordLane,Kidlington,OX51GB,UnitedKingdom Copyright©2023ElsevierLtd.Allrightsreserved. Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans, electronicormechanical,includingphotocopying,recording,oranyinformationstorage andretrievalsystem,withoutpermissioninwritingfromthepublisher.Detailsonhowto seekpermission,furtherinformationaboutthePublisher’spermissionspoliciesandour arrangementswithorganizationssuchastheCopyrightClearanceCenterandthe CopyrightLicensingAgency,canbefoundatourwebsite:www.elsevier.com/permissions. Thisbookandtheindividualcontributionscontainedinitareprotectedundercopyrightby thePublisher(otherthanasmaybenotedherein). Notices Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchand experiencebroadenourunderstanding,changesinresearchmethods,professional practices,ormedicaltreatmentmaybecomenecessary. Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgein evaluatingandusinganyinformation,methods,compounds,orexperimentsdescribed herein.Inusingsuchinformationormethodstheyshouldbemindfuloftheirownsafety andthesafetyofothers,includingpartiesforwhomtheyhaveaprofessionalresponsibility. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,or editors,assumeanyliabilityforanyinjuryand/ordamagetopersonsorpropertyasamatter ofproductsliability,negligenceorotherwise,orfromanyuseoroperationofanymethods, products,instructions,orideascontainedinthematerialherein. ISBN:978-0-323-89953-6 ForinformationonallWoodheadPublishingpublicationsvisitourwebsiteat https://www.elsevier.com/books-and-journals Publisher:MatthewDeans AcquisitionsEditor:SabrinaWebber EditorialProjectManager:AndreaGallegoOrtiz ProductionProjectManager:PremKumarKaliamoorthi CoverDesigner:MatthewLimbert TypesetbyTNQTechnologies Dedicated to our beloved teacher Prof. (Dr.) Biswanath Sa. List of contributors Bandar E. Al-Dhubiab Department of PharmaceuticalSciences, College of Clini- cal Pharmacy,KingFaisal University, Al-Ahsa, Saudi Arabia Ashique Al Hoque Department of Pharmaceutical Technology, Jadavpur Univer- sity, Kolkata, West Bengal, India AbulKalamAzad FacultyofPharmacy,PharmaceuticalTechnologyUnit,AIMST University, Kedah, Malaysia JayaBajpai BoseMemorialResearchLab,DepartmentofChemistry,Government Autonomous Science CollegeJabalpur, Madhya Pradesh,India A.K.Bajpai BoseMemorialResearchLab,DepartmentofChemistry,Government Autonomous Science CollegeJabalpur, Madhya Pradesh,India SaadBakrim LaboratoryofMolecularEngineering,ValorizationandEnvironment, Department of Sciences and Techniques, Polydisciplinary Faculty of Taroudant, Ibn ZohrUniversity, Taroudant,Souss-Massa, Morocco AbdelaaliBalahbib LaboratoryofBiodiversity,Ecology,andGenome,Facultyof Sciences, Mohammed VUniversity inRabat, Rabat, Rabat-Salé-Kénitra,Morocco Souvik Basak Dr. B.C. Roy College of Pharmacy & Allied Health Sciences, Dr. Meghnad Saha Sarani, Bidhan Nagar, Durgapur, West Bengal, India Anindita Behera School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemedto be University, Bhubaneswar,Odisha,India UttamKumarBhattacharyya GuptaCollegeofTechnologicalSciences,Asansol, West Bengal, India AbdelhakimBouyahya LaboratoryofHumanPathologiesBiology,Departmentof Biology,FacultyofSciences,andGenomicCenterofHumanPathologies,Facultyof Medicine and Pharmacy, Mohammed VUniversity inRabat, Rabat, Morocco Elizabeth Carvajal-Millan Biopolymers, Research Center for Food and Develop- ment,CIADA.C.,CarreteraGustavoE.AstiazaranRosasNo.46,Hermosillo,Sonora, Mexico xiv Listofcontributors Samrat Chakraborty Department of Pharmaceutical Technology, Jadavpur Uni- versity,Kolkata,WestBengal,India;GuptaCollegeofTechnologicalSciences,Asan- sol, West Bengal, India ApalaChakraborty DepartmentofPharmaceuticalTechnology,JadavpurUniver- sity,Kolkata, West Bengal, India Imane Chamkhi Centre GEOPAC, Laboratoire de Geobiodiversite et Patrimoine Naturel Université Mohammed V de, Institut Scientifique Rabat, Rabat, Rabat-Salé- Kénitra, Morocco Pronobesh Chattopadhyay Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur,Assam, India Rashmi Choubey Bose Memorial Research Lab, Department of Chemistry, Gov- ernmentAutonomousScience College Jabalpur, Madhya Pradesh,India HiraChoudhury DepartmentofPharmaceuticalTechnology,SchoolofPharmacy, International Medical University, Kuala Lumpur, Malaysia Avik Das Gupta Collegeof Technological Sciences, Asansol, West Bengal, India Monodip De Dr. B.C. Roy College of Pharmacy & Allied Health Sciences, Dr. Meghnad Saha Sarani, Bidhan Nagar, Durgapur,West Bengal, India Piyali Dey Faculty of Pharmaceutical Science, Assam down town University, Guwahati,Assam,India;PiyaliDey,AssistantProfessor,AssamdowntownUniver- sity,Guwahati, Assam, India