Crossroads between Innate and Adaptive Immunity III PDF
Preview Crossroads between Innate and Adaptive Immunity III
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research JOHN D. LAMBRIS, University of Pennsylvania RODOLFO PAOLETTI, University of Milan For further volumes: http://www.springer.com/series/5584 wwwwwwwwwwwwww Bali Pulendran Peter D. Katsikis • Stephen P. Schoenberger Editors Crossroads Between Innate and Adaptive Immunity III Editors Bali Pulendran, Ph.D. Stephen P. Schoenberger, Ph.D. Emory University La Jolla Institute for Allergy Emory Vaccine Center and Yerkes and Immunology National Primate Research Center Laboratory of Cellular Immunology 954 Gatewood Road 9420 Athena Circle Atlanta, GA 30329 La Jolla, CA 92037 USA USA [email protected] [email protected] Peter D. Katsikis, M.D., Ph.D. Drexel University College of Medicine Department of Microbiology and Immunology 2900 Queen Lane Philadelphia, PA 19129 USA [email protected] ISSN 0065-2598 ISBN 978-1-4419-5631-6 e-ISBN 978-1-4419-5632-3 DOI 10.1007/978-1-4419-5632-3 Springer New York Dordrecht Heidelberg London © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) Preface This volume presents a collection of reviews derived from work presented at the Aegean Conference, “3rd Crossroads between Innate and Adaptive Immunity,” which occured from September 27 to October 2, 2009 at the Minoa Palace Conference Center in Chania, Crete, Greece. This meeting was the third in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The various facets of the innate response, including dendritic cells, T cells, B cells, NK cells, NK-T cells and the complement cascade during the host response to pathogens and tumors is only now starting to be elucidated. The respective fields that focus on these immune cells and molecules have tended to be relatively compartmentalized, and yet emerging evidence points to the interconnectedness of these facets in coordinating the innate response, and its subsequent impact on the adaptive response. The goal of this confer- ence was to initiate cross-talk between these diverse immunological fields, and promote and facilitate discussion on the interactions between the innate immune response and the adaptive immune response and ultimately facilitate collaboration between these areas of study. Following on the footsteps of the outstanding success of its precursors, the “3rd Crossroads between Innate and Adaptive Immunity” Aegean Conference was highly successful in bringing together and connecting scientists and experts from around the world to address critical areas of Innate and Adaptive Immunity. v wwwwwwwwwwwwww Acknowledgements We are grateful to all the participants of this conference whose enthusiasm and willing- ness to share new data and discuss new ideas truly represent the lifeblood of the “Crossroads” experience. Those who have contributed chapters to this book deserve an extra measure of our gratitude, as we are keenly aware of the dedication they have shown to this field through their extraordinary efforts in this regard. We are indebted to our colleagues at Springer for giving us the support and opportunity to publish these proceedings in their Advances in Experimental Medicine and Biology Book Series, with special thanks to Samantha Lewis for her great help in assembling and formatting the chapters. As always, we are deeply indebted to the Aegean Con- ference Organization for the outstanding job they do in making this possible, and particularly to Dimitrios Lambris for his superb organizational, logistical and inter- personal skills, that make this meeting such an effortless pleasure for the three of us. Finally, we wish to express our most sincere gratitude to the various organizations that made this meeting possible, through their very generous support, including the Aegean Conferences, Centocor, Drexel University, Springer, Pfizer, and Kirin. We look forward to seeing all of you in 2011! Peter D. Katsikis M.D., Ph.D. Bali Pulendran, Ph.D. Stephen P. Schoenberger, Ph.D. vii wwwwwwwwwwwwww Contents 1 Is Transcription the Dominant Force During Dynamic Changes in Gene Expression? ............................................................... 1 Martin Turner 2 MicroRNAs: Key Components of Immune Regulation ...................... 15 Donald T. Gracias and Peter D. Katsikis 3 KIR/HLA: Genetic Clues for a Role of NK Cells in the Control of HIV ............................................................................. 27 Lena Fadda and Galit Alter 4 Natural Killer Cell Licensing During Viral Infection ......................... 37 Mark T. Orr and Lewis L. Lanier 5 Bridging Innate NK Cell Functions with Adaptive Immunity ....................................................................... 45 Emanuela Marcenaro, Simona Carlomagno, Silvia Pesce, Alessandro Moretta, and Simona Sivori 6 Control of Innate Immunity by Memory CD4 T Cells ....................... 57 Tara M. Strutt, K. Kai McKinstry, and Susan L. Swain 7 Strategies and Implications for Prime-Boost Vaccination to Generate Memory CD8 T Cells ........................................................ 69 Jeffrey C. Nolz and John T. Harty 8 Blimp1: Driving Terminal Differentiation to a T ................................ 85 Annie Xin, Stephen L. Nutt, Gabrielle T. Belz, and Axel Kallies 9 A New Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis ............................... 101 Vasiliki Koliaraki and George Kollias 10 Impact of Differential Glycosylation on IgG Activity ......................... 113 Anja Lux and Falk Nimmerjahn ix x Contents 11 Murine Model of Chronic Respiratory Inflammation ........................ 125 Amit A. Lugade, Paul N. Bogner, and Yasmin Thanavala 12 Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1 .................................. 143 Aftab A. Ansari, Ann E. Mayne, Yoshiaki Takahashi, and Kovit Pattanapanyasat 13 Influenza Vaccines: What Do We Want and How Can We Get It? ...................................................................... 161 Felix Geeraedts and Anke Huckriede
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