VOLUME 3 Dementia Second Edition WPA Series Evidence and Experience in Psychiatry Dementia,SecondEdition.EditedbyMarioMajandNormanSartorius. #2002JohnWiley&SonsLtd.ISBN: 0-470-84963-0 Other Titles in the WPA Series Evidence and Experience in Psychiatry Volume 1—Depressive Disorders, Second Edition Mario Maj and Norman Sartorius Volume 2—Schizophrenia, Second Edition Mario Maj and Norman Sartorius Volume 4—Obsessive-Compulsive Disorder, Second Edition Mario Maj, Norman Sartorius, Ahmed Okasha and Joseph Zohar Volume 5—Bipolar Disorder Mario Maj, Hagop S. Akiskal, Juan Jose´ Lo´pez-Ibor and Norman Sartorius VOLUME 3 Dementia Second Edition Edited by Mario Maj University of Naples, Italy Norman Sartorius University of Geneva, Switzerland WPA Series Evidence and Experience in Psychiatry Copyright#2002JohnWiley&SonsLtd,TheAtrium,SouthernGate,Chichester, WestSussexPO198SQ,England Telephone(+44)1243779777 Email(forordersandcustomerserviceenquiries):[email protected] VisitourHomePageonwww.wileyeurope.comorwww.wiley.com FirstEditionprintedin2000. AllRightsReserved.Nopartofthispublicationmaybereproduced,storedinaretrieval systemortransmittedinanyformorbyanymeans,electronic,mechanical,photocopying, recording,scanningorotherwise,exceptunderthetermsoftheCopyright,Designsand PatentsAct1988orunderthetermsofalicenceissuedbytheCopyrightLicensingAgency Ltd,90TottenhamCourtRoad,LondonW1T4LP,UK,withoutthepermissioninwritingof thePublisher.RequeststothePublishershouldbeaddressedtothePermissionsDepartment, JohnWiley&SonsLtd,TheAtrium,SouthernGate,Chichester,WestSussexPO198SQ, England,[email protected],orfaxedto(+44)1243770571. Thispublicationisdesignedtoprovideaccurateandauthoritativeinformationinregardto thesubjectmattercovered.ItissoldontheunderstandingthatthePublisherisnotengaged inrenderingprofessionalservices.Ifprofessionaladviceorotherexpertassistanceis required,theservicesofacompetentprofessionalshouldbesought. OtherWileyEditorialOffices JohnWiley&SonsInc.,111RiverStreet,Hoboken,NJ07030,USA Jossey-Bass,989MarketStreet,SanFrancisco,CA94103-1741,USA Wiley-VCHVerlagGmbH,Boschstr.12,D-69469Weinheim,Germany JohnWiley&SonsAustraliaLtd,33ParkRoad,Milton,Queensland4064,Australia JohnWiley&Sons(Asia)PteLtd,2ClementiLoop#02-01,JinXingDistripark,Singapore 129809 JohnWiley&SonsCanadaLtd,22WorcesterRoad,Etobicoke,Ontario,CanadaM9W 1L1‘ BritishLibraryCataloguinginPublicationData AcataloguerecordforthisbookisavailablefromtheBritishLibrary ISBN0-470-84963-0 Typesetin10/12ptTimesbyKolamInformationServicesPvt.Ltd,Pondicherry,India PrintedandboundinGreatBritainbyTJInternational,Padstow,Cornwall. Thisbookisprintedonacid-freepaperresponsiblymanufacturedfromsustainableforestry inwhichatleasttwotreesareplantedforeachoneusedforpaperproduction. Contents List of ReviewContributors xi Preface xiii CHAPTER1 DEFINITION AND EPIDEMIOLOGY OF DEMENTIA 1 Definition and Epidemiology of Dementia: AReview 1 A.S.Henderson and A.F. Jorm COMMENTARIES 1.1 The Continuing Evolutionof Dementia Epidemiology 34 M.Ganguli 1.2 Dementia: Hope forthe Future 36 S. Lovestone 1.3 Dementia: Much Information, Many Unanswered Questions 39 L.F. Jarvik 1.4 Vascular Factors andDementia 42 I.Skoog 1.5 Dementia: Known andUnknown 45 E.D. Caine 1.6 Dementia: a Public Health Emergency and a Scientific Challenge 47 L. Fratiglioni 1.7 Dementia: Plenty ofQuestions Still to Be Answered 50 R. Jacoby 1.8 Ratesand Risk Factors for Dementia: Evidence or Controversy? 52 P. Kragh-Sørensen, K. Andersen, A.Lolk and H.Nielsen 1.9 Dementia: the Public Health Challenge 55 K.I. Shulman 1.10 Definitionand Epidemiology of Dementia: Some Issues that Need Clarification 57 P.J.Whitehouse vi CONTENTS 1.11 Dementia: theChallenge for the Next Decade 59 A. Mann 1.12 Recent Progressinthe Definitionand Epidemiology ofDementia 62 A. Burns 1.13 Dementia: Some Controversial Issues 64 M.R.Jorge 1.14 Isthe Prevalence Rate of Alzheimer’s Disease Increasing in Japan? 