Cyclic Nucleotide Phosphodiesterases in Health and Disease PDF
Preview Cyclic Nucleotide Phosphodiesterases in Health and Disease
Cyclic Nucleotide Phosphodiesterases in Health and Disease edited by Joseph A. Beavo Sharron H. Francis Miles D. Houslay Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Group, an informa business Cover art was kindly provided by Dr. Robert X. Xu, Structural Sciences RTP, GlaxoSmithKline, Research Triangle Park, NC. CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2007 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Printed in the United States of America on acid-free paper 10 9 8 7 6 5 4 3 2 1 International Standard Book Number-10: 0-8493-9668-9 (Hardcover) International Standard Book Number-13: 978-0-8493-9668-7 (Hardcover) This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. No part of this book may be reprinted, reproduced, transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying, microfilming, and recording, or in any informa- tion storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http:// www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC) 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For orga- nizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging-in-Publication Data Cyclic nucleotide phosphodiesterases in health and disease / editors, Joseph Beavo, Sharron Francis, and Miles Houslay. p. ; cm. Includes bibliographical references and index. ISBN-13: 978-0-8493-9668-7 (alk. paper) ISBN-10: 0-8493-9668-9 (alk. paper) 1. Cyclic nucleotide phosphodiesterases. I. Beavo, Joseph. II. Francis, Sharron H. III. Houslay, Miles D. [DNLM: 1. Phosphoric Diester Hydrolases--physiology. 2. Nucleotides, Cyclic--physiology. 3. Phosphodiesterase Inhibitors--therapeutic use. QU 136 C9953 2006] QP609.C92C93 2006 612’.01513--dc22 2006018995 Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Preface The establishment of a Gordon Research Conference devoted to cyclic nucleotide phospho- diesterases has had an enormous impact on the field by facilitating collaborations and friendships and promoting research in this important area. The final impetus that led to the generationofthisbookwasnurturedfromthissource.Apocryphallyonecanprobablytrace its beginning to an afternoon on the veranda at the 2004 Gordon Conference in Italy where Joe and Miles had been taking in the ambiance of the site and therefore were susceptible to Sharron’s‘‘greatidea’’thatitwastimeforanother‘‘PDEBook.’’So,withsuchanauspicious start, and after Sharron agreed to help, we began this project for an all-encompassing book on ‘‘PDEology.’’ ThelastmajorbookcompendiumdedicatedtocyclicnucleotidePDEswaspublishedover 15 years ago.* During this time an enormous amount of progress has occurred in the PDE field so a revised update on this topic is clearly needed. For example, the number of PDEfamiliesinmammalshasincreasedfromfivetoeleven:threefamiliesarecAMP-specific; three families are cGMP-specific; and five families hydrolyze both cAMP and cGMP well. CharacterizationsofgeneticknockoutsforseveralPDEshavestartedtoappear. Thecrystal structures of catalytic domains for nine PDEs (some complexed with inhibitors or product) and one regulatory domain have been published. Intracellular binding partners for several PDEs have been found and evidence for select pools of cyclic nucleotides that modulate a variety of processes has led to an appreciation of the regulation of specific cyclic nucleotide poolsbydistinctPDEs.Fromaphysiologicalperspective,wearenowbeginningtounravelat leastsomeoftheuniquecellularrolesfordifferentPDEs.Fromamedicalperspectiveseveral PDE inhibitors are now approved for treatment of a number of different pathological conditions,andtheremarkablemedicalandfinancialsuccessofthePDE5-selectiveinhibitors 1 1 1 marketed as Viagra , Levitra , and Cialis has elevated these medications to blockbuster status. We have been very pleased that the authors for the various chapters in this volume have beenwillingtosetasidetimetocontributeinsuchapositiveway.Indevelopingthisproject, wehavetriedtonotonlycovereachPDEfamilybutalsotohavechaptersthathighlightkey