Current Trends in Lithium and Rubidium Therapy: Proceedings of an International Symposium on Lithium and Rubidium Therapy held in Venice, 29 September–1st October 1983 PDF
Preview Current Trends in Lithium and Rubidium Therapy: Proceedings of an International Symposium on Lithium and Rubidium Therapy held in Venice, 29 September–1st October 1983
Current Trends in Lithium and Rubidium Therapy Current Trends in Lithium and Rubidium Therapy EDITED BY Professor Giovanni (lmberto Corsini Department of Clinical Pharmacology University of CagJiari Italy Proceedings of an International Symposium on Uthium and Rubidium Therapy held in Venice, 29 September-1st October 1983 ~ M.TP PRESS LIM.ITED .- ~ a member of the KLUWER ACADEMIC PUBLISHERS GROUP , LANCASTER / BOSTON / THE HAGUE / DORDRECHT Published in the UK and Europe by MTP Press Limited Falcon House Lancaster, England British Ubrary Cataloguing in Publication Data Current trends in lithIum and rubidium therapy. 1 . Lithium-Therapeutic use 2. Rubidium-Therapeutic use I. Corsini, G. U. 616.89'18 RC483.5.L5 ISBN-13: 978-94-011-7320-9 Published in the USA by MTP Press A division of Kluwer Boston Inc 190 Old Derby Street Hingham, MA 02043, USA Library of Congress Cataloging in Publicatiqn Data International Symposium on Lithium and Rubidium Therapy (1983: Venice, Italy) Current trends in lithium and rubidium therapy. Includes bibliographical references. 1. Mental illness - Chemotherapy - Congresses. 2. Lithium - Therapeutic use - Congresses. 3. Rubidium Therapeutic use - Congresses. I. Corsini, Giovanni Umberto. II. Title. (DNLM: 1. Lithium-therapeutic use congresses. 2. Mental Disorders - drug therapy - congresses. 3. Rubidium - therapeutic use - congresses. Ovn.9 158c 1983) RC483.5.L5158 1983 616.89'18 84-10042 ISBN-13: 978-94-011-7320-9 e-ISBN-13: 978-94-011-7318-6 001: 10.1007/978-94-011-7318-6 Copyright © 1984 MTP Press Limited Softcover reprint of the hardcover 15t edition 1984 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying recording or otherwise, without prior permission from the p~blishers. Contents Preface ix List of Contributors xi Acknowledgements xvii PART I: INTRODUCTION AND HISTORICAL REVIEW Recent developments in lithium treatment and research M. Schou 3 2 Lithium treatment of mania and depression over one hundred years A. Amdisen 11 PART II: MECHANISM OF ACTION OF LITHIUM AND RUBIDIUM 3 Some recent and some not-so-recent findings on the behavioural effects of lithium in animals ~ N.Johnson 29 4 Opposite effects of lithium and rubidium on neurohormone stimulated cyclic AMP accumulation in rat brain A. Geisler, R. Klysner and P. H. Andersen 37 v vi CURRENT TRENDS IN LITHIUM AND RUBIDIUM THERAPY 5 The effect of rubidium and lithium on adenylate cyclase and neurotransmitter receptors R. H. Be/maker. R. Hamburger-Bar. M. Newman and J. Bannet 59 6 Does lithium prevent the development of dopamine receptor supersensitivity? Behavioural studies H. M. Calil and F. C. Rodrigues 77 PART III: CLINICAL ASPECTS OF LONG-TERM LITHIUM TREATMENT 7 Critical issues in the evaluation of long-term lithium treatment C. L. Cazzullo and E. Sacchetti 95 8 A prospective study of long-term lithium treatment. An interim report L. Smigan and C. Perris 111 9 Lithium dosage and prophylaxis. A double-blind controlled study A. Coppen and K. Wood 125 10 Lithium discontinuation in bipolar illness: a double-blind prospective controlled study J. Mendlewicz 135 11 Lithium treatment in schizoaffective patients M. Del Zompo. A. Bocchetta. C. Burrai. M. Melis. and G. U. Corsini 143 12 Static and kinetic study of the RBC/plasma lithium ratio in manic-depressive. schizoaffective and schizophrenic patients in thymic remission: significance for diagnosis and monitoring P. Deniker. H. Loo. J. P. Olie. C. Gay. C. Benkelfat. and P. Binet 151 13 Lithium prophylaxis in major affective disorders: on the specificity and sensitivity of some "new" predictors of treatment outcome E. Sacchetti. A. Vita. G. Conte and A. Pennati 165 14 Practical value of biological and psychological indicators in predicting response to lithium prophylaxis of manic depressive psychosis M. Maj. F. Arena. R. Pirozzi and D. Kemali 189 CURRENT TRENDS IN LITHIUM AND RUBIDIUM THERAPY vii 15 Outcome to treatment with lithium in affective patients and family history E. Smeraldi, F. Macciardi, M. Gasperini and L. Bellodi 201 16 Antidepressant-induced switch and outcome to lithium prophylaxis in bipolar patients G. Conte, A. Vita, A. Alciati, A. Pennati and E. Sacchetti 211 PART IV: CLINICAL ASPECTS OF LONG-TERM RUBIDIUM TREATMENT 17 Rubidium salts in depressed patients. An open pilot study using standardized techniques P. Sarteschi, G. F. Placidi, A. Lenzi, E. Rampello and G. B. Cassano 225 18 Preliminary results with rubidium in depressed patients