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Date of Document: December 22, 2018 CURRICULUM VITAE David R. Harder PhD Associate Dean, Adjunct Professor Department of Physiology OFFICE ADDRESS: Medical Education Building 8701 Watertown Plank Rd Milwaukee, WI 53226 EDUCATION: - 1972 B.S. Zoology, University of Wisconsin, Milwaukee, WI - 1975 M.S., Medical College of Wisconsin, Milwaukee, WI - 1976 PhD Biophysics, Medical College of Wisconsin, Milwaukee, WI POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: 1977 - 1978 Postdoctoral Fellow, Department of Physiology, University of Virginia Medical School, Charlottesville, VA FACULTY APPOINTMENTS: 09/1976 - 12/1976 Lecturer in Anatomy & Physiology, Dept. of Zoology, University of Wisconsin, Milwaukee, WI 1976 - 1977 Research Associate, Medical College of Wisconsin, Milwaukee, WI 1977 - 1978 Postdoctoral Fellow, Physiology, University of Virginia Medical School, P.O. Box 800793, Charlottesville, VA 22908 1978 - 1980 Assistant Professor of Physiology, College of Medicine, East Tennessee University, Johnson City, TN 1980 - 1983 Research Assistant Professor of Physiology & Biophysics, University of Vermont, Burlington, VT 1983 - 1987 Associate Professor, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 1983 - 1987 Associate Professor, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 1984 - 1987 Director, Neurology Research, Neurology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 1985 - Present Research Career Scientist, Veterans Administration Medical Center, Milwaukee, WI 1987 - Present Professor of Physiology, Medical College of Wisconsin, Milwaukee, WI 1992 - 2009 Director, Cardiovascular Research Center, Physiology, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 1994 - Present Professor of Medicine, Medical College of Wisconsin, Milwaukee, WI 2008 - 2015 Associate Dean for Research, Office of Research, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 2010 - 2015 Director for Mentoring, Clinical & Translational Science Institute, Education, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 2015 - 2017 Associate Dean for Mentoring, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 RESEARCH ADMINISTRATIVE APPOINTMENTS: 1 / 22 1984 - 1987 Director of Neurology Research, Medical College of Wisconsin, Milwaukee, WI 1992 - 2009 Director, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 2008 - Present Associate Dean for Research, Medical College of Wisconsin, Milwaukee, WI 2010 - Present Director for Mentoring, Clinical & Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI AWARDS AND HONORS: 1982 - 1987 American Heart Association Established Investigator Award 1985 - Present Research Career Scientist Award, Veterans Administration 01/1987 - Present Royal Society of Medicine, London 06/1990 - Present Elected as a Fellow in the Council for High Blood Pressure Research and Council on Circulation, American Heart Association 1990 - Present National Institutes of Health Method to Extend Research in Time (MERIT) Award 12/1997 Nominated for the Bristol-Myers Squibb Award for Distinguished Achievement in Cardiovascular/Metabolic Research, University of British Columbia, Vancouver 2000 Robert M. Berne Distinguished Lecturer Award, The American Physiological Society 12/2003 Distinguished Service Award, Medical College of Wisconsin 2007 Kohler Co. Endowed Chair in Cardiovascular Research, Medical College of Wisconsin 2009 Carl I. Wiggers Award - Highest award presented for outstanding career contributions made in the field of pressure-flow relationships in cardiovascular system., Cardiovascular Section of American Society of Physiology MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: Society for General Physiologists Biophysics Society American Physiological Society International Society for Heart Research (American Section) Scientific Council of the American Heart Association (Circulation Fellow) EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: Editorship 1999 - 2004 American Journal of Physiology: Heart & Circulatory Physiology, Editor-in-Chief Journal of Vascular Research, Associate Editor Stroke, Guest Editor Editorial Board Circulation Research Endothelium Journal of Cerebral Blood Flow and Metabolism Journal of Vascular Research Journal Review Stroke American Journal of Physiology - all sections Arteriosclerosis and Thrombosis Cardiovascular Research Circulation Research Endothelium European Journal of Pharmacology Hypertension Journal of Cardiovascular Pharmacology Journal of Cerebral Blood Flow and Metabolism Journal of Clinical Investigation Journal of Vascular Research Pflugers Archives 2 / 22 LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: 1996 Chairman, First Annual Meeting, Midwest Physiological Society NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: 1992 - 1995 Program Committee, Council for High Blood Pressure Research 1994 - 1997 Committee on Committees, American Physiological Society 1997 Finance Committee, American Physiological Society 2002 - Present Publication Committee, Council for High Blood Pressure Research 2004 - Present Finance Committee, World Congress for Microcirculation RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: Active Peer Review Title: VA Research Career Scientist Award Role: PI Dates: 05/1985 - Present Title: Anesthetic-Induced Cardiac Preconditioning Source: 1 P01 GM066730-05 NIH/NIGMS Role: Co-Director of Core Laboratory PI: ZJ Bosnjak Dates: 08/2008 - 07/2013 Title: Modification of Vascular Signaling in the Brain by ROS Source: RO1 Grant 5RO1 HL92105-02 Role: PI Dates: 01/2009 - 12/2013 Direct Funds: $414,259 (per year) Title: Medical Student Summer Research Training Program Source: NIH Grant: 1 T35 HL072483-28 Role: PI Dates: 08/2009 - 07/2014 Direct Funds: $164,462 (per year) Title: Hypertension Training Grant Source: NIH Grant: 5T32 HL007792-17 Role: PI Dates: 08/2009 - 07/2014 Direct Funds: $282,933 (per year) Title: Regulating Cerebral Microcirculation by Astrocytes Source: NIH Grant: 5 R01 HL033833-25 Role: PI Dates: 04/2010 - 03/2014 Direct Funds: $370,432 (per year) Title: Autoregulation of Cerebral Blood Flow Source: NIH/NHLBI R01 HL105997 Role: PI Dates: 12/2011 - 11/2015 Direct Funds: $635,680 (per year) 3 / 22 Prior Peer Review Title: Established Investigator Award - Cellular properties of cerebral arterial muscle Source: AHA #82-204 Dates: 07/1972 - 07/1987 Direct Funds: $183,750 Title: Membrane activation of cerebral vascular muscle Source: NIH HL 27862 Dates: 07/1978 - 07/1982 Direct Funds: $70,000 Title: Research