Dermatological Signs of Internal Disease, 4e Q Q Dermatological Signs of Internal Disease 4th Edition Jeffrey P. Callen MD Joseph L. Jorizzo MD Professor of Medicine (Dermatology) Professor and Former (Founding) Chair Chief, Division of Dermatology Department of Dermatology University of Louisville School of Medicine Wake Forest University School of Medicine Louisville KY Medical Center Boulevard USA Winston-Salem NC USA Jean L. Bolognia MD John J. Zone MD Professor of Dermatology Professor and Chair Department of Dermatology Department of Dermatology Yale University University of Utah New Haven CT Salt Lake City UT USA USA Warren W. Piette MD Professor and Chairman Department of Dermatology John H. Stroger Hospital of Cook County and Professor of Dermatology Rush University Medical Center Chicago IL USA Q an imprint of Elsevier Inc. © 2009, Elsevier Inc. All rights reserved. © Harcourt Brace Jovanovich 1988 © Harcourt Brace & Company 1995 © 2003, Elsevier Science Limited. All rights reserved First edition 1988 Second edition 1995 Third edition 2003 No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier’s Rights Department: phone: (+1) 215 239 3804 (US) or (+44) 1865 843830 (UK); fax: (+44) 1865 853333; e-mail: [email protected]. You may also complete your request on-line via the Elsevier website at http://www.elsevier.com/permissions. ISBN 978-1-4160-6111-3 British Library Cataloguing in Publication Data A catalogue record for this book is available from the British Library Library of Congress Cataloging in Publication Data A catalog record for this book is available from the Library of Congress Notice Medical knowledge is constantly changing. Standard safety precautions must be followed, but as new research and clinical experience broaden our knowledge, changes in treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current product information provided by the manufacturer of each drug to be administered to verify the recommended dose, the method and duration of administration, and contraindications. It is the responsibility of the practitioner, relying on experience and knowledge of the patient, to determine dosages and the best treatment for each individual patient. Neither the Publisher nor the author assume any liability for any injury and/or damage to persons or property arising from this publication. The Publisher Working together to grow The publisher’s libraries in developing countries policy is to use paper manufactured www.elsevier.com | www.bookaid.org | www.sabre.org from sustainable forests Printed in China Last digit is the print number: 9 8 7 6 5 4 3 2 Commissioning Editor: Claire Bonnett Development Editor: Nani Clansey Editorial Assistant: Rachael Harrison Project Manager: Alan Nicholson Design: Charles Gray Illustration Manager: Gillian Richards Q Marketing Managers: Clara Toombs/Courtney Ingram Preface In this fourth revision of our book we selected co-authors to tinues, and that important entities are covered and that dupli- completely revise many of the chapters. We rearranged, cation is avoided. As in the first three editions, we chose to shortened, or expanded other chapters to enhance our goal of provide suggested readings rather than an extensive reference providing the practicing physician, academic physician, or list. These suggested readings have been updated so that the resident with a teaching text that explores the relationship interested reader may delve into the most current literature. of the skin to internal diseases or conditions. Although col- We have continued the use of color photographs throughout leagues aided us in this revision, we continued to serve as this edition, and in many cases have found new photographs contributing editors to ensure that the spirit of the book con- for inclusion. Q vii Acknowledgments Dr Callen thanks Ms Sandra Lingle, who typed many drafts for allowing him the time to write by providing care for his previous editions and assisted with the many administrative patients in his absence. Dr Callen dedicates this book to his complexities involved in the production of this text. He thanks wife Susan, his children and grandchildren Amy, Dan, Liam the following physicians: L.G. Owen, MD; M.W. McCall, MD; and Aviva, and David, Laura, Judah and Noa. Carol L. Kulp-Shorten, MD; Jyoti B. Burruss, MD; Kristin O. Dr Jorizzo thanks his faculty, residents, and staff for their Donovan, MD; Shannon M. McAllister, MD; Alfred L. Knable, ongoing support. Dr Jorizzo dedicates this book to Irene MD; Timothy S. Brown, MD; David Daniels, MD; Janine Carros, to John, Michael and Melina, to Margaret and the late Malone, MD; Anna Hayden, MD; and Soon Bahrami, MD, for Joseph, and to Johanna and Paul. Q viii List of Contributors Jean L. Bolognia MD Edward W. Cowen MD, Steven R. Feldman MD, PhD Christopher B. Hansen MD Professor of Dermatology MHSc Professor of Dermatology and Assistant Professor of Dermatology Department of Dermatology Staff Clinician Pathology Department of Dermatology Yale University Dermatology Branch, CCR Wake Forest University University of Utah New Haven CT National Cancer Institute School of Medicine Salt Lake City UT USA National Institutes of Health Winston-Salem NC USA Bethesda MD USA Anneli R. Bowen MD USA Christina L. Haverstock MD Assistant Professor of Dermatology David Fiorentino MD, PhD Resident Physician Department of Dermatology Thomas G. Cropley MD, Professor of Dermatology Department of Dermatology University of Utah FAAD Associate Professor of Medicine Wake Forest University Salt Lake City UT Professor and Chairman (Rheumatology) Baptist Medical Center USA Department of Dermatology Department of Dermatology Winston-Salem NC University of Virginia Health Stanford University School of USA Susan Burgin MD System Medicine Assistant Professor of Dermatology Charlottesville VA Stanford CA Mark D. Herron MD Harvard Medical School, Boston USA USA Private Practice and