Demystifying COVID-19: Understanding the Disease, Its Diagnosis and Treatment Authored by Ozgur KARCIOGLU Department of Emergency Medicine University of Health Sciences Istanbul Education and Research Hospital Fatih, Istanbul, Turkey Selman YENIOCAK Department of Emergency Medicine, University of Health Sciences, Haseki Education and Research Hospital, Fatih, Istanbul, Turkey & Mandana HOSSEINZADEH Department of Emergency Medicine Cerkezkoy Community Hospital Tekirdağ, Turkey Demystifying COVID-19: Understanding the Disease, Its Diagnosis and Treatment Authors: Ozgur KARCIOGLU, Selman YENIOCAK & Mandana HOSSEINZADEH ISBN (Online): 978-1-68108-778-8 ISBN (Print): 978-1-68108-779-5 ISBN (Paperback): 978-1-68108-780-1 © 2021, Bentham Books imprint. Published by Bentham Science Publishers – Sharjah, UAE. All Rights Reserved BENTHAM SCIENCE PUBLISHERS LTD. End User License Agreement (for non-institutional, personal use) This is an agreement between you and Bentham Science Publishers Ltd. 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Email: [email protected] CONTENTS PREFACE ................................................................................................................................................ i CONSENT FOR PUBLICATION ................................................................................................ ii CONFLICT OF INTEREST ......................................................................................................... ii ACKNOWLEDGEMENTS ........................................................................................................... ii CHAPTER 1 CONTAGION OF THE PANDEMICS: THE SITUATION IN THE WORLD ...... 1 FATALITY AND MORTALITY DIFFERENCES BETWEEN COUNTRIES ....................... 4 WHICH COUNTRIES HAVE THE HIGHEST NUMBER OF CASES? ................................ 4 TO NORMALIZE OR NOT TO NORMALIZE, IT IS THE MAIN QUESTION! ................. 6 CONTAGIOUSNESS OF CORONAVIRUS ............................................................................... 10 IN WHAT WAYS IS CORONAVIRUS TRANSMITTED? ...................................................... 10 Where is The Contamination Happening? .............................................................................. 11 Is It Airborne? ......................................................................................................................... 11 Air Conditioning + 1 Patient = 10 Patients: Who is Guilty? .................................................. 11 How is The Air Conditioner Cleaned? .................................................................................... 14 How Should We Clean Our Air Conditioner? ........................................................................ 14 CONCLUSION ............................................................................................................................... 14 REFERENCES ............................................................................................................................... 15 CHAPTER 2 HOW CAN A COUNTRY DEFEAT COVID-19? VALUE OF R0, RT AND RE 17 WHAT ARE R0, RT, AND RE? .................................................................................................... 19 INCUBATION PERIOD ................................................................................................................ 20 PRINCIPLES OF SURVEILLANCE AND STRUGGLE WITH THE PANDEMIC: HOW COUNTRIES DIFFER FROM EACH OTHER? ....................................................................... 20 HOW EFFECTIVE IS HOME STAY, SOCIAL / INDIVIDUAL ISOLATION IN PREVENTING THE SPREAD OF COVID-19? ......................................................................... 20 BELGIUM HAS A VERY DIFFERENT CASE SITUATION .................................................. 21 HERD IMMUNITY AND THE 'SECOND WAVE' PROBLEM: MYTH OR TRUTH? ....... 24 IS THE ‘ORDINARY CITIZEN’ ALSO GUILTY? WHICH MISTAKES DID THEY DO IN THE PANDEMIC AND ‘NORMALIZATION’? ................................................................... 25 HOW DOES THIS DISEASE END? ............................................................................................ 26 THE SPANISH FLU EXPERIENCES OF 1918: DOES HISTORY LIGHT OUR WAY? .... 27 Why is It Called ‘Spanish Flu’? .............................................................................................. 27 Is It Different From Other Flu Syndromes? ............................................................................ 27 WHAT HAPPENED IN THE USA? ............................................................................................. 28 Mass Graves Were Opened in The Usa in September 1918 Due To Massive Death Toll ..... 28 REFERENCES ............................................................................................................................... 29 CHAPTER 3 COMORBID DISEASES AND COVID-19: COPD, SMOKING, OBESITY, DIABETES, CANCER, AND KIDNEY FAILURE ............................................................................. 31 THE RELATIONSHIP BETWEEN COVID-19 FATALITY RATE AND COMORBIDITIES ......................................................................................................................... 31 PULMONARY DISEASES AND COVID-19 .............................................................................. 34 Could COVID-19 Infection also Cause COPD-AA? .............................................................. 34 Are Patients with COPD or Asthma at High Risk for Contracting COVID-19? .......... 35 Are Patients with COPD at High Risk for Severe COVID-19 and Death? .................. 