IbrahimM.El-Sherbiny NanomedicineResearchLaboratories,CenterforMateri- als Science, Zewail City of Science and Technology,Giza,Egypt Naoual Elmenyiy Laboratory of Physiology, Pharmacology and Environmental Health, Faculty of Science, University Sidi Mohamed Ben Abdellah, Fez, Fez- Mekn(cid:1)es, Morocco NasreddineElOmari LaboratoryofHistology,Embryology,andCytogenetic,Fac- ulty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Rabat- Salé-Kénitra, Morocco Ouadie Mohamed El Yaagoubi Laboratory of Biochemistry, Environment and Agri-Food(URAC36)dFacultyofSciencesandTechniquesdMohammedia,Hassan II University Casablanca, Casablanca, Casablanca-Settat, Morocco Muhammad Asim Farooq Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences,MonashUniversity, Melbourne, VIC, Australia BapiGorain SchoolofPharmacy,FacultyofHealthandMedicalScience,Taylor’s University,SubangJaya,Selangor,Malaysia;DepartmentofPharmaceuticalSciences and Technology,Birla Institute ofTechnology, Mesra, Ranchi, India Listofcontributors xv Maryam Hakkour Laboratory of Biodiversity, Ecology, and Genome, Faculty of Sciences, Mohammed VUniversity inRabat, Rabat, Rabat-Salé-Kénitra,Morocco Md Saquib Hasnain Department of Pharmacy, Palamau Institute of Pharmacy, Chianki, Daltonganj, Jharkhand, India Amna Jabeen Faculty of Pharmacy, Lahore College of Pharmaceutical Sciences, Lahore,Punjab, Pakistan SumanMallik Narayana Super Speciality Hospital, Kolkata, West Bengal,India Amira Mansour Nanomedicine Research Laboratories, Center for Materials Sci- ence, ZewailCity ofScience and Technology, Giza, Egypt Mayra A. Mendez-Encinas Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Avenida Universidad e Irigoyen, Caborca, Sonora, Mexico BiswajitMukherjee DepartmentofPharmaceuticalTechnology,JadavpurUniver- sity, Kolkata, West Bengal, India AnroopB.Nair DepartmentofPharmaceuticalSciences,CollegeofClinicalPhar- macy, King Faisal University, Al-Ahsa,SaudiArabia AmitKumarNayak DepartmentofPharmaceutics,SeemantaInstituteofPharma- ceutical Sciences, Jharpokharia, Mayurbhanj, Odisha,India SantwanaPadhi KIITTechnologyBusinessIncubator,KIITDeemedtobeUniver- sity, Bhubaneswar, Odisha, India Anjali Pal Bose Memorial Research Lab, Department of Chemistry, Government Autonomous Science CollegeJabalpur, Madhya Pradesh,India ParthasarathiPanda Dr.B.C.RoyCollegeofPharmacy&AlliedHealthSciences, Dr. Meghnad Saha Sarani, Bidhan Nagar, Durgapur, West Bengal, India Brahamacharry Paul Department of Pharmaceutical Technology, Jadavpur Uni- versity,Kolkata, West Bengal, India Ng Yen Ping Faculty of Pharmacy, Clinical Pharmacy Unit, AIMST University, Kedah, Malaysia ShilpiRawat BoseMemorialResearchLab,DepartmentofChemistry,Government Autonomous Science CollegeJabalpur, Madhya Pradesh,India Somasree Ray Gupta College of Technological Sciences, Asansol, West Bengal, India MaliniSen GuptaCollegeofTechnologicalSciences,Asansol,WestBengal,India RamkrishnaSen DepartmentofPharmaceuticalTechnology,JadavpurUniversity, Kolkata, West Bengal, India xvi Listofcontributors Shalmoli Seth Gupta College of Technological Sciences, Asansol, West Bengal, India NatalieTrevaskis DrugDelivery, Disposition,andDynamics,MonashInstituteof Pharmaceutical Sciences, MonashUniversity, Melbourne, VIC, Australia DicksonPiusWande DepartmentofPharmaceuticsandPharmacyPractice,School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania Preface In the recent scenario, theranostic nanomedicines facilitate multifunctional activities including diagnosis and therapy of various diseases. Over the past few years, numerous therapeutic and diagnostic agents are being delivered at the targeted site withminimumsideeffectsandpropertherapeutic/diagnosticaction(s)foranextended period of time. An ideal theranostic nanomedicine not only genuinely diagnoses and detectsanydiseaseatitspreliminarystagebutalsoprovidesthemostfavorabletreat- ment.Thisbookentitled“DesignandApplicationsofTheranosticNanomedicines” coverstherecentinnovationsinthedesigningofnanomedicinescomposedofnatural and/or synthetic polymers and inorganic nanomaterials with their helpful theranostic applications.Italsoprovidesaconciseoverviewofutilityoftheamalgamatedactions ofthesetheranosticnanostructuresasnanomedicinesinthepharmaceuticalandhealth- care industry. This book also acts as an important reference for the readers and pro- vides detail information about targeted delivery of nanotheranostics and how they workas both diagnosticand therapeutic tools intreatingcomplex diseases. This bookisa collectionof 15chapters presenting different keytopicsrelated to nanomedicines, their designing and theranostic applications by the