G. U. Corsini, M. Reda, C. Burrai, A. Poddighe and N. Rudas 247 19 The use of rubidium chloride in depressive disorders: clinical aspects M. Casacchia, A. Rossi, V. Marola and G. Meco 255 PART V: NEW ASPECTS IN LITHIUM AND RUBIDIUM TREATMENT 20 The effect of lithium treatment in humans of psychophysiological increases and decreases in heart rate S. Chazan-Gologorsky, P. Golan, S. Kugelmass and R. H. Belmaker 263 21 Left ventricular performance following lithium treatment M. R. Pisano, R. Fonzo, M. Del Zompo, P. Bonomo, G. U. Corsini and A. Cherchi 273 22 Lithium carbonate and granulocyte function during cancer chemotherapy. Preliminary report S. Milani, G. Mustacchi, F. De Lazzer, P. Sandri, S. De Luyk, C. Piccinini, N. Ferrantelli, L. Linda and E. Rorai 281 23 Cancer chemotherapy induced neutropenia: effects of lithium carbonate E. T. Menichetti, R. R. Silva and R. Cellerino 287 viii CURRENT TRENDS IN LITHIUM AND RUBIDIUM THERAPY 24 Lithium and rubidium compounds in cluster headache: overview and perspectives F. Savoldi, G. Bono, G. C. Manzoni, G. Micieli, M. Lanfranchi and G. Nappi 299 25 Lithium therapy in cluster headache. Effect on iris neuro muscular junction M. Fanciullacci, U. Pietrini, M. Boccuni and F. Sicuteri 311 26 Changes in tubular enzymes during acute lithium treatment A. Lenzi, M. Tuoni, E. Rampello, R. Palla, P. Fornaro and G. F. Placidi 317 27 Prophylactic efficacy of carbamazepine in lithium-resistant affective disorders M. Del Zompo, C. Burrai, M. P. Piccardi, A. Marelli and G. U. Corsini 325 Preface Lithium research and therapy needs to be continually re-evaluated on the basis of modern methodological approaches in order to shed new light on the mechanism of action and to improve therapeutic use. This book. based on the proceedings of the "International Meeting on Lithium and Rubidium Therapy" held in Venice from September 30th to October 2nd 1983. is devoted to current trends in the pharmacology and clinical aspects of lithium and of a newly born therapeutic cation. rubidium. The first part of this volume deals with modern trends in behavioural and biochemical approaches to the mechanism of action of lithium. A larger consideration is reserved for lithium therapy from a clinical point of view and includes re-assessment of long-term treatment with regard to serum levels. biological and psychological predictors. side-effects and new therapeutic uses. A smaller section is concerned with some recent clinical studies on rubidium. This volume should be an invaluable aid to all psychiatrists and those who work in the field of research of these pharmacological active metals. G. U. Corsini List of contributors A. ALCIATI L. BELLODI Institute of Clinical Psychiatry Institute of Clinical Psychiatry University of Milan University of Milan Milan Milan Italy Italy R. H. BELMAKER A. AMDISEN Jerusalem Mental Health Center Psychopharmacology Research Unit Ezrath Nashim Aarhus University, Jerusalem Psychiatric Hospital. Israel Risskov, Denmark C. BENKELFAT P. H. ANDERSEN Mental Health Service Department of Pharmacology Hospital S.te Anne University of Copenhagen, Paris Copenhagen, Denmark France P. BINET F. ARENA Mental Health Service Psychiatric Clinic Hospital S.te Anne University of Naples Paris Naples France Italy A. BOCCHETTA J. BANNET Clinical Pharmacology Jerusalem Mental Health Center University of Cagliari Jerusalem Cagliari Israel Italy xi xii CURRENT TRENDS IN LITHIUM AND RUBIDIUM THERAPY M. BOCCUNI S. CHAZAN·GOLOGORSKY Institute of Internal Medicine Department of Psychology and Clinical Pharmacology Hebrew University University of Florence Jerusalem Florence Israel Italy A. CHERCHI G. BONO Department of Cardiology Headache Centre University of Cagliari University of Pavia Cagliari Pavia Italy Italy G.CONTE P. BONOMO Institute of Clinical Psychiatry University of Milan Department of Cardiology University of Cagliari Milan Cagliari Italy Italy A.COPPEN C. BURRAI MRC Neuropsychiatry Research Clinical Phamacology Laboratory University of Cagliari West Park Hospital Cagliari Epsom Italy Surrey England H. M. CAUL Department of Psychobiology G. U. CORSINI School of Medicine Clinical Pharmacology Sao Paolo University of Cagliari Brazil Cagliari Italy M. CASACCHIA Institute of Psychiatry F De LAZZER University of L' Aquila Centre for the Diagnosis and Aquila Treatment of Tumours Italy Trieste Italy G.B.CASSANO Institute of Clinical Psychiatry S. De LUYK University of Pisa Scientific Institute Burlo Garofolo Pisa Trieste Italy Italy C. L. CAZZULLO M. DeiZOMPO Institute of Clinical Psychiatry Clinical Pharmacology University of Milan University of Cagliari Milan Cagliari Italy Italy R. CELLERINO P. DENIKER Clinical Oncology Mental Health Service University of Ancona Hospital S.te Anne Ancona Paris Italy France
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