Career Development Award Source: NIH Dates: 1981 Source: AHA Award #772 Dates: 1981 Direct Funds: $100,380 Title: Cellular properties of cerebral arterial muscle Source: NIH Grant: HL-31871 Role: PI Dates: 07/1983 - 06/1986 Direct Funds: $144,759 Title: Merit Review Grant Source: VA #34440-02P Role: PI Dates: 10/1984 - 09/1987 Direct Funds: $219,100 Title: Mechanisms of pressure-induced myogenic tone in arteries Source: NIH Grant: HL-33833 Role: PI Dates: 04/1985 - 09/1990 Direct Funds: $411,669 Title: Project VIII: Cellular mechanisms of myogenic autoregulation in renal arteries Source: NIH Program Project Grant: HL-29587 PI: AW Cowley Dates: 03/1986 - 02/1988 Direct Funds: $136,039 Title: Cellular and ionic mechanisms of vasospasm and hypoxic dilation in cerebral arteries Source: VA Merit Review #3440-02P Role: PI Dates: 10/1987 - 02/1992 Direct Funds: $350,000 Title: Project 2: Activation of renal arterial muscle Source: NIH Program Project Grant: HL-29587 PI: AW Cowley Dates: 03/1988 - 02/1991 4 / 22 Direct Funds: $300,000 Title: Project 2 (Suppl): Mechanisms of renal vascular resetting in hypertension Source: NIH Program Project Grant: HL-29587 PI: AW Cowley Dates: 03/1991 - 02/1993 Direct Funds: $297,043 Title: Project 3: NO & 20-HETE Interaction in Control of Renal Function Source: NIH/NHLBI Grant: P01 HL29587-16 PI: R Roman Dates: 03/1998 - 02/2003 Direct Funds: $7,720 Title: Autoregulation and Hypoxic Dilation in the Brain Source: NIH Grant: 1 R01 NS32321 Role: PI Dates: 08/1998 - 03/2003 Title: Effect on ROS Species on Functional Hyperemia in the Brain Source: VA Merit Review 3440-06P Role: PI Dates: 1999 - 03/30/2008 Direct Funds: $106,500 (per year) Title: Post Doctoral Fellowship Source: American Heart Association, Northland Affiliate Role: Under the direction and resources of Dr. David Harder PI: Dr. David Gutterman Dates: 07/01/2001 - 06/30/2003 Title: Vascular Signaling by Free Radicals Source: NIH/NHLBI 1 P01 HL68769-02 Role: PI Dates: 04/2002 - 03/2007 Direct Funds: $1,037,547 (per year) Title: Mechanisms Regulating Cerebral Blood Flow Source: NIH/NHLBI Program Project Grant: P01 HL59996–06 Role: PI Dates: 02/2005 - 01/2011 Direct Funds: $1,378,340 (per year/jointly with Johns Hopkins University School of Medicine) INVITED LECTURES/WORKSHOPS/PRESENTATIONS: Local Invited Speaker, Stroke on the Move in Wisconsin Conference, Wisconsin Stroke Committee, Middleton, Wisconsin, 11/2005 - 11/2055 Metabolic Syndrome Symposium,, Milwaukee, WI, 02/2011 Regional University of Michigan Medical School, Department of Physiology, Ann Arbor, MI, 12/1984 Reversal of cerebral vasospasm in the primate, Upjohn Pharmaceuticals, Kalamazoo, Michigan, 06/1986 Department of Physiology Seminar, University of Cincinnati, 09/1987 The University of Miami, 12/1988 5 / 22 Department of Pathology, University of Chicago, 04/1991 University of Iowa, College of Medicine, Department of Medicine, Iowa City, IA, 08/1994 University of Missouri, Dalton Cardiovascular Research Center, Colombia, MO, 02/1998 Role of P450 Eicosanoids in Brain Angiogenesis and Functional Hyperemia, Cardiovascular Institute Seminar, Loyola University Medical Center, Maywood, Illinois, 05/2000 Physiology Invited Speaker, University of Missouri, Columbia, Missouri,, 02/2001 Speaker, University of Illinois Seminar, Chicago, Illinois, 01/2002 Invited Speaker, University of Indiana, Indianapolis, IN, 10/2003 Symposium honoring Dr. Erdos/Endowment Fund, University of Chicago, Illinois, 10/2005 Invited Speaker, Loyola University, Chicago, IL, 12/2007 National AHA Established Investigator Research Committee Meeting, Boston, Massachusetts, 02/1984 Uniformed Services University of the Health Sciences, Bethesda, Maryland, 03/1984 68th Annual Meeting of Federation of American Societies for Experimental Biology, St. Louis, Missouri, 04/1984 A.N. Richards Symposium, "Recent Advances in Arterial Disease"., Philadelphia Physiological Society, Philadelphia, Pennsylvania, 05/1984 Association of University Anesthetists Annual Meeting, Madison, Wisconsin, 05/1984 Conference on Pulmonary Vascular Reactivity, Dekkers, Colorado, 10/1984 University of Virginia, Department of Physiology, Charlottesville, Virginia, 03/1985 The Squibb Institute for Medical Research, Princeton, New Jersey, 05/1985 Symposium on smooth muscle, Federation of American Societies for Experimental Biology Research Conference, Sexton's River, Vermont, 06/1985 Cerebral Blood Flow Symposium, Federation of American Societies for Experimental Biology Annual Meeting, 04/1986 AHA 59th Scientific Sessions, Dallas, Texas, 11/1986 Berlex Pharmaceuticals, Cedar Grove, New Jersey, 10/1987 Summer Research Conference on Electrophysiological Mechanisms of Propagation and Activation of Cardiac and Smooth Muscle, Saxton's River, Vermont, 08/1988 The Graduate Hospital, Philadelphia, Pennsylvania, 10/1988 Dept. of Physiology, Texas A&M University, College of Medicine, 02/1990 FASEB Summer Research Conference on Renal Hemodynamics, Saxtons River, Vermont, 06/1992 American Nephrology Society, Baltimore, MD, 11/1992 Bowman Gray University, Department of Physiology, Winston Salem, North Carolina, 05/1993 FASEB Summer Research Conference, Cooper Mt., Colorado, 06/1994 University of Louisville, Coll. of Medicine, Dept. of Physiology, Louisville, Kentucky, 11/1994 Symposium on New Methodologies in Cerebral Circulation, Experimental Biology, 04/1995 FASEB Summer Research Conference, Saxtons River, Vermont, 06/1995 Johns Hopkins University School of Medicine, Department of Anesthesiology & Critical Care Medicine, Baltimore, Maryland, 01/1996 Gordon Research Conferences, Ventura, California, 02/1996 The University of Texas Health Science Center at San Antonio, Department of Physiology, San Antonio, Texas, 03/1996 Experimental Biology, Washington, D.C., 04/1996 Yale University, The John B. Pierce Laboratory, Center for Research in Health and the Environment, New Haven, Connecticut, 12/1996 Vascular Biology, New Orleans, Louisiana, 04/1997 FASEB Summer Conference on Endothelium and Cardiovascular Control, Copper Mountain, Colorado, 06/1997 Brain Satellite Symposium, Williamsburg, Virginia, 06/1997 University of Nevada-Reno, Department of Physiology, Reno, Nevada, 12/1997 Vascular and Myocardial Aspects of Ischemic Heart Disease, Incline Village, Nevada, 02/1998 University of Tennessee-Memphis, Dept of Physiology & Biophysics, 04/1998 Experimental Biology, San Francisco, California, 04/1998 Vascular Biology, San Francisco, California, 04/1998 Virginia Commonwealth University, Dept. of Pharmacology, Richmond, Virginia, 