therapeutic and biomedical areas. Inevitably we have missed out on some due to space or deadline limitations and we apologize for this. It has been our privilege to work in such an excitingfieldandinteractwithalargecommunityofenthusiasticandtalentedscientistsfrom allovertheworld.Weareverygratefultoallwhohavecontributedbothdirectlyandindirectly andtrustthatyouwillfindthisbooktobeavaluablereferencesource.Wewouldparticularly liketothankour‘‘betterhalves’’fortheirforbearancewhenwehaveeachbeenlockedaway editing,collating,phoning,cajoling,andwritingoverweekendsandevenings.Enjoy!! Miles, Joseph, and Sharron *Beavo,J.A.andHouslay,M.D.,1990.Cyclicnucleotidephosphodiesterases;structure,function,regulation,anddrug action,inMolecularPharmacologyofCellRegulation,1sted.,Houslay,M.D.,344pp.Chichester:JohnWiley&Sons. Editors Joseph A. Beavo is a professor of pharmacology at the University of Washington. He obtained a BS from Stetson University in Deland, Florida and then a PhD from Vanderbilt University in Nashville, Tennessee. He has been involved in research concerning cyclic nucleotide phosphodiesterases since his graduate work with Drs. Joel Hardman and Earl Sutherland in the 1960s. Heis an active member ofthe American Society forPharmacology andExperimentalTherapeuticsandtheNationalAcademyofSciences,havingservedonthe editorialboardsofjournalspublishedbybothorganizations.Hiscurrentresearchfocuseson the structural mechanisms of regulation of cyclic nucleotide phosphodiesterases and also on the functionalroles played by the different phosphodiesterase gene products. Sharron H. Francis is a research professor of molecular physiology and biophysics at Van- derbiltUniversitySchoolofMedicineinNashville,Tennessee.Sheobtainedherundergradu- ate degree with emphasis in biology and chemistry from the Western Kentucky State in Bowling Green; studies for her doctoral degree in physiology were performed at Vanderbilt University under the guidance of Jane Park, PhD. She did postdoctoral study with Dr. Herman Eisen at Washington University in St. Louis, Missouri and was a research fellow in the Laboratory of Biochemistry at the National Heart and Lung Institute in Bethesda, Maryland under the guidance of Earl Stadtman, PhD. She is an active member of the American Society for Biochemistry and Molecular Biology, served the Scientific Advisory BoardforCellPathways,Inc.,andalsohasservedasaconsultantfornumerouspharmaceu- tical companies. Her research interests focus on mechanisms involved in cGMP signaling, molecular characteristics of cGMP-dependent protein kinase, and phosphodiesterase-5, whicharetargetsofcGMP,andthefeaturesthatcontributetopotentinhibitionofphospho- diesterase-5byselectiveinhibitors. Miles D. Houslay is a Gardiner professor of biochemistry at the University of Glasgow, Scotland, UK. He obtained his first degree in biochemistry at the University of Wales in Cardiff and then his PhD from King’s College, Cambridge. He has held faculty positions at the Universities of Cambridge and Manchester. He is a fellow of the Royal Society of Edinburgh, Colworth Medal Holder of the British Biochemical Society, has served as mem- ber=chair of numerous grant agencies, and has consulted widely in the pharmaceutical industry. He has been involved in cell signaling research since its inception. His current research interest is focused on the role of phosphodiesterase-4 isoforms in underpinning cAMP compartmentalization and cross-talk processes and potential for identifying novel therapeutic opportunities. Contributors Einar M.Aandahl Jackie D. Corbin University ofOslo Vanderbilt UniversitySchool ofMedicine Oslo, Norway Nashville,Tennessee AniellaAbi-Gerges Rick H. Cote INSERM, Universityof Paris University ofNew Hampshire Cha^tenay-Malabry,France Durham,New Hampshire Joseph A. Beavo Shireen-A. Davies University ofWashington University ofGlasgow Seattle, Washington Glasgow,Scotland Andrew T.Bender Jonathan P.Day University ofWashington University ofGlasgow Seattle, Washington Glasgow,Scotland Emmanuel