Attending Dermatologist Montgomery AL Beth Israel Deaconess Medical Mark D.P. Davis MD Raechele Cochran Gathers USA Center, Boston Professor of Dermatology MD, FAAD BIDMC Dept of Dermatology Mayo Clinic Senior Staff Physician Warren R. Heymann MD Boston MA Rochester MN Henry Ford Health System Clinical Professor of Medicine and USA USA Department of Dermatology Pediatrics Detroit MI Head, Division of Dermatology Jeffrey P. Callen MD Boni E. Elewski MD USA University of Medicine and Professor of Medicine Professor of Dermatology Dentistry (Dermatology) Department of Dermatology Gary Goldenberg MD Robert Wood Johnson Medical Chief, Division of Dermatology University of Alabama at Assistant Professor of Dermatology School at Camden University of Louisville School of Birmingham Director, Dermatopathology Clinical Associate Professor of Medicine The Eye Foundation Laboratory Dermatology Louisville KY Birmingham AL University of Maryland School of University of Pennsylvania School USA USA Medicine of Medicine Baltimore MD Philadelphia PA Charles Camisa MD Joseph C. English III MD USA USA Chief Associate Professor of Division of Dermatology Dermatology Kenneth E. Greer MD J. Mark Jackson MD Medical Surgical Specialists Clinical Vice Chairman for Quality Professor of Dermatology Associate Clinical Professor Naples FL and Innovation Department of Dermatology Medicine/Dermatology USA Department of Dermatology University of Virginia Medical University of Louisville University of Pittsburgh Center Division of Dermatology Lisa M. Cohen MD Pittsburgh PA Charlottesville VA Dermatology Specialists PSC Clinical Assistant Professor USA USA Louisville KY Tufts University School of USA Medicine, Boston Vincent Falanga MD, FACP Marc E. Grossman MD, FACP and Co-Director, Caris Cohen DX Professor and Chairman Professor of Clinical Dermatology Joseph L. Jorizzo MD Newton MA Department of Dermatology and Columbia University Professor and Former (Founding) USA Skin Surgery College of Physicians and Chair Roger Williams Medical Center Surgeons Department of Dermatology Dennis L. Cooper MD Boston University White Plains NY Wake Forest University School of Professor of Internal Medicine Boston MA USA Medicine (Oncology) USA Winston-Salem NC Department of Internal Medicine USA Yale University New Haven CT USA Q ix List of Contributors George Kroumpouzos MD, Mary Gail Mercurio MD Ted Rosen MD Gary S. Wood MD PhD Assistant Professor of Dermatology Professor of Dermatology Johnson Professor and Chairman Clinical Assistant Professor of University of Rochester Medical Department of Dermatology Department of Dermatology Dermatology Center Baylor University Medical School University of Wisconsin Brown Medical School Department of Dermatology Houston TX Madison WI Boston MA Rochester NY USA USA USA USA Julie V. Schaffer MD Christopher B. Yelverton Andrew D. Lee MD Drew W. Miller MD Assistant Professor of Dermatology MD, MBA Chief Resident Resident in Dermatology and Pediatrics Resident Department of Dermatology Department of Dermatology Department of Dermatology Department of Dermatology Wake Forest University Wake Forest University School of New York University Wake Forest University School of School of Medicine Medicine New York NY Medicine Winston-Salem NC Winston-Salem NC USA Winston-Salem NC USA USA USA Kathryn Schwarzenberger Clive M. Liu MD Mohammad Reza Namazi MD Brad Alan Yentzer MD Board Certified Dermatologist MD Associate Professor of Medicine Senior Clinical Research Fellow Dermatology Associates of Seattle Assistant Professor of Dermatology and Director, Dermatology Department of Dermatology Seattle WA Department of Dermatology Residency Program Wake Forest University School of USA Shiraz University of Medical Division of Dermatology Medicine Sciences Fletcher Allen Health Care Winston-Salem NC Cheryl L. Lonergan MD Faghihi Hospital University of Vermont College of USA Dermatopathology Fellow Shiraz Medicine University of Virginia Health Iran Burlington VT Gil Yosipovitch MD System USA Professor Department of Pathology Julia R. Nunley MD Department of Dermatology, Charlottesville VA Professor Sarah L. Taylor MD, MPH, Neurobiology and Anatomy, and USA Department of Dermatology DABFM Regenerative Medicine Virginia Commonwealth University Fellow Wake Forest University School of B. Asher Louden MD Richmond VA Department of Dermatology Medicine Private Practice Dermatologist USA Wake Forest University Winston-Salem NC Mountain State Dermatology School of Medicine USA Vienna WV Manisha J. Patel MD Winston-Salem NC USA Assistant Professor USA John J. Zone MD Department of Dermatology Professor and Chair Aaron M. Loyd MD Johns Hopkins School of Medicine Michael D. Tharp MD Department of Dermatology Resident Physician Baltimore MD The Clark W. Finnerdi Professor University of Utah Department of Dermatology USA and Chair Salt Lake City UT Wake Forest University Department of Dermatology USA Baptist Medical Center Daniel J. Pearce MD Rush University Medical Center Winston-Salem NC Chief Resident Chicago IL Jeffrey Paul Zwerner MD, USA Department of Dermatology USA PhD Wake Forest University School of Clinical Instructor in Dermatology Susannah E. McClain MD Medicine Ruth Ann Vleugels MD Department of Dermatology Dermatology Resident Winston-Salem NC Harvard Medical School Stanford University Medical Center Department of Dermatology USA Department of Dermatology Stanford CA University of Maryland School of Boston MA USA Medicine Warren W. Piette MD USA Baltimore MD Professor and Chairman USA Department of Dermatology Stephen E. Wolverton MD John H. Stroger Hospital of Cook Professor of Clinical Dermatology Amy J. McMichael MD County Vice Chair of Clinical Affairs Associate Professor of Chicago IL Department of Dermatology Dermatology USA Indiana University School of Department of Dermatology Medicine Wake Forest University School of Indianapolis IN Medicine USA Winston-Salem NC USA Q x