Current Aspects of Blood Coagulation, Fibrinolysis, and Platelets

191 Pages·1993·5.166 MB·English

by  J. Stenflo, M. Selander, E. Persson, J. Astermark, C. Valcarce, T. Drakenberg (auth.), Ming-Ching Shen, Che-Ming Teng, Akikazu Takada (eds.)

The Second Sino-Japanese Symposium on Coagulaton, Fibrinolysis, and Platelets,
October 3 -5, 1992, Taipei, Taiwan.
M.-C. Shen · C.-M. Teng ·A. Takada(Eds.)
Current Aspects
of Blood Coagulation,
Fibrinolysis, and Platelets
With 100 Figures
Springer Japan KK
MING-CHING SHEN
Professor and Chairman, Department of Laboratory Medicine, National Taiwan
University Hospital, Taipei, Taiwan
CHE-MING TENG
Professor and Chairman, Department of Pharmacology, College of Medicine, National
Taiwan University, Taipei, Taiwan
AKIKAZU TAKADA
Professor and Chairman, Department of Physiology, Hamamatsu University, School of
Medicine, Hamamatsu, Shizuoka, 431-31 Japan
ISBN 978-4-431-70123-1 ISBN 978-4-431-68323-0 (eBook)
DOI 10.1007/978-4-431-68323-0
Printed on acid-free paper
©Springer Japan 1993
Originally published by Springer-Verlag Tokyo Berlin Heidelberg New York in 1993
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Preface
The first Sino-Japanese symposium on Coagulation, Fibrinolysis and
Platelets, originating from the Hamamatsu symposium, held in early 1990,
was held in Hanchow, Mainland China in October, 1990. During that
meeting, Taipei was selected as the next meeting place. We took great
pleasure in carrying out this noble endeavor and were honored to have
Professor Stenflo, Professor Hedner from Sweden, Professor Aoki and many
other distinguished scientists from Japan joining us on this Second
Sino-Japanese symposium. Our only regret was that our friends from
Mainland China did not attend.
The topics covered during the 3-day symposium included areas of
both basic and clinical research. The symposium has been an excellent
opportunity for all the participants to exchange ideas and improve their
expertise, and at the same time, to expand frontiers in the field of
coagulation, fibrinolysis and platelets. The symposium was very
successful both in terms of contributing greatly to raise the level of
research and development in the field of thrombosis and hemostasis and
in helping to promote international scientific cooperation and
friendship.
We would like to express our appreciation to the members of our
organizing and scientific committee for their devotion to this project.
We also wish to thank our National Science Council and Department of
Health, and the Asia and Pacific Council for Science and Technology, as
well as the many other sponsors for their financial support. Without
them, this instructive and invaluable symposium and this proceedings
would not have been possible.
Oct. 6, 1992 Ming-Ching Shen
CHe-Ming Teng
Akikazu Takada
Taipei, R.O.C.
Contents
Coagulation and its regulation
!.CALCIUM BINDING PROPERTIES OF VITAMIN K-DEPENDENT CLOTIING FACTORS.
J. Stenflo, M. Selander, E. Persson, J. Astermark, C. Valcarce and T. Drakenberg. 3
2.THROMBOMODULIN: ITS EXPRESSION AND RELEASE INTO THE ORCUlATION.
Nobuo Aoki, Shin-Ichi Ohdama and Kazunori Hirokawa. 14
3.RECOGNITION SITES FOR THROMBOMODULIN, PROCOAGUlANT AND ANTI
COAGULANT PROTEINS AROUND THE ACTIVE CENTER OF THROMBIN.
Koji Suzuki and Junji Nishioka. 17
4.HEPARIN-BINDING SITE(S) OF ANTITHROMBIN III, HISTIDINE-RICH GLYCOPROTEIN
AND ACTIVATED PROTEIN C.
T. Koide. 23
5.THE CLEAVAGE OF A SERINE PROTEASE INHIBITOR AT THE REACTIVE CENTER BY
ITS T ARGEf PROTEASE: ANALYSIS OF THE SUBSTRATE-LIKE FORM OF A SERPIN.