05/1998 6 / 22 Renal Hemodynamics: Integration of Endothelial, Epithelial, and Vascular Control Mechanisms, FASEB Summer Research Conference, Saxtons River, Vermont, 06/1998 52nd Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, Philadelphia, Pennsylvania, 09/1998 American Heart Association, 71st Scientific Sessions, Dallas, Texas, 11/1998 Winter Eicosanoid Conference, Baltimore, Maryland, 03/1999 Experimental Biology, Washington, DC, 04/1999 Vasoactive Substances Conference, Alexandria, Virginia, 05/1999 53rd Annual Council for High Blood Pressure Research, Orlando, Florida, 09/1999 Winter Conference on Brain Research, Breckenridge, Colorado, 01/2000 Winter Eicosanoid Conference, Baltimore, Maryland, 03/2000 Robert M. Berne Distinguished Lecturer of the APS Cardiovascular Section, Experimental Biology, San Diego, CA, 04/2000 Invited Speaker, New York Medical College, Valhalla, New York, 04/2001 Experimental Biology, Orlando, Florida, 04/2001 Speaker, Mechanisms of Vasodilation Symposium, Boston, Massachusetts, 05/2001 Speaker, Mechanisms of Vasodilation Symposium, Boston, Massachusetts, 05/2001 Speaker, University of Mississippi Seminar, Jackson, Mississippi, 10/2001 Winter Brain Conference, Aspen, Colorado (Snowmass Village), 01/2002 Speaker, Medical College of Georgia-Seminar, Augusta, Georgia, 02/2002 Winter Eicosanoid Conference, Baltimore, Maryland, 03/2002 Invited Speaker, Myogenic Centennial Conference, Stowe, VT, 06/2002 Winter Eicosanoid Conference, Baltimore, Maryland, 03/2003 Invited Speaker, Symposium on Eicosanoids and Cardiovascular Disease in honor of Dr. John McGiff, New York Medical College, Valhalla, New York, 05/2003 Moderator and presenter, 57th Annual Fall Conference for American Heart Association, Washington, DC, 09/2003 Winter Eicosanoid Conference, Baltimore, Maryland, 03/2004 Invited Speaker, Louisiana State University, New Orleans, Louisiana, 04/2004 Experimental Biology Conference, Washington, DC, 04/2004 Invited Speaker, Wake Forest University, Winston-Salem, North Carolina, 05/2004 Invited Speaker, Gordon Research Conference, Colby College, Waterville, Maine, 08/2004 Invited Speaker, Brain Uptake and Utilization of Fatty Acids, Lipids & Lipoproteins Conference, Bethesda, Maryland, 10/2004 Symposium Co-chair, Experimental Biology Conference, San Diego, California, 03/2005 Symposium Co-chair, 7th Annual Winter Eicosanoid Conference, Baltimore, Maryland, 03/2005 American Heart Association’s Scientific Sessions, Dallas, Texas, 11/2005 Invited Speaker, University of California, Los Angeles, CA, 02/2006 Symposium Co-chair, 8th Annual Winter Eicosanoid Conference, Baltimore, Maryland, 03/2006 Presenter, 4th Scientific Meeting of the TMJ Association, Bethesda, Maryland, 09/2006 Invited Speaker, Institute for Environmental Medicine, University of Pennsylvania Medical Center, 12/2006 Invited Speaker, Loma Linda University, Loma Linda, California, 02/2007 Symposium Co-chair and Presenter, 9th Annual Winter Eicosanoid Conference, Baltimore, Maryland, 03/2007 Invited Speaker, National Institute on Drug Abuse, Bethesda, MD, 05/2007 APS Cardiovascular Section 2009 Carl J. Wiggers Award, Experimental Biology, New Orleans, Louisiana, 04/2009 Speaker, Ion Channel Conference, Boston, MA, 10/2009 Winter Eicosanoid Conference, Baltimore, Maryland, 03/2011 Experimental Biology Conference, Washington, DC, 04/2011 Gebremedhin D, Zhang DX, Harder DR, Detection of TRPV4 channel current-like activity in Fawn Hooded rat (FHH) rat cerebral arterial muscle, Experimental Biology, San Diego, California, 04/02/2016 - 04/06/2016 International "Control of Excitation-Contraction Coupling and Contraction in Vascular Smooth Muscle", 5th International Congress on Vascular Neuroeffector Mechanisms, Paris, France, 05/1984 7 / 22 Erik K. Fernstrom Symposium on Neural Regulation of Brain Circulation: Effects of Neurotransmitters., Lund, Sweden, 06/1985 International Conference on Primary Pulmonary Hypertension, Sponsored by NIH/NHLBI, Philadelphia, Pennsylvania, 05/1987 Free University of Berlin, Berlin, Germany, 03/1989 International Conference on Myogenic Mechanisms, Maderia, Portugal, 03/1989 International Symposium on Endothelial Factors, Philadelphia, Pennsylvania, 04/1989 International Conference on Neurotransmission and Cerebrovascular Function, LaNapoule, France, 05/1989 International Heart Research Annual Meeting, Cincinnati, Ohio, 05/1991 Third International Symposium on Resistance Arteries, Denmark, 05/1991 Third International Symposium on Calcium and Gene Hypertension, Portland, Oregon, 07/1991 Sixth Grover Conference on Ion Channels in Smooth Muscle, Denver, Colorado, 10/1992 Tsumagoi Conference, Tokyo, Japan, 07/1994 - 01/1994 First Workshop on Endothelium-Derived Hyperpolarizing Factor, Paris, France, 06/1995 The University of British Columbia, Department of Pharmacology & Therapeutics, Vancouver, Canada, 01/1996 Satellite Symposium, Signal Transduction in the Endothelium, Vancouver, Canada, 09/1996 International Society for Heart Research (ISHR), The University of British Columbia, Vancouver, Canada, 07/1997 Symposium on signaling mechanisms in vascular smooth muscle, Sandbjerg, Denmark, 05/1998 Endothelium-Derived Hyperpolarizing Factor Workshop, Paris, France, 06/1998 Acta Physiological Scandinavica Symposium, Copenhagen, Denmark, 08/1999 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications, Florence, Italy, 06/2000 22nd meeting of the International Society for Heart Research (ISHR), Louisville, Kentucky, 06/2000 Cerebral vascular hyperpolarizing influences mechanistically inhibit blood flow autoregulation: a Yin-Yang hypothesis for hypothesis for cytochrome P450 metabolites, Third Workshop on Endothelium-Derived Hyperpolarizing Factor, Abbaye des Vaux de Cernay, France, 06/2000 XVII World Congress of International Society, Winnipeg, Canada, 07/2001 Invited Speaker, EDHF Workshop, Paris, France, 06/2002 Invited Speaker, 24th Annual Meeting of the ISHR, Madison, Wisconsin, 07/2002 Invited Speaker, XIV World Conference of Pharmacology, San Francisco, California, 07/2002 Invited Speaker, The University of British Columbia, Vancouver, B.C., 08/2002 Invited Speaker, ISHR, Mystic, Connecticut, 06/2003 Invited Speaker and Session Chair, 8th ISRA, Angers, France, 06/2004 Invited Speaker, International Society for Heart Research, North American Section, Toronto, Canada, 06/2006 Speaker, 5th Int’l EDHF Symposium, Tampere, Finland, 06/2008 Invited Co-Chair, Speaker, 11th Annual International Winter Eicosanoid Conference, 03/2009 Gebremedhin D, Zhang DX, Carver KA, Rau N, Roman RJ, Harder DR, Expression of CYP 4A-?