leading academi- cians, scientists, and researchers across the world. A concise sketch on each chapter contentshas been presentedfor thereaders to providea clear overview of this book. Chapter 1 entitled “Theranostic nanostructures as nanomedicines: Benefits, costs, and future challenges” focuses on the current research on nanostructure- based therapeutics and diagnostics systems, including benefits, costs, and future challenges. Chapter2entitled“Theranosticnanogels:Designandapplications”describesthe designsandapplicationsoftheranosticnanogelswithaparticularemphasisindiscus- sing theimaging modality usedfor thediagnostic function. Chapter3entitled“Exosomes:Anoveltoolfordiagnosisandtherapy”highlights variousfeatures ofexosomes, their roles indiagnosis, and therapeutic applications. Chapter 4 entitled “Engineered liposomes as drug delivery and imaging agents” reviewsthedevelopment,progress,andapplicationsofvariousengineeredliposomes for delivery of drugs and imaging agents, individually or in combinations as theranostics. Chapter5entitled“Polymericmicellesfortheranosticuses”addressescomprehen- sivediscussionsinvolvingdescriptionandpreparationofpolymericmicelles,mecha- nism of drug release from micelles, and their potential theranostic applications specially indifferent stagesof cancer therapy. xviii Preface Chapter 6 entitled “Dendrimers: An effective drug delivery and therapeutic approach”highlightstheusefulnessofdendriticstructuresandtheirpotentialapplica- tionsin thetreatment ofvarious diseases. Chapter 7 entitled “Nanocochleates: A novel lipid-based nanocarrier system for drugdelivery”coversrecentadvancementsinnanocochleate-baseddrugdeliverysys- tems with multiple aspects of nanocochleates such as their chemistry, components, mechanismofactions,methodsofpreparation,stability,advantages,characterization, applications, and currentcommercial status. Chapter8entitled“Theranosticapplicationsofnanoemulsionsinpulmonarydis- eases” deals withcomprehensivediscussionson the preparation and characterization of nanoemulsions, advantages and disadvantages of nanoemulsions, clearance of nanoemulsions, applications as novel theranostic tools (as nanoemulsion-based drug delivery systems and nanoemulsion-based diagnostics) in treatment/management of pulmonary diseases. Chapter9entitled“Polymericnanoparticlesastumor-targetingtheranosticplat- form”reviewsdifferentstrategiesdevelopedfortheapplicationofpolymericnanopar- ticles for tumor-targeting diagnosis and therapy, with a closer look at the recent studies, and discusses how the strategic development has progressed throughout the years for the bench-to-market conversion ofconcept tocommercialization. Chapter 10 entitled “Site-specific theranostic uses of stimuli responsive nanohy- drogels, design, and applications of theranostic nanomedicines” summarizes the importanceofnanohydrogels’responsetotheinternalstimulilikepH,redoxpotential, etc.,andexternalstimuliliketemperature,light,magneticfield,etc.,usedfortheranos- ticapplicationslikedeliveryofdrugsatthespecifictargetsiteswithcontrolledrelease kinetics to tumor tissue andother disease conditions aswellas disease diagnosis. Chapter 11 entitled “Ligand appended theranostic nanocarriers for targeted bloodebrain barrier” encompasses preliminary introduction of ligand-appended nanocarriers,theirsynthesis,characterization,andtheranosticapplicationsincrossing bloodebrain barrier with targeting abilities. The underlying challenges and future prospects havealso been highlighted for stimulating advanced research inthis area. Chapter 12 entitled “Nanotheranostics in CNS malignancy” presents a brief discussion on various types of nanotheranostic agents that are used in the treatment of glioma and central nervous system (CNS) malignancy including gold nanoparticles, quantum dots, magnetic nanoparticles, mesoporous silica nanoparticles, solid lipid nanoparticles, dendrimers, liposomes, etc. Chapter13entitled“Applicationofnanotheranosticsincancer”reviewsandeval- uatestheadvancesinthedevelopmentsofnanomedicinesforthetreatments,diagnostics,andtheranostics ofcancer. Thischapterhasalsodiscussedthelimitationsinthe provision of effective clinical usages of cancer nanotheranostics. Chapter 14 entitled “Self-assembled protein nanoparticles for multifunctional theranostic uses” discusses self-assembled protein-based nanomaterials in depth, withafocusonnanoparticles.Theirmultifunctionaltheranosticusesindeliveringther- apeutic medicines have also been explored with a practical discussion on how they might be useful as prospective techniques for efficient and safe delivery in the treatment/management ofdifferent diseases.