66 A. Homma CHAPTER 2 CLINICAL DIAGNOSIS OF DEMENTIA 69 Clinical Diagnosis of Dementia: AReview 69 B. Reisberg,E. Franssen, M.A. Shah, J. Weigel, M. Bobinskiand H.M. Wisniewski COMMENTARIES 2.1 The Value of Inclusive Diagnostic Thinking and Appreciating Developmental Variance 116 E.B. Larson 2.2 Reflectionson Retrogenesis 118 J. O’Brien 2.3 Dementia: Diagnosis,Progression and Retrogression 120 P.S. Sachdev 2.4 Staging of SevereAlzheimer’sDiseaseand the Concept ofRetrogenesis: Doorsto beOpened for Research and Clinical Practice 123 R. Heun 2.5 When DiagnosisisCertain, FunctionalScoresare Robust andRecommendableMarkersof the Progression of Alzheimer’s Disease 125 G. Ransmayr 2.6 Findings with theAid of FunctionalAssessment Staging (FAST) 127 Sir M.Roth 2.7 Two Decades of Longitudinal Research in Alzheimer’s Disease 130 S.I.Finkel 2.8 DiagnosingDementia: the Need for Improved Criteria 132 G. Gold CONTENTS vii 2.9 Pitfallsin DiagnosingAlzheimer’sDisease 135 I.Kloszewska 2.10 Evaluating thePerformanceof Measures to Assess Dementia 136 D.R.Gifford 2.11 Dementia as a Diagnostic Entity 139 S. Wibisono CHAPTER3 NEUROPSYCHOLOGICAL AND INSTRUMENTALDIAGNOSIS OF DEMENTIA 143 Neuropsychological and Instrumental Diagnosis of Dementia: AReview 143 O.Almkvist COMMENTARIES 3.1 Improving Diagnosisof Dementia 166 M.Rossor 3.2 The Contribution of Neuropsychologyto the Assessment of Dementia Syndromes 169 K. Ritchie 3.3 Neuropsychological and Instrumental Diagnosis of Dementia: theEvidence 171 P. Scheltens 3.4 Some Clinical Aspects andResearch Issues in the Neuropsychological Assessment ofDementia 173 A.U. Monsch 3.5 The Role of Cognitive andFunctional Evaluation in the Care of Patientswith Dementia 176 R.C. Mohs 3.6 Evaluating theCognitive Changes of Normal and Pathologic Aging 179 J.C. Morris and W.P. Goldman 3.7 Alzheimer’s DiseaseandOtherDegenerative Dementias: Need for anEarly Diagnosis 182 R. Mielkeand W.-D. Heiss 3.8 Neuropsychological and Instrumental Diagnosis of Dementia in aClinical Context 184 G.K.Wilcock 3.9 Neuropsychological Tests that are Helpfulto the Etiological Diagnosisof Dementia 187 F. Pasquier viii CONTENTS 3.10 The Importanceof anEarly Diagnosisin Alzheimer’s Disease 189 A. Nordberg 3.11 When Should We Use Which DiagnosticTools? 193 G. Stoppe 3.12 Factors Affecting Diagnosis in Dementia 195 A. Heerlein CHAPTER 4 PHARMACOLOGICAL TREATMENTOF DEMENTIA 199 PharmacologicalTreatment ofDementia: AReview 199 S.C.Samuels and K.L. Davis COMMENTARIES 4.1 Alzheimer’s Diseaseis Treatable 247 P.N.Tariot 4.2 Treatmentof Dementia: Where Do We Go from Here? 251 D.P. Devanand 4.3 The Future of Alzheimer’s Pharmacotherapeutics 253 E.R. Peskind 4.4 Outcome Measures and Ethical Issuesin the Pharmacotherapy ofAlzheimer’sDisease 256 G. Waldemar 4.5 From Bench to Bedside:How to Treat Dementia 259 S. Gauthier 4.6 Some Limitations inthe Drug Treatmentof Alzheimer’s Disease 262 B.E. Leonard 4.7 Issues Regarding the Pharmacotherapy of Dementia 266 K.L. Lanctoˆt 4.8 Treatmentof Cognitive andNon-cognitive Disturbances in Dementia 269 W. Samueland D.V. Jeste 4.9 Are There Concernsabout the ‘‘Real World’’ Effectiveness and Safetyof Medications for Alzheimer’s Disease? 272 L.S. Schneider 4.10 Phytoneuropsychotropics in Alzheimer’s Disease: Treatmentand/or Prevention 275 T.M.Itil CONTENTS ix CHAPTER5 PSYCHOSOCIAL INTERVENTIONS FOR DEMENTIA 279 Psychosocial Interventions for Dementia: AReview 279 F. Baro COMMENTARIES 5.1 Psychosocial Dimensions of Dementia Care 308 K.C. Buckwalter 5.2 First Experience, then Evidence, then Possibly New Criteria 312 M.Powell Lawton 5.3 The Development of Cognitive Neurorehabilitation for Alzheimer’s Disease 314 T. Asada 5.4 Psychosocial Interventions and Behavioural Treatments for Dementia 317 L. Teri 5.5 The Need for Greater Specificity in Psychosocial Interventions 319 C. Beck 5.6 Psychosocial Interventions in Dementia: the NatureandFocusof Intervention, Outcome Measurement and Qualityof Life 322 S. Banerjee 5.7 GeneralComments on Psychosocial Interventions for Dementia 325 E. Miller 5.8 ChangingTherapeuticParadigms 327 B. Groulx 5.9 Psychosocial Interventions in Dementia: Attitudes, Approaches, Therapiesand Qualityof Life 330 E. Chiu 5.10 The Importanceof Touch andContact 332 Y. Barak 5.11 The Need to Improvise and LookforEvidence 334 A.M. Ashour 5.12 The Need for Psychosocial Interventions in Dementia 337 M.Sua´rez Richards 5.13 Sharing and SupportingFamilies with Dementia 338 R. Srinivasa Murthy