-hydroxylase and formation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cultured rat brain astrocytes, 16th International Winter Eicosanoid Conference, Baltimore, Maryland, 03/13/2016 - 03/16/2016 COMMITTEE SERVICE: Medical College 1984 - 1987 Executive Committee, Department of Neurology 1985 - 1987 Chairman, Education Committee, Department of Neurology 1987 Neurobiology Director Search Committee 1990 - 1994 Rank and Tenure Committee 1991 Chairman, Cardiovascular Research Center Executive Committee 1992 - 1994 Basic Science Chair Committee 1992 - Present Strategic Research and Planning Committee 1997 - Present Clinical Research Center Advisory Board 1998 Cardiology Chair Search Committee 8 / 22 1999 - Present Research Space Advisory Board 2000 - Present Cardiovascular Strategy Committee 2000 - Present Budget Committee 2000 - Present Cardiovascular Board Development Committee 2000 - 2003 Technology Transfer Committee 2002 - Present Angiographic Suite Committee 2002 - Present Translational Medicine Committee 2002 - Present Executive Committee of the Faculty 2009 Grants and Awards Committee, MCW Foundation MEDICAL COLLEGE TEACHING ACTIVITIES: Medical Student Education 1983 - 1995 CNS physiology lectures to medical students in Dept. of Physiology Continuing Medical Education 2008 - Present Associate Dean for Research: the primary responsibility of this post is to mentor research intensive clinical faculty in the writing and prosecution of extramural grants, including VA Merit Review and Clinician investigator awards. Graduate Student Education 1983 - 1995 Graduate courses in cell physiology. Approximately 32 contact hours/year. Graduate courses in cell physiology and signal transduction. 2010 - Present Special course in NIH Grant Preparation “Methods in Grant Preparation” (Syllabus can be found on www.ctsi.mcw.edu ) EXTRAMURAL TEACHING: Medical Student Education 1978 - 1980 East Tennessee State University, Dept. of Physiology, Taught 25% of medical physiology lectures plus labs. (This was a new medical school.) Duties included developing curriculum, teaching labs, and course implementation for medical students. MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: Graduate Students PhD Students Advised Nabil Alkayed, Medical College of Wisconsin, 1996 Andrew Lang, Medical College of Wisconsin, 1997 Lucas Hart, Medical College of Wisconsin, 2009 Pallabi Sarkar, Medical College of Wisconsin, 2012 Students Advised Reza Taheri, Medical College of Wisconsin, 2002 Koryn Carver, Medical College of Wisconsin Postdoctoral Students C.F. Sanchez-Ferrer, M.D., Ph.D, Medical College of Wisconsin, Advisor P. Bonnet, M.D., Ph.D, Medical College of Wisconsin, Advisor D. Gebremedhin, Ph.D, Medical College of Wisconsin, Advisor Dr. Yunn-Ha Ma, Ph.D., Medical College of Wisconsin, Advisor Dr. K. Kauser, M.D., Medical College of Wisconsin, Advisor A. Hudetz, Ph.D, Medical College of Wisconsin, Advisor C. Cheliakine, M.D., Medical College of Wisconsin, Advisor P. Li, M.D., Medical College of Wisconsin, Advisor 9 / 22 W. Meng, Ph.D., Medical College of Wisconsin, Advisor E. Birks, DVM, Ph.D., Medical College of Wisconsin, Advisor N. Dovin, M.D., Medical College of Wisconsin, Advisor Meetha Medhora, Ph.D., Medical College of Wisconsin, Advisor Diane Munzenmaier, Ph.D., Medical College of Wisconsin, Advisor Drazen Zagorac, Medical College of Wisconsin, Advisor Johan Bylund, Medical College of Wisconsin, Advisor Ken Yamaura, Medical College of Wisconsin, Advisor Danica Jakovcevic, MD., Medical College of Wisconsin, Advisor Chenyang Zhang, Medical College of Wisconsin, Advisor Nadi Wickramasakera, Ph.D., Medical College of Wisconsin, Advisor Vidudala Prasad, Ph.D., Medical College of Wisconsin, Advisor Maia Terashvili, Ph.D., Medical College of Wisconsin, Advisor David Lourim, Ph. D., Medical College of Wisconsin, Advisor U. Wesselmann, M.D., Ph.D., Medical College of Wisconsin, Advisor J. Madden, Ph.D., Medical College of Wisconsin, Advisor P. Dernback, M.D, Medical College of Wisconsin, Advisor R. Gilbert, M.D, Medical College of Wisconsin, Advisor A. Waters, M.D., Medical College of Wisconsin, Advisor J. Smeda, Ph.D, Medical College of Wisconsin, Advisor ADVISORY ACTIVITIES / GRANT REVIEWS:: 1989 - 1993 National Institutes of Health; National Heart, Lung and Blood Institute, Bethesda, MD: Experimental Cardiovascular Sciences Study Section, Ad-Hoc 1989 - 1993 National Institutes of Health; National Heart, Lung and Blood Institute, Bethesda, MD: Clinical Sciences Study Section 1992 NIH Site Visit, Program Projects in Vascular Biology 1994 NIH delegate to Japan 1996 NIH, RFA Study Section on Mechanisms of Angiogenesis 1996 - 1999 National American Heart Association Molecular Signaling Study Section 2000 - Present NIH Experimental Cardiovascular Sciences (ECS) Study Section CONSULTANTSHIPS: Uniformed Services University, Department of Physiology, Bethesda, Maryland Squibb Institute for Medical Research, Upjohn Pharmaceuticals, Kalamazoo, Michigan Cytometix, Inc. - Cytometix, Inc., was founded in the Fall of 2004 as a partnership between TechStar and David Harder, Director of the Cardiovascular Center (CVC) at the Medical College of Wisconsin (MCW). Cytometix is a privately funded, emerging pharmaceutical company focused on pre-clinical development of a lipid compound for pain. Cytometix was awarded an SBIR grant to validate the prospective use of this analgesic therapy from the National Institute on Drug Abuse (NIDA). Cytometix is also in early development of a therapeutic for asthma. The company has obtained over $8million dollars in Private Investment Capital (Angel Investments). An IND Application from FDA is currently pending. We anticipate initiation of Phase 1 Clinical Trials beginning November 1 2012. Berlex Laboratories, Inc., University of Louisville, Department of Physiology RESEARCH INTERESTS: Mechanisms Controlling Autoregulation of Blood Flow Role of Ionic Mechanisms in Activating Arterial and Arteriolar Smooth Muscle Tumor Angiogenesis in Brain Pain – Behavioral Study Electrophysiology of Excitable Tissues -Ion channels -Voltage gated mechanisms -Receptor operated mechanisms Control of Renal Blood Flow Cytochrome P450 Metabolites in the Control of Vascular Smooth Muscle and Endothelium 10 / 22

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Journal of Vascular Research. Journal Review. Stroke. American Journal of Physiology - all sections. Arteriosclerosis and Thrombosis. Cardiovascular