Tetsumei Urano, Kiyohito Serizawa, Kenji Sakakibara, Leif Strandberg, Tor Ny, Yumiko Takada
and Akikazu Takada. 29
6.THE STRUCTURAL CHARACTERIZATION OF COAGUlATION FACTOR IX/FACTOR X
BINDING PROTEIN ISOlAT ED FROM THE VENOM OF TRIMERESURUS FlAV OVIRIDIS.
Takashi Morita and Hideko Atoda. 35
7.THE HEMOLYMPH COAGULATION SYSTEM OF SHRIMPS.
Inn-Ho Tsai, Yuh-Ling Chen and Jin-Hwa Chen. 41
Disorders of coagulation, fibrinolysis, platelets and thrombosis
8.STUDIES OF FACTOR VIII INHIBITORS IN CHINESE HEMOPHILIA A PATIENTS.
Ming-Ching Shen, Shu-Wha Lin, Pei-Chu Yang and Chin-Chin Huang. 49
9.HEMOPHILIA A: CHARACTERIZATION OF GENEriC DEFECfS BY THE SINGLE STRAND
CONFORMATION POLYMORPHISM (SSCP).
Shu-Wha Lin, Shu-Rung Lin and Ming-Ching Shen. 55
IO.POSSIBLE INVOLVEMENT OF PlATELET ACTIVATING FACTOR (PAF) IN TISSUE
FACTOR GENERATION AND THE PATHOGENESIS OF DISSEMINATED INTRA
VASCULAR COAGULATION (DIC).
Z. Terashita, M. Kawamura, Y. lmura and K. Nishikawa. 58
ll.PREVENTION OF VITAMIN K DEFICIENCY IN THE EARLY NEONATAL PERIOD-
PROPHYLACTIC ORAL ADMINISTRATION OF VATAMIN K (MK-4) TO PREGNANT
CASES--.
H. Shimada, E. takashima, M. Ikeuchi, Y. Ono, T. Hoshino, M. Nonogaki, M. Yamashita, K.
Paku, K. Ohkura, M. Sohma and S. Kasakura. 64
12.THE EFFECT OF ARGATROBAN ON THE ABILITY OF GLYCEROL TO INHIBIT
CEREBRAL EDEMA AND THE EFFECT OF THE CO-ADMINISTRATION OF
ARGATROBAN WITH T-PA AND HEPARIN ON BLEEDING TIME.
K. Tanabe, Y. Honda and M. Iwamoto. 70
VIII
13.EFFECTS OF ANTICOAGULANTS ON THROMBOLYSIS MEDIATED BY TISSUE
PLASMINOGEN ACTIVATOR IN EXPERIMENTAL THROMBOSIS MODEL.
Katsumi Nakagawa, Hajime Tsuji, Keizo Yamada, Mitsuru Yoneda, Osamu Takada, Yuka
Yamada, Haruchika Masuda, Masashi Uno, Toshiyuki Tamagaki, Masahito Yamagami, Kazuharu
Katoh, Katsumi Yamamoto, Kyoichiro Kobayashi, Shohei Sawada and Masao Nakagawa. 76
14.THE RELATIONSHIP BETWEEN PLASMA FIBRONECTIN RECEPTOR LEVELS AND
PREECLAMPSIA.
Naohiro Kanayama and Toshihiko Terao. 82
IS.HEMOSTA TIC AND FIBRINOLYTIC CHANGES IN HERPES ZOSTER.
Y. Yoshizawa, Y. Shinozaki, S.lzaki and K. Kitamura. 88
16.STUDY ON HYPERACTIVATED STATE OF COAGULATION AND FIBRINOLYSIS.
K.Deguchi, T. Tsukada, K. Oonishi, S.Murashima and M. Nishikawa. 93
17.FLOW' CYTOMETRIC ANALYSIS OF TUMOR-ASSOCIATED PROTEASES WITH SPECIAL
REFERENCE TO uPA/PAI-1 COMPLEX.
N. Moniwa, T. Terao, N. Chucholowski, M. Schmitt and H. Graeff. 98
18.RELATIONSHIPS BETWEEN THE CONCENTRATIONS OF u-PA, t-PA. PAI-I AND PAI-2IN
TUMOR TISSUES AND PERITONEAL WASHINGS, AND TUMOR PROGRESSION IN
GASTRIC CANCER.