35 How are The Follow-up and Treatment of COPD and COPD-AA Cases During The Pandemics? ................................................................................................................... 35 Are Systemic Corticosteroids (CST) Used in COPD-AA During Pandemic? ............... 35 Are There Any Changes For Asthma Patients? ...................................................................... 36 How is an Asthma Attack Treated While Infected with COVID-19? ............................ 36 Is the Use of Nebulizers Recommended in The Treatment of Asthma/COPD During The COVID-19 Outbreak? ............................................................................................ 36 Does Smoking and COPD Development Alter Expression of ACE2 Receptors? .................. 36 Does Smoking Affect Clinical Course? ......................................................................... 36 Is Smoking also Effective in Influenza? ........................................................................ 37 Is COVID-19 More Severe in Smokers? ....................................................................... 38 What are The Key Findings of Systematic Reviews and Meta-analyzes with High Level of Evidence? ........................................................................................................ 38 What is “Smoker’s Paradox” (SP), are There any Justifications? ............................... 38 OBESITY AND COVID-19 ........................................................................................................... 39 Numerical Data showing the Relationship between Obesity and COVID-19 ........................ 40 DIABETES AND COVID-19 ......................................................................................................... 42 In a Diabetic Patient Hospitalized in The COVID-19 Process, There will be 5 Essential Steps of Management .............................................................................................................. 43 CANCER AND COVID-19 ............................................................................................................ 44 Why are Cancer Patients More Disadvantaged in Terms of COVID-19? .............................. 44 Are There any More Special Risk Groups among People with Cancer? ................................ 45 Can Cancer be Diagnosed During The Pandemic Period, and can Interventions be Performed as Before? .............................................................................................................. 45 Are there Specific Difficulties in Diagnostic Interventions for COVID-19? ......................... 46 Are There Specific Difficulties for Cancer Patients Regarding Care and Treatment? ........... 46 Is there any Difference Regarding the Psychological Conditions of Cancer Patients in this Period? .................................................................................................................................... 46 THE RISK OF REACTIVE OR MAJOR DEPRESSION WILL BE FURTHER INCREASED ................................................................................................................................... 47 What are the General Messages? ............................................................................................ 47 RENAL FAILURE (RF), ACUTE KIDNEY INJURY (AKI) AND COVID-19 ....................... 47 LUNG-KIDNEY AXIS (LKA): A NEW PATHWAY FOR KIDNEY DAMAGE? ................. 48 CONCLUSION ............................................................................................................................... 49 REFERENCES ............................................................................................................................... 49 CHAPTER 4 RISKS AND LOSSES OF HEALTHCARE WORKERS IN THE PANDEMIC ERA ........................................................................................................................................................... 54 PHENOMENA PROVEN TO INCREASE THE RISK OF COVID-19 TRANSMISSION IN HCW ............................................................................................................................................... 55 Is COVID-19 Risky for HCW? ............................................................................................... 55 How much Risk COVID-19 Impose on HCW? ...................................................................... 56 HEADLINES FROM VARIOUS COUNTRIES ........................................................................ 56 THE SITUATION IN TURKEY ................................................................................................... 57 SITUATIONS INCREASING THE RISK OF INFECTION TO HCW ................................... 58 Findings ................................................................................................................................... 59 Precautions and Measures ....................................................................................................... 59 Personal Protective Equipment ............................................................................................... 60 Sequence of Control Measures ............................................................................................... 62 Infection Protection and Control Measures ............................................................................ 62 Psychosocial Problems in HCW During The Pandemics ....................................................... 65 What kind of Interventions can be Pursued to Support The Resilience and Mental Health of Frontline HCW During The Pandemic? ................................................................................. 