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Date of Document: December 22, 2018 CURRICULUM VITAE David R. Harder PhD Associate Dean, Adjunct Professor Department of Physiology OFFICE ADDRESS: Medical Education Building 8701 Watertown Plank Rd Milwaukee, WI 53226 EDUCATION: - 1972 B.S. Zoology, University of Wisconsin, Milwaukee, WI - 1975 M.S., Medical College of Wisconsin, Milwaukee, WI - 1976 PhD Biophysics, Medical College of Wisconsin, Milwaukee, WI POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: 1977 - 1978 Postdoctoral Fellow, Department of Physiology, University of Virginia Medical School, Charlottesville, VA FACULTY APPOINTMENTS: 09/1976 - 12/1976 Lecturer in Anatomy & Physiology, Dept. of Zoology, University of Wisconsin, Milwaukee, WI 1976 - 1977 Research Associate, Medical College of Wisconsin, Milwaukee, WI 1977 - 1978 Postdoctoral Fellow, Physiology, University of Virginia Medical School, P.O. Box 800793, Charlottesville, VA 22908 1978 - 1980 Assistant Professor of Physiology, College of Medicine, East Tennessee University, Johnson City, TN 1980 - 1983 Research Assistant Professor of Physiology & Biophysics, University of Vermont, Burlington, VT 1983 - 1987 Associate Professor, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 1983 - 1987 Associate Professor, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 1984 - 1987 Director, Neurology Research, Neurology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 1985 - Present Research Career Scientist, Veterans Administration Medical Center, Milwaukee, WI 1987 - Present Professor of Physiology, Medical College of Wisconsin, Milwaukee, WI 1992 - 2009 Director, Cardiovascular Research Center, Physiology, Cardiovascular Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 1994 - Present Professor of Medicine, Medical College of Wisconsin, Milwaukee, WI 2008 - 2015 Associate Dean for Research, Office of Research, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 2010 - 2015 Director for Mentoring, Clinical & Translational Science Institute, Education, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 2015 - 2017 Associate Dean for Mentoring, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 RESEARCH ADMINISTRATIVE APPOINTMENTS: 1 / 22 1984 - 1987 Director of Neurology Research, Medical College of Wisconsin, Milwaukee, WI 1992 - 2009 Director, Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, WI 2008 - Present Associate Dean for Research, Medical College of Wisconsin, Milwaukee, WI 2010 - Present Director for Mentoring, Clinical & Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI AWARDS AND HONORS: 1982 - 1987 American Heart Association Established Investigator Award 1985 - Present Research Career Scientist Award, Veterans Administration 01/1987 - Present Royal Society of Medicine, London 06/1990 - Present Elected as a Fellow in the Council for High Blood Pressure Research and Council on Circulation, American Heart Association 1990 - Present National Institutes of Health Method to Extend Research in Time (MERIT) Award 12/1997 Nominated for the Bristol-Myers Squibb Award for Distinguished Achievement in Cardiovascular/Metabolic Research, University of British Columbia, Vancouver 2000 Robert M. Berne Distinguished Lecturer Award, The American Physiological Society 12/2003 Distinguished Service Award, Medical College of Wisconsin 2007 Kohler Co. Endowed Chair in Cardiovascular Research, Medical College of Wisconsin 2009 Carl I. Wiggers Award - Highest award presented for outstanding career contributions made in the field of pressure-flow relationships in cardiovascular system., Cardiovascular Section of American Society of Physiology MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: Society for General Physiologists Biophysics Society American Physiological Society International Society for Heart Research (American Section) Scientific Council of the American Heart Association (Circulation Fellow) EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: Editorship 1999 - 2004 American Journal of Physiology: Heart & Circulatory Physiology, Editor-in-Chief Journal of Vascular Research, Associate Editor Stroke, Guest Editor Editorial Board Circulation Research Endothelium Journal of Cerebral Blood Flow and Metabolism Journal of Vascular Research Journal Review Stroke American Journal of Physiology - all sections Arteriosclerosis and Thrombosis Cardiovascular Research Circulation Research Endothelium European Journal of Pharmacology Hypertension Journal of Cardiovascular Pharmacology Journal of Cerebral Blood Flow and Metabolism Journal of Clinical Investigation Journal of Vascular Research Pflugers Archives 2 / 22 LOCAL/REGIONAL APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: 1996 Chairman, First Annual Meeting, Midwest Physiological Society NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: 1992 - 1995 Program Committee, Council for High Blood Pressure Research 1994 - 1997 Committee on Committees, American Physiological Society 1997 Finance Committee, American Physiological Society 2002 - Present Publication Committee, Council for High Blood Pressure Research 2004 - Present Finance Committee, World Congress for Microcirculation RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: Active Peer Review Title: VA Research Career Scientist Award Role: PI Dates: 05/1985 - Present Title: Anesthetic-Induced Cardiac Preconditioning Source: 1 P01 GM066730-05 NIH/NIGMS Role: Co-Director of Core Laboratory PI: ZJ Bosnjak Dates: 08/2008 - 07/2013 Title: Modification of Vascular Signaling in the Brain by ROS Source: RO1 Grant 5RO1 HL92105-02 Role: PI Dates: 01/2009 - 12/2013 Direct Funds: $414,259 (per year) Title: Medical Student Summer Research Training Program Source: NIH Grant: 1 T35 HL072483-28 Role: PI Dates: 08/2009 - 07/2014 Direct Funds: $164,462 (per year) Title: Hypertension Training Grant Source: NIH Grant: 5T32 HL007792-17 Role: PI Dates: 08/2009 - 07/2014 Direct Funds: $282,933 (per year) Title: Regulating Cerebral Microcirculation by Astrocytes Source: NIH Grant: 5 R01 HL033833-25 Role: PI Dates: 04/2010 - 03/2014 Direct Funds: $370,432 (per year) Title: Autoregulation of Cerebral Blood Flow Source: NIH/NHLBI R01 HL105997 Role: PI Dates: 12/2011 - 11/2015 Direct Funds: $635,680 (per year) 3 / 22 Prior Peer Review Title: Established Investigator Award - Cellular properties of cerebral arterial muscle Source: AHA #82-204 Dates: 07/1972 - 07/1987 Direct Funds: $183,750 Title: Membrane activation of cerebral vascular muscle Source: NIH HL 27862 Dates: 07/1978 - 07/1982 Direct Funds: $70,000 Title: Research Career Development