P. Bessay Eva Degerman Vanderbilt UniversitySchool Lund University of Medicine Lund, Sweden Nashville,Tennessee Sara A. Epperson Mitsi A. Blount Schoolof Medicine Vanderbilt UniversitySchool University ofCalifornia atSan Diego of Medicine La Jolla,California Nashville,Tennessee Laure Favot GraemeB. Bolger Poˆle BiologieSante´ UFRSFA University ofAlabama Poitiers, France atBirmingham Birmingham, Alabama Rodolphe Fischmeister Laurence L. Brunton INSERM, Universityof Paris Schoolof Medicine Chaˆtenay-Malabry, France University ofCalifornia atSan Diego La Jolla,California Sharron H. Francis Vanderbilt UniversitySchool ofMedicine Liliana R.V. Castro Nashville,Tennessee INSERM, Universityof Paris Chaˆtenay-Malabry,France Mark A. Giembycz University ofCalgary Marco Conti Instituteof Infection, Immunity Stanford UniversitySchool ofMedicine and Inflammation Stanford,California Calgary, Alberta, Canada LenaStenson Holst Claire Lugnier Lund University CNRS, Universite´ Louis Pasteur Lund, Sweden (Strasbourg I) Illkirch, France MilesD. Houslay University ofGlasgow M.R.MacLean Glasgow, Scotland University ofGlasgow Glasgow, Scotland Kye-Im Jeon University ofRochester School Vincent Manganiello of Medicine and Dentistry NationalInstitutes ofHealth Rochester, New York Bethesda, Maryland S.-L. CatherineJin Sergio E. Martinez Stanford University School University ofWashington of Medicine Seattle, Washington Stanford, California DonaldH. Maurice Junichi Kambayashi Queen’sUniversity Otsuka Maryland Medicinal Kingston, Ontario, Canada Laboratories LLC Rockville, Maryland JeffreyM.McKenna CelgeneCorporation HengmingKe San Diego,California The University of North Carolina Chapel Hill, NorthCarolina Frank S. Menniti Pfizer Global Researchand The´re`se Keravis Development Universite´ Louis Pasteur Groton, Connecticut (Strasbourg I) Illkirch, France Tamar Michaeli AlbertEinsteinCollege of Medicine Jun Kotera of Yeshiva University Tanabe Seiyaku Co. Ltd. Bronx,New York Saitama, Japan Eun-YiMoon Christina Kruuse Korea Instituteof Bioscience University ofCopenhagen and Biotechnology Glostrup, Denmark Taejon,Korea Adam Lerner Matthew A. Movsesian BostonMedical Center VA Salt Lake City Health Care System Boston, Massachusetts University ofUtah Salt Lake City, Utah Yongge Liu Otsuka Maryland Medicinal GeorgeW.Muller Laboratories, LLC CelgeneCorporation Rockville, Maryland Summit, New Jersey F. Murray ChristineA. Strick Schoolof Medicine Pfizer Global Research University ofCalifornia atSan Diego and Development La Jolla,California Groton,Connecticut David J. Nagel Kjetil Taske´n University ofRochester School University ofOslo of Medicineand Dentistry Oslo, Norway Rochester, New York Rothewelle Tate James M.O’Donnell University ofStrathclyde West Virginia University Health Glasgow,Scotland Sciences Center Morgantown, West Virginia Douglas G. Tilley ClinicalResearch Laboratory Kenji Omori Duke University Tanabe Seiyaku Co. Ltd. Durham,North Carolina Saitama, Japan Sanjay Tiwari N.J. Pyne University Hospital Schleswig-Holstein University ofStrathclyde Luebeck,Germany Glasgow, Scotland Gre´goire Vandecasteele Wito Richter INSERM, University of Paris Stanford UniversitySchool ofMedicine Chaˆtenay-Malabry, France Stanford,California ValeriaVasta Francesca Rochais University ofWashington INSERM, Universityof Paris Seattle, Washington Chaˆtenay-Malabry,France Huanchen Wang ChristopherJ. Schmidt The University ofNorthCarolina Pfizer Global Research and Development Chapel Hill, North Carolina Groton,Connecticut Laurent Wentzinger University ofBerne Thomas Seebeck Berne, Switzerland University ofBerne Berne, Switzerland Oliwia Witczak University ofOslo Yasmin Shakur Oslo, Norway OtsukaMaryland Medicinal Laboratories, LLC Chen Yan Rockville, Maryland University ofRochester School of MedicineandDentistry Antonio P. Silva Rochester, New York NovartisPharma AG Basel, Switzerland Han-TingZhang Carolyn J.Smith West Virginia University Health Medsn Inc. Sciences Center Jersey City, New Jersey Morgantown, West Virginia
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