66 IS THERE ANY GOOD NEWS TO CONVEY? ......................................................................... 67 CONCLUSION ............................................................................................................................... 68 REFERENCES ............................................................................................................................... 69 CHAPTER 5 WHAT KIND OF DISEASE IS THIS? SIGNS AND SYMPTOMS, PREDICTORS OF CLINICAL COURSE AND MANAGEMENT .............................................................................. 71 DO PATIENTS WHO ARE DIAGNOSED NECESSARILY HAVE SYMPTOMS? ............. 72 ASYMPTOMATIC AND SYMPTOMATIC… IS THERE A 3RD WAY? .............................. 73 Can A Mild-looking Patient Worsen Quickly? ....................................................................... 75 WHICH MARKERS CAN WE USE TO PREDICT CLINICAL WORSENING? ................. 76 RADIOLOGICAL CRITERIA ..................................................................................................... 78 TYPICAL CASE ............................................................................................................................. 79 HOW ARE COVID AND COUGH RELATED? ........................................................................ 81 Cough In Terms of Contagiousness ........................................................................................ 81 Pharmacological Methods To Relieve Cough ........................................................................ 82 GASTROINTESTINAL COMPLAINTS AND FINDINGS IN THE COURSE OF COVID- 19 ...................................................................................................................................................... 82 CORONA FACTS: WHICH IS CORRECT? .............................................................................. 84 CONCLUSION ............................................................................................................................... 89 REFERENCES ............................................................................................................................... 89 CHAPTER 6 DIAGNOSIS OF COVID-19: WHICH TESTS TO DO? LABORATORY AND RADIOLOGICAL ADJUNCTS TO RECOGNITION ....................................................................... 92 LABORATORY TESTS ................................................................................................................ 93 Cytokines and Related Findings ............................................................................................. 96 Laboratory Values Can Also Highlight The Stages of The Disease ....................................... 96 Do Antibody Tests Give Accurate Results In The Early Period After Infection? .................. 100 CHEST IMAGING - RADIOLOGICAL EXAMINATIONS .................................................... 101 Which Should We Choose? X-ray, CT, USG, or MR? .......................................................... 101 CASE EXAMPLE AND TIME COURSE OF THE DISEASE .................................................. 107 CONCLUSION ............................................................................................................................... 111 REFERENCES ............................................................................................................................... 112 CHAPTER 7 CARDIOVASCULAR DISEASE, MYOCARDITIS, INFARCTIONS, AND COVID-19 ................................................................................................................................................ 115 KEY FINDINGS FROM DIFFERENT DATABASE STUDIES ............................................... 115 ARE ETHNIC DIFFERENCES IMPORTANT FOR COVID-19? ........................................... 116 HT AND COVID-19 ....................................................................................................................... 117 MYOCARDIAL INJURY SEVERITY AND MORTALITY ..................................................... 119 How Much Myocardial Damage Occurs in COVID-19? ....................................................... 119 In Whom Does Myocardial Damage Occur and How Do We Identify It? ............................. 120 Any Pathological Finding? ..................................................................................................... 120 Global View of Myocardial Infarction (STEMI / NSTEMI) After COVID-19 ..................... 121 Did The Pandemic Affect Heart Attacks? .............................................................................. 122 What Should Be Done? ........................................................................................................... 125 COVID-19 and Myocardial Damage, Myocarditis ................................................................. 125 Fulminant Myocarditis (FM) ........................................................................................ 126 Symptoms and Signs in Myocarditis ............................................................................. 127 Ancillary Studies ........................................................................................................... 128 THROMBOTIC EVENTS, BLEEDING, COAGULOPATHIES, AND COVID-19 ............... 132 Cytokine-Mediated Alveolar Inflammation Triggers the Formation Of Microthrombi In The Pulmonary Vasculature, Which Can Culminate Into Thrombi Or Embolism In Severe Cases 133 Increased D-dimer, PT, aPTT, CRP, ESR, and PCT Levels Noted on Presentation were Found To Be Associated With Death In Covid-19 Patients (Al-Samkari et al., 2020) .......... 