Award Source: NIH Dates: 1981 Source: AHA Award #772 Dates: 1981 Direct Funds: $100,380 Title: Cellular properties of cerebral arterial muscle Source: NIH Grant: HL-31871 Role: PI Dates: 07/1983 - 06/1986 Direct Funds: $144,759 Title: Merit Review Grant Source: VA #34440-02P Role: PI Dates: 10/1984 - 09/1987 Direct Funds: $219,100 Title: Mechanisms of pressure-induced myogenic tone in arteries Source: NIH Grant: HL-33833 Role: PI Dates: 04/1985 - 09/1990 Direct Funds: $411,669 Title: Project VIII: Cellular mechanisms of myogenic autoregulation in renal arteries Source: NIH Program Project Grant: HL-29587 PI: AW Cowley Dates: 03/1986 - 02/1988 Direct Funds: $136,039 Title: Cellular and ionic mechanisms of vasospasm and hypoxic dilation in cerebral arteries Source: VA Merit Review #3440-02P Role: PI Dates: 10/1987 - 02/1992 Direct Funds: $350,000 Title: Project 2: Activation of renal arterial muscle Source: NIH Program Project Grant: HL-29587 PI: AW Cowley Dates: 03/1988 - 02/1991 4 / 22 Direct Funds: $300,000 Title: Project 2 (Suppl): Mechanisms of renal vascular resetting in hypertension Source: NIH Program Project Grant: HL-29587 PI: AW Cowley Dates: 03/1991 - 02/1993 Direct Funds: $297,043 Title: Project 3: NO & 20-HETE Interaction in Control of Renal Function Source: NIH/NHLBI Grant: P01 HL29587-16 PI: R Roman Dates: 03/1998 - 02/2003 Direct Funds: $7,720 Title: Autoregulation and Hypoxic Dilation in the Brain Source: NIH Grant: 1 R01 NS32321 Role: PI Dates: 08/1998 - 03/2003 Title: Effect on ROS Species on Functional Hyperemia in the Brain Source: VA Merit Review 3440-06P Role: PI Dates: 1999 - 03/30/2008 Direct Funds: $106,500 (per year) Title: Post Doctoral Fellowship Source: American Heart Association, Northland Affiliate Role: Under the direction and resources of Dr. David Harder PI: Dr. David Gutterman Dates: 07/01/2001 - 06/30/2003 Title: Vascular Signaling by Free Radicals Source: NIH/NHLBI 1 P01 HL68769-02 Role: PI Dates: 04/2002 - 03/2007 Direct Funds: $1,037,547 (per year) Title: Mechanisms Regulating Cerebral Blood Flow Source: NIH/NHLBI Program Project Grant: P01 HL59996–06 Role: PI Dates: 02/2005 - 01/2011 Direct Funds: $1,378,340 (per year/jointly with Johns Hopkins University School of Medicine) INVITED LECTURES/WORKSHOPS/PRESENTATIONS: Local Invited Speaker, Stroke on the Move in Wisconsin Conference, Wisconsin Stroke Committee, Middleton, Wisconsin, 11/2005 - 11/2055 Metabolic Syndrome Symposium,, Milwaukee, WI, 02/2011 Regional University of Michigan Medical School, Department of Physiology, Ann Arbor, MI, 12/1984 Reversal of cerebral vasospasm in the primate, Upjohn Pharmaceuticals, Kalamazoo, Michigan, 06/1986 Department of Physiology Seminar, University of Cincinnati, 09/1987 The University of Miami, 12/1988 5 / 22 Department of Pathology, University of Chicago, 04/1991 University of Iowa, College of Medicine, Department of Medicine, Iowa City, IA, 08/1994 University of Missouri, Dalton Cardiovascular Research Center, Colombia, MO, 02/1998 Role of P450 Eicosanoids in Brain Angiogenesis and Functional Hyperemia, Cardiovascular Institute Seminar, Loyola University Medical Center, Maywood, Illinois, 05/2000 Physiology Invited Speaker, University of Missouri, Columbia, Missouri,, 02/2001 Speaker, University of Illinois Seminar, Chicago, Illinois, 01/2002 Invited Speaker, University of Indiana, Indianapolis, IN, 10/2003 Symposium honoring Dr. Erdos/Endowment Fund, University of Chicago, Illinois, 10/2005 Invited Speaker, Loyola University, Chicago, IL, 12/2007 National AHA Established Investigator Research Committee Meeting, Boston, Massachusetts, 02/1984 Uniformed Services University of the Health Sciences, Bethesda, Maryland, 03/1984 68th Annual Meeting of Federation of American Societies for Experimental Biology, St. Louis, Missouri, 04/1984 A.N. Richards Symposium, "Recent Advances in Arterial Disease"., Philadelphia Physiological Society, Philadelphia, Pennsylvania, 05/1984 Association of University Anesthetists Annual Meeting, Madison, Wisconsin, 05/1984 Conference on Pulmonary Vascular Reactivity, Dekkers, Colorado, 10/1984 University of Virginia, Department of Physiology, Charlottesville, Virginia, 03/1985 The Squibb Institute for Medical Research, Princeton, New Jersey, 05/1985 Symposium on smooth muscle, Federation of American Societies for Experimental Biology Research Conference, Sexton's River, Vermont, 06/1985 Cerebral Blood Flow Symposium, Federation of American Societies for Experimental Biology Annual Meeting, 04/1986 AHA 59th Scientific Sessions, Dallas, Texas, 11/1986 Berlex Pharmaceuticals, Cedar Grove, New Jersey, 10/1987 Summer Research Conference on Electrophysiological Mechanisms of Propagation and Activation of Cardiac and Smooth Muscle, Saxton's River, Vermont, 08/1988 The Graduate Hospital, Philadelphia, Pennsylvania, 10/1988 Dept. of Physiology, Texas A&M University, College of Medicine, 02/1990 FASEB Summer Research Conference on Renal Hemodynamics, Saxtons River, Vermont, 06/1992 American Nephrology Society, Baltimore, MD, 11/1992 Bowman Gray University, Department of Physiology, Winston Salem, North Carolina, 05/1993 FASEB Summer Research Conference, Cooper Mt., Colorado, 06/1994 University of Louisville, Coll. of Medicine, Dept. of Physiology, Louisville, Kentucky, 11/1994 Symposium on New Methodologies in Cerebral Circulation, Experimental Biology, 04/1995 FASEB Summer Research Conference, Saxtons River, Vermont, 06/1995 Johns Hopkins University School of Medicine, Department of Anesthesiology & Critical Care Medicine, Baltimore, Maryland, 01/1996 Gordon Research Conferences, Ventura, California, 02/1996 The University of Texas Health Science Center at San Antonio, Department of Physiology, San Antonio, Texas, 03/1996 Experimental Biology, Washington, D.C., 04/1996 Yale University, The John B. Pierce Laboratory, Center for Research in Health and the Environment, New Haven, Connecticut, 12/1996 Vascular Biology, New Orleans, Louisiana, 04/1997 FASEB Summer Conference on Endothelium and Cardiovascular Control, Copper Mountain, Colorado, 06/1997 Brain Satellite Symposium, Williamsburg, Virginia, 06/1997 University of Nevada-Reno, Department of Physiology, Reno, Nevada, 12/1997 Vascular and Myocardial Aspects of Ischemic Heart Disease, Incline Village, Nevada, 02/1998 University of Tennessee-Memphis, Dept of Physiology & Biophysics, 04/1998 Experimental Biology, San Francisco, California, 04/1998 Vascular Biology, San Francisco, California, 04/1998 Virginia Commonwealth University, Dept. of Pharmacology, Richmond, Virginia, 05/1998 6 / 22 Renal Hemodynamics: Integration of Endothelial, Epithelial, and Vascular Control Mechanisms, FASEB Summer Research Conference, Saxtons River, Vermont, 06/1998 52nd Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, Philadelphia, Pennsylvania, 09/1998 American Heart Association, 71st Scientific Sessions, Dallas, Texas, 11/1998 Winter Eicosanoid Conference, Baltimore, Maryland, 03/1999 Experimental Biology, Washington, DC, 04/1999 Vasoactive Substances Conference, Alexandria, Virginia, 05/1999 53rd Annual Council for High Blood Pressure Research, Orlando, Florida, 09/1999 Winter Conference on Brain Research, Breckenridge, Colorado, 01/2000 Winter Eicosanoid Conference, Baltimore, Maryland, 03/2000 Robert M. Berne Distinguished Lecturer of the APS Cardiovascular Section, Experimental Biology, San Diego, CA, 04/2000 Invited Speaker, New York Medical College, Valhalla, New York, 04/2001 Experimental Biology, Orlando, Florida, 04/2001 Speaker, Mechanisms of Vasodilation Symposium, Boston, Massachusetts, 05/2001 Speaker, Mechanisms of Vasodilation Symposium, Boston, Massachusetts, 05/2001 Speaker, University of Mississippi Seminar, Jackson, Mississippi, 10/2001 Winter Brain Conference, Aspen, Colorado (Snowmass Village), 01/2002 Speaker, Medical College of Georgia-Seminar, Augusta, Georgia, 02/2002 Winter Eicosanoid Conference, Baltimore, Maryland, 03/2002 Invited Speaker, Myogenic Centennial Conference, Stowe, VT, 06/2002 Winter Eicosanoid Conference, Baltimore, Maryland, 03/2003 Invited Speaker, Symposium on Eicosanoids and Cardiovascular Disease in honor of Dr. John McGiff, New York Medical College, Valhalla, New York, 05/2003 Moderator and presenter, 57th Annual Fall Conference for American Heart Association, Washington, DC, 09/2003 Winter Eicosanoid Conference, Baltimore, Maryland, 03/2004 Invited Speaker, Louisiana State University, New Orleans, Louisiana, 04/2004 Experimental Biology Conference, Washington, DC, 04/2004 Invited Speaker, Wake Forest University, Winston-Salem, North Carolina, 05/2004 Invited Speaker, Gordon Research Conference, Colby College, Waterville, Maine, 08/2004 Invited Speaker, Brain Uptake and Utilization of Fatty Acids, Lipids & Lipoproteins Conference, Bethesda, Maryland, 10/2004 Symposium Co-chair, Experimental Biology Conference, San Diego, California, 03/2005 Symposium Co-chair, 7th Annual Winter Eicosanoid Conference, Baltimore, Maryland, 03/2005 American Heart Association’s Scientific Sessions, Dallas, Texas, 11/2005 Invited Speaker, University of California, Los Angeles, CA, 02/2006 Symposium Co-chair, 8th Annual Winter Eicosanoid Conference, Baltimore, Maryland, 03/2006 Presenter, 4th Scientific Meeting of the TMJ Association, Bethesda, Maryland, 09/2006 Invited Speaker, Institute for Environmental Medicine, University of Pennsylvania Medical Center, 12/2006 Invited Speaker, Loma Linda University, Loma Linda, California, 02/2007 Symposium Co-chair and Presenter, 9th Annual Winter Eicosanoid Conference, Baltimore, Maryland, 03/2007 Invited Speaker, National Institute on Drug Abuse, Bethesda, MD, 05/2007 APS Cardiovascular Section 2009 Carl J. Wiggers Award, Experimental Biology, New Orleans, Louisiana, 04/2009 Speaker, Ion Channel Conference, Boston, MA, 10/2009 Winter Eicosanoid Conference, Baltimore, Maryland, 03/2011 Experimental Biology Conference, Washington, DC, 04/2011 Gebremedhin D, Zhang DX, Harder DR, Detection of TRPV4 channel current-like activity in Fawn Hooded rat (FHH) rat cerebral arterial muscle, Experimental Biology, San Diego, California, 04/02/2016 - 04/06/2016 International "Control of Excitation-Contraction Coupling and Contraction in Vascular Smooth Muscle", 5th International Congress on Vascular Neuroeffector Mechanisms, Paris, France, 05/1984 7 / 22 Erik K. Fernstrom Symposium on Neural Regulation of Brain Circulation: Effects of Neurotransmitters., Lund, Sweden, 06/1985 International Conference on Primary Pulmonary Hypertension, Sponsored by NIH/NHLBI, Philadelphia, Pennsylvania, 05/1987 Free University of Berlin, Berlin, Germany, 03/1989 International Conference on Myogenic Mechanisms, Maderia, Portugal, 03/1989 International Symposium on Endothelial Factors, Philadelphia, Pennsylvania, 04/1989 International Conference on Neurotransmission and Cerebrovascular Function, LaNapoule, France, 05/1989 International Heart Research Annual Meeting, Cincinnati, Ohio, 05/1991 Third International Symposium on Resistance Arteries, Denmark, 05/1991 Third International Symposium on Calcium and Gene Hypertension, Portland, Oregon, 07/1991 Sixth Grover Conference on Ion Channels in Smooth Muscle, Denver, Colorado, 10/1992 Tsumagoi Conference, Tokyo, Japan, 07/1994 - 01/1994 First Workshop on Endothelium-Derived Hyperpolarizing Factor, Paris, France, 06/1995 The University of British Columbia, Department of Pharmacology & Therapeutics, Vancouver, Canada, 01/1996 Satellite Symposium, Signal Transduction in the Endothelium, Vancouver, Canada, 09/1996 International Society for Heart Research (ISHR), The University of British Columbia, Vancouver, Canada, 07/1997 Symposium on signaling mechanisms in vascular smooth muscle, Sandbjerg, Denmark, 05/1998 Endothelium-Derived Hyperpolarizing Factor Workshop, Paris, France, 06/1998 Acta Physiological Scandinavica Symposium, Copenhagen, Denmark, 08/1999 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications, Florence, Italy, 06/2000 22nd meeting of the International Society for Heart Research (ISHR), Louisville, Kentucky, 06/2000 Cerebral vascular hyperpolarizing influences mechanistically inhibit blood flow autoregulation: a Yin-Yang hypothesis for hypothesis for cytochrome P450 metabolites, Third Workshop on Endothelium-Derived Hyperpolarizing Factor, Abbaye des Vaux de Cernay, France, 06/2000 XVII World Congress of International Society, Winnipeg, Canada, 07/2001 Invited Speaker, EDHF Workshop, Paris, France, 06/2002 Invited Speaker, 24th Annual Meeting of the ISHR, Madison, Wisconsin, 07/2002 Invited Speaker, XIV World Conference of Pharmacology, San Francisco, California, 07/2002 Invited Speaker, The University of British Columbia, Vancouver, B.C., 08/2002 Invited Speaker, ISHR, Mystic, Connecticut, 06/2003 Invited Speaker and Session Chair, 8th ISRA, Angers, France, 06/2004 Invited Speaker, International Society for Heart Research, North American Section, Toronto, Canada, 06/2006 Speaker, 5th Int’l EDHF Symposium, Tampere, Finland, 06/2008 Invited Co-Chair, Speaker, 11th Annual International Winter Eicosanoid Conference, 03/2009 Gebremedhin D, Zhang DX, Carver KA, Rau N, Roman RJ, Harder DR, Expression of CYP 4A-?