N. Nishino, M. Nakamura, H. Konno, S. Baba, K. Aoki, 0. Yonekawa, E.Hamada. T. Kanno.
S. Takahashi, M. Cho, T. Urano, Y. Takada and A. Takada. 104
19.THE ROLE OF HEMODYNAMICS IN ATHEROGENESIS.
Kinji Sakakibara, Terue Sakakibara, Michael C.K. Chang and Shu Chien. 110
Fibrinolysis
20.THE PHYSIOLOGY OF THE FIBRINOLYTIC SYSTEM.
Akikazu Takada. 117
2I.CONFORMATIONAL CHANGE OF OLD-PLASMINOGEN: EFFECTS OF N-TERMINAL
PEPTIDES OF OLD-PLASMINOGEN.
Yumiko Takada, Tetsumei Urano, Salomi Takahashi, Kenji Sakakibara and Akikazu Takada. 123
22.EFFECT OF CALCIUM ION ON THE EUGLOBULIN CLOT LYSIS TIME: SIGNIFICANT
SHORTENING BY PHYSIOLOGICAL CONCENTRATION OF CALCIUM ION ION.
Yumi Kozima, Tetsumei Urano, Kenji Sakakibara, Kiyohito Serizawa, Yumiko Takada and
Akikazu Takada. 129
23.THE ROLE OF PLATELET PAI-l IN THE PLATELET RICH PLASMA CLOT LYSIS.
K. Serizawa, T. Urano, Y. Kozima, K. Sakakibara, Y. Takada and A. Takada. 135
24.THE DISSOCIATION OF a2-PLASMIN-INHIBITOR-PLASMIN COMPLEX TO ACTIVE
PLASMIN BY SDS TREATMENT.
Dong Yan, Tetsumei Urano, Yumiko Takada and Akikazu Takada. 140
Platelets and antithrombotic agents
25.COLLAGEN-INDUCED PLATELET AGGREGATION WAS MIMICKED BY SNAKE VENOM
PROTEIN AND INHIBITED BY PLANT COMPONENT.
Che-Ming Teng, Feng-Nien Ko, Chien-Huang Lin and Chong-Nan Lin. 147
IX
26.ANTIPLATELET ACTIVITY OF A THROMBIN-LIKE ENZYME IN EXPERIMENTAL
RABBITS.
Tur-Fu Huang and Mei-Chi Chang. 152
27.EFFECT OF PLASMINOGEN ACTIVATOR ON PLATELET AGGREGATION.
Akira Suehiro, Satoshi Higasa, Motoo Ueda, Yo shio Oura, Yasuharu Nishida and Eizo Kakishita.
159
28.ARACHIDONATE 12-LlPOXYGENASE OF HUMAN PLATELETS.
Shozo Yamamoto, Satoshi Matsuda, Jun Murakami, Yasuchika Yamamoto, Yumiko Konishi,
Chieko Yokoyama, Toshiya Arakawa, Yoshitaka, Takahashi, Tanihiro Yoshimoto, Yasuo Mimura
and Minoru Okuma. 165
29.CLINICAL EFFECT OF ANTIPLATELET THERAPY FOR CEREBRAL THROMBOSIS-
COMPARISON OF TWO GROUPS WITH DIFFERENT CONTROL OF HYPER
AGGREGABILITY --.
Y. Homma, A. Hattori, S. Ito, Niigata stroke and anti platelet therapy study group. 171
30.EFFECTS OF INTRACELLULAR pH ON THE ANTITHROMBOTIC PROPERTIES OF
HUMAN VASCULAR ENCOTHELIAL CELLS.
Masahito Yamagami, Shohei Sawada, Toshiyuki Tamagaki, Kyoichiro Kobayashi, Kazuharu Kato,
Katsumi Yamamoto, Kaoru Shirai, Keizo Yamada, Haruchika Masuda, Katsumi Nakagawa,
Hajime Tsuji and Masao Nakagawa. 175
31.IS PLATELET CYTOSOLIC FREE CALCIUM AND SEROTONIN CONCENTRATION
DIFFERENT BETWEEN HYPERTENSIVE AND NORMOTENSIVE CHINESE SUBJECTS?
Yu-An Ding, Tz-Chong Chou and Wei-Shou Hwang. 183
Coagulation and
its regulation