134 Additional Note: Mean Values Of Fibrinogen, Ferritin, Pct Are Also Higher In Patients With Thrombosis .................................................................................................................... 134 Pathological Mechanism ......................................................................................................... 135 CONCLUSION ............................................................................................................................... 138 REFERENCES ............................................................................................................................... 138 CHAPTER 8 GASTROINTESTINAL SIGNS AND SYMPTOMS IN THE COURSE OF COVID-19 ................................................................................................................................................ 143 INTRODUCTION .......................................................................................................................... 143 HOW IMPORTANT IS GIS IN THE PATHOPHYSIOLOGY OF THE VIRUS? ................. 144 Which GI Findings Do We Mention About? .......................................................................... 144 Children and GI Complaints ................................................................................................... 148 Inflammatory Bowel Diseases (IBD) and COVID-19 ............................................................ 149 Hepatic Damage and COVID-19 ............................................................................................ 149 CONCLUSION ............................................................................................................................... 151 REFERENCES ............................................................................................................................... 152 CHAPTER 9 IS OUR PSYCHOLOGY AFFECTED BY THE PANDEMIC? HOW? .................. 155 WHAT ARE STRESS REACTIONS? WHAT CAN WE DO? .................................................. 155 WHY ARE WE STRESSED DURING THIS PERIOD? ........................................................... 155 ADVERSE EMOTIONAL, PHYSICAL, OR COGNITIVE RESPONSES THAT ARISE IN RESPONSE TO THE EFFECTS OF THE COVID-19 PANDEMIC INCLUDE .................... 156 COVID-19 and our Psychology: What do the Researchers Say? ........................................... 157 COVID-19 and Dealing with Stress ....................................................................................... 158 Coping with Stress .................................................................................................................. 159 Awareness of Emotions .......................................................................................................... 161 Social Relations ...................................................................................................................... 162 Try not to Disturb your Routine and Sleep Patterns ............................................................... 163 Do Hobbies Work? ................................................................................................................. 163 What Does Physical Activity Bring us? .................................................................................. 163 Bias and Stigmatization .......................................................................................................... 164 CONCLUSION ............................................................................................................................... 164 REFERENCES ............................................................................................................................... 164 CHAPTER 10 COVID-19 AND OUR BRAIN: WHAT'S NEW? ..................................................... 166 INTRODUCTION .......................................................................................................................... 166 HOW CAN COVID-19 AFFECT THE BRAIN AND NERVOUS SYSTEM? ......................... 168 WHAT KIND OF DAMAGE DOES COVID-19 CAUSE IN THE BRAIN? ............................ 168 WHAT KINDS OF NEUROLOGICAL SIGNS AND SYMPTOMS DO COVID-19 CAN BE EVIDENT? ...................................................................................................................................... 169 DOES IT HAVE LONG-TERM EFFECTS ON THE CNS? ..................................................... 170 EFFECTS OF COVID-19 ON PEOPLE WITH NEUROLOGICAL DISORDERS ............... 170 DOES COVID-19 INCREASE THE RISK OF STROKE? ........................................................ 171 MANY PATIENTS MENTION LOSS OF SMELL / TASTE ................................................... 171 IS THERE AN ASSOCIATION BETWEEN ANOSMIA AND RESPIRATORY FAILURE? 172 DOES COVID-19 TRIGGER BRAIN TISSUE INFLAMMATION (ENCEPHALITIS)? ..... 173 WHAT ARE THE TREATMENT METHODS AFTER COVID-19 INFLICTS THE CNS? 175 CONCLUSION ............................................................................................................................... 175 REFERENCES ............................................................................................................................... 175 CHAPTER 11 COVID-19 PNEUMONIA AND ARDS: THE REAL KILLER? ............................ 179 DEFINITION .................................................................................................................................. 179 CLINICAL FEATURES ................................................................................................................ 