-hydroxylase and formation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cultured rat brain astrocytes, 16th International Winter Eicosanoid Conference, Baltimore, Maryland, 03/13/2016 - 03/16/2016 COMMITTEE SERVICE: Medical College 1984 - 1987 Executive Committee, Department of Neurology 1985 - 1987 Chairman, Education Committee, Department of Neurology 1987 Neurobiology Director Search Committee 1990 - 1994 Rank and Tenure Committee 1991 Chairman, Cardiovascular Research Center Executive Committee 1992 - 1994 Basic Science Chair Committee 1992 - Present Strategic Research and Planning Committee 1997 - Present Clinical Research Center Advisory Board 1998 Cardiology Chair Search Committee 8 / 22 1999 - Present Research Space Advisory Board 2000 - Present Cardiovascular Strategy Committee 2000 - Present Budget Committee 2000 - Present Cardiovascular Board Development Committee 2000 - 2003 Technology Transfer Committee 2002 - Present Angiographic Suite Committee 2002 - Present Translational Medicine Committee 2002 - Present Executive Committee of the Faculty 2009 Grants and Awards Committee, MCW Foundation MEDICAL COLLEGE TEACHING ACTIVITIES: Medical Student Education 1983 - 1995 CNS physiology lectures to medical students in Dept. of Physiology Continuing Medical Education 2008 - Present Associate Dean for Research: the primary responsibility of this post is to mentor research intensive clinical faculty in the writing and prosecution of extramural grants, including VA Merit Review and Clinician investigator awards. Graduate Student Education 1983 - 1995 Graduate courses in cell physiology. Approximately 32 contact hours/year. Graduate courses in cell physiology and signal transduction. 2010 - Present Special course in NIH Grant Preparation “Methods in Grant Preparation” (Syllabus can be found on www.ctsi.mcw.edu ) EXTRAMURAL TEACHING: Medical Student Education 1978 - 1980 East Tennessee State University, Dept. of Physiology, Taught 25% of medical physiology lectures plus labs. (This was a new medical school.) Duties included developing curriculum, teaching labs, and course implementation for medical students. MCW STUDENTS, FACULTY, RESIDENTS AND CLINICAL/RESEARCH FELLOWS MENTORED: Graduate Students PhD Students Advised Nabil Alkayed, Medical College of Wisconsin, 1996 Andrew Lang, Medical College of Wisconsin, 1997 Lucas Hart, Medical College of Wisconsin, 2009 Pallabi Sarkar, Medical College of Wisconsin, 2012 Students Advised Reza Taheri, Medical College of Wisconsin, 2002 Koryn Carver, Medical College of Wisconsin Postdoctoral Students C.F. Sanchez-Ferrer, M.D., Ph.D, Medical College of Wisconsin, Advisor P. Bonnet, M.D., Ph.D, Medical College of Wisconsin, Advisor D. Gebremedhin, Ph.D, Medical College of Wisconsin, Advisor Dr. Yunn-Ha Ma, Ph.D., Medical College of Wisconsin, Advisor Dr. K. Kauser, M.D., Medical College of Wisconsin, Advisor A. Hudetz, Ph.D, Medical College of Wisconsin, Advisor C. Cheliakine, M.D., Medical College of Wisconsin, Advisor P. Li, M.D., Medical College of Wisconsin, Advisor 9 / 22 W. Meng, Ph.D., Medical College of Wisconsin, Advisor E. Birks, DVM, Ph.D., Medical College of Wisconsin, Advisor N. Dovin, M.D., Medical College of Wisconsin, Advisor Meetha Medhora, Ph.D., Medical College of Wisconsin, Advisor Diane Munzenmaier, Ph.D., Medical College of Wisconsin, Advisor Drazen Zagorac, Medical College of Wisconsin, Advisor Johan Bylund, Medical College of Wisconsin, Advisor Ken Yamaura, Medical College of Wisconsin, Advisor Danica Jakovcevic, MD., Medical College of Wisconsin, Advisor Chenyang Zhang, Medical College of Wisconsin, Advisor Nadi Wickramasakera, Ph.D., Medical College of Wisconsin, Advisor Vidudala Prasad, Ph.D., Medical College of Wisconsin, Advisor Maia Terashvili, Ph.D., Medical College of Wisconsin, Advisor David Lourim, Ph. D., Medical College of Wisconsin, Advisor U. Wesselmann, M.D., Ph.D., Medical College of Wisconsin, Advisor J. Madden, Ph.D., Medical College of Wisconsin, Advisor P. Dernback, M.D, Medical College of Wisconsin, Advisor R. Gilbert, M.D, Medical College of Wisconsin, Advisor A. Waters, M.D., Medical College of Wisconsin, Advisor J. Smeda, Ph.D, Medical College of Wisconsin, Advisor ADVISORY ACTIVITIES / GRANT REVIEWS:: 1989 - 1993 National Institutes of Health; National Heart, Lung and Blood Institute, Bethesda, MD: Experimental Cardiovascular Sciences Study Section, Ad-Hoc 1989 - 1993 National Institutes of Health; National Heart, Lung and Blood Institute, Bethesda, MD: Clinical Sciences Study Section 1992 NIH Site Visit, Program Projects in Vascular Biology 1994 NIH delegate to Japan 1996 NIH, RFA Study Section on Mechanisms of Angiogenesis 1996 - 1999 National American Heart Association Molecular Signaling Study Section 2000 - Present NIH Experimental Cardiovascular Sciences (ECS) Study Section CONSULTANTSHIPS: Uniformed Services University, Department of Physiology, Bethesda, Maryland Squibb Institute for Medical Research, Upjohn Pharmaceuticals, Kalamazoo, Michigan Cytometix, Inc. - Cytometix, Inc., was founded in the Fall of 2004 as a partnership between TechStar and David Harder, Director of the Cardiovascular Center (CVC) at the Medical College of Wisconsin (MCW). Cytometix is a privately funded, emerging pharmaceutical company focused on pre-clinical development of a lipid compound for pain. Cytometix was awarded an SBIR grant to validate the prospective use of this analgesic therapy from the National Institute on Drug Abuse (NIDA). Cytometix is also in early development of a therapeutic for asthma. The company has obtained over $8million dollars in Private Investment Capital (Angel Investments). An IND Application from FDA is currently pending. We anticipate initiation of Phase 1 Clinical Trials beginning November 1 2012. Berlex Laboratories, Inc., University of Louisville, Department of Physiology RESEARCH INTERESTS: Mechanisms Controlling Autoregulation of Blood Flow Role of Ionic Mechanisms in Activating Arterial and Arteriolar Smooth Muscle Tumor Angiogenesis in Brain Pain – Behavioral Study Electrophysiology of Excitable Tissues -Ion channels -Voltage gated mechanisms -Receptor operated mechanisms Control of Renal Blood Flow Cytochrome P450 Metabolites in the Control of Vascular Smooth Muscle and Endothelium 10 / 22

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Journal of Vascular Research. Journal Review. Stroke. American Journal of Physiology - all sections. Arteriosclerosis and Thrombosis. Cardiovascular
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