181 DIAGNOSIS .................................................................................................................................... 182 THE MOST COMMON CT FINDINGS ON PRESENTATION (ADAPTED FROM PAN ET AL, 2020) ................................................................................................................................... 184 DIFFERENTIAL DIAGNOSES .................................................................................................... 190 OTHER SITUATIONS TO BE DISTINGUISHED .................................................................... 190 SERUM ANTIBODY DETECTION ............................................................................................ 191 LABORATORY FINDINGS ......................................................................................................... 191 RISK FACTORS FOR SEVERE DISEASE ................................................................................ 192 ARDS ............................................................................................................................................... 193 Treatment of Pneumonia and ARDS ...................................................................................... 197 Hypoxia Management in Severe and Critical COVID-19 Patient ................................ 197 Specific Drug Treatments ....................................................................................................... 199 CONCLUSION ............................................................................................................................... 202 REFERENCES ............................................................................................................................... 203 CHAPTER 12 PREGNANCY, COVID-19, AND CHILDREN: DANGEROUS TRIO? ............... 207 WHAT ARE THE CHARACTERISTICS OF PREGNANT WOMEN WITH COVID-19? 208 Should there be a Different Warning for Pregnant Healthcare Workers? .............................. 208 Could the Pregnant Women with Covid-19 Transmit the Disease to the Baby? .................... 208 How is Protection from Covid-19 during Pregnancy? ............................................................ 209 What are the General Treatment Methods in Pregnant Women? ........................................... 209 Are the Drugs used in the Treatment of Covid-19 Harmful during Pregnancy? .................... 210 Can the Woman with COVID-19 Breastfeed her Baby? ........................................................ 210 Is there Anything to Pay Attention to After Birth? ................................................................. 210 Can Children Take COVID-19 Medications Used by Adults? ............................................... 211 COVID-19 IN CHILDREN: IT IS NOT A FAIRY TALE, IT IS A REALITY ....................... 212 Are the Children “Carriers of COVID-19”? ........................................................................... 213 Are the Signs and Symptoms in Children Different from Adults? ......................................... 213 Is COVID-19 more Risky for Children with Asthma or Allergies? What are the Risks? ...... 215 Are the Laboratory Findings Different in Children? .............................................................. 216 Which Children get COVID-19? ............................................................................................ 216 How is the Covid-19 Virus Transmitted to Children? ............................................................ 217 Should Masks and Gloves be used for Children who are Going Out Necessarily? ................ 217 Since The Mortality Rate in Children is Close to Zero, Covid-19 has Nothing to do with Children, Right? ...................................................................................................................... 217 Should Children be Locked up at Home? ............................................................................... 218 Does the Baby's Breastfeeding Affect the Covid-19 Clinical Course? .................................. 218 How is the Diagnosis Made? .................................................................................................. 219 Imaging Principles for Pediatric COVID-19 Suspected Cases ............................................... 219 Can Sequential Cxr be Requested? ......................................................................................... 220 Can CXR be Ordered After Recovery? .................................................................................. 220 Discharge Criteria ................................................................................................................... 221 How Can we Tell Kids About COVID-19? ............................................................................ 222 CONCLUSION ............................................................................................................................... 225 REFERENCES ............................................................................................................................... 226 CHAPTER 13 COVID-19 AND THE ELDERLY: IS IT DIFFERENT FROM THE YOUNG? 229 WHAT KIND OF SYMPTOMS SHOULD RAISE SUSPICION OF COVID-19 IN THE ELDERLY? ..................................................................................................................................... 230 IS THERE ANY DIFFERENCE BETWEEN OTHER EPIDEMICS AND COVID-19 IN THIS REGARD? ............................................................................................................................ 230 IS COVID-19 DIFFERENT IN THE ELDERLY? ...................................................................... 230